Information on EC 4.1.1.25 - Tyrosine decarboxylase

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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea

EC NUMBER
COMMENTARY
4.1.1.25
-
RECOMMENDED NAME
GeneOntology No.
Tyrosine decarboxylase
REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
L-tyrosine = tyramine + CO2
show the reaction diagram
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
decarboxylation
-
-
-
-
PATHWAY
KEGG Link
MetaCyc Link
(S)-reticuline biosynthesis I
-
(S)-reticuline biosynthesis II
-
Biosynthesis of secondary metabolites
-
hydroxycinnamic acid tyramine amides biosynthesis
-
Isoquinoline alkaloid biosynthesis
-
Metabolic pathways
-
methanofuran biosynthesis
-
octopamine biosynthesis
-
salidroside biosynthesis
-
Tyrosine metabolism
-
SYSTEMATIC NAME
IUBMB Comments
L-tyrosine carboxy-lyase (tyramine-forming)
A pyridoxal-phosphate protein. The bacterial enzyme also acts on 3-hydroxytyrosine and, more slowly, on 3-hydroxyphenylalanine.
SYNONYMS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
AADC
P54768
-
AtTYDC
Q8RY79
-
Decarboxylase, tyrosine
-
-
-
-
ELI5
-
-
-
-
L-(-)-Tyrosine apodecarboxylase
-
-
-
-
L-amino acid decarboxylase
Q8RY79
-
L-amino acid decarboxylase
P54768
-
L-amino acid decarboxylase
-
-
L-Tyrosine decarboxylase
-
-
-
-
PsTYDC1
P54768
-
PsTYDC2
P54768
-
TDC
-
-
-
-
TDC
Enterococcus faecalis DISAV1022
-
-
-
TDC
-
gene name
TDC
Lactobacillus brevis IOEB 9809
-
; gene name
-
TYDC
Citrus sp.
-
-
TYDC
-
-
TYDC
Q6BD07
-
TYDC
-
-
TYDC
P54768
-
TYDC
Papaver somniferum TYDC-2
-
-
-
TYDC/DODC
-
-
-
-
TYR decarboxylase
-
-
TyrDC
Q8RY79
-
TyrDC
Lactobacillus brevis IOEB 9809
-
-
-
tyrosine decarboxylase
-
-
tyrosine decarboxylase
-
-
tyrosine decarboxylase
Papaver somniferum TYDC-2
-
-
-
tyrosine decarboxylase-2
-
-
Tyrosine/Dopa decarboxylase
-
-
-
-
tyrosine/Dopa decarboxylase-1
P54768
-
tyrosine/Dopa decarboxylase-2
P54768
-
CAS REGISTRY NUMBER
COMMENTARY
9002-09-9
-
ORGANISM
COMMENTARY
LITERATURE
SEQUENCE CODE
SEQUENCE DB
SOURCE
Citrus sp.
-
-
-
Manually annotated by BRENDA team
dTdc1; dTdc2
-
-
Manually annotated by BRENDA team
strain DISAV1022
-
-
Manually annotated by BRENDA team
strain EF37
-
-
Manually annotated by BRENDA team
Enterococcus faecalis DISAV1022
strain DISAV1022
-
-
Manually annotated by BRENDA team
Enterococcus faecalis EF37
strain EF37
-
-
Manually annotated by BRENDA team
california poppy
-
-
Manually annotated by BRENDA team
strain IOEB 9809
SwissProt
Manually annotated by BRENDA team
strain IOEB 9809
-
-
Manually annotated by BRENDA team
strain IOEB 9809, isolated from wine
-
-
Manually annotated by BRENDA team
strains IOEB 9809, isolated from wine, and ATCC 367
-
-
Manually annotated by BRENDA team
Lactobacillus brevis IOEB 9809
-
-
-
Manually annotated by BRENDA team
Lactobacillus brevis IOEB 9809
strain IOEB 9809
SwissProt
Manually annotated by BRENDA team
Lactobacillus brevis IOEB 9809
strain IOEB 9809
-
-
Manually annotated by BRENDA team
Lactobacillus brevis IOEB 9809
strain IOEB 9809, isolated from wine
-
-
Manually annotated by BRENDA team
subspecies Lactobacillus curvatus curvatus
-
-
Manually annotated by BRENDA team
strain ATCC 14917, gene tdc
UniProt
Manually annotated by BRENDA team
Lactococcus lactis subsp. cremoris CCDM 824
-
-
-
Manually annotated by BRENDA team
Lactococcus lactis subsp. lactis CCDM 1004
-
-
-
Manually annotated by BRENDA team
migratorioides R.F., locust
-
-
Manually annotated by BRENDA team
cv. Xanthi
-
-
Manually annotated by BRENDA team
cultivar Dongjin
UniProt
Manually annotated by BRENDA team
; TYDC-2
-
-
Manually annotated by BRENDA team
opium poppy
SwissProt
Manually annotated by BRENDA team
opium poppy, TyDC gene family with about 15 members, TyDC5
-
-
Manually annotated by BRENDA team
Papaver somniferum TYDC-2
TYDC-2
-
-
Manually annotated by BRENDA team
expressed in Solanum tuberosum L. cv. Desiree
SwissProt
Manually annotated by BRENDA team
overexpressed in Solanum tuberosum
-
-
Manually annotated by BRENDA team
parsley, TyrDC-2
-
-
Manually annotated by BRENDA team
Thalictrum rugosum
-
-
-
Manually annotated by BRENDA team
Thalictrum rugosum
meadow rue
-
-
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
malfunction
-
Malpighian tubules isolated from Tdc1f03311 homozygous flies show no significant depolarization of their transepithelial potential or diuresis in response to tyrosine while retaining normal sensitivity to tyramine, the null mutant allele of the neuronal TDC isoform Tdc2 has no effect on either tyrosine or tyramine sensitivity
physiological function
-
synthesis of tyramine by Tdc1 in the principal cells of the Malpighian tubule is required for physiological responses to tyrosine
Ki VALUE [mM]
Ki VALUE [mM] Maximum
INHIBITOR
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
IMAGE
8
-
tyramine
-
strain ATCC 367
13
-
tyramine
-
strain IOEB 9809
IC50 VALUE [mM]
IC50 VALUE [mM] Maximum
INHIBITOR
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
IMAGE
6.37
-
(2S)-2-amino-3-(3-hydroxyphenyl)-2-methylpropanoic acid
-
IC50: 6.37 mM
9.4
-
(2S)-2-amino-3-(4-hydroxyphenyl)-2-methylpropanoic acid
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IC50: 9.4 mM
0.0004
-
3-hydroxybenzyl-hydrazine
-
potent inhibitor, IC50: 0.0004 mM
1.8
-
alpha-methyl-2,4-dihydroxyphenylalanine
-
IC50: 1.8 mM
SPECIFIC ACTIVITY [µmol/min/mg]
SPECIFIC ACTIVITY MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
0.00000243
-
Q7B9Y8
pH 5, 37C, purified TDC
0.18
-
Thalictrum rugosum
-
-
1058
-
-
pH 5, 25C
additional information
-
-
highly sensitive and rapid spectrophotometric assay
additional information
-
-
the pCO2 electrode is a good tool for kinetic studies
additional information
-
Q7B9Y8
not detectable in crude extract, but in the soluble fraction
pI VALUE
pI VALUE MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
5
-
-
isoelectric focusing
PDB
SCOP
CATH
ORGANISM
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)
GENERAL STABILITY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
rapid loss of activity during purification
-
stabilized in presence of pyridoxal 5'-phosphate
-
unstable to freezing
-
complete inactivation of purified TDC by freezing at -20C, unstable during purification, washing of purified extract with sodium acetate buffer, pH 5, by ultracentrifugation results in complete loss of activity, partially restored by 0.2 mM pyridoxal 5-phosphate
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enzyme is stable during preparation, pyridoxal 5-phosphate, glycerol, EDTA and 2-mercaptoethanol stabilize
Q7B9Y8
L-tyrosine and pyridoxal 5-phosphate stabilize
-
stabilized in presence of pyridoxal 5'-phosphate
Thalictrum rugosum
-
ORGANIC SOLVENT
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
Ethanol
-
12%, slight inhibition of activity in cell suspension, not: up to 10%
STORAGE STABILITY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
2C, purified enzyme is relatively stable
-
-20C, stable
Q7B9Y8
-20C, TDC from strain IOEB 9809, 0.2 M sodium acetate, pH 5, 0.2 mM pyridoxal 5-phosphate, 3.6 mM L-tyrosine, at least 2 months, stable
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-20C, TDC from strain IOEB 9809, 0.2 M sodium acetate, pH 5, 24 h, 60% loss of activity
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4, 0.2 mM pyridoxal 5-phosphate, 3 days, stable
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4C, crude extract, progressive loss of activity
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4C, repeated storage, half-life: 1.5 days
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4C, TDC from strain IOEB 9809, 0.2 M sodium acetate, pH 5, 0.2 mM pyridoxal 5-phosphate, 3.6 mM L-tyrosine, 15 days, 50% loss of activity
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4C, TDC from strain IOEB 9809, 0.2 M sodium acetate, pH 5, 24 h, 85% loss of activity
-
ENGINEERING
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
additional information
-
the mutant allele of Tdc1, Tdc1f03311, reduces expression of the mature Tdc1 transcript by greater than 100fold
additional information
-
fusion construct of tyrosine decarboxylase and tyramine N-hydroycinnamoyltransferase