Reference on EC 5.6.1.3 - plus-end-directed kinesin ATPase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Vale, R.D.; Reese, T.S.; Sheetz, M.P.
Identification of a novel force-generating protein, kinesin, involved in microtubule-based motility
Cell
42
39-50
1985
Bos taurus, Doryteuthis pealeii
Mitchison, T.J.
The role of microtubule polarity in the movement of kinesin and kinetochores
J. Cell Sci. Suppl.
5
121-128
1986
Homo sapiens, Doryteuthis pealeii, Strongylocentrotus purpuratus
Schnapp, B.J.; Crise, B.; Sheetz, M.P.; Reese, T.S.; Khan, S.
Delayed start-up of kinesin-driven microtubule gliding following inhibition by adenosine 5'-[beta,gamma-imido]triphosphate
Proc. Natl. Acad. Sci. USA
87
10053-10057
1990
Doryteuthis pealeii
Schnapp, B.J.; Reese, T.S.; Bechtold, R.
Kinesin is bound with high affinity to squid axon organelles that move to the plus-end of microtubules
J. Cell Biol.
119
389-399
1992
Drosophila sp. (in: flies), Doryteuthis pealeii
Lippincott-Schwartz, J.; Cole, N.B.; Marotta, A.; Conrad, P.A.; Bloom, G.S.
Kinesin is the motor for microtubule-mediated Golgi-to-ER membrane traffic [published errata appear in J Cell Biol 1995 Mar;128(5):following 988 and 1995 May;129(3):893]
J. Cell Biol.
128
293-306
1995
Homo sapiens
Endow, S.A.
Determinants of motor polarity in the kinesin proteins
Biophys. J.
68
271S-274S
1995
Arabidopsis sp., Aspergillus sp., Drosophila sp. (in: flies), Homo sapiens, Schizosaccharomyces pombe
Kuriyama, R.; Kofron, M.; Essner, R.; Kato, T.; Dragas-Granoic, S.; Omoto, C.K.; Khodjakov, A.
Characterization of a minus end-directed kinesin-like motor protein from cultured mammalian cells
J. Cell Biol.
129
1049-1059
1995
Arabidopsis sp., Aspergillus sp., Drosophila sp. (in: flies), Homo sapiens, Strongylocentrotus purpuratus
Yamazaki, H.; Nakata, T.; Okada, Y.; Hirokawa, N.
KIF3A/B: a heterodimeric kinesin superfamily protein that works as a microtubule plus end-directed motor for membrane organelle transport
J. Cell Biol.
130
1387-1399
1995
Bos taurus, Chlamydomonas sp., Mus musculus
Song, H.; Endow, S.A.
Binding sites on microtubules of kinesin motors of the same or opposite polarity
Biochemistry
35
11203-11209
1996
Drosophila sp. (in: flies), Xenopus laevis
Nakagawa, T.; Tanaka, Y.; Matsuoka, E.; Kondo, S.; Okada, Y.; Noda, Y.; Kanai, Y.; Hirokawa, N.
Identification and classification of 16 new kinesin superfamily (KIF) proteins in mouse genome
Proc. Natl. Acad. Sci. USA
94
9654-9659
1997
Saccharomyces cerevisiae, Caenorhabditis elegans, Mus musculus, Xenopus laevis
Santama, N.; Krijnse-Locker, J.; Griffiths, G.; Noda, Y.; Hirokawa, N.; Dotti, C.G.
KIF2beta, a new kinesin superfamily protein in non-neuronal cells, is associated with lysosomes and may be implicated in their centrifugal translocation
EMBO J.
17
5855-5867
1998
Cricetulus griseus, Homo sapiens, Mus musculus, Trypanosoma cruzi, Xenopus laevis
Lane, J.D.; Allan, V.J.
Microtubule-based endoplasmic reticulum motility in Xenopus laevis: activation of membrane-associated kinesin during development
Mol. Biol.
10
1909-1922
1999
Doryteuthis pealeii, Tetrahymena sp., Xenopus laevis
Kirchner, J.; Woehlke, G.; Schliwa, M.
Universal and unique features of kinesin motors: insights from a comparison of fungal and animal conventional kinesins
Biol. Chem.
380
915-921
1999
Bos taurus, Caenorhabditis elegans, Drosophila melanogaster, Drosophila sp. (in: flies), Fusarium solani, Homo sapiens, Doryteuthis pealeii, Mus musculus, Neurospora crassa, Rattus norvegicus, Strongylocentrotus purpuratus, Ustilago maydis
Pollock, N.; de Hostos, E.L.; Turck, C.W.; Vale, R.D.
Reconstitution of membrane transport powered by a novel dimeric kinesin motor of the Unc104/KIF1A family purified from Dictyostelium
J. Cell Biol.
147
493-506
1999
Caenorhabditis elegans, Dictyostelium discoideum, Thermomyces lanuginosus, Mus musculus
Rice, S.; Lin, A.W.; Safer, D.; Hart, C.L.; Naber, N.; Carragher, B.O.; Cain, S.M.; Pechatnikova, E.; Wilson-Kubalek, E.M.; Whittaker, M.; Pate, E.; Cooke, R.; Taylor, E.W.; Milligan, R.A.; Vale, R.D.
A structural change in the kinesin motor protein that drives motility
Nature
402
778-784
1999
Homo sapiens, Rattus norvegicus
Case, R.B.; Rice, S.; Hart, C.L.; Ly, B.; Vale, R.D.
Role of the kinesin neck linker and catalytic core in microtubule-based motility
Curr. Biol.
10
157-160
2000
Homo sapiens, Rattus norvegicus
Tomishige, M.; Vale, R.D.
Controlling kinesin by reversible disulfide cross-linking. Identifying the motility-producing conformational change
J. Cell Biol.
151
1081-1092
2000
Homo sapiens
Walker, R.A.
Ncd and kinesin motor domains interact with both alpha- and beta-tubulin
Proc. Natl. Acad. Sci. USA
92
5960-5964
1995
Drosophila sp. (in: flies)
Crevel, I.M.; Lockhart, A.; Cross, R.A.
Weak and strong states of kinesin and ncd
J. Mol. Biol.
257
66-76
1996
Drosophila sp. (in: flies)
Blocker, A.; Severin, F.F.; Burkhardt, J.K.; Bingham, J.B.; Yu, H.; Olivo, J.C.; Schroer, T.A.; Hyman, A.A.; Griffiths, G.
Molecular requirements for bi-directional movement of phagosomes along microtubules
J. Cell Biol.
137
113-129
1997
Mus musculus
Varadi, A.; Tsuboi, T.; Johnson-Cadwell, L.I.; Allan, V.J.; Rutter, G.A.
Kinesin I and cytoplasmic dynein orchestrate glucose-stimulated insulin-containing vesicle movements in clonal MIN6 beta-cells
Biochem. Biophys. Res. Commun.
311
272-282
2003
Mus musculus
Farrell, C.M.; Mackey, A.T.; Klumpp, L.M.; Gilbert, S.P.
The role of ATP hydrolysis for kinesin processivity
J. Biol. Chem.
277
17079-17087
2002
Drosophila melanogaster
Reddy, V.S.; Reddy, A.S.
The calmodulin-binding domain from a plant kinesin functions as a modular domain in conferring Ca2+-calmodulin regulation to animal plus- and minus-end kinesins
J. Biol. Chem.
277
48058-48065
2002
Arabidopsis thaliana
Cochran, J.C.; Sontag, C.A.; Maliga, Z.; Kapoor, T.M.; Correia, J.J.; Gilbert, S.P.
Mechanistic analysis of the mitotic kinesin Eg5
J. Biol. Chem.
279
38861-38870
2004
Homo sapiens
Jouvenet, N.; Monaghan, P.; Way, M.; Wileman, T.
Transport of African swine fever virus from assembly sites to the plasma membrane is dependent on microtubules and conventional kinesin
J. Virol.
78
7990-8001
2004
Chlorocebus aethiops
Zhang, J.; Li, S.; Fischer, R.; Xiang, X.
Accumulation of cytoplasmic dynein and dynactin at microtubule plus ends in Aspergillus nidulans is kinesin dependent
Mol. Biol. Cell
14
1479-1488
2003
Aspergillus nidulans
Cha, B.J.; Serbus, L.R.; Koppetsch, B.S.; Theurkauf, W.E.
Kinesin I-dependent cortical exclusion restricts pole plasm to the oocyte posterior
Nat. Cell Biol.
4
592-598
2002
Drosophila melanogaster
Kikkawa, M.; Sablin, E.P.; Okada, Y.; Yajima, H.; Fletterick, R.J.; Hirokama, N.
Switch-based mechanism of kinesin motors
Nature
411
439-445
2004
Mus musculus
Okada, Y.; Higuchi, H.; Hirokawa, N.
Processivity of the single-headed kinesin KIF1A through biased binding to tubulin
Nature
424
574-577
2003
Mus musculus
Cochran, J.C.; Krzysiak, T.C.; Gilbert, S.P.
Pathway of ATP hydrolysis by monomeric kinesin Eg5
Biochemistry
45
12334-12344
2006
Homo sapiens
Hoepfner, S.; Severin, F.; Cabezas, A.; Habermann, B.; Runge, A.; Gillooly, D.; Stenmark, H.; Zerial, M.
Modulation of receptor recycling and degradation by the endosomal kinesin KIF16B
Cell
121
437-450
2005
Homo sapiens (Q96L93)
Moores, C.A.; Cooper, J.; Wagenbach, M.; Ovechkina, Y.; Wordeman, L.; Milligan, R.A.
The role of the kinesin-13 neck in microtubule depolymerization
Cell Cycle
5
1812-1815
2006
Cricetulus griseus
Awan, A.; Bernstein, M.; Hamasaki, T.; Satir, P.
Cloning and characterization of Kin5, a novel Tetrahymena ciliary kinesin II
Cell Motil. Cytoskeleton
58
1-9
2004
Tetrahymena thermophila (Q7YUC7)
Zhang, Y.; Sperry, A.O.
Comparative analysis of two C-terminal kinesin motor proteins: KIFC1 and KIFC5A
Cell Motil. Cytoskeleton
58
213-230
2004
Mus musculus
Dastidar, P.G.; Majumder, S.; Lohia, A.
Eh Klp5 is a divergent member of the kinesin 5 family that regulates genome content and microtubular assembly in Entamoeba histolytica
Cell. Microbiol.
9
316-328
2006
Entamoeba histolytica
Zhang, Y.; Oko, R.; van der Hoorn, F.A.
Rat kinesin light chain 3 associates with spermatid mitochondria
Dev. Biol.
275
23-33
2004
Rattus norvegicus
Sanchez-Perez, I.; Renwick, S.J.; Crawley, K.; Karig, I.; Buck, V.; Meadows, J.C.; Franco-Sanchez, A.; Fleig, U.; Toda, T.; Millar, J.B.
The DASH complex and Klp5/Klp6 kinesin coordinate bipolar chromosome attachment in fission yeast
EMBO J.
24
2931-2943
2005
Schizosaccharomyces pombe
Krzysiak, T.C.; Wendt, T.; Sproul, L.R.; Tittmann, P.; Gross, H.; Gilbert, S.P.; Hoenger, A.
A structural model for monastrol inhibition of dimeric kinesin Eg5
EMBO J.
25
2263-2273
2006
Homo sapiens
Jimeno, D.; Lillo, C.; Roberts, E.A.; Goldstein, L.S.B.; Williams, D.S.
Kinesin-2 and photoreceptor cell death: requirement of motor subunits
Exp. Eye Res.
82
351-353
2006
Mus musculus
Jimeno, D.; Feiner, L.; Lillo, C.; Teofilo, K.; Goldstein, L.S.; Pierce, E.A.; Williams, D.S.
Analysis of kinesin-2 function in photoreceptor cells using synchronous Cre-loxP knockout of Kif3a with RHO-Cre
Invest. Ophthalmol. Vis. Sci.
47
5039-5046
2006
Gallus gallus
Adio, S.; Bloemink, M.; Hartel, M.; Leier, S.; Geeves, M.A.; Woehlke, G.
Kinetic and mechanistic basis of the non-processive Kinesin-3 motor NcKin3
J. Biol. Chem.
248
37782-37793
2006
Neurospora crassa
Auerbach, S.D.; Johnson, K.A.
Alternating site ATPase pathway of rat conventional kinesin
J. Biol. Chem.
280
37048-37060
2005
Rattus norvegicus
Skoufias, D.A.; DeBonis, S.; Saoudi, Y.; Lebeau, L.; Crevel, I.; Cross, R.; Wade, R.H.; Hackney, D.; Kozielski, F.
S-trityl-L-cysteine is a reversible, tight binding inhibitor of the human kinesin Eg5 that specifically blocks mitotic progression
J. Biol. Chem.
281
17559-17569
2006
Homo sapiens
Kinoshita, K.; Noetzel, T.L.; Arnal, I.; Drechsel, D.N.; Hyman, A.A.
Global and local control of microtubule destabilization promoted by a catastrophe kinesin MCAK/XKCM1
J. Muscle Res. Cell Motil.
27
107-114
2006
Xenopus sp.
Marx, A.; Mueller, J.; Mandelkow, E.M.; Hoenger, A.; Mandelkow, E.
Interaction of kinesin motors, microtubules, and MAPs
J. Muscle Res. Cell Motil.
27
125-137
2006
Rattus norvegicus
Mueller, J.; Perrone, C.A.; Bower, R.; Cole, D.G.; Porter, M.E.
The FLA3 KAP subunit is required for localization of kinesin-2 to the site of flagellar assembly and processive anterograde intraflagellar transport
Mol. Biol. Cell
16
1341-1354
2005
Chlamydomonas sp.
Schuchardt, I.; Assmann, D.; Thines, E.; Schuberth, C.; Steinberg, G.
Myosin-V, kinesin-1, and kinesin-3 cooperate in hyphal growth of the fungus Ustilago maydis
Mol. Biol. Cell
16
5191-5201
2005
Ustilago maydis
Kopp, P.; Lammers, R.; Aepfelbacher, M.; Woehlke, G.; Rudel, T.; Machuy, N.; Steffen, W.; Linder, S.
The kinesin KIF1C and microtubule plus ends regulate podosome dynamics in macrophages
Mol. Biol. Cell
17
2811-2823
2006
Homo sapiens
Straube, A.; Hause, G.; Fink, G.; Steinberg, G.
Conventional kinesin mediates microtubule-microtubule interactions in vivo
Mol. Biol. Cell
17
907-916
2006
Ustilago maydis
Valentine, M.T.; Fordyce, P.M.; Krzysiak, T.C.; Gilbert, S.P.; Block, S.M.
Individual dimers of the mitotic kinesin motor Eg5 step processively and support substantial loads in vitro
Nat. Cell Biol.
8
470-476
2006
Homo sapiens
Gupta, M.L.; Carvalho, P.; Roof, D.M.; Pellman, D.
Plus end-specific depolymerase activity of Kip3, a kinesin-8 protein, explains its role in positioning the yeast mitotic spindle
Nat. Cell Biol.
8
913-923
2006
Saccharomyces cerevisiae
Varga, V.; Helenius, J.; Tanaka, K.; Hyman, A.A.; Tanaka, T.U.; Howard, J.
Yeast kinesin-8 depolymerizes microtubules in a length-dependent manner
Nat. Cell Biol.
8
957-962
2006
Saccharomyces cerevisiae
Kwok, B.H.; Kapitein, L.C.; Kim, J.H.; Peterman, E.J.; Schmidt, C.F.; Kapoor, T.M.
Allosteric inhibition of kinesin-5 modulates its processive directional motility
Nat. Chem. Biol.
2
480-485
2006
Xenopus laevis
Kapitein, L.C.; Peterman, E.J.; Kwok, B.H.; Kim, J.H.; Kapoor, T.M.; Schmidt, C.F.
The bipolar mitotic kinesin Eg5 moves on both microtubules that it crosslinks
Nature
435
114-118
2005
Xenopus sp.
Helenius, J.; Brouhard, G.; Kalaidzidis, Y.; Diez, S.; Howard, J.
The depolymerizing kinesin MCAK uses lattice diffusion to rapidly target microtubule ends
Nature
441
115-119
2006
Homo sapiens
Okumura, H.; Nakazawa, J.; Tsuganezawa, K.; Usui, T.; Osada, H.; Matsumoto, T.; Tanaka, A.; Yokoyama, S.
Phenothiazine and carbazole-related compounds inhibit mitotic kinesin Eg5 and trigger apoptosis in transformed culture cells
Toxicol. Lett.
166
44-52
2006
Homo sapiens
Brown, C.L.; Maier, K.C.; Stauber, T.; Ginkel, L.M.; Wordeman, L.; Vernos, I.; Schroer, T.A.
Kinesin-2 is a motor for late endosomes and lysosomes
Traffic
6
1114-1124
2005
Homo sapiens
Rickert, K.W.; Schaber, M.; Torrent, M.; Neilson, L.A.; Tasber, E.S.; Garbaccio, R.; Coleman, P.J.; Harvey, D.; Zhang, Y.; Yang, Y.; Marshall, G.; Lee, L.; Walsh, E.S.; Hamilton, K.; Buser, C.A.
Discovery and biochemical characterization of selective ATP competitive inhibitors of the human mitotic kinesin KSP
Arch. Biochem. Biophys.
469
220-231
2008
Homo sapiens (P52732), Homo sapiens
Yonekura, H.; Nomura, A.; Ozawa, H.; Tatsu, Y.; Yumoto, N.; Uyeda, T.Q.
Mechanism of tail-mediated inhibition of kinesin activities studied using synthetic peptides
Biochem. Biophys. Res. Commun.
343
420-427
2006
Homo sapiens
Marx, A.; Mueller, J.; Mandelkow, E.M.; Woehlke, G.; Bouchet-Marquis, C.; Hoenger, A.; Mandelkow, E.
X-ray structure and microtubule interaction of the motor domain of Neurospora crassa NcKin3, a kinesin with unusual processivity
Biochemistry
47
1848-1861
2008
Neurospora crassa
Klein, E.; DeBonis, S.; Thiede, B.; Skoufias, D.A.; Kozielski, F.; Lebeau, L.
New chemical tools for investigating human mitotic kinesin Eg5
Bioorg. Med. Chem.
15
6474-6488
2007
Homo sapiens
Roehlk, C.; Rohlfs, M.; Leier, S.; Schliwa, M.; Liu, X.; Parsch, J.; Woehlke, G.
Properties of the Kinesin-1 motor DdKif3 from Dictyostelium discoideum
Eur. J. Cell Biol.
87
237-249
2008
Dictyostelium discoideum
Luo, L.; Carson, J.D.; Molnar, K.S.; Tuske, S.J.; Coales, S.J.; Hamuro, Y.; Sung, C.M.; Sudakin, V.; Auger, K.R.; Dhanak, D.; Jackson, J.R.; Huang, P.S.; Tummino, P.J.; Copeland, R.A.
Conformation-dependent ligand regulation of ATP hydrolysis by human KSP - activation of basal hydrolysis and inhibition of microtubule-stimulated hydrolysis by a single, small molecule modulator
J. Am. Chem. Soc.
130
7584-7591
2008
Homo sapiens
Yamada, M.D.; Nakajima, Y.; Maeda, H.; Maruta, S.
Photocontrol of kinesin ATPase activity using an azobenzene derivative
J. Biochem.
142
691-698
2007
Mus musculus
Parrish, C.A.; Adams, N.D.; Auger, K.R.; Burgess, J.L.; Carson, J.D.; Chaudhari, A.M.; Copeland, R.A.; Diamond, M.A.; Donatelli, C.A.; Duffy, K.J.; Faucette, L.F.; Finer, J.T.; Huffman, W.F.; Hugger, E.D.; Jackson, J.R.; Knight, S.D.; Luo, L.; Moore, M.L.; Newlander, K.A.; Ridgers, L.H.; Sakowicz, R.; Shaw, A.N.; Sung, C.-H.M.
Novel ATP-competitive kinesin spindle protein inhibitors
J. Med. Chem.
50
4939-4952
2007
Homo sapiens
Luo, L.; Parrish, C.A.; Nevins, N.; McNulty, D.E.; Chaudhari, A.M.; Carson, J.D.; Sudakin, V.; Shaw, A.N.; Lehr, R.; Zhao, H.; Sweitzer, S.; Lad, L.; Wood, K.W.; Sakowicz, R.; Annan, R.S.; Huang, P.S.; Jackson, J.R.; Dhanak, D.; Copeland, R.A.; Auger, K.R.
ATP-competitive inhibitors of the mitotic kinesin KSP that function via an allosteric mechanism
Nat. Chem. Biol.
3
722-726
2007
Homo sapiens
Alonso, M.C.; Drummond, D.R.; Kain, S.; Hoeng, J.; Amos, L.; Cross, R.A.
An ATP gate controls tubulin binding by the tethered head of kinesin-1
Science
316
120-123
2007
Neurospora crassa, Rattus norvegicus
Thoresen, T.; Gelles, J.
Processive movement by a kinesin heterodimer with an inactivating mutation in one head
Biochemistry
47
9514-9521
2008
Drosophila melanogaster
Hackney, D.D.; Baek, N.; Snyder, A.C.
Half-site inhibition of dimeric kinesin head domains by monomeric tail domains
Biochemistry
48
3448-3456
2009
Drosophila melanogaster
Taba, T.; Edamatsu, M.; Toba, S.; Shibata, K.; Imafuku, Y.; Toyoshima, Y.Y.; Tawada, K.; Yamada, A.
Direction and speed of microtubule movements driven by kinesin motors arranged on catchin thick filaments
Cell Motil. Cytoskeleton
65
816-826
2008
Rattus norvegicus
Yildiz, A.; Tomishige, M.; Gennerich, A.; Vale, R.D.
Intramolecular strain coordinates kinesin stepping behavior along microtubules
Cell
134
1030-1041
2008
Homo sapiens
Cochran, J.C.; Sindelar, C.V.; Mulko, N.K.; Collins, K.A.; Kong, S.E.; Hawley, R.S.; Kull, F.J.
ATPase cycle of the nonmotile kinesin NOD allows microtubule end tracking and drives chromosome movement
Cell
136
110-122
2009
Drosophila melanogaster
van den Wildenberg, S.M.; Tao, L.; Kapitein, L.C.; Schmidt, C.F.; Scholey, J.M.; Peterman, E.J.
The homotetrameric kinesin-5 KLP61F preferentially crosslinks microtubules into antiparallel orientations
Curr. Biol.
18
1860-1864
2008
Drosophila melanogaster
Mans, D.A.; Lolkema, M.P.; van Beest, M.; Daenen, L.G.; Voest, E.E.; Giles, R.H.
Mobility of the von Hippel-Lindau tumour suppressor protein is regulated by kinesin-2
Exp. Cell Res.
314
1229-1236
2008
Mus musculus
Bisbal, M.; Wojnacki, J.; Peretti, D.; Ropolo, A.; Sesma, J.; Jausoro, I.; Caceres, A.
KIF4 mediates anterograde translocation and positioning of ribosomal constituents to axons
J. Biol. Chem.
284
9489-9497
2009
Rattus norvegicus
Kapitein, L.C.; Kwok, B.H.; Weinger, J.S.; Schmidt, C.F.; Kapoor, T.M.; Peterman, E.J.
Microtubule cross-linking triggers the directional motility of kinesin-5
J. Cell Biol.
182
421-428
2008
Xenopus laevis
Martinez, N.W.; Xue, X.; Berro, R.G.; Kreitzer, G.; Resh, M.D.
Kinesin KIF4 regulates intracellular trafficking and stability of the human immunodeficiency virus type 1 Gag polyprotein
J. Virol.
82
9937-9950
2008
Homo sapiens
Grissom, P.M.; Fiedler, T.; Grishchuk, E.L.; Nicastro, D.; West, R.R.; McIntosh, J.R.
Kinesin-8 from fission yeast: a heterodimeric, plus-end-directed motor that can couple microtubule depolymerization to cargo movement
Mol. Biol. Cell
20
963-972
2009
Schizosaccharomyces pombe
Adio, S.; Jaud, J.; Ebbing, B.; Rief, M.; Woehlke, G.
Dissection of kinesins processivity
PLoS ONE
4
e4612
2009
Neurospora crassa
Dietrich, K.A.; Sindelar, C.V.; Brewer, P.D.; Downing, K.H.; Cremo, C.R.; Rice, S.E.
The kinesin-1 motor protein is regulated by a direct interaction of its head and tail
Proc. Natl. Acad. Sci. USA
105
8938-8943
2008
Homo sapiens
Asenjo, A.B.; Sosa, H.
A mobile kinesin-head intermediate during the ATP-waiting state
Proc. Natl. Acad. Sci. USA
106
5657-5662
2009
Homo sapiens
Schiemann, K.; Finsinger, D.; Zenke, F.; Amendt, C.; Knoechel, T.; Bruge, D.; Buchstaller, H.P.; Emde, U.; Staehle, W.; Anzali, S.
The discovery and optimization of hexahydro-2H-pyrano[3,2-c]quinolines (HHPQs) as potent and selective inhibitors of the mitotic kinesin-5
Bioorg. Med. Chem. Lett.
20
1491-1495
2010
Homo sapiens (P52732), Homo sapiens
Barsanti, P.A.; Wang, W.; Ni, Z.J.; Duhl, D.; Brammeier, N.; Martin, E.; Bussiere, D.; Walter, A.O.
The discovery of tetrahydro-beta-carbolines as inhibitors of the kinesin Eg5
Bioorg. Med. Chem. Lett.
20
157-160
2010
Homo sapiens (P52732)
Verbrugge, S.; Lechner, B.; Woehlke, G.; Peterman, E.J.
Alternating-site mechanism of kinesin-1 characterized by single-molecule FRET using fluorescent ATP analogues
Biophys. J.
97
173-182
2009
Homo sapiens
Adio, S.; Woehlke, G.
Properties of the kinesin-3 NcKin3 motor domain and implications for neck function
FEBS J.
276
3641-3655
2009
Neurospora crassa
Zhang, M.; Zhang, B.; Qian, Q.; Yu, Y.; Li, R.; Zhang, J.; Liu, X.; Zeng, D.; Li, J.; Zhou, Y.
Brittle Culm 12, a dual-targeting kinesin-4 protein, controls cell-cycle progression and wall properties in rice
Plant J.
63
312-328
2010
Oryza sativa Japonica Group
Masuda, N.; Shimodaira, T.; Shiu, S.J.; Tokai-Nishizumi, N.; Yamamoto, T.; Ohsugi, M.
Microtubule stabilization triggers the plus-end accumulation of Kif18A/kinesin-8
Cell Struct. Funct.
36
261-267
2011
Homo sapiens (Q8NI77)
Uchimura, S.; Oguchi, Y.; Hachikubo, Y.; Ishiwata, S.; Muto, E.
Key residues on microtubule responsible for activation of kinesin ATPase
EMBO J.
29
1167-1175
2010
Homo sapiens
Friel, C.T.; Howard, J.
The kinesin-13 MCAK has an unconventional ATPase cycle adapted for microtubule depolymerization
EMBO J.
30
3928-3939
2011
Homo sapiens
Abualhasan, M.; Good, J.; Wittayanarakul, K.; Anthony, N.; Berretta, G.; Rath, O.; Kozielski, F.; Sutcliffe, O.; MacKay, S.
Doing the methylene shuffle - Further insights into the inhibition of mitotic kinesin Eg5 with S-trityl L-cysteine
Eur. J. Med. Chem.
54
483-498
2012
Homo sapiens
Umezu, N.; Umeki, N.; Mitsui, T.; Kondo, K.; Maruta, S.
Characterization of a novel rice kinesin O12 with a calponin homology domain
J. Biochem.
149
91-101
2011
Oryza sativa Japonica Group (AK065586)
Zhao, Y.C.; Kull, F.J.; Cochran, J.C.
Modulation of the kinesin ATPase cycle by neck linker docking and microtubule binding
J. Biol. Chem.
285
25213-25220
2010
Homo sapiens (P52732), Homo sapiens
Parke, C.; Wojcik, E.; Kim, S.; Worthylake, D.
ATP hydrolysis in Eg5 kinesin involves a catalytic two-water mechanism
J. Biol. Chem.
285
5859-5867
2010
Homo sapiens
Nagarajan, S.; Skoufias, D.A.; Kozielski, F.; Pae, A.N.
Receptor-ligand interaction-based virtual screening for novel Eg5/kinesin spindle protein inhibitors
J. Med. Chem.
55
2561-2573
2012
Homo sapiens
Hu, L.; Hu, H.; Li, Z.
A kinetoplastid-specific kinesin is required for cytokinesis and for maintenance of cell morphology in Trypanosoma brucei
Mol. Microbiol.
83
565-578
2012
Trypanosoma brucei (Q57XC6), Trypanosoma brucei, Trypanosoma brucei 427 (Q57XC6)
Yang, X.Y.; Chen, Z.W.; Xu, T.; Qu, Z.; Pan, X.D.; Qin, X.H.; Ren, D.T.; Liu, G.Q.
Arabidopsis kinesin KP1 specifically interacts with VDAC3, a mitochondrial protein, and regulates respiration during seed germination at low temperature
Plant Cell
23
1093-1106
2011
Arabidopsis thaliana
Yokoyama, H.; Sawada, J.; Katoh, S.; Matsuno, K.; Ogo, N.; Ishikawa, Y.; Hashimoto, H.; Fujii, S.; Asai, A.
Structural basis of new allosteric inhibition in kinesin spindle protein Eg5
ACS Chem. Biol.
10
1128-1136
2015
Homo sapiens (P52732)
Braun, J.; Moeckel, M.M.; Strittmatter, T.; Marx, A.; Groth, U.; Mayer, T.U.
Synthesis and biological evaluation of optimized inhibitors of the mitotic kinesin Kif18A
ACS Chem. Biol.
10
554-560
2015
Homo sapiens (Q8NI77), Homo sapiens
Chakraborty, S.; Zheng, W.
Decrypting the structural, dynamic, and energetic basis of a monomeric kinesin interacting with a tubulin dimer in three ATPase states by all-atom molecular dynamics simulation
Biochemistry
54
859-869
2015
Homo sapiens (P33176), Homo sapiens
Shang, Z.; Zhou, K.; Xu, C.; Csencsits, R.; Cochran, J.C.; Sindelar, C.V.
High-resolution structures of kinesin on microtubules provide a basis for nucleotide-gated force-generation
eLife
3
e04686
2014
Homo sapiens (P33176)
DeBerg, H.A.; Blehm, B.H.; Sheung, J.; Thompson, A.R.; Bookwalter, C.S.; Torabi, S.F.; Schroer, T.A.; Berger, C.L.; Lu, Y.; Trybus, K.M.; Selvin, P.R.
Motor domain phosphorylation modulates kinesin-1 transport
J. Biol. Chem.
288
32612-32621
2013
Homo sapiens (Q12756), Mus musculus (Q61768)
Muretta, J.M.; Behnke-Parks, W.M.; Major, J.; Petersen, K.J.; Goulet, A.; Moores, C.A.; Thomas, D.D.; Rosenfeld, S.S.
Loop L5 assumes three distinct orientations during the ATPase cycle of the mitotic kinesin Eg5: a transient and time-resolved fluorescence study
J. Biol. Chem.
288
34839-34849
2013
Homo sapiens
Wang, W.; Shen, T.; Guerois, R.; Zhang, F.; Kuerban, H.; Lv, Y.; Gigant, B.; Knossow, M.; Wang, C.
New insights into the coupling between microtubule depolymerization and ATP hydrolysis by kinesin-13 protein Kif2C
J. Biol. Chem.
290
18721-18731
2015
Homo sapiens (Q99661)
Hu, H.; Hu, L.; Yu, Z.; Chasse, A.E.; Chu, F.; Li, Z.
An orphan kinesin in trypanosomes cooperates with a kinetoplastid-specific kinesin to maintain cell morphology by regulating subpellicular microtubules
J. Cell Sci.
125
4126-4136
2012
Trypanosoma brucei (Q383K3), Trypanosoma brucei
Chang, Q.; Nitta, R.; Inoue, S.; Hirokawa, N.
Structural basis for the ATP-induced isomerization of kinesin
J. Mol. Biol.
425
1869-1880
2013
Mus musculus (P33174)
Arellano-Santoyo, H.; Geyer, E.A.; Stokasimov, E.; Chen, G.Y.; Su, X.; Hancock, W.; Rice, L.M.; Pellman, D.
A tubulin binding switch underlies Kip3/Kinesin-8 depolymerase activity
Dev. Cell
42
37-51.e8
2017
Saccharomyces cerevisiae (P53086), Saccharomyces cerevisiae
Atherton, J.; Yu, I.M.; Cook, A.; Muretta, J.M.; Joseph, A.; Major, J.; Sourigues, Y.; Clause, J.; Topf, M.; Rosenfeld, S.S.; Houdusse, A.; Moores, C.A.
The divergent mitotic kinesin MKLP2 exhibits atypical structure and mechanochemistry
eLife
6
e27793
2017
Homo sapiens (O95235), Mus musculus (P97329)
Tao, L.; Fasulo, B.; Warecki, B.; Sullivan, W.
Tum/RacGAP functions as a switch activating the Pav/kinesin-6 motor
Nat. Commun.
7
11182
2016
Drosophila melanogaster
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