EC Number   |
General Information |
Reference |
|---|
   3.2.1.35 | malfunction |
enzyme deficiency reduces survival in macrophages compared to the wild type and stimulates a significantly higher release of proinflammatory cytokines, such as interleukin (IL)-1beta, IL-6, and tumor necrosis factor alpha than the wild type in macrophages as well as in mice |
-, 729824 |
| 3.2.1.35 | malfunction |
HYAL5-deficient epididymal sperm is functionally normal, the loss of SPAM1 results in a remarkably increased accumulation of sperm on the surface or outer edge of the cumulus |
702526 |
| 3.2.1.35 | malfunction |
patients with inflammatory bowel disease have lower platelet HYAL2 levels and activity than healthy controls |
750174 |
| 3.2.1.35 | physiological function |
although fully fertile, Hyal3 null sperm shows delayed cumulus penetration and reduced acrosomal exocytosis. Spam1 null mutants lacking sperm adhesion molecule 1 have significantly diminished Hyal3 activity |
716289 |
| 3.2.1.35 | physiological function |
generation of a deletion mutant in the Caenorhabditis elegans orthologue of mammalian hyaluronidase, Hya-1. Mutant animals are viable and grossly normal, but exhibit defects in vulval morphogenesis and egg-laying and show increased staining with alcian blue, consistent with an accumulation of glycosaminoglycan. A hya-1::GFP reporter is expressed in a restricted pattern in somatic tissues of the animal with strongest expression in the intestine, the PLM sensory neurons and the vulva. Total protein extracts from wild-type animals exhibit chondroitin-degrading but not hyaluronan-degrading activity. Chondroitinase activities are observed at both neutral and acidic pH conditions while both neutral and acidic activities are absent in extracts from Hya-1 mutant strains |
716095 |
| 3.2.1.35 | physiological function |
human platelets degrade the proinflammatory matrix hyaluronan through the activity of HYAL2 and platelet activation causes the immediate translocation of HYAL2 from a distinct population of alpha-granules to platelet surfaces where it exerts its catalytic activity |
750174 |
| 3.2.1.35 | physiological function |
Hyal2, through direct interactions with CD44 and possibly some pericellular hyaluronidase activity requiring acidic foci, suppresses the formation or the stability of the glycocalyx, modulates ezrin-radixin-moesin-related cytoskeletal interactions, and diminishes cell motility |
704586 |
| 3.2.1.35 | physiological function |
hyaluronidase has a strong influence on the intracellular survival of Streptococcus agalactiae and proinflammatory cytokine expression, suggesting that it plays a key role in pathogenicity |
-, 729824 |
| 3.2.1.35 | physiological function |
SPAM1 is involved in sperm penetration through the cumulus matrix |
702526 |
| 3.2.1.35 | physiological function |
the enzyme play a special role in the testes of adult mice being involved in the maturation of sperm or during fertilization |
730003 |
