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show all sequences of 1.2.1.48

Crystal structure of the NADP+-dependent aldehyde dehydrogenase from Vibrio harveyi: structural implications for cofactor specificity and affinity

Ahvazi, B.; Coulombe, R.; Delarge, M.; Vedadi, M.; Zhang, L.; Meighen, E.; Vrielink, A.; Biochem. J. 349, 853-861 (2000)

Data extracted from this reference:

Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Vibrio harveyi
-
-
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
long-chain aldehyde + NAD+ + H2O
-
390326
Vibrio harveyi
long-chain acid anion + NADH
-
390326
Vibrio harveyi
?
Cofactor
Cofactor
Commentary
Organism
Structure
NADP+
very high specificity and affinity, the residue Arg-210 contributes to the high cofactor affinity through a pi stacking interaction with the adenine ring system of the cofactor
Vibrio harveyi
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
NADP+
very high specificity and affinity, the residue Arg-210 contributes to the high cofactor affinity through a pi stacking interaction with the adenine ring system of the cofactor
Vibrio harveyi
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
long-chain aldehyde + NAD+ + H2O
-
390326
Vibrio harveyi
long-chain acid anion + NADH
-
390326
Vibrio harveyi
?
Other publictions for EC 1.2.1.48
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [C]
Temperature Range [C]
Temperature Stability [C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [C] (protein specific)
Temperature Range [C] (protein specific)
Temperature Stability [C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
741853
Kitamura
Mouse aldehyde dehydrogenase ...
Mus musculus
Biochem. J.
465
79-87
2015
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4
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743336
Keller
A gatekeeper helix determines ...
Homo sapiens
Nat. Commun.
5
4439
2014
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1
6
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3
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724462
Kitamura
Substrate specificity, plasma ...
Homo sapiens
Biochim. Biophys. Acta
1831
1395-1401
2013
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3
3
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725656
Keller
Monitoring of fatty aldehyde d ...
Homo sapiens, Mus musculus, Rattus norvegicus
J. Lipid Res.
51
1554-1559
2010
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17
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9
3
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1
1
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697840
Kato
Gene cloning and characterizat ...
Geobacillus thermoleovorans, Geobacillus thermoleovorans B23
Extremophiles
14
33-39
2009
1
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1
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3
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4
13
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13
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1
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19
1
1
1
2
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1
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1
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1
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670286
Rizzo
Sjoegren-Larsson syndrome: Mol ...
Homo sapiens
Mol. Genet. Metab.
90
1-9
2007
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1
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693389
Lloyd
Characterisation of recombinan ...
Homo sapiens
J. Enzyme Inhib. Med. Chem.
22
584-590
2007
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1
1
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7
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8
1
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1
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1
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10
1
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8
1
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1
1
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7
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8
1
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10
1
1
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8
1
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670285
Gloerich
Bezafibrate induces FALDH in h ...
Homo sapiens
Mol. Genet. Metab.
89
111-115
2006
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1
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4
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668881
Rizzo
Sjoegren-Larsson syndrome: div ...
Homo sapiens
Hum. Mutat.
26
1-10
2005
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655703
Carney
Sjogren-Larsson syndrome: seve ...
Homo sapiens
Hum. Mutat.
24
186
2004
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1
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656268
Demozay
Fatty aldehyde dehydrogenase: ...
Rattus norvegicus
J. Biol. Chem.
279
6261-6270
2004
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656817
van den Brink
Identification of fatty aldehy ...
Homo sapiens
Mol. Genet. Metab.
82
33-37
2004
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390325
Ishige
Long-chain aldehyde dehydrogen ...
Acinetobacter sp., Acinetobacter sp. M-1
Appl. Environ. Microbiol.
66
3481-3486
2000
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1
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10
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1
3
1
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7
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1
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1
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19
2
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2
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1
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1
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10
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2
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390326
Ahvazi
Crystal structure of the NADP+ ...
Vibrio harveyi
Biochem. J.
349
853-861
2000
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390324
Kelson
Human liver fatty aldehyde deh ...
Homo sapiens
Biochim. Biophys. Acta
1335
99-110
1997
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-
10
22
1
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1
1
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2
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1
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2
1
2
23
1
-
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2
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1
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1
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1
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10
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22
1
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1
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1
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2
1
2
23
1
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2
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1
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390327
Croteau
Crystallization and preliminar ...
Vibrio harveyi
Protein Sci.
5
2130-2132
1996
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1
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390323
Ueda
Long-chain aldehyde dehydrogen ...
Candida tropicalis, Yarrowia lipolytica
Methods Enzymol.
188
176-178
1990
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390318
Jenkins
-
Subcellular fractionation of C ...
Candida albicans
J. Gen. Microbiol.
129
1171-1185
1983
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5
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94404
Moreau
-
Enzymes of wax ester catabolis ...
Simmondsia chinensis
Methods Enzymol.
71
804-813
1981
1
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2
2
1
2
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1
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1
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7
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347796
Yamada
Subcellular localization of lo ...
Candida tropicalis
Arch. Microbiol.
128
145-151
1980
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4
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389732
Moreau
Oxidation of fatty alcohol in ...
Simmondsia chinensis
Arch. Biochem. Biophys.
194
422-430
1979
1
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390320
Meighen
Induction of fatty aldehyde de ...
Vibrio harveyi
Biochem. Biophys. Res. Commun.
69
423-430
1976
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