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1.14.14.127: methyl farnesoate epoxidase

This is an abbreviated version!
For detailed information about methyl farnesoate epoxidase, go to the full flat file.

Word Map on EC 1.14.14.127

Reaction

methyl (2E,6E)-farnesoate
+
[reduced NADPH-hemoprotein reductase]
 +
O2
=
juvenile hormone III
 +
[oxidized NADPH-hemoprotein reductase]
 +
H2O

Synonyms

CYP15A1, CYP15A1 protein, EC 1.14.13.202, EcMFE, methylfarnesoate epoxidase, MFE

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.14.127 methyl farnesoate epoxidase

IC50 Value

IC50 Value on EC 1.14.14.127 - methyl farnesoate epoxidase

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IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0109
1-(2-methylpropyl)-5-[4-([4-[3-(trifluoromethyl)-3H-diaziren-3-yl]benzyl]oxy)phenyl]-1H-imidazole
Diploptera punctata
-
pH 7.3, 30°C
0.06
5-(2-(benzyloxy)phenyl)-1-(3,7-dimethyloct-6-en-1-yl)-1H-imidazole
Diploptera punctata
pH 7.7, 30°C, inhibition of methyl (2E,6E)-farnesoate epoxidation by recombinant CYP15A1 in a reconstituted system
0.0002
5-(3-[[(2E)-3,7-dimethylocta-2,6-dien-1-yl]oxy]phenyl)-1-(2-methylpropyl)-1H-imidazole
Diploptera punctata
pH 7.7, 30°C, inhibition of methyl (2E,6E)-farnesoate epoxidation by recombinant CYP15A1 in a reconstituted system
0.000025
5-[3-(benzyloxy)phenyl]-1-(2-methylpropyl)-1H-imidazole
Diploptera punctata
pH 7.7, 30°C, inhibition of methyl (2E,6E)-farnesoate epoxidation by recombinant CYP15A1 in a reconstituted system
0.0003
[4-([4-[1-(2-methylpropyl)-1H-imidazol-5-yl]phenoxy]methyl)phenyl](phenyl)methanone
Diploptera punctata
-
pH 7.3, 30°C