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(4Z,7E)-N,N'-dihydroxy-2,2-dimethyl-5,6-dihydro-2H-benzimidazole-4,7-diimine
-
(5Z)-2-amino-5-(2-nitrobenzylidene)-1,3-thiazol-4(5H)-one
-
1,4-dioxo-1,2,3,4-tetrahydronaphthalen-2-yl 2,3,4-tri-O-acetylpentopyranoside
-
1-(2-nitrobenzyl)-1H-indole-3-carbaldehyde
-
10H-indeno[2,1-e]tetrazolo[1,5-b][1,2,4]triazin-10-one
-
2,4-bis[2-(4-hydroxyphenyl)propan-2-yl]phenol
-
2-(benzylsulfanyl)-3-(morpholin-4-yl)-2,3-dihydronaphthalene-1,4-dione
-
2-chloro-N-[5-([2-oxo-2-[(4-sulfamoylphenyl)amino]ethyl]sulfanyl)-1,3,4-thiadiazol-2-yl]acetamide
-
2-hydroxy-2-(2-hydroxy-6-oxocyclohex-2-en-1-yl)-1H-indene-1,3(2H)-dione
-
2-thioxo-3-[(E)-(3,3,5-trimethylcyclohexylidene)amino]-1,3-thiazolidin-4-one
-
2-[(2-chloro-5-nitrobenzoyl)amino]-5-iodobenzoic acid
-
2-[(3-formyl-1H-indol-1-yl)methyl]benzonitrile
-
3,3'-(4H-1,2,4-triazole-3,5-diyl)bis(4-nitro-1,2,5-oxadiazole)
-
3-[(2E)-2-[1-(3,4-dimethoxyphenyl)ethylidene]hydrazinyl]benzoic acid
-
3-[(E)-(2,6-difluorobenzylidene)amino]-2-thioxo-1,3-thiazolidin-4-one
-
3-[(E)-(4-methoxybenzylidene)amino]-2-thioxo-1,3-thiazolidin-4-one
-
4,4'-(phenylmethanediyl)bis[2-(4-chlorophenyl)-5-methyl-2,4-dihydro-3H-pyrazol-3-one]
-
4,4'-[(4-hydroxyphenyl)methanediyl]bis(2-heptyl-5-methyl-2,4-dihydro-3H-pyrazol-3-one)
-
4-(morpholin-4-yl)naphthalene-1,2-dione
-
4-(piperidin-1-yl)naphthalene-1,2-dione
-
4-nitro-1,6-dihydrobenzo[1,2-d:3,4-d']bis[1,2,3]triazole
-
4-nitro-7-[[(1-phenyl-1H-tetrazol-5-yl)sulfanyl]methyl]-2,1,3-benzothiadiazole
-
4-[(1,4-dioxo-1,2,3,4-tetrahydronaphthalen-2-yl)sulfanyl]butanoic acid
-
5,6-dichloro-2,1,3-benzothiadiazole-4,7-diol
-
5-[(E)-benzylideneamino]-6-[(2-hydroxyethyl)amino]pyrimidine-2,4(1H,3H)-dione
-
5-[(E)-[[1-(2-chlorobenzyl)-1H-indol-3-yl]methylidene]amino]-1,3-dihydro-2H-benzimidazol-2-one
-
5-[[5-hydroxy-3-methyl-1-(4-methylphenyl)-1H-pyrazol-4-yl]methylidene]-1,3-diphenyl-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
-
6,11-dioxo-5a,6,11,11a-tetrahydronaphtho[2',3':4,5][1,3]thiazolo[3,2-a]pyridin-12-ium
-
9H-indeno[1,2-b][1,2,5]oxadiazolo[3,4-e]pyrazin-9-one
-
biphenyl-3,3'-dicarbaldehyde
-
isoniazide
isoniazide-induced seizures are mediated primarily through competition with the cofactor pyridoxal 5'-phosphate resulting in the inhibition of GAD activity
methyl 2-amino-3-oxo-3H-phenothiazine-1-carboxylate
-
methyl 2-[[(2-methylimidazo[1,2-a]pyridin-3-yl)carbonyl]amino]benzoate
-
N-(2-hydroxy-1,3-dioxo-2,3-dihydro-1H-inden-2-yl)benzamide
-
N-[4,7-dioxo-6-(phenylamino)-4,7-dihydro-2,1,3-benzoxadiazol-5-yl]acetamide
-
N-[4,7-dioxo-6-(piperidin-1-yl)-4,7-dihydro-2,1,3-benzoxadiazol-5-yl]acetamide
-
naphtho[2',3':4,5]imidazo[1,2-a]pyridine-6,11-dione
-
[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)oxy]acetic acid
-
(4Z,7E)-N,N'-dihydroxy-2,2-dimethyl-5,6-dihydro-2H-benzimidazole-4,7-diimine
-
(5Z)-2-amino-5-(2-nitrobenzylidene)-1,3-thiazol-4(5H)-one
-
1,4-dioxo-1,2,3,4-tetrahydronaphthalen-2-yl 2,3,4-tri-O-acetylpentopyranoside
-
1-(2-nitrobenzyl)-1H-indole-3-carbaldehyde
-
1-Methylimidazole
-
about 85% residual activity at 5 mM, about 77% residual activity at 10 mM, about 65% residual activity at 20 mM
10H-indeno[2,1-e]tetrazolo[1,5-b][1,2,4]triazin-10-one
-
2,4-bis[2-(4-hydroxyphenyl)propan-2-yl]phenol
-
2-(benzylsulfanyl)-3-(morpholin-4-yl)-2,3-dihydronaphthalene-1,4-dione
-
2-chloro-N-[5-([2-oxo-2-[(4-sulfamoylphenyl)amino]ethyl]sulfanyl)-1,3,4-thiadiazol-2-yl]acetamide
-
2-hydroxy-2-(2-hydroxy-6-oxocyclohex-2-en-1-yl)-1H-indene-1,3(2H)-dione
-
2-thioxo-3-[(E)-(3,3,5-trimethylcyclohexylidene)amino]-1,3-thiazolidin-4-one
-
2-[(2-chloro-5-nitrobenzoyl)amino]-5-iodobenzoic acid
-
2-[(3-formyl-1H-indol-1-yl)methyl]benzonitrile
-
3,3'-(4H-1,2,4-triazole-3,5-diyl)bis(4-nitro-1,2,5-oxadiazole)
-
3,4,5-Trihydroxybenzoic acid
-
-
3,4-dihydroxybenzoic acid
-
-
3,5-Dihydroxybenzoic acid
-
-
3-Mercaptopropionic acid
-
-
3-[(2E)-2-[1-(3,4-dimethoxyphenyl)ethylidene]hydrazinyl]benzoic acid
-
3-[(E)-(2,6-difluorobenzylidene)amino]-2-thioxo-1,3-thiazolidin-4-one
-
3-[(E)-(4-methoxybenzylidene)amino]-2-thioxo-1,3-thiazolidin-4-one
-
4,4'-(phenylmethanediyl)bis[2-(4-chlorophenyl)-5-methyl-2,4-dihydro-3H-pyrazol-3-one]
-
4,4'-[(4-hydroxyphenyl)methanediyl]bis(2-heptyl-5-methyl-2,4-dihydro-3H-pyrazol-3-one)
-
4,5-Dihydroxyisophthalic acid
-
-
4-(morpholin-4-yl)naphthalene-1,2-dione
-
4-(piperidin-1-yl)naphthalene-1,2-dione
-
4-Aminohex-5-ynoic acid
-
-
4-bromoisophthalic acid
-
-
4-methylimidazole
-
about 75% residual activity at 5 mM, about 70% residual activity at 10 mM, about 58% residual activity at 20 mM
4-nitro-1,6-dihydrobenzo[1,2-d:3,4-d']bis[1,2,3]triazole
-
4-nitro-7-[[(1-phenyl-1H-tetrazol-5-yl)sulfanyl]methyl]-2,1,3-benzothiadiazole
-
4-[(1,4-dioxo-1,2,3,4-tetrahydronaphthalen-2-yl)sulfanyl]butanoic acid
-
5,5'-dithiobis(2-nitrobenzoate)
-
-
5,6-dichloro-2,1,3-benzothiadiazole-4,7-diol
-
5-[(E)-benzylideneamino]-6-[(2-hydroxyethyl)amino]pyrimidine-2,4(1H,3H)-dione
-
5-[(E)-[[1-(2-chlorobenzyl)-1H-indol-3-yl]methylidene]amino]-1,3-dihydro-2H-benzimidazol-2-one
-
5-[[5-hydroxy-3-methyl-1-(4-methylphenyl)-1H-pyrazol-4-yl]methylidene]-1,3-diphenyl-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
-
6,11-dioxo-5a,6,11,11a-tetrahydronaphtho[2',3':4,5][1,3]thiazolo[3,2-a]pyridin-12-ium
-
9H-indeno[1,2-b][1,2,5]oxadiazolo[3,4-e]pyrazin-9-one
-
biphenyl-3,3'-dicarbaldehyde
-
DL-4-Amino-4-phosphonobutyrate
-
-
Glutamate gamma-hydroxamate
-
weak
Isonicotinic acid hydrazide
-
-
L-aspartate beta-hydroxamate
-
weak
Mercaptosuccinic acid
-
-
methyl 2-amino-3-oxo-3H-phenothiazine-1-carboxylate
-
methyl 2-[[(2-methylimidazo[1,2-a]pyridin-3-yl)carbonyl]amino]benzoate
-
N-(2-hydroxy-1,3-dioxo-2,3-dihydro-1H-inden-2-yl)benzamide
-
N-[4,7-dioxo-6-(phenylamino)-4,7-dihydro-2,1,3-benzoxadiazol-5-yl]acetamide
-
N-[4,7-dioxo-6-(piperidin-1-yl)-4,7-dihydro-2,1,3-benzoxadiazol-5-yl]acetamide
-
naphtho[2',3':4,5]imidazo[1,2-a]pyridine-6,11-dione
-
p-hydroxymercuribenzoate
-
-
[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)oxy]acetic acid
-
additional information
inhibitor screening, overview
-
additional information
inhibitor screening, overview
-
additional information
-
inhibitor screening, overview
-
additional information
-
-
-
additional information
inhibitor screening, overview
-
additional information
inhibitor screening, overview
-
additional information
-
inhibitor screening, overview
-
additional information
-
downregulation of reelin and GAD67 expression by the increase of DNA-methyltransferase 1-mediated hypermethylation of promoters in GABAergic interneurons of the telencephalon
-
additional information
-
glutamate reduces the expression of isozymes GAD65 and GAD67, glutamate's suppressing effect on GAD protein isoforms is significantly attenuated by preincubation with the cysteine protease inhibitor N-acetyl-L-leucyl-L-leucyl-L-norleucinal via blockade of calpain and cathepsin protease activities, overview
-
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0.0123
(4Z,7E)-N,N'-dihydroxy-2,2-dimethyl-5,6-dihydro-2H-benzimidazole-4,7-diimine
Mus musculus
pH 8.0, 37°C, recombinant enzyme
0.0033
(5Z)-2-amino-5-(2-nitrobenzylidene)-1,3-thiazol-4(5H)-one
Mus musculus
pH 8.0, 37°C, recombinant enzyme
0.004
1,4-dioxo-1,2,3,4-tetrahydronaphthalen-2-yl 2,3,4-tri-O-acetylpentopyranoside
Mus musculus
pH 8.0, 37°C, recombinant enzyme
0.0069
1-(2-nitrobenzyl)-1H-indole-3-carbaldehyde
Mus musculus
pH 8.0, 37°C, recombinant enzyme
0.002
10H-indeno[2,1-e]tetrazolo[1,5-b][1,2,4]triazin-10-one
Mus musculus
pH 8.0, 37°C, recombinant enzyme
0.0777
2,4-bis[2-(4-hydroxyphenyl)propan-2-yl]phenol
Mus musculus
pH 8.0, 37°C, recombinant enzyme
0.0073
2-(benzylsulfanyl)-3-(morpholin-4-yl)-2,3-dihydronaphthalene-1,4-dione
Mus musculus
pH 8.0, 37°C, recombinant enzyme
0.0087
2-chloro-N-[5-([2-oxo-2-[(4-sulfamoylphenyl)amino]ethyl]sulfanyl)-1,3,4-thiadiazol-2-yl]acetamide
Mus musculus
pH 8.0, 37°C, recombinant enzyme
0.0042
2-hydroxy-2-(2-hydroxy-6-oxocyclohex-2-en-1-yl)-1H-indene-1,3(2H)-dione
Mus musculus
pH 8.0, 37°C, recombinant enzyme
0.01
2-thioxo-3-[(E)-(3,3,5-trimethylcyclohexylidene)amino]-1,3-thiazolidin-4-one
Mus musculus
pH 8.0, 37°C, recombinant enzyme
0.0845
2-[(2-chloro-5-nitrobenzoyl)amino]-5-iodobenzoic acid
Mus musculus
pH 8.0, 37°C, recombinant enzyme
0.0089
2-[(3-formyl-1H-indol-1-yl)methyl]benzonitrile
Mus musculus
pH 8.0, 37°C, recombinant enzyme
0.0004
3,3'-(4H-1,2,4-triazole-3,5-diyl)bis(4-nitro-1,2,5-oxadiazole)
Mus musculus
pH 8.0, 37°C, recombinant enzyme
0.1
3-[(2E)-2-[1-(3,4-dimethoxyphenyl)ethylidene]hydrazinyl]benzoic acid
Mus musculus
above, pH 8.0, 37°C, recombinant enzyme
0.0064
3-[(E)-(2,6-difluorobenzylidene)amino]-2-thioxo-1,3-thiazolidin-4-one
Mus musculus
pH 8.0, 37°C, recombinant enzyme
0.012
4,4'-(phenylmethanediyl)bis[2-(4-chlorophenyl)-5-methyl-2,4-dihydro-3H-pyrazol-3-one]
Mus musculus
pH 8.0, 37°C, recombinant enzyme
0.0138
4,4'-[(4-hydroxyphenyl)methanediyl]bis(2-heptyl-5-methyl-2,4-dihydro-3H-pyrazol-3-one)
Mus musculus
pH 8.0, 37°C, recombinant enzyme
0.0029
4-(morpholin-4-yl)naphthalene-1,2-dione
Mus musculus
pH 8.0, 37°C, recombinant enzyme
0.003
4-(piperidin-1-yl)naphthalene-1,2-dione
Mus musculus
pH 8.0, 37°C, recombinant enzyme
0.0077
4-nitro-1,6-dihydrobenzo[1,2-d:3,4-d']bis[1,2,3]triazole
Mus musculus
pH 8.0, 37°C, recombinant enzyme
0.1
4-nitro-7-[[(1-phenyl-1H-tetrazol-5-yl)sulfanyl]methyl]-2,1,3-benzothiadiazole
Mus musculus
above, pH 8.0, 37°C, recombinant enzyme
0.0064
4-[(1,4-dioxo-1,2,3,4-tetrahydronaphthalen-2-yl)sulfanyl]butanoic acid
Mus musculus
pH 8.0, 37°C, recombinant enzyme
0.0033
5,6-dichloro-2,1,3-benzothiadiazole-4,7-diol
Mus musculus
pH 8.0, 37°C, recombinant enzyme
0.0069
5-[(E)-benzylideneamino]-6-[(2-hydroxyethyl)amino]pyrimidine-2,4(1H,3H)-dione
Mus musculus
pH 8.0, 37°C, recombinant enzyme
0.0065
5-[(E)-[[1-(2-chlorobenzyl)-1H-indol-3-yl]methylidene]amino]-1,3-dihydro-2H-benzimidazol-2-one
Mus musculus
pH 8.0, 37°C, recombinant enzyme
0.0558
5-[[5-hydroxy-3-methyl-1-(4-methylphenyl)-1H-pyrazol-4-yl]methylidene]-1,3-diphenyl-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
Mus musculus
pH 8.0, 37°C, recombinant enzyme
0.0023
6,11-dioxo-5a,6,11,11a-tetrahydronaphtho[2',3':4,5][1,3]thiazolo[3,2-a]pyridin-12-ium
Mus musculus
pH 8.0, 37°C, recombinant enzyme
0.0143
9H-indeno[1,2-b][1,2,5]oxadiazolo[3,4-e]pyrazin-9-one
Mus musculus
pH 8.0, 37°C, recombinant enzyme
0.0049
biphenyl-3,3'-dicarbaldehyde
Mus musculus
pH 8.0, 37°C, recombinant enzyme
0.0005
carboxymethoxylamine
Mus musculus
pH 8.0, 37°C, recombinant enzyme
0.001
methyl 2-amino-3-oxo-3H-phenothiazine-1-carboxylate
Mus musculus
pH 8.0, 37°C, recombinant enzyme
0.0065
methyl 2-[[(2-methylimidazo[1,2-a]pyridin-3-yl)carbonyl]amino]benzoate
Mus musculus
pH 8.0, 37°C, recombinant enzyme
0.0076
N-(2-hydroxy-1,3-dioxo-2,3-dihydro-1H-inden-2-yl)benzamide
Mus musculus
pH 8.0, 37°C, recombinant enzyme
0.0012
N-[4,7-dioxo-6-(phenylamino)-4,7-dihydro-2,1,3-benzoxadiazol-5-yl]acetamide
Mus musculus
pH 8.0, 37°C, recombinant enzyme
0.0022
N-[4,7-dioxo-6-(piperidin-1-yl)-4,7-dihydro-2,1,3-benzoxadiazol-5-yl]acetamide
Mus musculus
pH 8.0, 37°C, recombinant enzyme
0.0041
naphtho[2',3':4,5]imidazo[1,2-a]pyridine-6,11-dione
Mus musculus
pH 8.0, 37°C, recombinant enzyme
0.1
[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)oxy]acetic acid
Mus musculus
above, pH 8.0, 37°C, recombinant enzyme
0.0266
(4Z,7E)-N,N'-dihydroxy-2,2-dimethyl-5,6-dihydro-2H-benzimidazole-4,7-diimine
Mus musculus
pH 8.0, 37°C, recombinant enzyme
0.0418
(5Z)-2-amino-5-(2-nitrobenzylidene)-1,3-thiazol-4(5H)-one
Mus musculus
pH 8.0, 37°C, recombinant enzyme
0.012
1,4-dioxo-1,2,3,4-tetrahydronaphthalen-2-yl 2,3,4-tri-O-acetylpentopyranoside
Mus musculus
pH 8.0, 37°C, recombinant enzyme
0.0142
1-(2-nitrobenzyl)-1H-indole-3-carbaldehyde
Mus musculus
pH 8.0, 37°C, recombinant enzyme
0.0047
10H-indeno[2,1-e]tetrazolo[1,5-b][1,2,4]triazin-10-one
Mus musculus
pH 8.0, 37°C, recombinant enzyme
0.1
2,4-bis[2-(4-hydroxyphenyl)propan-2-yl]phenol
Mus musculus
above, pH 8.0, 37°C, recombinant enzyme
0.0209
2-(benzylsulfanyl)-3-(morpholin-4-yl)-2,3-dihydronaphthalene-1,4-dione
Mus musculus
pH 8.0, 37°C, recombinant enzyme
0.0052
2-chloro-N-[5-([2-oxo-2-[(4-sulfamoylphenyl)amino]ethyl]sulfanyl)-1,3,4-thiadiazol-2-yl]acetamide
Mus musculus
pH 8.0, 37°C, recombinant enzyme
0.0108
2-hydroxy-2-(2-hydroxy-6-oxocyclohex-2-en-1-yl)-1H-indene-1,3(2H)-dione
Mus musculus
pH 8.0, 37°C, recombinant enzyme
0.0127
2-thioxo-3-[(E)-(3,3,5-trimethylcyclohexylidene)amino]-1,3-thiazolidin-4-one
Mus musculus
pH 8.0, 37°C, recombinant enzyme
0.1
2-[(2-chloro-5-nitrobenzoyl)amino]-5-iodobenzoic acid
Mus musculus
above, pH 8.0, 37°C, recombinant enzyme
0.0126
2-[(3-formyl-1H-indol-1-yl)methyl]benzonitrile
Mus musculus
pH 8.0, 37°C, recombinant enzyme
0.0002
3,3'-(4H-1,2,4-triazole-3,5-diyl)bis(4-nitro-1,2,5-oxadiazole)
Mus musculus
pH 8.0, 37°C, recombinant enzyme
0.1
3-[(2E)-2-[1-(3,4-dimethoxyphenyl)ethylidene]hydrazinyl]benzoic acid
Mus musculus
above, pH 8.0, 37°C, recombinant enzyme
0.0079
3-[(E)-(2,6-difluorobenzylidene)amino]-2-thioxo-1,3-thiazolidin-4-one
Mus musculus
pH 8.0, 37°C, recombinant enzyme
0.0072
4,4'-(phenylmethanediyl)bis[2-(4-chlorophenyl)-5-methyl-2,4-dihydro-3H-pyrazol-3-one]
Mus musculus
pH 8.0, 37°C, recombinant enzyme
0.013
4,4'-[(4-hydroxyphenyl)methanediyl]bis(2-heptyl-5-methyl-2,4-dihydro-3H-pyrazol-3-one)
Mus musculus
pH 8.0, 37°C, recombinant enzyme
0.0045
4-(morpholin-4-yl)naphthalene-1,2-dione
Mus musculus
pH 8.0, 37°C, recombinant enzyme
0.0047
4-(piperidin-1-yl)naphthalene-1,2-dione
Mus musculus
pH 8.0, 37°C, recombinant enzyme
0.065
4-nitro-1,6-dihydrobenzo[1,2-d:3,4-d']bis[1,2,3]triazole
Mus musculus
pH 8.0, 37°C, recombinant enzyme
0.1
4-nitro-7-[[(1-phenyl-1H-tetrazol-5-yl)sulfanyl]methyl]-2,1,3-benzothiadiazole
Mus musculus
above, pH 8.0, 37°C, recombinant enzyme
0.0112
4-[(1,4-dioxo-1,2,3,4-tetrahydronaphthalen-2-yl)sulfanyl]butanoic acid
Mus musculus
pH 8.0, 37°C, recombinant enzyme
0.0083
5,6-dichloro-2,1,3-benzothiadiazole-4,7-diol
Mus musculus
pH 8.0, 37°C, recombinant enzyme
0.0104
5-[(E)-benzylideneamino]-6-[(2-hydroxyethyl)amino]pyrimidine-2,4(1H,3H)-dione
Mus musculus
pH 8.0, 37°C, recombinant enzyme
0.0129
5-[(E)-[[1-(2-chlorobenzyl)-1H-indol-3-yl]methylidene]amino]-1,3-dihydro-2H-benzimidazol-2-one
Mus musculus
pH 8.0, 37°C, recombinant enzyme
0.0593
5-[[5-hydroxy-3-methyl-1-(4-methylphenyl)-1H-pyrazol-4-yl]methylidene]-1,3-diphenyl-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
Mus musculus
pH 8.0, 37°C, recombinant enzyme
0.0057
6,11-dioxo-5a,6,11,11a-tetrahydronaphtho[2',3':4,5][1,3]thiazolo[3,2-a]pyridin-12-ium
Mus musculus
pH 8.0, 37°C, recombinant enzyme
0.1
9H-indeno[1,2-b][1,2,5]oxadiazolo[3,4-e]pyrazin-9-one
Mus musculus
above, pH 8.0, 37°C, recombinant enzyme
0.0049
biphenyl-3,3'-dicarbaldehyde
Mus musculus
pH 8.0, 37°C, recombinant enzyme
0.001
carboxymethoxylamine
Mus musculus
pH 8.0, 37°C, recombinant enzyme
0.002 - 4
methyl 2-amino-3-oxo-3H-phenothiazine-1-carboxylate
Mus musculus
pH 8.0, 37°C, recombinant enzyme
0.0125
methyl 2-[[(2-methylimidazo[1,2-a]pyridin-3-yl)carbonyl]amino]benzoate
Mus musculus
pH 8.0, 37°C, recombinant enzyme
0.0164
N-(2-hydroxy-1,3-dioxo-2,3-dihydro-1H-inden-2-yl)benzamide
Mus musculus
pH 8.0, 37°C, recombinant enzyme
0.0022
N-[4,7-dioxo-6-(phenylamino)-4,7-dihydro-2,1,3-benzoxadiazol-5-yl]acetamide
Mus musculus
pH 8.0, 37°C, recombinant enzyme
0.0044
N-[4,7-dioxo-6-(piperidin-1-yl)-4,7-dihydro-2,1,3-benzoxadiazol-5-yl]acetamide
Mus musculus
pH 8.0, 37°C, recombinant enzyme
0.0591
naphtho[2',3':4,5]imidazo[1,2-a]pyridine-6,11-dione
Mus musculus
pH 8.0, 37°C, recombinant enzyme
0.1
[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)oxy]acetic acid
Mus musculus
above, pH 8.0, 37°C, recombinant enzyme
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Wu, J.Y.; Matsuda, T.; Roberts, E.
Purification and characterization of glutamate decarboxylase from mouse brain
J. Biol. Chem.
248
3029-3034
1973
Mus musculus
brenda
Roberts, E.; Frankel, S.
Further studies of glutamic acid decarboxylase in brain
J. Biol. Chem.
190
505-512
1951
Mus musculus
brenda
Youngs, T.L.; Tunnicliff, G.
Substrate analogues and divalent cations as inhibitors of glutamate decarboxylase from Escherichia coli
Biochem. Int.
23
915-922
1991
Escherichia coli, Mus musculus
brenda
Tunnicliff, G.
Action of inhibitors on brain glutamate decarboxylase
Int. J. Biochem.
27
1235-1241
1990
Gallus gallus, Mus musculus, Rattus norvegicus, Sus scrofa
brenda
Liu, C.P.
Glutamic acid decarboxylase-specific CD4+ regulatory T cells
Ann. N. Y. Acad. Sci.
1079
161-170
2006
Mus musculus
brenda
Wu, H.; Jin, Y.; Buddhala, C.; Osterhaus, G.; Cohen, E.; Jin, H.; Wei, J.; Davis, K.; Obata, K.; Wu, J.Y.
Role of glutamate decarboxylase (GAD) isoform, GAD65, in GABA synthesis and transport into synaptic vesicles - Evidence from GAD65-knockout mice studies
Brain Res.
1154
80-83
2007
Mus musculus
brenda
Obata, K.; Hirono, M.; Kume, N.; Kawaguchi, Y.; Itohara, S.; Yanagawa, Y.
GABA and synaptic inhibition of mouse cerebellum lacking glutamate decarboxylase 67
Biochem. Biophys. Res. Commun.
370
429-433
2008
Mus musculus
brenda
Sha, D.; Jin, Y.; Wu, H.; Wei, J.; Lin, C.H.; Lee, Y.H.; Buddhala, C.; Kuchay, S.; Chishti, A.H.; Wu, J.Y.
Role of mu-calpain in proteolytic cleavage of brain L-glutamic acid decarboxylase
Brain Res.
1207
9-18
2008
Homo sapiens, Mus musculus, Rattus norvegicus
brenda
Schlosser, M.; Walschus, U.; Kloeting, I.; Walther, R.
Determination of glutamic acid decarboxylase (GAD65) in pancreatic islets and its in vitro and in vivo degradation kinetics in serum using a highly sensitive enzyme immunoassay
Dis. Markers
24
191-198
2008
Homo sapiens, Mus musculus, Rattus norvegicus, Sus scrofa, Rattus norvegicus LEW-1A
brenda
Monnerie, H.; Le Roux, P.D.
Glutamate alteration of glutamic acid decarboxylase (GAD) in GABAergic neurons: the role of cysteine proteases
Exp. Neurol.
213
145-153
2008
Mus musculus, Mus musculus BALB/c
brenda
Bergado-Acosta, J.R.; Sangha, S.; Narayanan, R.T.; Obata, K.; Pape, H.C.; Stork, O.
Critical role of the 65-kDa isoform of glutamic acid decarboxylase in consolidation and generalization of Pavlovian fear memory
Learn. Mem.
15
163-171
2008
Mus musculus
brenda
Wei, J.; Wu, J.Y.
Post-translational regulation of L-glutamic acid decarboxylase in the brain
Neurochem. Res.
33
1459-1465
2008
Mus musculus, Rattus norvegicus, Homo sapiens (Q05329), Homo sapiens (Q99259)
brenda
Alonso-Espinaco, V.; Elezgarai, I.; Diez-Garcia, J.; Puente, N.; Knoepfel, T.; Grandes, P.
Subcellular localization of the voltage-gated potassium channels Kv3.1b and Kv3.3 in the cerebellar dentate nucleus of glutamic acid decarboxylase 67-green fluorescent protein transgenic mice
Neuroscience
155
1059-1069
2008
Mus musculus, Mus musculus C57BL/6
brenda
El Idrissi, A.; L'Amoreaux, W.J.
Selective resistance of taurine-fed mice to isoniazide-potentiated seizures: In vivo functional test for the activity of glutamic acid decarboxylase
Neuroscience
156
693-699
2008
Mus musculus (P48320)
brenda
Kaneko, K.; Tamamaki, N.; Owada, H.; Kakizaki, T.; Kume, N.; Totsuka, M.; Yamamoto, T.; Yawo, H.; Yagi, T.; Obata, K.; Yanagawa, Y.
Noradrenergic excitation of a subpopulation of GABAergic cells in the basolateral amygdala via both activation of nonselective cationic conductance and suppression of resting K+ conductance: A study using glutamate decarboxylase 67-green fluorescent prote
Neuroscience
157
781-797
2008
Mus musculus
brenda
Satta, R.; Maloku, E.; Zhubi, A.; Pibiri, F.; Hajos, M.; Costa, E.; Guidotti, A.
Nicotine decreases DNA methyltransferase 1 expression and glutamic acid decarboxylase 67 promoter methylation in GABAergic interneurons
Proc. Natl. Acad. Sci. USA
105
16356-16361
2008
Homo sapiens, Mus musculus
brenda
Sangha, S.; Narayanan, R.T.; Bergado-Acosta, J.R.; Stork, O.; Seidenbecher, T.; Pape, H.C.
Deficiency of the 65 kDa isoform of glutamic acid decarboxylase impairs extinction of cued but not contextual fear memory
J. Neurosci.
29
15713-15720
2009
Mus musculus
brenda
Kubo, K.; Nishikawa, K.; Hardy-Yamada, M.; Ishizeki, J.; Yanagawa, Y.; Saito, S.
Altered responses to propofol, but not ketamine, in mice deficient in the 65-kilodalton isoform of glutamate decarboxylase
J. Pharmacol. Exp. Ther.
329
592-599
2009
Mus musculus
brenda
Kubo, K.; Nishikawa, K.; Ishizeki, J.; Hardy-Yamada, M.; Yanagawa, Y.; Saito, S.
Thermal hyperalgesia via supraspinal mechanisms in mice lacking glutamate decarboxylase 65
J. Pharmacol. Exp. Ther.
331
162-169
2009
Mus musculus
brenda
Sivertsen, T.; Nygaard, A.K.; Mathisen, G.; Fonnum, F.
Effects of 4-methylimidazole on cerebral glutamate decarboxylase activity and specific GABA receptor binding in mice
Toxicol. Mech. Methods
19
214-218
2009
Mus musculus, Mus musculus B6D2
brenda
Ilg, T.; Berger, M.; Noack, S.; Rohwer, A.; Gassel, M.
Glutamate decarboxylase of the parasitic arthropods Ctenocephalides felis and Rhipicephalus microplus: gene identification, cloning, expression, assay development, identification of inhibitors by high throughput screening and comparison with the orthologs
Insect Biochem. Mol. Biol.
43
162-177
2013
Ctenocephalides felis (K7WYY0), Ctenocephalides felis, Rhipicephalus microplus (K7XPX5), Rhipicephalus microplus, Drosophila melanogaster (P20228), Drosophila melanogaster, Mus musculus (P48318), Mus musculus (P48320), Mus musculus
brenda