Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
plasma membrane | - |
Rattus norvegicus | 5886 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | required | Rattus norvegicus | |
Mg2+ | required | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ADP + H2O | Rattus norvegicus | - |
AMP + phosphate | - |
? | |
ADP + H2O | Rattus norvegicus Sprague-Dawley | - |
AMP + phosphate | - |
? | |
ATP + 2 H2O | Rattus norvegicus | - |
AMP + 2 phosphate | - |
? | |
ATP + 2 H2O | Rattus norvegicus Sprague-Dawley | - |
AMP + 2 phosphate | - |
? | |
ATP + H2O | Rattus norvegicus | ATP incubated with NTPDase2 is readily converted into ADP, but very poorly into AMP | ADP + phosphate | - |
? | |
ATP + H2O | Rattus norvegicus Sprague-Dawley | ATP incubated with NTPDase2 is readily converted into ADP, but very poorly into AMP | ADP + phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | O35795 | NTPDase2 | - |
Rattus norvegicus | P97687 | NTPDase1 | - |
Rattus norvegicus | Q5DRK1 | NTPDase8 | - |
Rattus norvegicus Sprague-Dawley | O35795 | NTPDase2 | - |
Rattus norvegicus Sprague-Dawley | P97687 | NTPDase1 | - |
Rattus norvegicus Sprague-Dawley | Q5DRK1 | NTPDase8 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
bile canaliculus | - |
Rattus norvegicus | - |
fibroblast | - |
Rattus norvegicus | - |
fibroblast | portal fibroblasts | Rattus norvegicus | - |
hepatocyte | restricted to the canalicular membrane domain of hepatocytes | Rattus norvegicus | - |
liver | expression of isozymes NTPDase1, -2, and -8 in distinct liver compartments in normal and fibrotic rat liver | Rattus norvegicus | - |
additional information | enzyme tissue localization by in situ immunohistochemistry, overview | Rattus norvegicus | - |
smooth muscle cell | - |
Rattus norvegicus | - |
vascular endothelial cell | - |
Rattus norvegicus | - |
vascular system | cells in the vascular external layer | Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ADP + H2O | - |
Rattus norvegicus | AMP + phosphate | - |
? | |
ADP + H2O | - |
Rattus norvegicus Sprague-Dawley | AMP + phosphate | - |
? | |
ATP + 2 H2O | - |
Rattus norvegicus | AMP + 2 phosphate | - |
? | |
ATP + 2 H2O | sequential dephosphorylation of ATP to ADP and then AMP | Rattus norvegicus | AMP + 2 phosphate | - |
? | |
ATP + 2 H2O | - |
Rattus norvegicus Sprague-Dawley | AMP + 2 phosphate | - |
? | |
ATP + 2 H2O | sequential dephosphorylation of ATP to ADP and then AMP | Rattus norvegicus Sprague-Dawley | AMP + 2 phosphate | - |
? | |
ATP + H2O | ATP incubated with NTPDase2 is readily converted into ADP, but very poorly into AMP | Rattus norvegicus | ADP + phosphate | - |
? | |
ATP + H2O | ATP incubated with NTPDase2 is readily converted into ADP, but very poorly into AMP | Rattus norvegicus Sprague-Dawley | ADP + phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ATPase | - |
Rattus norvegicus |
CD39 | - |
Rattus norvegicus |
CD39L1 | - |
Rattus norvegicus |
NTPDase1 | - |
Rattus norvegicus |
NTPDase1/CD39 | - |
Rattus norvegicus |
NTPDase2 | - |
Rattus norvegicus |
NTPDase2/CD39L1 | - |
Rattus norvegicus |
NTPDase8 | - |
Rattus norvegicus |
nucleoside triphosphate diphosphohydrolase | - |
Rattus norvegicus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Rattus norvegicus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Rattus norvegicus |
General Information | Comment | Organism |
---|---|---|
metabolism | plasma membrane-bound NTPDases, namely NTPDase1/CD39, NTPDase2/CD39L1, and NTPDase8, represent the major liver ectonucleotidase activities | Rattus norvegicus |