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Literature summary for 6.3.1.9 extracted from

  • Spinks, D.; Torrie, L.S.; Thompson, S.; Harrison, J.R.; Frearson, J.A.; Read, K.D.; Fairlamb, A.H.; Wyatt, P.G.; Gilbert, I.H.
    Design, synthesis and biological evaluation of Trypanosoma brucei trypanothione synthetase inhibitors (2012), ChemMedChem, 7, 95-106.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 6.3.1.9

Application

Application Comment Organism
drug development the enzyme is a target for drug development for treatment of human African trypanosomiasis caused by Trypanosoma brucei gambiense and rhodesiense Trypanosoma brucei

Inhibitors

Inhibitors Comment Organism Structure
1,3,5-trimethyl-N-[(5-methyl-2-phenyl-2H-1,2,3-triazol-4-yl)methyl]-1H-pyrazole-4-sulfonamide
-
 Trypanosoma brucei
1-(3-(1-isobutyl-1H-pyrazol-4-yl)-1H-indazol-1-yl)-3,3-dimethylbutan-2-one
-
 Trypanosoma brucei
1-(3-(1H-indol-4-yl)-1H-indazol-1-yl)-3,3-dimethylbutan-2-one
-
 Trypanosoma brucei
1-(3-(3-chlorophenyl)-1H-indazol-1-yl)-3,3-dimethylbutan-2-one
-
 Trypanosoma brucei
1-(3-(3-fluorophenyl)-1H-indazol-1-yl)-3,3-dimethylbutan-2-one
-
 Trypanosoma brucei
1-(3-(3-pyridyl)-1H-indazol-1-yl)-3,3-dimethylbutan-2-one
-
 Trypanosoma brucei
1-(3-(4-chlorophenyl)-1H-indazol-1-yl)-3,3-dimethylbutan-2-one
-
 Trypanosoma brucei
1-(3-(furan-2-yl)-1H-indazol-1-yl)-3,3-dimethylbutan-2-one
-
 Trypanosoma brucei
1-(3-phenyl-1H-indazol-1-yl)-3,3-dimethylbutan-2-one
-
 Trypanosoma brucei
1-(5-(3,5-dichlorophenyl)-2H-tetrazol-2-yl)-3,3-dimethylbutan-2-one
-
 Trypanosoma brucei
1-(5-(3,5-dichlorophenyl)-2H-tetrazol-2-yl)butan-2-one
-
 Trypanosoma brucei
1-(5-(3,5-dichlorophenyl)-2H-tetrazol-2-yl)propan-2-one
-
 Trypanosoma brucei
1-(5-(3,5-difluorophenyl)-2H-tetrazol-2-yl)-3,3-dimethylbutan-2-one
-
 Trypanosoma brucei
1-(5-(3-fluorophenyl)-2H-tetrazol-2-yl)-3,3-dimethylbutan-2-one
-
 Trypanosoma brucei
1-(tert-butylsulfonylmethyl)-3-(3-fluorophenyl)-1H-indazole
-
 Trypanosoma brucei
1-[5-(3-chloro-4-methylphenyl)-2H-tetrazol-2-yl]-3,3-dimethylbutan-2-one
-
 Trypanosoma brucei
2,4-dimethyl-N-[(5-methyl-2-phenyl-2H-1,2,3-triazol-4-yl)methyl]-1,3-thiazole-5-sulfonamide
-
 Trypanosoma brucei
2,4-dimethyl-N-[(5-methyl-2-phenyl-2H-1,2,3-triazol-4-yl)methyl]thiophene-3-sulfonamide
-
 Trypanosoma brucei
2,6-dichloro-N-[(2-phenyl-1,3-thiazol-4-yl)methyl]benzenesulfonamide
-
 Trypanosoma brucei
2,6-dichloro-N-[(3-phenyl-1,2,4-oxadiazol-5-yl)methyl]benzenesulfonamide
-
 Trypanosoma brucei
2,6-difluoro-N-[(2-phenyl-1,3-thiazol-4-yl)methyl]benzenesulfonamide
-
 Trypanosoma brucei
2,6-dimethoxy-N-[(5-methyl-2-phenyl-2H-1,2,3-triazol-4-yl)methyl]benzenesulfonamide
-
 Trypanosoma brucei
2-((tert-butylsulfonyl)methyl)-4-(2-fluorophenyl)thiazole
-
 Trypanosoma brucei
2-((tert-butylsulfonyl)methyl)-4-(2-methylphenyl)thiazole
-
 Trypanosoma brucei
2-((tert-butylsulfonyl)methyl)-4-(3-chlorophenyl)thiazole
-
 Trypanosoma brucei
2-((tert-butylsulfonyl)methyl)-4-(3-methoxyphenyl)thiazole
-
 Trypanosoma brucei
2-((tert-butylsulfonyl)methyl)-4-(phenyl)thiazole
-
 Trypanosoma brucei
2-(3-(3-fluorophenyl)-1H-indazol-1-yl)-1-(piperidin-1-yl)ethanone
-
 Trypanosoma brucei
2-(3-(3-fluorophenyl)-1H-indazol-1-yl)-N,N-dimethylacetamide
-
 Trypanosoma brucei
2-(3-(3-fluorophenyl)-1H-indazol-1-yl)-N-(2-(4-methylpiperazin-1-yl)ethyl)acetamide
-
 Trypanosoma brucei
2-(3-(3-fluorophenyl)-1H-indazol-1-yl)-N-(3-(4-methylpiperazin-1-yl)propyl)acetamide
-
 Trypanosoma brucei
2-(5-(3,5-dichlorophenyl)-2H-tetrazol-2-yl)-N,N-dimethylacetamide
-
 Trypanosoma brucei
2-(5-(3,5-difluorophenyl)-2H-tetrazol-2-yl)-1-phenylethanone
-
 Trypanosoma brucei
2-(tert-butylsulfonylmethyl)-4-(3-trifluoromethylphenyl)thiazole
-
 Trypanosoma brucei
2-methyl-N-((5-methyl-2-phenyl-2H-1,2,3-triazol-4-yl)methyl)propane-2-sulfonamide
-
 Trypanosoma brucei
3,3-dimethyl-1-(3-(1-methyl-1H-indol-4-yl)-1H-indazol-1-yl)butan-2-one
-
 Trypanosoma brucei
3,3-dimethyl-1-(3-(naphthalen-2-yl)-1H-indazol-1-yl)butan-2-one
-
 Trypanosoma brucei
3,3-dimethyl-1-(3-(pyridin-4-yl)-1H-indazol-1-yl)butan-2-one
-
 Trypanosoma brucei
3,3-dimethyl-1-(3-(thiophen-3-yl)-1H-indazol-1-yl)butan-2-one
-
 Trypanosoma brucei
3,3-dimethyl-1-(5-phenyl-2H-tetrazol-2-yl)butan-2-one
-
 Trypanosoma brucei
3,3-dimethyl-1-[5-[3-(trifluoromethyl)phenyl]-2H-tetrazol-2-yl]butan-2-one
-
 Trypanosoma brucei
3,3-dimethyl-1-[5-[4-(trifluoromethyl)phenyl]-2H-tetrazol-2-yl]butan-2-one
-
 Trypanosoma brucei
3,5-dichloro-N-[(2-phenyl-1,3-thiazol-4-yl)methyl]benzenesulfonamide
-
 Trypanosoma brucei
3-((3-(3-fluorophenyl)-1H-indazol-1-yl)methyl)-5-methylisoxazole
-
 Trypanosoma brucei
3-((3-(3-fluorophenyl)-1H-indazol-1-yl)methyl)-5-phenylisoxazole
-
 Trypanosoma brucei
3-(3-fluorophenyl)-1-(pyridin-2-ylmethyl)-1H-indazole
-
 Trypanosoma brucei
3-(3-fluorophenyl)-1-(pyridin-3-ylmethyl)-1H-indazole
-
 Trypanosoma brucei
3-(tert-butylsulfonylmethyl)-1-(3-fluorophenyl)-1H-indazole
-
 Trypanosoma brucei
3-(tert-butylsulfonylmethyl)-1-phenyl-1H-indazole
-
 Trypanosoma brucei
4-((3-(3-fluorophenyl)-1H-indazol-1-yl)methyl)-2,5-dimethyloxazole
-
 Trypanosoma brucei
4-acetyl-N-[(2-phenyl-1,3-thiazol-4-yl)methyl]benzenesulfonamide
-
 Trypanosoma brucei
4-methoxy-N-[(3-phenyl-1,2,4-oxadiazol-5-yl)methyl]benzenesulfonamide
-
 Trypanosoma brucei
4-methoxy-N-[[3-(2-methylphenyl)-1,2,4-oxadiazol-5-yl]methyl]benzenesulfonamide
-
 Trypanosoma brucei
4-methyl-N-[(2-phenyl-1,3-thiazol-4-yl)methyl]benzenesulfonamide
-
 Trypanosoma brucei
methyl (3-phenyl-1H-indazol-1-yl)acetate
-
 Trypanosoma brucei
additional information synthesis and inhibitory potencies of indazole analogue inhibitors, overview Trypanosoma brucei
N,N-dibenzyl-2-[3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl]acetamide
-
 Trypanosoma brucei
N,N-diethyl-2-(3-(3-fluorophenyl)-1H-indazol-1-yl)acetamide
-
 Trypanosoma brucei
N,N-diethyl-2-(3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)acetamide
-
 Trypanosoma brucei
N-(1-phenylethyl)-2-[3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl]acetamide
-
 Trypanosoma brucei
N-(2-(dimethylamino)ethyl)-2-(3-(3-fluorophenyl)-1H-indazol-1-yl)acetamide
-
 Trypanosoma brucei
N-(2-methoxyethyl)-2-[3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl]acetamide
-
 Trypanosoma brucei
N-(2-phenylethyl)-2-[3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl]acetamide
-
 Trypanosoma brucei
N-(3-(1H-imidazol-1-yl)propyl)-2-(3-(3-fluorophenyl)-1H-indazol-1-yl)acetamide
-
 Trypanosoma brucei
N-(3-(dimethylamino)propyl)-2-(3-(3-fluorophenyl)-1H-indazol-1-yl)acetamide
-
 Trypanosoma brucei
N-(4-chlorobenzyl)-2-(3-(3-fluorophenyl)-1H-indazol-1-yl)acetamide
-
 Trypanosoma brucei
N-(4-chlorobenzyl)-2-(3-(trifluoromethyl)-4,5,6,7-tetrahydro-1Hindazol-1-yl)acetamide
-
 Trypanosoma brucei
N-(4-[methyl[(3-phenyl-1,2,4-oxadiazol-5-yl)methyl]sulfamoyl]phenyl)acetamide
-
 Trypanosoma brucei
N-(4-[[(3-phenyl-1,2,4-oxadiazol-5-yl)methyl]sulfamoyl]phenyl)acetamide
-
 Trypanosoma brucei
N-(butan-2-yl)-2-[3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl]acetamide
-
 Trypanosoma brucei
N-(thiophen-2-ylmethyl)-2-[3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl]acetamide
-
 Trypanosoma brucei
N-cyclohexyl-2-[3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl]acetamide
-
 Trypanosoma brucei
N-methyl-(3-(dimethylamino)propyl)-2-(3-(3-fluorophenyl)-1H-indazol-1-yl)acetamide
-
 Trypanosoma brucei
N-phenyl-2-[3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl]acetamide
-
 Trypanosoma brucei
N-propyl-2-[3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl]acetamide
-
 Trypanosoma brucei
N-[(2-phenyl-1,3-thiazol-4-yl)methyl]naphthalene-2-sulfonamide
-
 Trypanosoma brucei
N-[(3-phenyl-1,2,4-oxadiazol-5-yl)methyl]benzenesulfonamide
-
 Trypanosoma brucei
N-[(5-methyl-2-phenyl-2H-1,2,3-triazol-4-yl)methyl]naphthalene-1-sulfonamide
-
 Trypanosoma brucei
N-[(5-methyl-2-phenyl-2H-1,2,3-triazol-4-yl)methyl]thiophene-2-sulfonamide
-
 Trypanosoma brucei
N-[4-([[3-(2-chlorophenyl)-1,2,4-oxadiazol-5-yl]methyl]sulfamoyl)phenyl]acetamide
-
 Trypanosoma brucei
N-[4-([[3-(2-methylphenyl)-1,2,4-oxadiazol-5-yl]methyl]sulfamoyl)phenyl]acetamide
-
 Trypanosoma brucei
N-[[3-(2-chlorophenyl)-1,2,4-oxadiazol-5-yl]methyl]benzenesulfonamide
-
 Trypanosoma brucei
N-[[3-(2-methylphenyl)-1,2,4-oxadiazol-5-yl]methyl]benzenesulfonamide
-
 Trypanosoma brucei
tert-butyl-4-(2-(2-(3-(3-fluorophenyl)-1H-indazol-1-yl)acetamido)ethyl)piperazine-1-carboxylate
-
 Trypanosoma brucei

Organism

Organism UniProt Comment Textmining
Trypanosoma brucei
-
-
-

Synonyms

Synonyms Comment Organism
Trypanothione synthetase
-
 Trypanosoma brucei
TryS
-
 Trypanosoma brucei

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000045
-
 pH and temperature not specified in the publication Trypanosoma brucei N-(3-(dimethylamino)propyl)-2-(3-(3-fluorophenyl)-1H-indazol-1-yl)acetamide
0.00008
-
 pH and temperature not specified in the publication Trypanosoma brucei 3-(tert-butylsulfonylmethyl)-1-(3-fluorophenyl)-1H-indazole
0.00009
-
 pH and temperature not specified in the publication Trypanosoma brucei 1-(3-(3-fluorophenyl)-1H-indazol-1-yl)-3,3-dimethylbutan-2-one
0.00011
-
 pH and temperature not specified in the publication Trypanosoma brucei 2-(3-(3-fluorophenyl)-1H-indazol-1-yl)-N,N-dimethylacetamide
0.00012
-
 pH and temperature not specified in the publication Trypanosoma brucei 1-(tert-butylsulfonylmethyl)-3-(3-fluorophenyl)-1H-indazole
0.00014
-
 pH and temperature not specified in the publication Trypanosoma brucei 2-(3-(3-fluorophenyl)-1H-indazol-1-yl)-1-(piperidin-1-yl)ethanone
0.000145
-
 pH and temperature not specified in the publication Trypanosoma brucei N-(2-(dimethylamino)ethyl)-2-(3-(3-fluorophenyl)-1H-indazol-1-yl)acetamide
0.00015
-
 above, pH and temperature not specified in the publication Trypanosoma brucei 1-(3-phenyl-1H-indazol-1-yl)-3,3-dimethylbutan-2-one
0.00017
-
 pH and temperature not specified in the publication Trypanosoma brucei N-methyl-(3-(dimethylamino)propyl)-2-(3-(3-fluorophenyl)-1H-indazol-1-yl)acetamide
0.0002
-
 pH and temperature not specified in the publication Trypanosoma brucei N,N-diethyl-2-(3-(3-fluorophenyl)-1H-indazol-1-yl)acetamide
0.00022
-
 pH and temperature not specified in the publication Trypanosoma brucei 3-(tert-butylsulfonylmethyl)-1-phenyl-1H-indazole
0.0003
-
 pH and temperature not specified in the publication Trypanosoma brucei 1-(5-(3,5-dichlorophenyl)-2H-tetrazol-2-yl)-3,3-dimethylbutan-2-one
0.0003
-
 pH and temperature not specified in the publication Trypanosoma brucei 3,3-dimethyl-1-(3-(pyridin-4-yl)-1H-indazol-1-yl)butan-2-one
0.00035
-
 pH and temperature not specified in the publication Trypanosoma brucei 1-(3-(3-chlorophenyl)-1H-indazol-1-yl)-3,3-dimethylbutan-2-one
0.00035
-
 pH and temperature not specified in the publication Trypanosoma brucei N-(3-(1H-imidazol-1-yl)propyl)-2-(3-(3-fluorophenyl)-1H-indazol-1-yl)acetamide
0.0004
-
 pH and temperature not specified in the publication Trypanosoma brucei 2-((tert-butylsulfonyl)methyl)-4-(3-chlorophenyl)thiazole
0.0004
-
 above, pH and temperature not specified in the publication Trypanosoma brucei 3,3-dimethyl-1-(3-(thiophen-3-yl)-1H-indazol-1-yl)butan-2-one
0.0006
-
 pH and temperature not specified in the publication Trypanosoma brucei 2-(5-(3,5-dichlorophenyl)-2H-tetrazol-2-yl)-N,N-dimethylacetamide
0.00083
-
 pH and temperature not specified in the publication Trypanosoma brucei 2-(3-(3-fluorophenyl)-1H-indazol-1-yl)-N-(3-(4-methylpiperazin-1-yl)propyl)acetamide
0.00086
-
 pH and temperature not specified in the publication Trypanosoma brucei 2-(3-(3-fluorophenyl)-1H-indazol-1-yl)-N-(2-(4-methylpiperazin-1-yl)ethyl)acetamide
0.0011
-
 pH and temperature not specified in the publication Trypanosoma brucei 2-((tert-butylsulfonyl)methyl)-4-(2-fluorophenyl)thiazole
0.0011
-
 pH and temperature not specified in the publication Trypanosoma brucei 2-(tert-butylsulfonylmethyl)-4-(3-trifluoromethylphenyl)thiazole
0.0012
-
 pH and temperature not specified in the publication Trypanosoma brucei 2-((tert-butylsulfonyl)methyl)-4-(phenyl)thiazole
0.0015
-
 pH and temperature not specified in the publication Trypanosoma brucei 1-(5-(3-fluorophenyl)-2H-tetrazol-2-yl)-3,3-dimethylbutan-2-one
0.0017
-
 pH and temperature not specified in the publication Trypanosoma brucei N-[4-([[3-(2-methylphenyl)-1,2,4-oxadiazol-5-yl]methyl]sulfamoyl)phenyl]acetamide
0.0019
-
 pH and temperature not specified in the publication Trypanosoma brucei 1-(3-(furan-2-yl)-1H-indazol-1-yl)-3,3-dimethylbutan-2-one
0.0019
-
 pH and temperature not specified in the publication Trypanosoma brucei 1-(5-(3,5-difluorophenyl)-2H-tetrazol-2-yl)-3,3-dimethylbutan-2-one
0.002 4 above, pH and temperature not specified in the publication Trypanosoma brucei N-[(2-phenyl-1,3-thiazol-4-yl)methyl]naphthalene-2-sulfonamide
0.0022
-
 pH and temperature not specified in the publication Trypanosoma brucei 2,4-dimethyl-N-[(5-methyl-2-phenyl-2H-1,2,3-triazol-4-yl)methyl]-1,3-thiazole-5-sulfonamide
0.0026
-
 above, pH and temperature not specified in the publication Trypanosoma brucei 1,3,5-trimethyl-N-[(5-methyl-2-phenyl-2H-1,2,3-triazol-4-yl)methyl]-1H-pyrazole-4-sulfonamide
0.0027
-
 pH and temperature not specified in the publication Trypanosoma brucei 1-(5-(3,5-dichlorophenyl)-2H-tetrazol-2-yl)butan-2-one
0.0029
-
 pH and temperature not specified in the publication Trypanosoma brucei 3-(3-fluorophenyl)-1-(pyridin-2-ylmethyl)-1H-indazole
0.0029
-
 pH and temperature not specified in the publication Trypanosoma brucei tert-butyl-4-(2-(2-(3-(3-fluorophenyl)-1H-indazol-1-yl)acetamido)ethyl)piperazine-1-carboxylate
0.003
-
 pH and temperature not specified in the publication Trypanosoma brucei 1-(3-(3-pyridyl)-1H-indazol-1-yl)-3,3-dimethylbutan-2-one
0.003
-
 pH and temperature not specified in the publication Trypanosoma brucei N-(4-chlorobenzyl)-2-(3-(trifluoromethyl)-4,5,6,7-tetrahydro-1Hindazol-1-yl)acetamide
0.0032
-
 pH and temperature not specified in the publication Trypanosoma brucei 2-((tert-butylsulfonyl)methyl)-4-(2-methylphenyl)thiazole
0.0035
-
 pH and temperature not specified in the publication Trypanosoma brucei 3,3-dimethyl-1-[5-[3-(trifluoromethyl)phenyl]-2H-tetrazol-2-yl]butan-2-one
0.0037
-
 above, pH and temperature not specified in the publication Trypanosoma brucei 1-(3-(1H-indol-4-yl)-1H-indazol-1-yl)-3,3-dimethylbutan-2-one
0.0037
-
 above, pH and temperature not specified in the publication Trypanosoma brucei N-[4-([[3-(2-chlorophenyl)-1,2,4-oxadiazol-5-yl]methyl]sulfamoyl)phenyl]acetamide
0.0039
-
 pH and temperature not specified in the publication Trypanosoma brucei N-(thiophen-2-ylmethyl)-2-[3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl]acetamide
0.004
-
 pH and temperature not specified in the publication Trypanosoma brucei 4-methoxy-N-[[3-(2-methylphenyl)-1,2,4-oxadiazol-5-yl]methyl]benzenesulfonamide
0.0045
-
 pH and temperature not specified in the publication Trypanosoma brucei 3-(3-fluorophenyl)-1-(pyridin-3-ylmethyl)-1H-indazole
0.005
-
 pH and temperature not specified in the publication Trypanosoma brucei N-(2-phenylethyl)-2-[3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl]acetamide
0.0056
-
 pH and temperature not specified in the publication Trypanosoma brucei N-(1-phenylethyl)-2-[3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl]acetamide
0.0058
-
 pH and temperature not specified in the publication Trypanosoma brucei 3,5-dichloro-N-[(2-phenyl-1,3-thiazol-4-yl)methyl]benzenesulfonamide
0.0059
-
 pH and temperature not specified in the publication Trypanosoma brucei N-(4-[[(3-phenyl-1,2,4-oxadiazol-5-yl)methyl]sulfamoyl]phenyl)acetamide
0.0061
-
 pH and temperature not specified in the publication Trypanosoma brucei 2,6-difluoro-N-[(2-phenyl-1,3-thiazol-4-yl)methyl]benzenesulfonamide
0.0063
-
 pH and temperature not specified in the publication Trypanosoma brucei 2,6-dichloro-N-[(2-phenyl-1,3-thiazol-4-yl)methyl]benzenesulfonamide
0.0065
-
 pH and temperature not specified in the publication Trypanosoma brucei 1-(5-(3,5-dichlorophenyl)-2H-tetrazol-2-yl)propan-2-one
0.0072
-
 pH and temperature not specified in the publication Trypanosoma brucei 1-[5-(3-chloro-4-methylphenyl)-2H-tetrazol-2-yl]-3,3-dimethylbutan-2-one
0.0085
-
 pH and temperature not specified in the publication Trypanosoma brucei N-[(5-methyl-2-phenyl-2H-1,2,3-triazol-4-yl)methyl]thiophene-2-sulfonamide
0.0087
-
 pH and temperature not specified in the publication Trypanosoma brucei 4-acetyl-N-[(2-phenyl-1,3-thiazol-4-yl)methyl]benzenesulfonamide
0.0088
-
 pH and temperature not specified in the publication Trypanosoma brucei 3,3-dimethyl-1-(5-phenyl-2H-tetrazol-2-yl)butan-2-one
0.011
-
 pH and temperature not specified in the publication Trypanosoma brucei 4-methoxy-N-[(3-phenyl-1,2,4-oxadiazol-5-yl)methyl]benzenesulfonamide
0.012
-
 pH and temperature not specified in the publication Trypanosoma brucei 2-((tert-butylsulfonyl)methyl)-4-(3-methoxyphenyl)thiazole
0.012
-
 pH and temperature not specified in the publication Trypanosoma brucei N-(butan-2-yl)-2-[3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl]acetamide
0.013
-
 pH and temperature not specified in the publication Trypanosoma brucei N-propyl-2-[3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl]acetamide
0.015
-
 pH and temperature not specified in the publication Trypanosoma brucei N,N-diethyl-2-(3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)acetamide
0.015
-
 pH and temperature not specified in the publication Trypanosoma brucei N-[[3-(2-methylphenyl)-1,2,4-oxadiazol-5-yl]methyl]benzenesulfonamide
0.016
-
 pH and temperature not specified in the publication Trypanosoma brucei 2,6-dichloro-N-[(3-phenyl-1,2,4-oxadiazol-5-yl)methyl]benzenesulfonamide
0.02
-
 pH and temperature not specified in the publication Trypanosoma brucei methyl (3-phenyl-1H-indazol-1-yl)acetate
0.024
-
 pH and temperature not specified in the publication Trypanosoma brucei 2,4-dimethyl-N-[(5-methyl-2-phenyl-2H-1,2,3-triazol-4-yl)methyl]thiophene-3-sulfonamide
0.025
-
 pH and temperature not specified in the publication Trypanosoma brucei N-[[3-(2-chlorophenyl)-1,2,4-oxadiazol-5-yl]methyl]benzenesulfonamide
0.028
-
 above, pH and temperature not specified in the publication Trypanosoma brucei 4-((3-(3-fluorophenyl)-1H-indazol-1-yl)methyl)-2,5-dimethyloxazole
0.03
-
 above, pH and temperature not specified in the publication Trypanosoma brucei N-(2-methoxyethyl)-2-[3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl]acetamide
0.037
-
 above, pH and temperature not specified in the publication Trypanosoma brucei 2-methyl-N-((5-methyl-2-phenyl-2H-1,2,3-triazol-4-yl)methyl)propane-2-sulfonamide
0.045
-
 pH and temperature not specified in the publication Trypanosoma brucei 2-(5-(3,5-difluorophenyl)-2H-tetrazol-2-yl)-1-phenylethanone
0.05
-
 pH and temperature not specified in the publication Trypanosoma brucei N-(4-[methyl[(3-phenyl-1,2,4-oxadiazol-5-yl)methyl]sulfamoyl]phenyl)acetamide
0.05
-
 pH and temperature not specified in the publication Trypanosoma brucei N-[(3-phenyl-1,2,4-oxadiazol-5-yl)methyl]benzenesulfonamide
0.1
-
 pH and temperature not specified in the publication Trypanosoma brucei 1-(3-(1-isobutyl-1H-pyrazol-4-yl)-1H-indazol-1-yl)-3,3-dimethylbutan-2-one
0.1
-
 pH and temperature not specified in the publication Trypanosoma brucei 1-(3-(4-chlorophenyl)-1H-indazol-1-yl)-3,3-dimethylbutan-2-one
0.1
-
 pH and temperature not specified in the publication Trypanosoma brucei 2,6-dimethoxy-N-[(5-methyl-2-phenyl-2H-1,2,3-triazol-4-yl)methyl]benzenesulfonamide
0.1
-
 pH and temperature not specified in the publication Trypanosoma brucei 3,3-dimethyl-1-(3-(naphthalen-2-yl)-1H-indazol-1-yl)butan-2-one
0.1
-
 pH and temperature not specified in the publication Trypanosoma brucei 3-((3-(3-fluorophenyl)-1H-indazol-1-yl)methyl)-5-methylisoxazole
0.1
-
 pH and temperature not specified in the publication Trypanosoma brucei 4-methyl-N-[(2-phenyl-1,3-thiazol-4-yl)methyl]benzenesulfonamide
0.1
-
 pH and temperature not specified in the publication Trypanosoma brucei N,N-dibenzyl-2-[3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl]acetamide
0.1
-
 pH and temperature not specified in the publication Trypanosoma brucei N-(4-chlorobenzyl)-2-(3-(3-fluorophenyl)-1H-indazol-1-yl)acetamide
0.1
-
 above, pH and temperature not specified in the publication Trypanosoma brucei 3,3-dimethyl-1-(3-(1-methyl-1H-indol-4-yl)-1H-indazol-1-yl)butan-2-one
0.1
-
 above, pH and temperature not specified in the publication Trypanosoma brucei 3,3-dimethyl-1-[5-[4-(trifluoromethyl)phenyl]-2H-tetrazol-2-yl]butan-2-one
0.1
-
 above, pH and temperature not specified in the publication Trypanosoma brucei 3-((3-(3-fluorophenyl)-1H-indazol-1-yl)methyl)-5-phenylisoxazole
0.1
-
 above, pH and temperature not specified in the publication Trypanosoma brucei N-cyclohexyl-2-[3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl]acetamide
0.1
-
 above, pH and temperature not specified in the publication Trypanosoma brucei N-phenyl-2-[3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl]acetamide
0.1
-
 above, pH and temperature not specified in the publication Trypanosoma brucei N-[(5-methyl-2-phenyl-2H-1,2,3-triazol-4-yl)methyl]naphthalene-1-sulfonamide