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Literature summary for 6.3.1.9 extracted from

  • Fitzgerald, M.P.; Madsen, J.M.; Coleman, M.C.; Teoh, M.L.; Westphal, S.G.; Spitz, D.R.; Radi, R.; Domann, F.E.
    Transgenic biosynthesis of trypanothione protects Escherichia coli from radiation-induced toxicity (2010), Radiat. Res., 174, 290-296.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Trypanosoma cruzi

Protein Variants

Protein Variants Comment Organism
additional information introduction of the trypanothione synthetase and reductase genes from Trypanosoma cruzi into Escherichia coli results in decreased intracellular levels of reactive oxygen species. Escherichia coli genomic DNA is protected from radiation-induced DNA damage by 4.6fold in the presence of trypanothione compared to control bacteria. The transgenic Escherichia coli expressing trypanothione are 4.3fold more resistant to killing by 137Cs gamma-radiation Trypanosoma cruzi

Organism

Organism UniProt Comment Textmining
Trypanosoma cruzi
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