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1.13.11.57: gallate dioxygenase

This is an abbreviated version!
For detailed information about gallate dioxygenase, go to the full flat file.

Word Map on EC 1.13.11.57

Reaction

3,4,5-Trihydroxybenzoate
+
O2
=
(1E)-4-oxobut-1-ene-1,2,4-tricarboxylate

Synonyms

DesB, GA dioxygenase, GALA, gallate 3,4-dioxygenase

ECTree

     1 Oxidoreductases
         1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)
             1.13.11 With incorporation of two atoms of oxygen
                1.13.11.57 gallate dioxygenase

Inhibitors

Inhibitors on EC 1.13.11.57 - gallate dioxygenase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2,2'-dipyridyl
-
2 mM 2,2'-dipyridyl, a specific Fe2+-chelator, abolishes the gallate dioxygenase activity completely
2-Methoxy-4-methylphenol
20.8% inhibition at 5 mM
4-nitrocatechol
H2O2
-
hydrogen peroxide at 1 mM reduces the gallate dioxygenase activity to 15%, and the activity can be partially restored (50% activity of the untreated enzyme) upon addition of 10 mM ascorbate
protocatechuate
most potent inhibitor with mixed (competitive and non-competitive) inhibition profile, 49% inhibition at 5 mM
syringaldehyde
least potent inhibitor, 8.66% inhibition at 5 mM
syringate
16.3% inhibition at 5 mM
vanilliate
24.2% inhibition at 5 mM
-
Vanillin
11.3% inhibition at 5 mM