1.3.1.48: 13,14-dehydro-15-oxoprostaglandin 13-reductase
This is an abbreviated version!
For detailed information about 13,14-dehydro-15-oxoprostaglandin 13-reductase, go to the full flat file.
Reaction
11alpha-hydroxy-9,15-dioxoprostanoate +
NAD(P)+=
(13E)-11alpha-hydroxy-9,15-dioxoprost-13-enoate +
NAD(P)H +
H+
Synonyms
15-hydroxyprostaglandin dehydrogenase, 15-keto-PG reductase, 15-ketoprostaglandin DELTA-13-reductase, 15-ketoprostaglandin DELTA13-reductase, 15-ketoprostaglandinDELTA13-reductase, 15-oxoprostaglandin 13-oxidase, 15-oxoprostaglandin 13-reductase, 15-oxoprostaglandin DELTA13-reductase, 15-oxoprostaglandin-DELTA13-reductase, 15-PGDH, Ad-PGR, bifunctional leukotriene B4 12-hydroxydehydrogenase/15-oxo-prostaglandin 13-reductase, bifunctional LTB4 12-hydroxydehydrogenase/15-oxo-prostaglandin 13-reductase, DELTA13-15-ketoprostaglandin reductase, leukotriene B4 12-hydroxydehydrogenase/15-ketoprostaglandin 13-reductase, leukotriene B4 dehydrogenase, leukotriene B4-12-hydroxydehydrogenase/15-oxo-prostaglandin 13-reductase, LTB4 12-HD/PGR, LTBDH/PGR, NAD(P)H-dependent alkenal/one oxidoreductase, PG reductase, PGR, PGR-2, PGR1, prostaglandin 13-reductase, prostaglandin DELTA13-reductase, prostaglandin reductase 1, reductase, 15-oxo-DELTA13-prostaglandin
ECTree
KM Value
KM Value on EC 1.3.1.48 - 13,14-dehydro-15-oxoprostaglandin 13-reductase
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0.093
(5S,12R)-dihydroxy-(6E,8Z,10Z,14E)-eicosatetraenoic acid
-
-
0.0085
15-keto-prostaglandin E2
-
-
0.0075
15-ketoprostaglandin A1
-
-
0.0112
15-ketoprostaglandin B1
-
-
0.001 - 0.0344
15-ketoprostaglandin E1
0.0078 - 0.07
15-ketoprostaglandin E2
0.0592 - 0.184
15-ketoprostaglandin F1alpha
0.000213 - 0.1088
15-ketoprostaglandin F2alpha
0.21
4-hydroxy-2-hexenal
-
-
0.12 - 0.461
4-hydroxy-2-nonenal
0.258
6,15-diketo-prostaglandin F1alpha
-
-
1.7
alpha-methylcinnamaldehyde
-
-
0.0277 - 0.039
benzylidene acetone
0.1399
benzylidene acetonphenone
-
in 100 mM phosphate buffer (pH 7.4), at 25°C
0.075 - 1.426
cinnamaldehyde
0.0791
cinnamoylthiophene
-
in 100 mM phosphate buffer (pH 7.4), at 25°C
0.11
ethylvinylketone
-
-
0.01
leukotriene B4
-
recombinant enzyme
0.1289
Methyl vinyl ketone
-
in 100 mM phosphate buffer (pH 7.4), at 25°C
0.58
methylvinylketone
-
-
0.063
nicotinamide hypoxanthine dinucleotide
-
-
0.0123
phenyl propenyl ketone
-
in 100 mM phosphate buffer (pH 7.4), at 25°C
0.063
reduced nicotinamide hypoxanthine dinucleotide phosphate
-
-
-
0.41
trans,trans-2,4-nonadienal
-
-
0.06
trans-2-dodecenal
-
-
1 - 2.194
trans-2-hexenal
0.046
trans-2-nonenal
-
-
0.001
15-ketoprostaglandin E1
-
-
0.0039
15-ketoprostaglandin E1
-
-
0.0077
15-ketoprostaglandin E1
-
-
0.0083
15-ketoprostaglandin E1
-
recombinant enzyme
0.01
15-ketoprostaglandin E1
-
human placenta
0.03
15-ketoprostaglandin E1
-
bovine lung
0.0344
15-ketoprostaglandin E1
in 0.1 M Tris-HCl (pH 7.4), at 37°C
0.0078
15-ketoprostaglandin E2
-
in 100 mM phosphate buffer (pH 7.4), at 25°C
0.0127
15-ketoprostaglandin E2
-
-
0.0182
15-ketoprostaglandin E2
-
recombinant enzyme
0.019
15-ketoprostaglandin E2
-
-
0.0496
15-ketoprostaglandin E2
in 0.1 M Tris-HCl (pH 7.4), at 37°C
0.062
15-ketoprostaglandin E2
-
-
0.07
15-ketoprostaglandin E2
-
-
0.0592
15-ketoprostaglandin F1alpha
in 0.1 M Tris-HCl (pH 7.4), at 37°C
0.184
15-ketoprostaglandin F1alpha
-
-
0.000213
15-ketoprostaglandin F2alpha
-
-
0.0108
15-ketoprostaglandin F2alpha
-
-
0.1088
15-ketoprostaglandin F2alpha
in 0.1 M Tris-HCl (pH 7.4), at 37°C
0.12
4-hydroxy-2-nonenal
-
-
0.461
4-hydroxy-2-nonenal
-
in 100 mM phosphate buffer (pH 7.4), at 25°C
0.0277
benzylidene acetone
-
in 100 mM phosphate buffer (pH 7.4), at 25°C
0.039
benzylidene acetone
-
-
0.075
cinnamaldehyde
-
-
1.426
cinnamaldehyde
-
in 100 mM phosphate buffer (pH 7.4), at 25°C
0.032
NADH
-
-
0.16
NADH
-
recombinant enzyme
0.005 - 0.009
NADPH
-
-
0.016
NADPH
-
recombinant enzyme
0.0946
NADPH
in 0.1 M Tris-HCl (pH 7.4), at 37°C
1
trans-2-hexenal
-
-
2.194
trans-2-hexenal
-
in 100 mM phosphate buffer (pH 7.4), at 25°C
1.3.1.48 13,14-dehydro-15-oxoprostaglandin 13-reductase
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