Crystallization (Comment) | Organism |
---|---|
crystal structure analysis, PDB IDs 4HNA, 1BG2, and 1II6, structure modeling | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | modeling reveals allosterically coupled motions driving the APO to ATP transition of ATPase states, binding free energy analysis | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | required | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O + a kinesin associated with a microtubule at position n | Homo sapiens | - |
ADP + phosphate + a kinesin associated with a microtubule at position n+1 (toward the plus end) | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P33176 | kinesin-1 heavy chain | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O + a kinesin associated with a microtubule at position n | - |
Homo sapiens | ADP + phosphate + a kinesin associated with a microtubule at position n+1 (toward the plus end) | - |
? | |
ATP + H2O + a kinesin associated with a microtubule at position n | modeling reveals key nucleotide-dependent changes in the structure and flexibility of the nucleotide-binding pocket and the tubulin-binding site, and allosterically coupled motions driving the APO to ATP transition of ATPase states, extension and shortening of alpha4 helix during the ATPase cycle | Homo sapiens | ADP + phosphate + a kinesin associated with a microtubule at position n+1 (toward the plus end) | structural mechanism of ADP release | ? | |
additional information | key residues involved in kinesin-tubulin binding | Homo sapiens | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
dimer | molecular dynamics simulation and atomic details of the structural dynamics and energetics of three major ATPase states (ADP, APO, and ATP state) of a human kinesin-1 monomer in complex with a tubulin dimer | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
kinesin-1 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
additional information | molecular dynamics simulation and atomic details of the structural dynamics and energetics of three major ATPase states (ADP, APO, and ATP state) of a human kinesin-1 monomer in complex with a tubulin dimer | Homo sapiens |