1.2.1.75: malonyl-CoA reductase (malonate semialdehyde-forming)

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Reaction

Synonyms

bi-functional malonyl-CoA reductase, malonate semialdehyde reductase, malonate-semialdehyde dehydrogenase, malonyl CoA reductase (malonate semialdehyde-forming), malonyl-CoA reductase, MCR, More, MSAR

ECTree

1 Oxidoreductases

1.2 Acting on the aldehyde or oxo group of donors

1.2.1 With NAD⁺ or NADP⁺ as acceptor

1.2.1.75 malonyl-CoA reductase (malonate semialdehyde-forming)

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Results	in table
1	Activating Compound
8	AA Sequence
8	Application
1	CAS Registry Number
13	Cloned(Commentary)
25	Cofactor
4	Crystallization (Commentary)
3	Expression
13	General Information
1	IC50 Value
2	Inhibitors
2	kcat/KM [mM/s]
7	KM Value [mM]
1	Localization
6	Metals/Ions
10	Molecular Weight [Da]
19	Natural Substrates/ Products (Substrates)
28	Organism
8	Pathway
14	PDB ID
3	pH Optimum
4	pH Range
34	Protein Variants
5	Purification (Commentary)
3	Reaction
25	Reference
3	Source Tissue
4	Specific Activity [micromol/min/mg]
37	Substrates and Products (Substrate)
14	Subunits
43	Synonyms
1	Systematic Name
4	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 1.2.1.75 - malonyl-CoA reductase (malonate semialdehyde-forming)

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malonate semialdehyde:NADP+ oxidoreductase (malonate semialdehyde-forming)

Requires Mg2+. Catalyses the reduction of malonyl-CoA to malonate semialdehyde, a key step in the 3-hydroxypropanoate and the 3-hydroxypropanoate/4-hydroxybutanoate cycles, autotrophic CO2 fixation pathways found in some green non-sulfur phototrophic bacteria and some thermoacidophilic archaea, respectively [1,2]. The enzyme from Sulfolobus tokodaii has been purified, and found to contain one RNA molecule per two subunits [3]. The enzyme from Chloroflexus aurantiacus is bifunctional, and also catalyses the next reaction in the pathway, EC 1.1.1.298 [3-hydroxypropionate dehydrogenase (NADP+)] [4].