1.3.1.48: 13,14-dehydro-15-oxoprostaglandin 13-reductase

This is an abbreviated version!
For detailed information about 13,14-dehydro-15-oxoprostaglandin 13-reductase, go to the full flat file.

Word Map on EC 1.3.1.48

1.3.1.48

eicosanoids

15-hydroxyprostaglandins

15-pgdh

cyclooxygenases

acylfulvene

Reaction

(13E)-11alpha-hydroxy-9,15-dioxoprost-13-enoate

Synonyms

15-hydroxyprostaglandin dehydrogenase, 15-keto-PG reductase, 15-ketoprostaglandin DELTA-13-reductase, 15-ketoprostaglandin DELTA13-reductase, 15-ketoprostaglandinDELTA13-reductase, 15-oxoprostaglandin 13-oxidase, 15-oxoprostaglandin 13-reductase, 15-oxoprostaglandin DELTA13-reductase, 15-oxoprostaglandin-DELTA13-reductase, 15-PGDH, Ad-PGR, bifunctional leukotriene B4 12-hydroxydehydrogenase/15-oxo-prostaglandin 13-reductase, bifunctional LTB4 12-hydroxydehydrogenase/15-oxo-prostaglandin 13-reductase, DELTA13-15-ketoprostaglandin reductase, leukotriene B4 12-hydroxydehydrogenase/15-ketoprostaglandin 13-reductase, leukotriene B4 dehydrogenase, leukotriene B4-12-hydroxydehydrogenase/15-oxo-prostaglandin 13-reductase, LTB4 12-HD/PGR, LTBDH/PGR, NAD(P)H-dependent alkenal/one oxidoreductase, PG reductase, PGR, PGR-2, PGR1, prostaglandin 13-reductase, prostaglandin DELTA13-reductase, prostaglandin reductase 1, reductase, 15-oxo-DELTA13-prostaglandin

ECTree

1 Oxidoreductases

1.3 Acting on the CH-CH group of donors

1.3.1 With NAD⁺ or NADP⁺ as acceptor

1.3.1.48 13,14-dehydro-15-oxoprostaglandin 13-reductase

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Results	in table
2927	AA Sequence
1	CAS Registry Number
9	Cloned(Commentary)
21	Cofactor
3	Crystallization (Commentary)
35	Disease/ Diagnostics
3	General Information
22	IC50 Value
55	Inhibitors
5	Ki Value [mM]
72	KM Value [mM]
3	Localization
1	Metals/Ions
9	Molecular Weight [Da]
10	Natural Substrates/ Products (Substrates)
21	Organism
6	Pathway
22	PDB ID
3	pH Optimum
2	pH Range
13	Purification (Commentary)
1	Reaction
4	Reaction Type
21	Reference
31	Source Tissue
22	Specific Activity [micromol/min/mg]
8	Storage Stability
123	Substrates and Products (Substrate)
3	Subunits
31	Synonyms
1	Systematic Name
7	Temperature Optimum [°C]
28	Turnover Number [1/s]

Specific Activity

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Specific Activity on EC 1.3.1.48 - 13,14-dehydro-15-oxoprostaglandin 13-reductase

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0.00026

Bos taurus

enzyme activity in cornea, substrate 15-ketoprostaglandin, cofactor NADPH

390825

0.000389

Bos taurus

enzyme activity in retina, substrate 15-ketoprostaglandin, cofactor NADPH

390825

0.00085

Bos taurus

enzyme activity in retinal pigment epithelium, substrate 15-ketoprostaglandin, cofactor NADPH

390825

0.000945

Bos taurus

enzyme purified from iris-ciliary cytosol

390825

0.0012

Bos taurus

enzyme activity in ciliary body, substrate 15-ketoprostaglandin, cofactor NADPH

390825

0.00145

Bos taurus

enzyme activity in iris, substrate 15-ketoprostaglandin, cofactor NADPH

0.0405

0.115

using 15-ketoprostaglandin E1 as a substrate, at 37°C

687562

0.1784

Mus musculus

Q8VDQ1

using 15-ketoprostaglandin E2 as a substrate, at 37°C

687562

0.2064

Mus musculus

Q8VDQ1

using 15-ketoprostaglandin F1alpha as a substrate, at 37°C

687562

0.2309

Mus musculus

Q8VDQ1

using 15-ketoprostaglandin F2alpha as a substrate, at 37°C

0.393

0.425

1.067

2.05

2.56

2.6

recombinant enzyme expressed in Escherichia coli

390827

additional information

4 entries