Information on EC 3.6.1.5 - apyrase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Specify your search results
Mark a special word or phrase in this record:
Select one or more organisms in this record:
Show additional data
Do not include text mining results
Include (text mining) results (more...)
Include results (AMENDA + additional results, but less precise; more...)


The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea

EC NUMBER
COMMENTARY
3.6.1.5
-
RECOMMENDED NAME
GeneOntology No.
apyrase
REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
a nucleoside 5'-diphosphate + H2O = a nucleoside 5'-phosphate + phosphate
show the reaction diagram
(1b)
-
-
-
a nucleoside 5'-triphosphate + 2 H2O = a nucleoside 5'-phosphate + 2 phosphate
show the reaction diagram
overall reaction
-
-
-
a nucleoside 5'-triphosphate + H2O = a nucleoside 5'-diphosphate + phosphate
show the reaction diagram
(1a)
-
-
-
REACTION TYPE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
phosphorous acid anhydride hydrolysis
-
-
-
-
PATHWAY
KEGG Link
MetaCyc Link
Purine metabolism
-
Pyrimidine metabolism
-
UTP and CTP dephosphorylation II
-
SYSTEMATIC NAME
IUBMB Comments
nucleoside triphosphate phosphohydrolase (nucleoside monophosphoate-forming)
Apyrases are active against both di- and triphosphate nucleotides (NDPs and NTPs) and hydrolyse NTPs to nucleotide monophosphates (NMPs) in two distinct successive phosphate-releasing steps, with NDPs as intermediates. They differ from ATPases, which specifically hydrolyse ATP, by hydrolysing both ATP and ADP. The eukaryotic enzymes requires Ca2+, but Mg2+ can substitute. Most of the ecto-ATPases that occur on the cell surface and hydrolyse extracellular nucleotides belong to this enzyme family.
SYNONYMS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
5'-nucleotidase
A7LH73, A7LH74
-
adenosine diphosphatase
-
-
-
-
ADPase
-
-
-
-
Apy 1
Q06K73
isoform
Apy 2
Q06K77
isoform
APY-1
-
-
APY1
-
isoform
APY2
-
isoform
APY2-type apyrase
G1UFQ9
-
Apyrase
-
-
Apyrase
-
-
Apyrase
Q6QHT8
-
ATP diphosphohydrolase
E0D877
-
ATP diphosphohydrolase
-
-
ATP diphosphohydrolase
Q9FEA6
-
ATP diphosphohydrolase
A1BXT9
-
ATP diphosphohyrolase
-
-
ATP-diphosphatase
-
-
-
-
ATP-diphosphohydrolase
-
-
-
-
ATP-diphosphohydrolase
-
-
ATP-diphosphohydrolase 2
A1BXT9
-
ATPase
O93295
-
ATPase
O35795
-
ATPase
P97687, Q5DRK1
-
ATPase
Rattus norvegicus Sprague-Dawley
O35795, P97687, Q5DRK1
-
-
ATPase 2
A1BXT9
-
ATPDase
-
-
-
-
ATPDase2
A1BXT9
-
Ca2+-activated nucleoside diphosphatase
Q5CXD0
-
CApy
Q5CXD0
gene name
CD39
-
-
CD39
-
-
CD39
Rattus norvegicus Sprague-Dawley
P97687
-
-
CD39 antigen
-
-
-
-
CD39-like ATP diphosphohydrolase
A1BXT9
-
CD39L1
O35795
-
CD39L1
Rattus norvegicus Sprague-Dawley
O35795
-
-
E-NTPDase
-
-
E-NTPDase
P55772
-
E-NTPDase 3
-
-
ecto-5'-nucleotidase
-
-
ecto-5'-nucleotidase
A7LH73, A7LH74
-
ecto-apyrase
-
-
ecto-apyrase
-
-
ecto-apyrase
Q9FVC2
-
ecto-apyrase
-
-
ecto-ATP diphosphohydrolase
-
-
ecto-ATP diphosphohydrolase
Candida parapsilosis CCT3834
-
-
-
ecto-ATP diphosphohydrolase
Q5CXD0
-
ecto-ATP-diphosphohydrolase
-
-
ecto-ATPase
-
-
ecto-ATPase
Candida parapsilosis CCT3834
-
-
-
ecto-ATPDase
Q6QHT8
-
ecto-NTPDase
Q6QHT8
-
Ecto-NTPDase1
Q6QHT8
-
ecto-nucleoside triphosphate diphosphohydrolase
-
-
ecto-nucleoside triphosphate diphosphohydrolase
-
-
ecto-nucleoside triphosphate diphosphohydrolase
-
-
ecto-nucleoside triphosphate-diphosphohydrolase
-
-
ecto-nucleoside-triphosphate-diphosphohydrolase
Q6QHT8
-
ectoapyrase
-
-
ectoapyrase
-
-
ectoapyrase
-
-
ectonucleoside triphosphate diphosphohydrolase
-
-
ectonucleoside triphosphate diphosphohydrolase
P55772
-
Golgi nucleoside diphosphatase
-
-
-
-
GS50
-
-
GS52
-
-
GS52
-
-
GS52
Q9FVC2
-
HB6
-
-
-
-
LALP1
Q9NQZ7
-
LALP1
Q3TCT4
-
MpAPY2
G1UFQ9
-
NTPase
-
-
NTPDase 1
P97687
-
NTPDase 2
Q5SPY7
-
NTPDase 3
-
-
NTPDase 5
-
-
NTPDase 6
-
-
NTPDase 8
O93295
-
NTPDase1
-
-
-
-
NTPDase1
-
-
NTPDase1
P55772
-
NTPDase1
P97687
-
NTPDase1
Rattus norvegicus Sprague-Dawley
P97687
-
-
NTPDase1
-
-
NTPDase1/CD39
P97687
-
NTPDase1/CD39
Rattus norvegicus Sprague-Dawley
P97687
-
-
NTPDase2
Q5SPY7
-
NTPDase2
O35795
-
NTPDase2
Rattus norvegicus Sprague-Dawley
O35795
-
-
NTPDase2/CD39L1
O35795
-
NTPDase2/CD39L1
Rattus norvegicus Sprague-Dawley
O35795
-
-
NTPDase3
-
-
-
-
NTPDase8
O93295
-
NTPDase8
Q5DRK1
-
NTPDase8
Rattus norvegicus Sprague-Dawley
Q5DRK1
-
-
nucleoside triphosphatase
-
-
nucleoside triphosphate diphosphohydrolase
Q9FVC2
-
nucleoside triphosphate diphosphohydrolase
Q5SPY7
-
nucleoside triphosphate diphosphohydrolase
O35795
-
nucleoside triphosphate diphosphohydrolase
P97687, Q5DRK1
-
nucleoside triphosphate diphosphohydrolase
Rattus norvegicus Sprague-Dawley
O35795, P97687, Q5DRK1
-
-
nucleoside triphosphate diphosphohydrolase
-
-
nucleoside triphosphate diphosphohydrolase 1
P97687
-
nucleoside triphosphate diphosphohydrolase 8
O93295
-
nucleoside triphosphate diphosphohydrolase-1, NDPDase 1
-
-
nucleoside triphosphate diphosphohydrolase-3
Q8BFW6
-
nucleoside triphosphate-diphosphohydrolase
-
-
potato-specific apyrase
-
-
Lymphoid cell activation antigen
-
-
-
-
additional information
-
Lpg1905 is a prokaryotic member of the CD39/NTPDase1 family of enzymes
additional information
A7LH73, A7LH74
the apyrase belongs to the 5'-nucleotidase family
additional information
-, A1BXT9
the enzyme belongs to the apyrase family
additional information
-
apyrase belongs to the actin superfamily of proteins and is a member of the NTPDase family
CAS REGISTRY NUMBER
COMMENTARY
9000-95-7
-
ORGANISM
COMMENTARY
LITERATURE
SEQUENCE CODE
SEQUENCE DB
SOURCE
; recombinant enzyme
-
-
Manually annotated by BRENDA team
isozymes APY1 and APY2
-
-
Manually annotated by BRENDA team
Candida parapsilosis CCT3834
-
-
-
Manually annotated by BRENDA team
chick-pea
-
-
Manually annotated by BRENDA team
enzymes NT5E-1 and NT5E-2 encoded by genes CG4827 and CG30104
-
-
Manually annotated by BRENDA team
expression in Lotus japonicus
-
-
Manually annotated by BRENDA team
cv. Williams 82, GS50 and GS52 genes
-
-
Manually annotated by BRENDA team
wild soybean
UniProt
Manually annotated by BRENDA team
variant TM-1
-
-
Manually annotated by BRENDA team
-
Swissprot
Manually annotated by BRENDA team
-
Q5SPY7
UniProt
Manually annotated by BRENDA team
hLALP70 and the splice variant hLALP70v
-
-
Manually annotated by BRENDA team
recombinant enzyme
-
-
Manually annotated by BRENDA team
barley
-
-
Manually annotated by BRENDA team
-
Swissprot
Manually annotated by BRENDA team
-
Swissprot
Manually annotated by BRENDA team
genes Entpd1, 2, 3, 5, 6, and Entpd8
-
-
Manually annotated by BRENDA team
Swiss strain, male
SwissProt
Manually annotated by BRENDA team
mouse
-
-
Manually annotated by BRENDA team
Orchopeas howardi
-
-
-
Manually annotated by BRENDA team
isozyme I; collected from the Upington region in the Western Cape, South Africa by sifting of sand, isozyme I
UniProt
Manually annotated by BRENDA team
isozyme II; collected from the Upington region in the Western Cape, South Africa by sifting of sand, isozyme II
UniProt
Manually annotated by BRENDA team
Oropsylla bacchi
-
-
-
Manually annotated by BRENDA team
isotypes P0, P1, P2, P3, P4
-
-
Manually annotated by BRENDA team
variant Alaska
UniProt
Manually annotated by BRENDA team
NTPDase1
UniProt
Manually annotated by BRENDA team
NTPDase2
UniProt
Manually annotated by BRENDA team
NTPDase8
UniProt
Manually annotated by BRENDA team
recombinant enzyme expressed in Xenopus laevis oocyte
-
-
Manually annotated by BRENDA team
Rattus norvegicus Sprague-Dawley
NTPDase1
UniProt
Manually annotated by BRENDA team
Rattus norvegicus Sprague-Dawley
NTPDase2
UniProt
Manually annotated by BRENDA team
Rattus norvegicus Sprague-Dawley
NTPDase8
UniProt
Manually annotated by BRENDA team
ATP-diphosphohydrolase 2; BH strain, gene ATPDase2
SwissProt
Manually annotated by BRENDA team
BH strain, gene ATPDase1
-
-
Manually annotated by BRENDA team
recombinant enzyme expressed in Pichia pastoris
-
-
Manually annotated by BRENDA team
varieties Pimpernel and Desiree
-
-
Manually annotated by BRENDA team
variety Desiree, low ATPase/ADPase ratio; variety Pimpernel, high ATPase/ADPase ratio
-
-
Manually annotated by BRENDA team
strain RIA 57
-
-
Manually annotated by BRENDA team
Streptomyces aureofaciens RIA
strain RIA 57
-
-
Manually annotated by BRENDA team
enzyme belongs to E-type ATPase/NTPDase family; enzyme called NTPDase1; pig
Uniprot
Manually annotated by BRENDA team
enzyme belongs to E-type ATPase/NTPDase family; pig
-
-
Manually annotated by BRENDA team
cysticerci
-
-
Manually annotated by BRENDA team
five N-glycosylated isoforms of 88, 82, 79,68, and 67 kDa molecular masses
-
-
Manually annotated by BRENDA team
precursor molecule, 79 kDa isoform
SwissProt
Manually annotated by BRENDA team
Triticosecale Wittmack
triticale
-
-
Manually annotated by BRENDA team
wild-type strains Y, CL, and Be-62, and hybrid strain and CL Brener
Swissprot
Manually annotated by BRENDA team
expression during all developmental stages tested
-
-
Manually annotated by BRENDA team
PDB
SCOP
CATH
ORGANISM
Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152 / DSM 7513)
Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152 / DSM 7513)
Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152 / DSM 7513)
Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152 / DSM 7513)
Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152 / DSM 7513)
Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152 / DSM 7513)
Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152 / DSM 7513)
Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152 / DSM 7513)
Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152 / DSM 7513)
Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152 / DSM 7513)
Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152 / DSM 7513)
Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152 / DSM 7513)
Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152 / DSM 7513)
Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152 / DSM 7513)
Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152 / DSM 7513)
Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152 / DSM 7513)
Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152 / DSM 7513)
ORGANIC SOLVENT
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
perchloric acid
-
enzyme remains active
Renatured/COMMENTARY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
recombinant rCApy from inclusion bodies after expression in Escherichia coli strain BL21(DE3), resuspended in 20 mM sodium phosphate, pH 7.4, 500 mM NaCl, 6 M guanidine hydrochloride
-, Q5CXD0
using 8 M urea, 50 mM Tris-HCl (pH 8.0), 1 mM EDTA and 1 mM dithiothreitol; using 8 M urea, 50 mM Tris-HCl (pH 8.0), 1 mM EDTA and 1 mM dithiothreitol
-, Q06K73, Q06K77