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1.14.14.127: methyl farnesoate epoxidase

This is an abbreviated version!
For detailed information about methyl farnesoate epoxidase, go to the full flat file.

Word Map on EC 1.14.14.127

Reaction

methyl (2E,6E)-farnesoate
+
[reduced NADPH-hemoprotein reductase]
 +
O2
=
juvenile hormone III
 +
[oxidized NADPH-hemoprotein reductase]
 +
H2O

Synonyms

CYP15A1, CYP15A1 protein, EC 1.14.13.202, EcMFE, methylfarnesoate epoxidase, MFE

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.14.127 methyl farnesoate epoxidase

Inhibitors

Inhibitors on EC 1.14.14.127 - methyl farnesoate epoxidase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1-(2-methylpropyl)-5-[4-([4-[3-(trifluoromethyl)-3H-diaziren-3-yl]benzyl]oxy)phenyl]-1H-imidazole
-
bifunctional compound, inhibits juvenile hormone III synthesis by intact glands as well as methyl farnesoate epoxidation by gland homogenates. Using the compound, a radiolabeled and photoactivatable diazirine or benzophenone group can be introduced to label the hydrophobic substrate binding site of the enzyme
5-(2-(benzyloxy)phenyl)-1-(3,7-dimethyloct-6-en-1-yl)-1H-imidazole
-
5-(3-[[(2E)-3,7-dimethylocta-2,6-dien-1-yl]oxy]phenyl)-1-(2-methylpropyl)-1H-imidazole
-
5-[3-(benzyloxy)phenyl]-1-(2-methylpropyl)-1H-imidazole
-
carbon monoxide/oxygen atmosphere
-
half-maximal inhibition at a CO/O ratio of 4.0. Inhibition is reversed by white-light irradiation
-
cytochrome c
-
inhibition by oxidized cytochrome c, 20 microM, 52.4% residual activity
methyl (2E,6E)-3,7-dimethyl-8-(3,4-methylenedioxyphenoxy)-octadienoate
-
inhibits juvenile hormone biosynthesis in vitro by spontaneously active glands, presumably by direct inhibition of the epoxidase, and also inhibits the production of total methyl ester
NADP+
-
2 mM, 57.2% residual activity
[4-([4-[1-(2-methylpropyl)-1H-imidazol-5-yl]phenoxy]methyl)phenyl](phenyl)methanone
-
bifunctional compound, inhibits juvenile hormone III synthesis by intact glands as well as methyl farnesoate epoxidation by gland homogenates. Using the compound, a radiolabeled and photoactivatable diazirine or benzophenone group can be introduced to label the hydrophobic substrate binding site of the enzyme
additional information
-