1.1.1.38: malate dehydrogenase (oxaloacetate-decarboxylating)
This is an abbreviated version!
For detailed information about malate dehydrogenase (oxaloacetate-decarboxylating), go to the full flat file.
Word Map on EC 1.1.1.38
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1.1.1.38
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glucose-6-phosphate
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lipogenic
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phosphoenolpyruvate
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lipogenesis
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isocitrate
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adipose
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citrate
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thyroid
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acetyl-coa
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carboxykinase
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co2
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6-phosphogluconate
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cholesterol
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triglyceride
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succinate
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nadp+
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1.1.1.40
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triiodothyronine
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l-malate
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tricarboxylic
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nadp+-dependent
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6-phosphate
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pentose
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nadp-malic
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nadp-me
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atp-citrate
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triacylglycerols
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pigeon
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fumarate
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oleaginous
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nadp-linked
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anaplerotic
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mesophyll
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refeeding
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pepck
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phosphoglucomutase
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refeed
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oxalacetate
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alpha-glycerophosphate
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dikinase
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nadph-generating
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ascaris
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panicum
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nadp-isocitrate
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crassulacean
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circinelloides
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hydrogenosomal
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5'-deiodinase
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mortierella
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alpina
- 1.1.1.38
- glucose-6-phosphate
-
lipogenic
- phosphoenolpyruvate
-
lipogenesis
- isocitrate
- adipose
- citrate
- thyroid
- acetyl-coa
-
carboxykinase
- co2
- 6-phosphogluconate
- cholesterol
- triglyceride
- succinate
- nadp+
-
1.1.1.40
- triiodothyronine
- l-malate
-
tricarboxylic
-
nadp+-dependent
- 6-phosphate
- pentose
-
nadp-malic
- nadp-me
-
atp-citrate
- triacylglycerols
-
pigeon
- fumarate
-
oleaginous
-
nadp-linked
-
anaplerotic
- mesophyll
-
refeeding
- pepck
- phosphoglucomutase
-
refeed
- oxalacetate
- alpha-glycerophosphate
- dikinase
-
nadph-generating
- ascaris
- panicum
-
nadp-isocitrate
-
crassulacean
- circinelloides
- hydrogenosomal
- 5'-deiodinase
-
mortierella
- alpina
Reaction
Synonyms
m-NAD(P)-ME, maeA, malic enzyme, malic enzyme 2, ME2, MHD, mitochondrial malic enzyme ME2, mitochondrial NAD(P) malic enzyme, mitochondrial NAD(P) malic enzyme ME2, mitochondrial NAD(P)+-dependent malic enzyme, mitochondrial NAD-malic enzyme, NAD+-dependent malic enzyme, NAD-dependent ME, NAD-malic enzyme, NAD-ME, NAD-specific malic enzyme, NADH-dependent malic enzyme, pyruvic-malic carboxylase
ECTree
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General Information
General Information on EC 1.1.1.38 - malate dehydrogenase (oxaloacetate-decarboxylating)
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malfunction
metabolism
isoform Me2 funnels glucose carbons into malate-aspartate shuttle to sustain glycolysis
physiological function
the mitochondrial malic enzyme isoform Me2 functionally couples the mitochondria with aerobic glycolysis in osteoblasts
additional information
knockdown of ME2 does not inhibit insulin release stimulated by glucose, pyruvate or 2-aminobicyclo [2,2,1]heptane-2-carboxylic acid-plus-glutamine
malfunction
enzyme inactivation improves the anaerobic production of four-carbon dicarboxylic acids by recombinant Escherichia coli strains expressing oxaloacetate-forming pyruvate carboxylase
malfunction
knockdown of isoform Me2 markedly reduces the glycolytic flux and impairs osteoblast proliferation and differentiation
the molecular basis for the different allosteric properties and quaternary structural stability of m-NAD(P)-ME, EC 1.1.1.38 and c-NADP-ME, EC 1.1.1.40. The structural features near the fumarate binding site and the dimer interface are highly related to the quaternary structural stability of c-NADP-ME and m-NAD(P)-ME. Lys57 plays functional roles in both the allosteric regulation and the subunit-subunit interaction of humanm-NAD(P)-ME
additional information
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the molecular basis for the different allosteric properties and quaternary structural stability of m-NAD(P)-ME, EC 1.1.1.38 and c-NADP-ME, EC 1.1.1.40. The structural features near the fumarate binding site and the dimer interface are highly related to the quaternary structural stability of c-NADP-ME and m-NAD(P)-ME. Lys57 plays functional roles in both the allosteric regulation and the subunit-subunit interaction of humanm-NAD(P)-ME