1.2.1.48: long-chain-aldehyde dehydrogenase
This is an abbreviated version!
For detailed information about long-chain-aldehyde dehydrogenase, go to the full flat file.
Word Map on EC 1.2.1.48
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1.2.1.48
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sls
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ichthyosis
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spastic
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faldh
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aldh3a2
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neurocutaneous
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diplegia
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tetraplegia
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sjogren-larsson
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amadhs
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phytanic
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aminoaldehyde
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photophobia
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larsson
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quadriplegia
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alcohol:nad+
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glistening
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medicine
- 1.2.1.48
- sls
- ichthyosis
- spastic
- faldh
- aldh3a2
-
neurocutaneous
- diplegia
- tetraplegia
-
sjogren-larsson
- amadhs
-
phytanic
- aminoaldehyde
-
photophobia
-
larsson
- quadriplegia
-
alcohol:nad+
-
glistening
- medicine
Reaction
Synonyms
ALDH, ALDH10, ALDH3A2, Aldh3b1, ALDH3B2, ALDH3B3, Bt-Aldh, dehydrogenase, long-chain aliphatic aldehyde, FAldDH, FALDH, fatty aldehyde dehydrogenase, fatty aldehyde:NAD+ oxidoreductase, long-chain aldehyde dehydrogenase, long-chain fatty aldehyde dehydrogenase, long-chain-aldehyde dehydrogenase, membrane-bound fatty aldehyde dehydrogenase
ECTree
1.2.1.48 long-chain-aldehyde dehydrogenaseAdvanced search results
results (
results (Substrates Products
Substrates Products on EC 1.2.1.48 - long-chain-aldehyde dehydrogenase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
2-hydroxyhexadecanal + NAD+ + H2O
2-hydroxyhexadecanoic acid + NADH + 2 H+
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-
-
-
?
4,4'-diapolycopendial + NAD+ + H2O
4,4'-diapolycopen-4'-al-4-oic acid + NADH + H+
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-
-
-
?
a long-chain aldehyde + NAD+ + H2O
a long-chain carboxylate + NADH + 2 H+
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-
-
?
dihydrophytal + NAD+ + H2O
(3R,S,7R,11R)-3,7,11,15-tetramethylhexadecanoic acid + NADH
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-
-
?
hexanal + NAD+ + H2O
hexanoic acid + NADH + H+
50% of the activity with tetradecanal
-
-
?
m-fluorobenzaldehyde + NAD+ + H2O
m-fluorobenzoic acid + NADH + H+
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-
-
?
m-methylbenzaldehyde + NAD+ + H2O
m-methylbenzoic acid + NADH
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36% activity toward tetradecanal
-
?
o-fluorobenzaldehyde + NAD+ + H2O
o-fluorobenzoic acid + NADH + H+
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-
-
?
p-chlorobenzaldehyde + NAD+ + H2O
p-chlorobenzoic acid + NADH + H+
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-
-
?
p-fluorobenzaldehyde + NAD+ + H2O
p-fluorobenzoic acid + NADH + H+
-
-
-
?
trans-2-decenal + NAD+ + H2O
trans-2-decenoic acid + NADH
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32% activity toward tetradecanal
-
?
trans-cinnamaldehyde + NAD+ + H2O
trans-cinnamic acid + NADH
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38% activity toward tetradecanal
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?
benzaldehyde + NAD+ + H2O
benzoate + NADH + H+
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66% activity toward tetradecanal
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?
benzaldehyde + NAD+ + H2O
benzoate + NADH + H+
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66% activity toward tetradecanal
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?
benzaldehyde + NAD+ + H2O
benzoate + NADH + H+
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-
-
?
cis,cis-9,12-octadecadienal + NAD+ + H2O
cis,cis-9,12-octadecadienoic acid + NADH
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-
-
?
cis,cis-9,12-octadecadienal + NAD+ + H2O
cis,cis-9,12-octadecadienoic acid + NADH
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major substrate
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-
?
cis,cis-9,12-octadecadienal + NAD+ + H2O
cis,cis-9,12-octadecadienoic acid + NADH
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major substrate
-
-
?
cis,cis-9,12-octadecadienal + NAD+ + H2O
cis,cis-9,12-octadecadienoic acid + NADH
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major substrate
-
-
?
cis-9-hexadecenal + NAD+ + H2O
cis-9-hexadecenoic acid + NADH
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31% activity toward tetradecanal
-
?
dodecanal + NAD+ + H2O
dodecanoic acid + NADH + H+
50% of the activity with tetradecanal
-
-
?
long-chain aldehyde + NAD+
?
-
the enzyme plays a significant role in n-alkane utilization, especially in intracellular wax ester synthesis
-
-
?
long-chain aldehyde + NAD+
?
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in microsomes and mitochondria: provides long-chain fatty acids to be utilized for lipid synthesis
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-
?
long-chain aldehyde + NAD+
?
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in peroxisomes: provides long-chain fatty acids to be degraded via beta-oxidation to yield energy and cell constituents
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-
?
long-chain aldehyde + NAD+
?
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mobilization of intracellular wax esters in the cotyledon during germination
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-
?
long-chain aldehyde + NAD+
?
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enzyme is a functional part of the bioluminescent system
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-
?
long-chain aldehyde + NAD+
?
-
in microsomes and mitochondria: provides long-chain fatty acids to be utilized for lipid synthesis
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-
?
long-chain aldehyde + NAD+
?
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in peroxisomes: provides long-chain fatty acids to be degraded via beta-oxidation to yield energy and cell constituents
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-
?
long-chain aldehyde + NAD+ + H2O
long-chain acid anion + NADH
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-
-
?
long-chain aldehyde + NAD+ + H2O
long-chain acid anion + NADH
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-
-
?
long-chain aldehyde + NAD+ + H2O
long-chain acid anion + NADH
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-
-
?
long-chain aldehyde + NAD+ + H2O
long-chain acid anion + NADH
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-
-
?
long-chain aldehyde + NAD+ + H2O
long-chain acid anion + NADH
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-
-
?
long-chain aldehyde + NAD+ + H2O
long-chain acid anion + NADH
-
-
-
?
long-chain aldehyde + NAD+ + H2O
long-chain acid anion + NADH
-
-
-
?
long-chain aldehyde + NAD+ + H2O
long-chain acid anion + NADH
-
-
-
?
octanal + NAD+ + H2O
octanoic acid + NADH + H+
50% of the activity with tetradecanal
-
-
?
phytenal + NAD+
phytenic acid + NADH
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the enzyme is involved in the breakdown of phytol
-
-
?
tetradecanal + NAD+ + H2O
tetradecanoic acid + NADH
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highest activity
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?
tetradecanal + NAD+ + H2O
tetradecanoic acid + NADH
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highest activity
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?
tetradecanal + NAD+ + H2O
tetradecanoic acid + NADH + H+
-
-
-
?
additional information
?
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enzyme has high activity against aliphatic long-chain aldehydes such as tetradecanal, Bt-Aldh represents thermophilic aldehyde dehydrogenases responsible for degradation of long-chain alkanes
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-
?
additional information
?
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enzyme displays high activity against aliphatic long-chain aldehydes such as tetradecanal
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-
?
additional information
?
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enzyme has high activity against aliphatic long-chain aldehydes such as tetradecanal, Bt-Aldh represents thermophilic aldehyde dehydrogenases responsible for degradation of long-chain alkanes
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-
?
additional information
?
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enzyme displays high activity against aliphatic long-chain aldehydes such as tetradecanal
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?
additional information
?
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poor substrates: acetaldehyde, propionaldehyde, crotonaldehyde, glutaraldehyde, benzaldehyde, retinaldehyde
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-
?
additional information
?
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Sjögren-Larsson syndrom is an inherited neurocutaneous disease caused by mutations in the ALDH3A2 gene that codes for fatty aldehyde dehydrogenase, an enzyme involved in lipid metabolism. A rich diversity of mutations and haplotype associations is demonstrated in Sjögren-Larsson syndrom
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-
?
additional information
?
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catalytically important residues to be involved in alcohol and aldehyde oxidation are Gln-120, Glu-207, Cys-241, Phe-333, Tyr-410 and His-411
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-
?
additional information
?
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the C-terminal gatekeeper helix is important for directing the substrate specificity of FALDH towards long-chain fatty aldehydes. Substrate funnel properties and substrate specificity, overview
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?
additional information
?
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the C-terminal gatekeeper helix is important for directing the substrate specificity of FALDH towards long-chain fatty aldehydes. Substrate funnel properties and substrate specificity, overview
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-
?
additional information
?
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the enzyme ALDH3B2 exhibits broad substrate preferences from medium- to long-chain aldehydes
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?
additional information
?
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the enzyme ALDH3B2 exhibits broad substrate preferences from medium- to long-chain aldehydes
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?
additional information
?
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the enzyme ALDH3B2 exhibits broad substrate preferences from medium- to long-chain aldehydes
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-
?
additional information
?
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the enzyme ALDH3B3 exhibits broad substrate preferences from medium- to long-chain aldehydes
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-
?
additional information
?
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the enzyme ALDH3B3 exhibits broad substrate preferences from medium- to long-chain aldehydes
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-
?
additional information
?
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the enzyme ALDH3B3 exhibits broad substrate preferences from medium- to long-chain aldehydes
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-
?
additional information
?
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the enzyme plays an important role in insulin action and is deregulated in states associated with altered insulin signaling
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-
?
