Literature summary for 1.14.14.127 extracted from

Andersen, J.F.; Ceruso, M.; Unnithan, G.C.; Kuwano, E.; Prestwich, G.D.; Feyereisen, R.
Photoaffinity labeling of methyl farnesoate epoxidase in cockroach corpora allata (1995), Insect Biochem. Mol. Biol., 25, 713-719.

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Inhibitors

Inhibitors	Comment	Organism	Structure
1-(2-methylpropyl)-5-[4-([4-[3-(trifluoromethyl)-3H-diaziren-3-yl]benzyl]oxy)phenyl]-1H-imidazole	bifunctional compound, inhibits juvenile hormone III synthesis by intact glands as well as methyl farnesoate epoxidation by gland homogenates. Using the compound, a radiolabeled and photoactivatable diazirine or benzophenone group can be introduced to label the hydrophobic substrate binding site of the enzyme	Diploptera punctata
[4-([4-[1-(2-methylpropyl)-1H-imidazol-5-yl]phenoxy]methyl)phenyl](phenyl)methanone	bifunctional compound, inhibits juvenile hormone III synthesis by intact glands as well as methyl farnesoate epoxidation by gland homogenates. Using the compound, a radiolabeled and photoactivatable diazirine or benzophenone group can be introduced to label the hydrophobic substrate binding site of the enzyme	Diploptera punctata

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
55000	-	x * 55000, SDS-PAGE	Diploptera punctata

Organism

Organism	UniProt	Comment	Textmining
Diploptera punctata	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
corpus allatum	-	Diploptera punctata	-

Subunits

Subunits	Comment	Organism
?	x * 55000, SDS-PAGE	Diploptera punctata

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.0003	-	pH 7.3, 30°C	Diploptera punctata	[4-([4-[1-(2-methylpropyl)-1H-imidazol-5-yl]phenoxy]methyl)phenyl](phenyl)methanone
0.0109	-	pH 7.3, 30°C	Diploptera punctata	1-(2-methylpropyl)-5-[4-([4-[3-(trifluoromethyl)-3H-diaziren-3-yl]benzyl]oxy)phenyl]-1H-imidazole

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Release 2023.1 (January 2023)