Reference on EC 3.4.24.15 - thimet oligopeptidase and Organism(s) Rattus norvegicus and UniProt Accession P24155
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AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Dahms, P.; Mentlein, R.
Purification of the main somatostatin-degrading proteases from rat and pig brains, their action on other neuropeptides, and their identification as endopeptidases 24.15 and 24.16
Eur. J. Biochem.
208
145-154
1992
Rattus norvegicus, Sus scrofa
McKie, N.; Dando, P.M.; Brown, M.A.; Barrett, A.J.
Rat thimet oligopeptidase: large-scale expression in Escherichia coli and characterization of the recombinant enzyme
Biochem. J.
309
203-207
1995
Rattus norvegicus
Tisljar, U.; Barrett, A.J.
Thiol-dependent metallo-endopeptidase characteristics of Pz-peptidase in rat and rabbit
Biochem. J.
267
531-533
1990
Oryctolagus cuniculus, Rattus norvegicus
Orlowski, M.; Reznik, S.; Ayala, J.; Pierotti, A.R.
Endopeptidase 24.15 from rat testes. Isolation of the enzyme and its specificity toward synthetic and natural peptides, including enkephalin-containing peptides
Biochem. J.
261
951-958
1989
Rattus norvegicus
Barrett, A.J.; Brown, M.A.; Dando, P.M.; Knight, C.G.; McKie, N.; Rawlings, N.D.; Serizawa, A.
Thimet oligopeptidase and oligopeptidase M or neurolysin
Methods Enzymol.
248
529-556
1995
Homo sapiens, Rattus norvegicus
Pierotti, A.; Dong, K.W.; Glucksman, M.J.; Orlowski, M.; Roberts, J.L.
Molecular cloning and primary structure of rat testes metalloendopeptidase EC 3.4.24.15 [published erratum appears in Biochemistry 1994 Jan 18;33(2):622]
Biochemistry
29
10323-10329
1990
Rattus norvegicus
Orlowski, M.; Michaud, C.; Chu, T.G.
A soluble metalloendopeptidase from rat brain. Purification of the enzyme and determination of specificity with synthetic and natural peptides
Eur. J. Biochem.
135
81-88
1983
Rattus norvegicus
Oliveira, V.; Campos, M.; Hemerly, J.P.; Ferro, E.S.; Camargo, A.C.; Juliano, M.A.; Juliano, L.
Selective neurotensin-derived internally quenched fluorogenic substrates for neurolysin (EC 3.4.24.16): comparison with thimet oligopeptidase (EC 3.4.24.15) and neprilysin (EC 3.4.24.11)
Anal. Biochem.
292
257-265
2001
Rattus norvegicus
Shrimpton, C.N.; Abbenante, G.; Lew, R.A.; Smith, A.I.
Development and characterization of novel potent and stable inhibitors of endopeptidase EC 3.4.24.15
Biochem. J.
345
351-356
2000
Rattus norvegicus
-
Oliveira, V.; Campos, M.; Melo, R.L.; Ferro, E.S.; Camargo, A.C.; Juliano, M.A.; Juliano, L.
Substrate specificity characterization of recombinant metallo oligo-peptidases thimet oligopeptidase and neurolysin
Biochemistry
40
4417-4425
2001
Rattus norvegicus
Steer, D.; Lew, R.; Perlmutter, P.; Smith, A.I.; Aguilar, M.I.
Inhibitors of metalloendopeptidase EC 3.4.24.15 and EC 3.4.24.16 stabilized against proteolysis by the incorporation of beta-amino acids
Biochemistry
41
10819-10826
2002
Rattus norvegicus
Portaro, F.C.; Hayashi, M.A.; Silva, C.L.; de Camargo, A.C.
Free ATP inhibits thimet oligopeptidase (EC 3.4.24.15) activity, induces autophosphorylation in vitro, and controls oligopeptide degradation in macrophage
Eur. J. Biochem.
268
887-894
2001
Rattus norvegicus
Lew, R.A.; Boulos, E.; Stewart, K.M.; Perlmutter, P.; Harte, M.F.; Bond, S.; Reeve, S.B.; Norman, M.U.; Lew, M.J.; Aguilar, M.I.; Smith, I.
Substrate analogues incorporating b-amino acids: potential application for peptidase inhibition
FASEB J.
15
1664-1666
2001
Rattus norvegicus
Sigman, J.A.; Edwards, S.R.; Pabon, A.; Glucksman, M.J.; Wolfson, A.J.
pH dependence studies provide insight into the structure and mechanism of thimet oligopeptidase (EC 3.4.24.15)
FEBS Lett.
545
224-228
2003
Rattus norvegicus (P24155)
Rioli, V.; Gozzo, F.C.; Heimann, A.S.; Linardi, A.; Krieger, J.E.; Shida, C.S.; Almeida, P.C.; Hyslop, S.; Eberlin, M.N.; Ferro, E.S.
Novel natural peptide substrates for endopeptidase 24.15, neurolysin, and angiotensin-converting enzyme
J. Biol. Chem.
278
8547-8555
2003
Rattus norvegicus
Molina, H.M.; Carmona, A.K.; Kouyoumdjian, M.; Borges, D.R.
Thimet oligopeptidase EC 3.4.24.15 is a major liver kininase
Life Sci.
67
509-520
2000
Rattus norvegicus
Sigman, J.A.; Patwa, T.H.; Tablante, A.V.; Joseph, C.D.; Glucksman, M.J.; Wolfson, A.J.
Flexibility in substrate recognition by thimet oligopeptidase as revealed by denaturation studies
Biochem. J.
388
255-261
2005
Rattus norvegicus (P24155)
Oliveira, V.; Garrido, P.A.; Rodrigues, C.C.; Colquhoun, A.; Castro, L.M.; Almeida, P.C.; Shida, C.S.; Juliano, M.A.; Juliano, L.; Camargo, A.C.; Hyslop, S.; Roberts, J.L.; Grum-Tokars, V.; Glucksman, M.J.; Ferro, E.S.
Calcium modulates endopeptidase 24.15 (EC 3.4.24.15) membrane association, secondary structure and substrate specificity
FEBS J.
272
2978-2992
2005
Rattus norvegicus
Saric, T.; Graef, C.I.; Goldberg, A.L.
Pathway for degradation of peptides generated by proteasomes: a key role for thimet oligopeptidase and other metallopeptidases
J. Biol. Chem.
279
46723-46732
2004
Homo sapiens, Rattus norvegicus
Jeske, N.A.; Berg, K.A.; Cousins, J.C.; Ferro, E.S.; Clarke, W.P.; Glucksman, M.J.; Roberts, J.L.
Modulation of bradykinin signaling by EP24.15 and EP24.16 in cultured trigeminal ganglia
J. Neurochem.
97
13-21
2006
Rattus norvegicus
Ahmed, M.M.; Arif, M.; Chikuma, T.; Kato, T.
Pentylenetetrazol-induced seizures affect the levels of prolyl oligopeptidase, thimet oligopeptidase and glial proteins in rat brain regions, and attenuation by MK-801 pretreatment
Neurochem. Int.
47
248-259
2005
Rattus norvegicus
Machado, M.F.; Rioli, V.; Dalio, F.M.; Castro, L.M.; Juliano, M.A.; Tersariol, I.L.; Ferro, E.S.; Juliano, L.; Oliveira, V.
The role of Tyr605 and Ala607 of thimet oligopeptidase and Tyr606 and Gly608 of neurolysin in substrate hydrolysis and inhibitor binding
Biochem. J.
404
279-288
2007
Rattus norvegicus
Demasi, M.; Piassa Filho, G.M.; Castro, L.M.; Ferreira, J.C.; Rioli, V.; Ferro, E.S.
Oligomerization of the cysteinyl-rich oligopeptidase EP24.15 is triggered by S-glutathionylation
Free Radic. Biol. Med.
44
1180-1190
2008
Rattus norvegicus
Bruce, L.A.; Sigman, J.A.; Randall, D.; Rodriguez, S.; Song, M.M.; Dai, Y.; Elmore, D.E.; Pabon, A.; Glucksman, M.J.; Wolfson, A.J.
Hydrogen bond residue positioning in the 599-611 loop of thimet oligopeptidase is required for substrate selection
FEBS J.
275
5607-5617
2008
Rattus norvegicus
Berti, D.A.; Morano, C.; Russo, L.C.; Castro, L.M.; Cunha, F.M.; Zhang, X.; Sironi, J.; Klitzke, C.F.; Ferro, E.S.; Fricker, L.D.
Analysis of intracellular substrates and products of thimet oligopeptidase (EC 3.4.24.15) in human embryonic kidney 293 cells
J. Biol. Chem.
284
14105-14116
2009
Rattus norvegicus
Wu, T.J.; Pierotti, A.R.; Jakubowski, M.; Sheward, W.J.; Glucksman, M.J.; Smith, A.I.; King, J.C.; Fink, G.; Roberts, J.L.
Endopeptidase EC 3.4.24.15 presence in the rat median eminence and hypophysial portal blood and its modulation of the luteinizing hormone surge
J. Neuroendocrinol.
9
813-822
1997
Rattus norvegicus
Cleverly, K.; Wu, T.J.
Is the metalloendopeptidase EC 3.4.24.15 (EP24.15), the enzyme that cleaves luteinizing hormone-releasing hormone (LHRH), an activating enzyme?
Reproduction
139
319-330
2010
Rattus norvegicus
Dalio, F.M.; Visniauskas, B.; Bicocchi, E.S.; Perry, J.C.; Freua, R.; Gesteira, T.F.; Nader, H.B.; Machado, M.F.; Tufik, S.; Ferro, E.S.; Andersen, M.L.; Toledo, C.A.; Chagas, J.R.; Oliveira, V.
Acute cocaine treatment increases thimet oligopeptidase in the striatum of rat brain
Biochem. Biophys. Res. Commun.
419
724-727
2012
Rattus norvegicus (P24155), Rattus norvegicus Wistar (P24155)
Simoes, P.S.; Visniauskas, B.; Perosa, S.R.; Yacubian, E.M.; Centeno, R.; Canzian, M.; Lopes-Cendes, I.; Maurer Morelli, C.V.; Carrete, H.; Cavalheiro, E.A.; Tufik, S.; Chagas, J.R.; Mazzacoratti, M.d.a..G.
Expression and activity of thimet oligopeptidase (TOP) are modified in the hippocampus of subjects with temporal lobe epilepsy (TLE)
Epilepsia
55
754-762
2014
Rattus norvegicus (P24155), Homo sapiens (P52888), Homo sapiens
Pereira, M.G.; Souza, L.L.; Becari, C.; Duarte, D.A.; Camacho, F.R.; Oliveira, J.A.; Gomes, M.D.; Oliveira, E.B.; Salgado, M.C.; Garcia-Cairasco, N.; Costa-Neto, C.M.
Angiotensin II-independent angiotensin-(1-7) formation in rat hippocampus: involvement of thimet oligopeptidase
Hypertension
62
879-885
2013
Rattus norvegicus (P24155), Rattus norvegicus Wistar (P24155)
