Reference on EC 6.3.1.9 - trypanothione synthase
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Nadeau, K.C.
Biochemical studies on protein folding chaperones (HSP90 and cyclophilin) and on trypanosomal enzymes (trypanothione and glutathionylspermidine synthetases) (heat shock protein)
Diss. Abstr. Int. B
56
3744
1995
Crithidia fasciculata
-
Smith, K.; Nadeau, K.; Bradley, M.; Walsh, C.; Fairlamb, A.H.
Purification of glutathionylspermidine and trypanothione synthetase from Crithidia fasciculata
Protein Sci.
1
874-883
1992
Crithidia fasciculata
Tetaud, E.; Manai, F.; Barrett, M.P.; Nadeau, K.; Walsh, C.T.; Fairlamb, A.H.
Cloning and characterization of the two enzymes responsible for trypanothione biosynthesis in Crithidia fasciculata
J. Biol. Chem.
273
19383-19390
1998
Crithidia fasciculata (O60993), Crithidia fasciculata
Henderson, G.B.; Yamaguchi, M.; Novoa, L.; Fairlamb, A.H.; Cerami, A.
Biosynthesis of the trypanosomatid metabolite trypanothione: purification and characterization of trypanothione synthetase from Crithidia fasciculata
Biochemistry
29
3924-3929
1990
Crithidia fasciculata
Ondarza, R.N.; Hernandez, E.; Iturbe, A.; Hurtado, G.; Tamayo, E.M.
Detection by HPLC of a trypanothione synthetase activity in vitro from Entamoeba histolytica
Biotechnol. Appl. Biochem.
30
41-45
1999
Crithidia luciliae, Entamoeba histolytica
-
Oza, S.L.; Tetaud, E.; Ariyanayagam, M.R.; Warnon, S.S.; Fairlamb, A.H.
A Single Enzyme Catalyses Formation of Trypanothione from Glutathione and Spermidine in Trypanosoma cruzi
J. Biol. Chem.
277
35853-35861
2002
Trypanosoma cruzi (Q9GT49), Trypanosoma cruzi
Ariyanayagam, M.R.; Oza, S.L.; Guther, M.L.S.; Fairlamb, A.H.
Phenotypic analysis of trypanothione synthetase knockdown in the African trypanosome
Biochem. J.
391
425-432
2005
Trypanosoma brucei
Comini, M.A.; Guerrero, S.A.; Haile, S.; Menge, U.; Lunsdorf, H.; Flohe, L.
Valdiation of Trypanosoma brucei trypanothione synthetase as drug target
Free Radic. Biol. Med.
36
1289-1302
2004
Trypanosoma brucei
Comini, M.; Menge, U.; Wissing, J.; Flohe, L.
Trypanothione synthesis in Crithidia revisited
J. Biol. Chem.
280
6850-6860
2005
Crithidia fasciculata (Q5DM89), Crithidia fasciculata
Oza, S.L.; Shaw, M.P.; Wyllie, S.; Fairlamb, A.H.
Trypanothione biosynthesis in Leishmania major
Mol. Biochem. Parasitol.
139
107-116
2005
Leishmania major (Q711P7), Leishmania major
Oza, S.L.; Wyllie, S.; Fairlamb, A.H.
Mapping the functional synthetase domain of trypanothione synthetase from Leishmania major
Mol. Biochem. Parasitol.
149
117-120
2006
Leishmania major (Q711P7), Leishmania major
Fyfe, P.K.; Oza, S.L.; Fairlamb, A.H.; Hunter, W.N.
Leishmania trypanothione synthetase-amidase structure reveals a basis for regulation of conflicting synthetic and hydrolytic activities
J. Biol. Chem.
283
17672-17680
2008
Leishmania major (Q711P7)
Comini, M.A.; Dirdjaja, N.; Kaschel, M.; Krauth-Siegel, R.L.
Preparative enzymatic synthesis of trypanothione and trypanothione analogues
Int. J. Parasitol.
39
1059-1062
2009
Crithidia fasciculata
Torrie, L.S.; Wyllie, S.; Spinks, D.; Oza, S.L.; Thompson, S.; Harrison, J.R.; Gilbert, I.H.; Wyatt, P.G.; Fairlamb, A.H.; Frearson, J.A.
Chemical validation of trypanothione synthetase: a potential drug target for human trypanosomiasis
J. Biol. Chem.
284
36137-36145
2009
Trypanosoma brucei
Wyllie, S.; Oza, S.L.; Patterson, S.; Spinks, D.; Thompson, S.; Fairlamb, A.H.
Dissecting the essentiality of the bifunctional trypanothione synthetase-amidase in Trypanosoma brucei using chemical and genetic methods
Mol. Microbiol.
74
529-540
2009
Trypanosoma brucei
Fitzgerald, M.P.; Madsen, J.M.; Coleman, M.C.; Teoh, M.L.; Westphal, S.G.; Spitz, D.R.; Radi, R.; Domann, F.E.
Transgenic biosynthesis of trypanothione protects Escherichia coli from radiation-induced toxicity
Radiat. Res.
174
290-296
2010
Trypanosoma cruzi
Saudagar, P.; Dubey, V.K.
Cloning, expression, characterization and inhibition studies on trypanothione synthetase, a drug target enzyme, from Leishmania donovani
Biol. Chem.
392
1113-1122
2011
Leishmania donovani (G5D5D5), Leishmania donovani, Leishmania donovani UR6 (G5D5D5)
Spinks, D.; Torrie, L.S.; Thompson, S.; Harrison, J.R.; Frearson, J.A.; Read, K.D.; Fairlamb, A.H.; Wyatt, P.G.; Gilbert, I.H.
Design, synthesis and biological evaluation of Trypanosoma brucei trypanothione synthetase inhibitors
ChemMedChem
7
95-106
2012
Trypanosoma brucei
Leroux, A.E.; Haanstra, J.R.; Bakker, B.M.; Krauth-Siegel, R.L.
Dissecting the catalytic mechanism of Trypanosoma brucei trypanothione synthetase by kinetic analysis and computational modeling
J. Biol. Chem.
288
23751-23764
2013
Trypanosoma brucei, Trypanosoma brucei 449
Koch, O.; Cappel, D.; Nocker, M.; Jaeger, T.; Flohe, L.; Sotriffer, C.A.; Selzer, P.M.
Molecular dynamics reveal binding mode of glutathionylspermidine by trypanothione synthetase
PLoS ONE
8
e56788
2013
Leishmania major
Vazquez, C.; Mejia-Tlachi, M.; Gonzalez-Chavez, Z.; Silva, A.; Rodriguez-Zavala, J.S.; Moreno-Sanchez, R.; Saavedra, E.
Buthionine sulfoximine is a multitarget inhibitor of trypanothione synthesis in Trypanosoma cruzi
FEBS Lett.
591
3881-3894
2017
Trypanosoma cruzi, Trypanosoma cruzi DTU I
Sousa, A.F.; Gomes-Alves, A.G.; Benitez, D.; Comini, M.A.; Flohe, L.; Jaeger, T.; Passos, J.; Stuhlmann, F.; Tomas, A.M.; Castro, H.
Genetic and chemical analyses reveal that trypanothione synthetase but not glutathionylspermidine synthetase is essential for Leishmania infantum
Free Radic. Biol. Med.
73
229-238
2014
Leishmania infantum (A4I2Z3), Leishmania infantum, Leishmania infantum MHOM / MA / 67 / ITMAP263 (A4I2Z3)
Benitez, D.; Medeiros, A.; Fiestas, L.; Panozzo-Zenere, E.A.; Maiwald, F.; Prousis, K.C.; Roussaki, M.; Calogeropoulou, T.; Detsi, A.; Jaeger, T.; Sarlauskas, J.; Peterlin Masic, L.; Kunick, C.; Labadie, G.R.; Flohe, L.; Comini, M.A.
Identification of novel chemical scaffolds inhibiting trypanothione synthetase from pathogenic trypanosomatids
PLoS Negl. Trop. Dis.
10
e0004617
2016
Leishmania infantum (A4I2Z3), Leishmania infantum, Leishmania infantum JPCM5 /MHOM / MA / 67 / ITMAP263 (A4I2Z3), Trypanosoma brucei brucei (Q8IEX1), Trypanosoma brucei brucei 427 (Q8IEX1), Trypanosoma cruzi (Q9GT49), Trypanosoma cruzi, Trypanosoma cruzi CL Brener (Q9GT49)
Equbal, A.; Suman, S.S.; Anwar, S.; Singh, K.P.; Zaidi, A.; Sardar, A.H.; Das, P.; Ali, V.
Stage-dependent expression and up-regulation of trypanothione synthetase in amphotericin B resistant Leishmania donovani
PLoS ONE
9
e97600
2014
Leishmania donovani (Q8IFU8), Leishmania donovani, Leishmania donovani MHOM / IN / 80 / Dd8 (Q8IFU8), Leishmania donovani MHOM / IN / 83 / Ag (Q8IFU8)
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