1.2.1.75: malonyl-CoA reductase (malonate semialdehyde-forming)
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Reaction
Synonyms
bi-functional malonyl-CoA reductase, malonate semialdehyde reductase, malonate-semialdehyde dehydrogenase, malonyl CoA reductase (malonate semialdehyde-forming), malonyl-CoA reductase, MCR, More, MSAR
ECTree
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Crystallization
Crystallization on EC 1.2.1.75 - malonyl-CoA reductase (malonate semialdehyde-forming)
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crystallization trials of the full-length MCR fail, thus production of the N-terminal domain (MCRND, Met1-Pro567) and the C-terminal domain (MCRCD, Gly568-Val1230) separately, X-ray diffraction structure determination and analysis at resolutions of 2.20 and 1.80 A, respectively, by a single-wavelength anomalous dispersion (SAD) method
N-terminal domain, hanging drop vapor diffusion method, using 10% (w/v) PEG3350, 200 mM lithium sulfate, 100 mM Tris-HCl, pH 8.0. C-terminal domain, hanging drop vapor diffusion method, using 1.6 M lithium sulfate and 100 mM HEPES, pH 8.0
malonyl-CoA reductase in the substrate-free state at 2.05 A resolution and in complex with NADP+ at 1.9 A resolution and in complex with CoA at 2.4 A resolution