Reference on EC 3.4.22.57 - caspase-4
Please use the Reference Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Garcia-Calvo, M.; Peterson, E.P.; Leiting, B.; Ruel, R.; Nicholson, D.W.; Thornberry, N.A.
Inhibition of human caspases by peptide-based and macromolecular inhibitors
J. Biol. Chem.
273
32608-32613
1998
Homo sapiens
Garcia-Calvo, M.; Peterson, E.P.; Rasper, D.M.; Vaillancourt, J.P.; Zamboni, R.; Nicholson, D.W.; Thornberry, N.A.
Purification and catalytic properties of human caspase family members
Cell Death Differ.
6
362-369
1999
Homo sapiens
Chang, H.Y.; Yang, X.
Proteases from cell suicide: functions and regulation of caspases
Microbiol. Mol. Biol. Rev.
64
821-846
2000
Homo sapiens
Thornberry, N.A.; Rano, T.A.; Peterson, E.P.; et al.
A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis
J. Biol. Chem.
272
17907-17911
1997
Homo sapiens
van de Craen, M.; Vandenabeele, P.; Declercq, W.; van den Brande, I.; van Loo, G.; Molemans, F.; Schotte, P.; van Criekinge, W.; Beyaert, R.; Fiers, W.
Characterization of seven murine caspase family members
FEBS Lett.
403
61-69
1997
BRENDA: Mus musculus (P70343), Mus musculus
Textmining: Homo sapiens
Talanian, R.V.; Quinlan, C.; Trautz, S.; Hackett, M.C.; Mankovich, J.A.; Banach, D.; Ghayur, T.; Brady, K.D.; Wong, W.W.
Substrate specificities of caspase family proteases
J. Biol. Chem.
272
9677-9682
1997
Homo sapiens
Margolin, N.; Raybuck, S.A.; Wilson, K.P.; Chen, W.; Fox, T.; Gu, Y.; Livingston, D.J.
Substrate and inhibitor specificity of interleukin-1beta-converting enzyme and related caspases
J. Biol. Chem.
272
7223-7228
1997
Homo sapiens
Wang, S.; Miura, M.; Jung, Y.K.; Zhu, H.; Gagliardini, V.; Shi, L.; Greenberg, A.H.; Yuan, J.
Identification and characterization of Ich-3, a member of the interleukin-1beta converting enzyme (ICE)/Ced-3 family and an upstream regulator of ICE
J. Biol. Chem.
271
20580-20587
1996
Mus musculus (P70343), Mus musculus C57BL/6 X CBA (P70343)
Munday N.A.; Vaillancourt J.P.; Ali A.; Casano F.J.; Miller D.K.; Molineaux S.M.; Yamin T.T.; Yu V.L.; Nicholson D.W.
Molecular cloning and pro-apoptotic activity of ICErelII and ICErelIII, members of the ICE/CED-3 family of cysteine proteases
J. Biol. Chem.
270
15870-15876
1995
Homo sapiens (P49662)
Kamada, S.; Funahashi, Y.; Tsujimoto, Y.
Caspase-4 and caspase-5, members of the ICE/CED-3 family of cysteine proteases, are CrmA-inhibitable proteases
Cell Death Differ.
4
473-478
1997
Homo sapiens
Fassy, F.; Krebs, O.; Rey, H.; Komara, B.; Gillard, C.; Capdevila, C.; Yea, C.; Faucheu, C.; Blanchet, A.M.; Miossec, C.; Diu-Hercend, A.
Enzymic activity of two caspases related to interleukin-1beta-converting enzyme
Eur. J. Biochem.
253
76-83
1998
Homo sapiens
Faucheu, C.; Diu, A.; Chan, A.W.E.; Blanchet, A.M.; Miossec, C.; Herve, F.; Collard-Dutilleul, V.; Gu, Y.; Aldape, R.A.; Lippke, J.A.; Rocher, C.; Su, M.S.S.; Livingston, D.J.; Hercend, T.; Lalanne, J.L.
A novel human protease similar to the interleukin-1 beta converting enzyme induces apoptosis in transfected cells
EMBO J.
14
1914-1922
1995
Homo sapiens (P49662)
Kamens, J.; Paskind, M.; Hugunin, M.; Talanian, R.V.; Allen, H.; Banach, D.; Bump, N.J.; Hackett, M.C.; Johnston, C.G.; Li, P.; Mankovich, J.A.; Terranova, M.; Ghayur, T.
Identification and characterization of ICH-2, a novel member of the interleukin-1 beta-converting enzyme family of cysteine proteases
J. Biol. Chem.
270
15250-15256
1995
Homo sapiens (P49662)
Wang, X.; Narayanan, M.; Bruey, J.M.; Rigamonti, D.; Cattaneo, E.; Reed, J.C.; Friedlander, R.M.
Protective role of Cop in Rip2/caspase-1/caspase-4-mediated HeLa cell death
Biochim. Biophys. Acta
1762
742-754
2006
Homo sapiens
Hitomi, J.; Katayama, T.; Eguchi, Y.; Kudo, T.; Taniguchi, M.; Koyama, Y.; Manabe, T.; Yamagishi, S.; Bando, Y.; Imaizumi, K.; Tsujimoto, Y.; Tohyama, M.
Involvement of caspase-4 in endoplasmic reticulum stress-induced apoptosis and Abeta-induced cell death
J. Cell Biol.
165
347-356
2004
Homo sapiens
Mulugeta, S.; Maguire, J.A.; Newitt, J.L.; Russo, S.J.; Kotorashvili, A.; Beers, M.F.
Misfolded BRICHOS SP-C mutant proteins induce apoptosis via caspase-4- and cytochrome c-related mechanisms
Am. J. Physiol. Lung Cell Mol. Physiol.
293
L720-L729
2007
Homo sapiens
Lakshmanan, U.; Porter, A.G.
Caspase-4 interacts with TNF receptor-associated factor 6 and mediates lipopolysaccharide-induced NF-kappaB-dependent production of IL-8 and CC chemokine ligand 4 (macrophage-inflammatory protein-1)
J. Immunol.
179
8480-8490
2007
BRENDA: Homo sapiens (P49662), Homo sapiens
Textmining: Mus musculus
Yukioka, F.; Matsuzaki, S.; Kawamoto, K.; Koyama, Y.; Hitomi, J.; Katayama, T.; Tohyama, M.
Presenilin-1 mutation activates the signaling pathway of caspase-4 in endoplasmic reticulum stress-induced apoptosis
Neurochem. Int.
52
683-687
2008
Homo sapiens
Yi, J.Y.; Hirabayashi, Y.; Choi, Y.K.; Kodama, Y.; Kanno, J.; Han, J.H.; Inoue, T.; Yoon, B.I.
Benzene activates caspase-4 and -12 at the transcription level, without an association with apoptosis, in mouse bone marrow cells lacking the p53 gene
Arch. Toxicol.
83
795-803
2009
BRENDA: Mus musculus
Textmining: Mus sp.
Koehn, S.; Trueck, M.; Poehlmann, T.G.; Schleussner, E.; Markert, U.R.; Seyfarth, L.
Assessment of caspase-4 released free AFC by RP-HPLC and fluorescence detection
J. Chromatogr. B
874
111-114
2008
Homo sapiens
Kajiwara, Y.; Akram, A.; Katsel, P.; Haroutunian, V.; Schmeidler, J.; Beecham, G.; Haines, J.L.; Pericak-Vance, M.A.; Buxbaum, J.D.
FE65 binds Teashirt, inhibiting expression of the primate-specific caspase-4
PLoS ONE
4
e5071
2009
BRENDA: Homo sapiens, no activity in Mus musculus
Textmining: Mus musculus
Sollberger, G.; Strittmatter, G.E.; Kistowska, M.; French, L.E.; Beer, H.D.
Caspase-4 is required for activation of inflammasomes
J. Immunol.
188
1992-2000
2012
Homo sapiens
Yamamuro, A.; Kishino, T.; Ohshima, Y.; Yoshioka, Y.; Kimura, T.; Kasai, A.; Maeda, S.
Caspase-4 directly activates caspase-9 in endoplasmic reticulum stress-induced apoptosis in SH-SY5Y cells
J. Pharmacol. Sci.
115
239-243
2011
Homo sapiens
Valentin-Acevedo, A.; Sinquett, F.L.; Covey, L.R.
c-Rel deficiency increases caspase-4 expression and leads to ER stress and necrosis in EBV-transformed cells
PLoS ONE
6
e25467
2011
Homo sapiens
Kobayashi, T.; Ogawa, M.; Sanada, T.; Mimuro, H.; Kim, M.; Ashida, H.; Akakura, R.; Yoshida, M.; Kawalec, M.; Reichhart, J.M.; Mizushima, T.; Sasakawa, C.
The Shigella OspC3 effector inhibits caspase-4, antagonizes inflammatory cell death, and promotes epithelial infection
Cell Host Microbe
13
570-583
2013
BRENDA: Cavia porcellus, Homo sapiens
Textmining: Shigella
Grimstad, O.; Husebye, H.; Espevik, T.
TLR3 mediates release of IL-1beta and cell death in keratinocytes in a caspase-4 dependent manner
J. Dermatol. Sci.
72
45-53
2013
Homo sapiens
Kajiwara, Y.; Schiff, T.; Voloudakis, G.; Gama Sosa, M.A.; Elder, G.; Bozdagi, O.; Buxbaum, J.D.
A critical role for human caspase-4 in endotoxin sensitivity
J. Immunol.
193
335-343
2014
BRENDA: Homo sapiens
Textmining: Rodentia, Mus musculus, Mus sp.
Yang, H.J.; Wang, M.; Wang, L.; Cheng, B.F.; Lin, X.Y.; Feng, Z.W.
NF-kappaB regulates caspase-4 expression and sensitizes neuroblastoma cells to Fas-induced apoptosis
PLoS ONE
10
e0117953
2015
Homo sapiens
Chen, N.; Ou, Z.; Zhang, W.; Zhu, X.; Li, P.; Gong, J.
Cathepsin B regulates non-canonical NLRP3 inflammasome pathway by modulating activation of caspase-11 in Kupffer cells
Cell Prolif.
51
e12487
2018
Homo sapiens (P07858), Homo sapiens
Schmid-Burgk, J.L.; Gaidt, M.M.; Schmidt, T.; Ebert, T.S.; Bartok, E.; Hornung, V.
Caspase-4 mediates non-canonical activation of the NLRP3 inflammasome in human myeloid cells
Eur. J. Immunol.
45
2911-2917
2015
Homo sapiens (P49662), Homo sapiens
Bitto, N.J.; Baker, P.J.; Dowling, J.K.; Wray-McCann, G.; De Paoli, A.; Tran, L.S.; Leung, P.L.; Stacey, K.J.; Mansell, A.; Masters, S.L.; Ferrero, R.L.
Membrane vesicles from Pseudomonas aeruginosa activate the noncanonical inflammasome through caspase-5 in human monocytes
Immunol. Cell Biol.
96
1120-1130
2018
Homo sapiens, Homo sapiens (P51878)
Vigano, E.; Diamond, C.E.; Spreafico, R.; Balachander, A.; Sobota, R.M.; Mortellaro, A.
Human caspase-4 and caspase-5 regulate the one-step non-canonical inflammasome activation in monocytes
Nat. Commun.
6
8761
2015
Homo sapiens (P49662), Homo sapiens
Lagrange, B.; Benaoudia, S.; Wallet, P.; Magnotti, F.; Provost, A.; Michal, F.; Martin, A.; Di Lorenzo, F.; Py, B.F.; Molinaro, A.; Henry, T.
Human caspase-4 detects tetra-acylated LPS and cytosolic Francisella and functions differently from murine caspase-11
Nat. Commun.
9
242
2018
BRENDA: Homo sapiens (P49662), Homo sapiens
Textmining: Francisella, Mus musculus
Casson, C.N.; Yu, J.; Reyes, V.M.; Taschuk, F.O.; Yadav, A.; Copenhaver, A.M.; Nguyen, H.T.; Collman, R.G.; Shin, S.
Human caspase-4 mediates noncanonical inflammasome activation against gram-negative bacterial pathogens
Proc. Natl. Acad. Sci. USA
112
6688-6693
2015
Homo sapiens (P49662), Homo sapiens
An, J.; Kim, S.H.; Hwang, D.; Lee, K.E.; Kim, M.J.; Yang, E.G.; Kim, S.Y.; Chung, H.S.
Caspase-4 disaggregates lipopolysaccharide micelles via LPS-CARD interaction
Sci. Rep.
9
826
2019
BRENDA: Homo sapiens (P49662), Homo sapiens
Textmining: Escherichia coli
Jun, HK; Jung, YJ; Ji, S; An, SJ; Choi, BK
Caspase-4 activation by a bacterial surface protein is mediated by cathepsin G in human gingival fibroblasts.
Cell Death Differ
25
380-391
2018
Homo sapiens, Treponema denticola, Treponema pallidum
Lin, RT; Cai, RR; Zhang, PF; Lin, YX
[Apoptosis and expression of Caspase 3 and Caspase 4 in neurocytes of refractory human temporal lobe epilepsy].
Zhonghua Yi Xue Za Zhi
96
522-5
2016
Homo sapiens
Akhter, A; Caution, K; Abu Khweek, A; Tazi, M; Abdulrahman, BA; Abdelaziz, DH; Voss, OH; Doseff, AI; Hassan, H; Azad, AK; Schlesinger, LS; Wewers, MD; Gavrilin, MA; Amer, AO
Caspase-11 promotes the fusion of phagosomes harboring pathogenic bacteria with lysosomes by modulating actin polymerization.
Immunity
37
35-47
2012
Homo sapiens, Mus musculus
Aachoui, Y; Kajiwara, Y; Leaf, IA; Mao, D; Ting, JP; Coers, J; Aderem, A; Buxbaum, JD; Miao, EA
Canonical Inflammasomes Drive IFN-? to Prime Caspase-11 in Defense against a Cytosol-Invasive Bacterium.
Cell Host Microbe
18
320-32
2015
bacterium, Homo sapiens, Mus musculus, Mus sp.
Lin, R; Sun, Y; Li, C; Xie, C; Wang, S
Identification of differentially expressed genes in human lymphoblastoid cells exposed to irradiation and suppression of radiation-induced apoptosis with antisense oligonucleotides against caspase-4.
Oligonucleotides
17
314-26
2007
Homo sapiens
Bian, ZM; Elner, SG; Elner, VM
Dual Involvement of Caspase-4 in Inflammatory and ER Stress-Induced Apoptotic Responses in Human Retinal Pigment Epithelial Cells.
Invest Ophthalmol Vis Sci
2009
Homo sapiens
Binet, F; Chiasson, S; Girard, D
Evidence that endoplasmic reticulum (ER) stress and caspase-4 activation occur in human neutrophils.
Biochem Biophys Res Commun
391
18-23
2010
Homo sapiens
Mao, ZG; Jiang, CC; Yang, F; Thorne, RF; Hersey, P; Zhang, XD
TRAIL-induced apoptosis of human melanoma cells involves activation of caspase-4.
Apoptosis
15
1211-22
2010
Homo sapiens
KoraMagazi, A; Wang, D; Yousef, B; Guerram, M; Yu, F
Rhein triggers apoptosis via induction of endoplasmic reticulum stress, caspase-4 and intracellular calcium in primary human hepatic HL-7702 cells.
Biochem Biophys Res Commun
2016
Homo sapiens
Cheung, KT; Sze, DM; Chan, KH; Leung, PH
Involvement of caspase-4 in IL-1 beta production and pyroptosis in human macrophages during dengue virus infection.
Immunobiology
223
356-364
0
Homo sapiens, Dengue virus
Quach, J; Moreau, F; Sandall, C; Chadee, K
Entamoeba histolytica-induced IL-1? secretion is dependent on caspase-4 and gasdermin D.
Mucosal Immunol
12
323-339
2019
Entamoeba
Yin, P; Guo, X; Yang, W; Yan, S; Yang, S; Zhao, T; Sun, Q; Liu, Y; Li, S; Li, XJ
Caspase-4 mediates cytoplasmic accumulation of TDP-43 in the primate brains.
Acta Neuropathol
137
919-937
2019
Primates, Platyrrhini, Homo sapiens, Mus musculus
Goddard, PJ; Sanchez-Garrido, J; Slater, SL; Kalyan, M; Ruano-Gallego, D; Marchs, O; Fernndez, L; Frankel, G; Shenoy, AR
Enteropathogenic Escherichia coli Stimulates Effector-Driven Rapid Caspase-4 Activation in Human Macrophages.
Cell Rep
27
1008-1017.e6
2019
Escherichia coli, Homo sapiens
Benaoudia, S; Martin, A; Puig Gamez, M; Gay, G; Lagrange, B; Cornut, M; Krasnykov, K; Claude, JB; Bourgeois, CF; Hughes, S; Gillet, B; Allatif, O; Corbin, A; Ricci, R; Henry, T
A genome-wide screen identifies IRF2 as a key regulator of caspase-4 in human cells.
EMBO Rep
20
e48235
2019
Homo sapiens
Srisaowakarn, C; Pudla, M; Ponpuak, M; Utaisincharoen, P
Caspase-4 Mediates Restriction of Burkholderia pseudomallei in Human Alveolar Epithelial Cells.
Infect Immun
88
2020
Homo sapiens, Burkholderia pseudomallei, Bacteria, Mus musculus
Wandel, MP; Kim, BH; Park, ES; Boyle, KB; Nayak, K; Lagrange, B; Herod, A; Henry, T; Zilbauer, M; Rohde, J; MacMicking, JD; Randow, F
Guanylate-binding proteins convert cytosolic bacteria into caspase-4 signaling platforms.
Nat Immunol
21
880-891
2020
Bacteria, Homo sapiens
Santos, JC; Boucher, D; Schneider, LK; Demarco, B; Dilucca, M; Shkarina, K; Heilig, R; Chen, KW; Lim, RYH; Broz, P
Human GBP1 binds LPS to initiate assembly of a caspase-4 activating platform on cytosolic bacteria.
Nat Commun
11
3276
2020
Bacteria, Homo sapiens
Ding, PH; Yang, MX; Wang, NN; Jin, LJ; Dong, Y; Cai, X; Chen, LL
Porphyromonas gingivalis-Induced NLRP3 Inflammasome Activation and Its Downstream Interleukin-1? Release Depend on Caspase-4.
Front Microbiol
11
1881
2020
Porphyromonas
Terlizzi, M; Molino, A; Colarusso, C; Somma, P; De Rosa, I; Troisi, J; Scala, G; Salvi, R; Pinto, A; Sorrentino, R
Altered lung tissue lipidomic profile in caspase-4 positive non-small cell lung cancer (NSCLC) patients.
Oncotarget
11
3515-3525
2020
Homo sapiens
Terlizzi, M; Colarusso, C; De Rosa, I; Somma, P; Curcio, C; Aquino, RP; Panico, L; Salvi, R; Zito Marino, F; Botti, G; Pinto, A; Sorrentino, R
Identification of a novel subpopulation of Caspase-4 positive non-small cell lung Cancer patients.
J Exp Clin Cancer Res
39
242
2020
Homo sapiens, Mus sp.
Goodarzi, Z; Soleimanjahi, H; Arefian, E; Saberfar, E
The effect of bovine rotavirus and its nonstructural protein 4 on ER stress-mediated apoptosis in HeLa and HT-29 cells.
Tumour Biol
2015
Rotavirus
Moorwood, C; Barton, ER
Caspase-12 ablation preserves muscle function in the mdx mouse.
Hum Mol Genet
23
5325-41
2014
Mus musculus, Homo sapiens, Mus sp.
Blasche, S; Mrtl, M; Steuber, H; Siszler, G; Nisa, S; Schwarz, F; Lavrik, I; Gronewold, TM; Maskos, K; Donnenberg, MS; Ullmann, D; Uetz, P; Kgl, M
The E. coli Effector Protein NleF Is a Caspase Inhibitor.
PLoS One
8
e58937
2013
Saccharomyces cerevisiae
Seth-Pasricha, M; Bidle, KA; Bidle, KD
Specificity of archaeal caspase activity in the extreme halophile Haloferax volcanii.
Environ Microbiol Rep
5
263-71
2013
Haloferax volcanii
Seth-Pasricha, M; Senn, S; Sanman, LE; Bogyo, M; Nanda, V; Bidle, KA; Bidle, KD
Catalytic linkage between caspase activity and proteostasis in Archaea.
Environ Microbiol
21
286-298
2019
Haloferax volcanii
Bruchova, H; Borovanova, T; Klamova, H; Brdicka, R
Gene expression profiling in chronic myeloid leukemia patients treated with hydroxyurea.
Leuk Lymphoma
43
1289-95
2002
Homo sapiens
Jun, HK; Jung, YJ; Choi, BK
Treponema denticola, Porphyromonas gingivalis, and Tannerella forsythia induce cell death and release of endogenous danger signals.
Arch Oral Biol
73
72-78
2017
Porphyromonas gingivalis, Tannerella forsythia
Droin, N; Dubrez, L; Eymin, B; Renvoizé, C; Bréard, J; Dimanche-Boitrel, MT; Solary, E
Upregulation of CASP genes in human tumor cells undergoing etoposide-induced apoptosis.
Oncogene
16
2885-94
1998
Homo sapiens
Lee, HZ; Liu, WZ; Hsieh, WT; Tang, FY; Chung, JG; Leung, HW
Oxidative stress involvement in Physalis angulata-induced apoptosis in human oral cancer cells.
Food Chem Toxicol
47
561-70
2009
Paracapnia angulata
Ma, X; Li, Y; Shen, W; Oladejo, AO; Yang, J; Jiang, W; Imam, BH; Wu, X; Ding, X; Yang, Y; Wang, S; Yan, Z
LPS Mediates Bovine Endometrial Epithelial Cell Pyroptosis Directly Through Both NLRP3 Classical and Non-Classical Inflammasome Pathways.
Front Immunol
12
676088
2021
Bos taurus
Lin, CH; Nicol, CJB; Cheng, YC; Chen, SJ; Yen, CH; Huang, RN; Chiang, MC
Rosiglitazone rescues human neural stem cells from amyloid-beta induced ER stress via PPAR? dependent signaling.
Exp Cell Res
370
312-321
2018
Homo sapiens
Ettcheto, M; Junyent, F; de Lemos, L; Pallas, M; Folch, J; Beas-Zarate, C; Verdaguer, E; Gmez-Sintes, R; Lucas, JJ; Auladell, C; Camins, A
Mice Lacking Functional Fas Death Receptors Are Protected from Kainic Acid-Induced Apoptosis in the Hippocampus.
Mol Neurobiol
52
120-9
2015
Mus sp., Hippocampus
Fisch, D; Bando, H; Clough, B; Hornung, V; Yamamoto, M; Shenoy, AR; Frickel, EM
Human GBP1 is a microbe-specific gatekeeper of macrophage apoptosis and pyroptosis.
EMBO J
2019
Homo sapiens, Mus musculus
Fisch, D; Bando, H; Clough, B; Hornung, V; Yamamoto, M; Shenoy, AR; Frickel, EM
Human GBP1 is a microbe-specific gatekeeper of macrophage apoptosis and pyroptosis.
EMBO J
38
e100926
2019
Homo sapiens, Mus musculus
Silva, TC; de Andrade, PB; Paiva-Martins, F; Valento, P; Pereira, DM
In Vitro Anti-Inflammatory and Cytotoxic Effects of Aqueous Extracts from the Edible Sea Anemones Anemonia sulcata and Actinia equina.
Int J Mol Sci
18
2017
Homo sapiens
Silwedel, C; Haarmann, A; Fehrholz, M; Claus, H; Speer, CP; Glaser, K
More than just inflammation: Ureaplasma species induce apoptosis in human brain microvascular endothelial cells.
J Neuroinflammation
16
38
2019
Ureaplasma
Eckhart, L; Ballaun, C; Hermann, M; VandeBerg, JL; Sipos, W; Uthman, A; Fischer, H; Tschachler, E
Identification of novel mammalian caspases reveals an important role of gene loss in shaping the human caspase repertoire.
Mol Biol Evol
25
831-41
2008
Primates
Fltsch, A; Schroeder, T; Barandun, J; Ackermann, R; Bhlmann, M; Grtter, MG
Specific targeting of human caspases using designed ankyrin repeat proteins.
Biol Chem
395
1243-52
2014
Homo sapiens
Chang, CM; Wang, ML; Lu, KH; Yang, YP; Juang, CM; Wang, PH; Hsu, RJ; Yu, MH; Chang, CC
Integrating the dysregulated inflammasome-based molecular functionome in the malignant transformation of endometriosis-associated ovarian carcinoma.
Oncotarget
9
3704-3726
2018
Transformation
Akamatsu, K; Shibata, MA; Ito, Y; Sohma, Y; Azuma, H; Otsuki, Y
Riluzole induces apoptotic cell death in human prostate cancer cells via endoplasmic reticulum stress.
Anticancer Res
29
2195-204
2009
Electron
Misch, EA
Legionella: virulence factors and host response.
Curr Opin Infect Dis
2016
Legionella
Hagar, JA; Miao, EA
Detection of cytosolic bacteria by inflammatory caspases.
Curr Opin Microbiol
17
61-6
2014
Bacteria, Shigella, Homo sapiens, Mus musculus
Nagamatsu, K; Hannan, TJ; Guest, RL; Kostakioti, M; Hadjifrangiskou, M; Binkley, J; Dodson, K; Raivio, TL; Hultgren, SJ
Dysregulation of Escherichia coli ?-hemolysin expression alters the course of acute and persistent urinary tract infection.
Proc Natl Acad Sci U S A
112
E871-80
2015
Mus musculus
Song, F; Hou, J; Chen, Z; Cheng, B; Lei, R; Cui, P; Sun, Y; Wang, H; Fang, X
Sphingosine-1-phosphate Receptor 2 Signaling Promotes Caspase-11-dependent Macrophage Pyroptosis and Worsens Escherichia coli Sepsis Outcome.
Anesthesiology
129
311-320
2018
Homo sapiens
Holly, MK; Han, X; Zhao, EJ; Crowley, SM; Allaire, JM; Knodler, LA; Vallance, BA; Smith, JG
Salmonella enterica Infection of Murine and Human Enteroid-Derived Monolayers Elicits Differential Activation of Epithelium-Intrinsic Inflammasomes.
Infect Immun
88
2020
Homo sapiens
Cheng, Q; Pan, J; Zhou, ZL; Yin, F; Xie, HY; Chen, PP; Li, JY; Zheng, PQ; Zhou, L; Zhang, W; Liu, J; Lu, LM
Caspase-11/4 and gasdermin D-mediated pyroptosis contributes to podocyte injury in mouse diabetic nephropathy.
Acta Pharmacol Sin
2020
Mus musculus, Homo sapiens
Dilucca, M; Ramos, S; Shkarina, K; Santos, JC; Broz, P
Guanylate-Binding Protein-Dependent Noncanonical Inflammasome Activation Prevents Burkholderia thailandensis-Induced Multinucleated Giant Cell Formation.
mBio
12
e0205421
2021
Bacteria, Burkholderia
Oh, C; Verma, A; Hafeez, M; Hogland, B; Aachoui, Y
Shigella OspC3 suppresses murine cytosolic LPS sensing.
iScience
24
102910
2021
Shigella, Homo sapiens
Li, Y; Li, B; Liu, Y; Wang, H; He, M; Liu, Y; Sun, Y; Meng, W
Porphyromonas gingivalis lipopolysaccharide affects oral epithelial connections via pyroptosis.
J Dent Sci
16
1255-1263
2021
Homo sapiens
Imamura, R; Wang, Y; Kinoshita, T; Suzuki, M; Noda, T; Sagara, J; Taniguchi, S; Okamoto, H; Suda, T
Anti-Inflammatory Activity of PYNOD and Its Mechanism in Humans and Mice.
J Immunol
2010
Mus sp., Mus musculus
Binet, F; Chiasson, S; Girard, D
Interaction between arsenic trioxide (ATO) and human neutrophils.
Hum Exp Toxicol
2010
Homo sapiens
Huang, HN; Rajanbabu, V; Pan, CY; Chan, YL; Hui, CF; Chen, JY; Wu, CJ
Modulation of the immune-related gene responses to protect mice against Japanese encephalitis virus using the antimicrobial peptide, tilapia hepcidin 1-5.
Biomaterials
32
6804-14
2011
Mus sp.
Chattoraj, P; Yang, Q; Khandai, A; Al-Hendy, O; Ismail, N
TLR2 and Nod2 Mediate Resistance or Susceptibility to Fatal Intracellular Ehrlichia Infection in Murine Models of Ehrlichiosis.
PLoS One
8
e58514
2013
Mus sp.
Oberemok, VV; Laikova, KV; Zaitsev, AS; Gushchin, VA; Skorokhod, OA
The RING for gypsy moth control: Topical application of fragment of its nuclear polyhedrosis virus anti-apoptosis gene as insecticide.
Pestic Biochem Physiol
131
32-9
2016
Hexapoda
Silva, LR; Girard, D
Human eosinophils are direct targets to nanoparticles: Zinc oxide nanoparticles (ZnO) delay apoptosis and increase the production of the pro-inflammatory cytokines IL-1? and IL-8.
Toxicol Lett
259
11-20
2016
Homo sapiens
Pinto, AP; da Rocha, AL; Pereira, BC; Oliveira, LD; Morais, GP; Moura, LP; Ropelle, ER; Pauli, JR; da Silva, AS
Excessive training is associated with endoplasmic reticulum stress but not apoptosis in the hypothalamus of mice.
Appl Physiol Nutr Metab
42
354-360
2017
Mus musculus
Wu, Q; Zhu, YH; Xu, J; Liu, X; Duan, C; Wang, MJ; Wang, JF
Lactobacillus rhamnosus GR-1 Ameliorates Escherichia coli-Induced Activation of NLRP3 and NLRC4 Inflammasomes With Differential Requirement for ASC.
Front Microbiol
9
1661
2018
Lacticaseibacillus rhamnosus
Simard, JC; Vallieres, F; de Liz, R; Lavastre, V; Girard, D
Silver Nanoparticles Induce Degradation of the Endoplasmic Reticulum Stress Sensor Activating Transcription Factor-6 Leading to Activation of the NLRP-3 Inflammasome.
J Biol Chem
290
5926-39
2015
Homo sapiens
Hu, S; Snipas, SJ; Vincenz, C; Salvesen, G; Dixit, VM
Caspase-14 is a novel developmentally regulated protease.
J Biol Chem
273
29648-53
1998
Mus sp.
Gao, J; Cui, JZ; Wang, A; Chen, HHR; Fong, A; Matsubara, JA
The reduction of XIAP is associated with inflammasome activation in RPE: implications for AMD pathogenesis.
J Neuroinflammation
16
171
2019
Mus sp.
Chen, S; Yang, D; Wen, Y; Jiang, Z; Zhang, L; Jiang, J; Chen, Y; Hu, T; Wang, Q; Zhang, Y; Liu, Q
Dysregulated hemolysin liberates bacterial outer membrane vesicles for cytosolic lipopolysaccharide sensing.
PLoS Pathog
14
e1007240
2018
Enterobacteriaceae, Homo sapiens
Hsu, JL; Chou, JW; Chen, TF; Hsu, JT; Su, FY; Lan, JL; Wu, PC; Hu, CM; Lee, EY; Lee, WH
Glutathione peroxidase 8 negatively regulates caspase-4/11 to protect against colitis.
EMBO Mol Med
12
e9386
2020
Homo sapiens, Mus musculus
Li, S; Wang, SM; Yang, YB; Liu, QO
[Effect of Viqi Chutan Recipe on Caspase-4 and DNA-PK of Cell Apoptosis Approach in Transplanted Lung Cancer A549 Cells in Nude Mice].
Zhong Yao Cai
38
1247-50
2015
Mus sp.
Hu, Y; Benedict, MA; Wu, D; Inohara, N; Núñez, G
Bcl-XL interacts with Apaf-1 and inhibits Apaf-1-dependent caspase-9 activation.
Proc Natl Acad Sci U S A
95
4386-91
1998
Nematoda
Yamamuro, A; Kishino, T; Ohshima, Y; Yoshioka, Y; Kimura, T; Kasai, A; Maeda, S
Caspase-4 Directly Activates Caspase-9 in Endoplasmic Reticulum Stress-Induced Apoptosis in SH-SY5Y Cells.
J Pharmacol Sci
115
239-243
2011
Homo sapiens
Roberts, JS; Yilmaz, ?
Dangerous Liaisons: Caspase-11 and Reactive Oxygen Species Crosstalk in Pathogen Elimination.
Int J Mol Sci
16
23337-54
2015
Homo sapiens, Mus musculus, Porphyromonas gingivalis
Kajiwara, Y; McKenzie, A; Dorr, N; Gama Sosa, MA; Elder, G; Schmeidler, J; Dickstein, DL; Bozdagi, O; Zhang, B; Buxbaum, JD
The human-specific CASP4 gene product contributes to Alzheimer-related synaptic and behavioural deficits.
Hum Mol Genet
2016
Homo sapiens, Mus sp., Hippocampus
Thurston, TL; Matthews, SA; Jennings, E; Alix, E; Shao, F; Shenoy, AR; Birrell, MA; Holden, DW
Growth inhibition of cytosolic Salmonella by caspase-1 and caspase-11 precedes host cell death.
Nat Commun
7
13292
2016
Homo sapiens, Mus musculus
Papoff, G; Presutti, D; Lalli, C; Bolasco, G; Santini, S; Manelfi, C; Fustaino, V; Alem, S; Ruberti, G
CASP4 gene silencing in epithelial cancer cells leads to impairment of cell migration, cell-matrix adhesion and tissue invasion.
Sci Rep
8
17705
2018
Bacteria, Homo sapiens
Zas?ona, Z; Flis, E; Wilk, MM; Carroll, RG; Palsson-McDermott, EM; Hughes, MM; Diskin, C; Banahan, K; Ryan, DG; Hooftman, A; Misiak, A; Kearney, J; Lochnit, G; Bertrams, W; Greulich, T; Schmeck, B; McElvaney, OJ; Mills, KHG; Lavelle, EC; Wygrecka, M; Creagh, EM; O'Neill, LAJ
Caspase-11 promotes allergic airway inflammation.
Nat Commun
11
1055
2020
Homo sapiens
Bibo-Verdugo, B; Snipas, SJ; Kolt, S; Poreba, M; Salvesen, GS
Extended subsite profiling of the pyroptosis effector protein gasdermin D reveals a region recognized by inflammatory caspase-11.
J Biol Chem
295
11292-11302
2020
Homo sapiens
Linder, A; Hornung, V
Irgm2 and Gate-16 put a break on caspase-11 activation.
EMBO Rep
21
e51787
2020
Mus musculus
Salskov-Iversen, ML; Johansen, C; Kragballe, K; Iversen, L
Caspase-5 expression is upregulated in lesional psoriatic skin.
J Invest Dermatol
131
670-6
2011
Homo sapiens
Baker, PJ; Boucher, D; Bierschenk, D; Tebartz, C; Whitney, PG; D'Silva, DB; Tanzer, MC; Monteleone, M; Robertson, AA; Cooper, MA; Alvarez-Diaz, S; Herold, MJ; Bedoui, S; Schroder, K; Masters, SL
NLRP3 inflammasome activation downstream of cytoplasmic LPS recognition by both caspase-4 and caspase-5.
Eur J Immunol
45
2918-26
2015
Bacteria, Homo sapiens, Salmonella enterica subsp. enterica serovar Typhimurium
Bolvar, BE; Brown-Suedel, AN; Rohrman, BA; Charendoff, CI; Yazdani, V; Belcher, JD; Vercellotti, GM; Flanagan, JM; Bouchier-Hayes, L
Noncanonical Roles of Caspase-4 and Caspase-5 in Heme-Driven IL-1? Release and Cell Death.
J Immunol
206
1878-1889
2021
Homo sapiens
Obeng, EA; Boise, LH
Caspase-12 and caspase-4 are not required for caspase-dependent endoplasmic reticulum stress-induced apoptosis.
J Biol Chem
280
29578-87
2005
Homo sapiens, Mus musculus
Kim, SJ; Zhang, Z; Hitomi, E; Lee, YC; Mukherjee, AB
Endoplasmic reticulum stress-induced caspase-4 activation mediates apoptosis and neurodegeneration in INCL.
Hum Mol Genet
15
1826-34
2006
Homo sapiens, Mus musculus
Sansanwal, P; Kambham, N; Sarwal, MM
Caspase-4 may play a role in loss of proximal tubules and renal injury in nephropathic cystinosis.
Pediatr Nephrol
2009
Homo sapiens
Matsuzaki, S; Hiratsuka, T; Kuwahara, R; Katayama, T; Tohyama, M
Caspase-4 is partially cleaved by calpain via the impairment of Ca2+ homeostasis under the ER stress.
Neurochem Int
56
352-6
2010
Homo sapiens, Chelator
Koyama, Y; Hiratsuka, T; Matsuzaki, S; Yamagishi, S; Kato, S; Katayama, T; Tohyama, M
Familiar amyotrophic lateral sclerosis (FALS)-linked SOD1 mutation accelerates neuronal cell death by activating cleavage of caspase-4 under ER stress in an in vitro model of FALS.
Neurochem Int
57
838-43
2010
Homo sapiens
Yang, Z; Zhang, XQ; Dinney, CN; Benedict, WF
Direct cytotoxicity produced by adenoviral-mediated interferon ? gene transfer in interferon-resistant cancer cells involves ER stress and caspase 4 activation.
Cancer Gene Ther
18
609-16
2011
Homo sapiens
Tian, J; An, X; Niu, L
Correlation between NF-?B signal pathway-mediated caspase-4 activation and Kawasaki disease.
Exp Ther Med
13
3333-3336
2017
Homo sapiens, Transformation
Terlizzi, M; Colarusso, C; De Rosa, I; De Rosa, N; Somma, P; Curcio, C; Sanduzzi, AZ; Micheli, P; Molino, A; Saccomanno, A; Salvi, R; Aquino, RP; Pinto, A; Sorrentino, R
Circulating and tumor-associated caspase-4: a novel diagnostic and prognostic biomarker for non-small cell lung cancer.
Oncotarget
9
19356-19367
2018
Homo sapiens
Platnich, JM; Chung, H; Lau, A; Sandall, CF; Bondzi-Simpson, A; Chen, HM; Komada, T; Trotman-Grant, AC; Brandelli, JR; Chun, J; Beck, PL; Philpott, DJ; Girardin, SE; Ho, M; Johnson, RP; MacDonald, JA; Armstrong, GD; Muruve, DA
Shiga Toxin/Lipopolysaccharide Activates Caspase-4 and Gasdermin D to Trigger Mitochondrial Reactive Oxygen Species Upstream of the NLRP3 Inflammasome.
Cell Rep
25
1525-1536.e7
2018
Escherichia coli, Homo sapiens, Mus musculus
Jiao, Y; Wang, L; Lu, L; Liu, J; Li, X; Zhao, H; Hou, Z; Zheng, B
The Role of Caspase-4 and NLRP1 in MCF7 Cell Pyroptosis Induced by hUCMSC-Secreted Factors.
Stem Cells Int
2020
8867115
2020
Homo sapiens
Cai, R; Wang, Q; Zhu, G; Zhu, L; Tao, Z
Increased expression of caspase 1 during active phase of connective tissue disease.
PeerJ
7
e7321
2019
Homo sapiens
Garca de la Cadena, S; Massieu, L
Caspases and their role in inflammation and ischemic neuronal death. Focus on caspase-12.
Apoptosis
21
763-77
2016
Homo sapiens, Rodentia
Liu, Q; Zhang, S; Sun, Z; Guo, X; Zhou, H
E3 ubiquitin ligase Nedd4 is a key negative regulator for non-canonical inflammasome activation.
Cell Death Differ
2019
Homo sapiens, Mus musculus
Kerur, N; Fukuda, S; Banerjee, D; Kim, Y; Fu, D; Apicella, I; Varshney, A; Yasuma, R; Fowler, BJ; Baghdasaryan, E; Marion, KM; Huang, X; Yasuma, T; Hirano, Y; Serbulea, V; Ambati, M; Ambati, VL; Kajiwara, Y; Ambati, K; Hirahara, S; Bastos-Carvalho, A; Ogura, Y; Terasaki, H; Oshika, T; Kim, KB; Hinton, DR; Leitinger, N; Cambier, JC; Buxbaum, JD; Kenney, MC; Jazwinski, SM; Nagai, H; Hara, I; West, AP; Fitzgerald, KA; Sadda, SR; Gelfand, BD; Ambati, J
cGAS drives noncanonical-inflammasome activation in age-related macular degeneration.
Nat Med
24
50-61
2018
Homo sapiens, Mus musculus
Napier, BA; Brubaker, SW; Sweeney, TE; Monette, P; Rothmeier, GH; Gertsvolf, NA; Puschnik, A; Carette, JE; Khatri, P; Monack, DM
Complement pathway amplifies caspase-11-dependent cell death and endotoxin-induced sepsis severity.
J Exp Med
213
2365-2382
2016
Homo sapiens
Yang, X; Wang, J; Liu, C; Grizzle, WE; Yu, S; Zhang, S; Barnes, S; Koopman, WJ; Mountz, JD; Kimberly, RP; Zhang, HG
Cleavage of p53-vimentin complex enhances tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis of rheumatoid arthritis synovial fibroblasts.
Am J Pathol
167
705-19
2005
Homo sapiens
Costa, RO; Ferreiro, E; Cardoso, SM; Oliveira, CR; Pereira, CM
ER Stress-Mediated Apoptotic Pathway Induced by Amyloid-beta.
J Alzheimers Dis
2010
Homo sapiens
Tang, Y; Chen, J; Li, J; Zheng, Y; Zhong, X; Huang, S; Chen, B; Peng, B; Zou, X; Chen, X
Pristimerin synergistically sensitizes conditionally reprogrammed patient derived-primary hepatocellular carcinoma cells to sorafenib through endoplasmic reticulum stress and ROS generation by modulating Akt/FoxO1/p27kip1 signaling pathway.
Phytomedicine
86
153563
2021
Porzana carolina
Soffientini, U; Beaton, N; Baweja, S; Weiss, E; Bihari, C; Habtesion, A; Patel, V; Paradis, V; Sharma, A; Luong, TV; Hall, A; Nadar, A; Sarin, S; Chokshi, S; Williams, R; Py, B; Moreau, R; Jalan, R; Mehta, G
The Lipopolysaccharide-Sensing Caspase(s)-4/11 Are Activated in Cirrhosis and Are Causally Associated With Progression to Multi-Organ Injury.
Front Cell Dev Biol
9
668459
2021
Homo sapiens
Ghavami, S; Sharma, P; Yeganeh, B; Ojo, OO; Jha, A; Mutawe, MM; Kashani, HH; Los, MJ; Klonisch, T; Unruh, H; Halayko, AJ
Airway mesenchymal cell death by mevalonate cascade inhibition: Integration of autophagy, unfolded protein response and apoptosis focusing on Bcl2 family proteins.
Biochim Biophys Acta
1843
1259-1271
2014
Homo sapiens
Rudy, A; López-Antón, N; Barth, N; Pettit, GR; Dirsch, VM; Schulze-Osthoff, K; Rehm, M; Prehn, JH; Vogler, M; Fulda, S; Vollmar, AM
Role of Smac in cephalostatin-induced cell death.
Cell Death Differ
15
1930-40
2008
Sipunculus nudus
Takemoto, K; Miyata, S; Takamura, H; Katayama, T; Tohyama, M
Mitochondrial TRAP1 regulates the unfolded protein response in the endoplasmic reticulum.
Neurochem Int
2011
Homo sapiens
Jang, Y; Kim, J; Ko, JW; Kwon, YH
Homocysteine induces PUMA-mediated mitochondrial apoptosis in SH-SY5Y cells.
Amino Acids
2016
Homo sapiens, Puma concolor
Varga, OIu; Ignat'ev, VK; Riabkov, VA; Volkova, TO; Kruchek, MM
[Activity of genetically programmed cell death of lymphocytes in rheumatoid arthritis]
Ter Arkh
78
14-9
2006
Homo sapiens
Mezache, L; Mikhail, M; Garofalo, M; Nuovo, GJ
Reduced miR-512 and the Elevated Expression of Its Targets cFLIP and MCL1 Localize to Neurons With Hyperphosphorylated Tau Protein in Alzheimer Disease.
Appl Immunohistochem Mol Morphol
23
615-23
2015
Areas
Shi, J; Zhao, Y; Wang, Y; Gao, W; Ding, J; Li, P; Hu, L; Shao, F
Inflammatory caspases are innate immune receptors for intracellular LPS.
Nature
514
187-92
2014
Homo sapiens, Mus musculus
Knodler, LA; Crowley, SM; Sham, HP; Yang, H; Wrande, M; Ma, C; Ernst, RK; Steele-Mortimer, O; Celli, J; Vallance, BA
Noncanonical inflammasome activation of caspase-4/caspase-11 mediates epithelial defenses against enteric bacterial pathogens.
Cell Host Microbe
16
249-56
2014
Escherichia, Homo sapiens
Rivers-Auty, J; Brough, D
Potassium efflux fires the canon: Potassium efflux as a common trigger for canonical and noncanonical NLRP3 pathways.
Eur J Immunol
45
2758-61
2015
Bacteria, Homo sapiens, Mus musculus
Man, SM; Karki, R; Kanneganti, TD
Molecular mechanisms and functions of pyroptosis, inflammatory caspases and inflammasomes in infectious diseases.
Immunol Rev
277
61-75
2017
Homo sapiens, Mus musculus
Basova, LV; Tang, X; Umasume, T; Gromova, A; Zyrianova, T; Shmushkovich, T; Wolfson, A; Hawley, D; Zoukhri, D; Shestopalov, VI; Makarenkova, HP
Manipulation of Panx1 Activity Increases the Engraftment of Transplanted Lacrimal Gland Epithelial Progenitor Cells.
Invest Ophthalmol Vis Sci
58
5654-5665
2017
Mus musculus
Chu, LH; Indramohan, M; Ratsimandresy, RA; Gangopadhyay, A; Morris, EP; Monack, DM; Dorfleutner, A; Stehlik, C
The oxidized phospholipid oxPAPC protects from septic shock by targeting the non-canonical inflammasome in macrophages.
Nat Commun
9
996
2018
Homo sapiens, Mus musculus
Feng, S; Fox, D; Man, SM
Mechanisms of Gasdermin Family Members in Inflammasome Signaling and Cell Death.
J Mol Biol
430
3068-3080
2018
Homo sapiens, Mus musculus
Yuan, YY; Xie, KX; Wang, SL; Yuan, LW
Inflammatory caspase-related pyroptosis: mechanism, regulation and therapeutic potential for inflammatory bowel disease.
Gastroenterol Rep (Oxf)
6
167-176
2018
Homo sapiens
Rathinam, VAK; Zhao, Y; Shao, F
Innate immunity to intracellular LPS.
Nat Immunol
20
527-533
2019
Varanidae, Homo sapiens, Rodentia
Kuriakose, T; Kanneganti, TD
Pyroptosis in Antiviral Immunity.
Curr Top Microbiol Immunol
2019
Homo sapiens, Mus musculus, Mus sp.
Matikainen, S; Nyman, TA; Cypryk, W
Function and Regulation of Noncanonical Caspase-4/5/11 Inflammasome.
J Immunol
204
3063-3069
2020
Bacteria, Homo sapiens, Mus musculus
Chadha, S; Behl, T; Bungau, S; Kumar, A; Arora, R; Gupta, A; Uddin, MS; Zengin, G; Aleya, L; Setia, D; Arora, S
Mechanistic insights into the role of pyroptosis in rheumatoid arthritis.
Curr Res Transl Med
68
151-158
2020
Homo sapiens
Downs, KP; Nguyen, H; Dorfleutner, A; Stehlik, C
An overview of the non-canonical inflammasome.
Mol Aspects Med
76
100924
2020
Bacteria
Chen, Q; Zheng, J; Wang, D; Liu, Q; Kang, L; Gao, X; Lin, Z
Nitrosonisoldipine is a selective inhibitor of inflammatory caspases and protects against pyroptosis and related septic shock.
Eur J Immunol
2021
Homo sapiens, Mus musculus
Jiang, M; Sun, X; Liu, S; Tang, Y; Shi, Y; Bai, Y; Wang, Y; Yang, Q; Yang, Q; Jiang, W; Yuan, H; Jiang, Q; Cai, J
Caspase-11-Gasdermin D-Mediated Pyroptosis Is Involved in the Pathogenesis of Atherosclerosis.
Front Pharmacol
12
657486
2021
Homo sapiens
Bateman, G; Hill, B; Knight, R; Boucher, D
Great balls of fire: activation and signalling of inflammatory caspases.
Biochem Soc Trans
49
1311-1324
2021
Homo sapiens, Mus sp.
Hidvegi, T; Schmidt, BZ; Hale, P; Perlmutter, DH
Accumulation of mutant alpha1-antitrypsin Z in the endoplasmic reticulum activates caspases-4 and -12, NFkappaB, and BAP31 but not the unfolded protein response.
J Biol Chem
280
39002-15
2005
Homo sapiens, Mus musculus
Frank, AK; Leu, JI; Zhou, Y; Devarajan, K; Nedelko, T; Klein-Szanto, A; Hollstein, M; Murphy, ME
The codon 72 polymorphism of p53 regulates interaction with NF-{kappa}B and transactivation of genes involved in immunity and inflammation.
Mol Cell Biol
31
1201-13
2011
Mus musculus
Koehn, S; Schaefer, HW; Ludwig, M; Haag, N; Schubert, US; Seyfarth, L; Imhof, D; Markert, UR; Poehlmann, TG
Cell-specific RNA interference by peptide-inhibited-peptidase-activated siRNAs.
J RNAi Gene Silencing
6
422-30
2010
Homo sapiens
Flood, B; Oficjalska, K; Laukens, D; Fay, J; O'Grady, A; Caiazza, F; Heetun, Z; Mills, KH; Sheahan, K; Ryan, EJ; Doherty, GA; Kay, E; Creagh, EM
Altered expression of caspases-4 and -5 during inflammatory bowel disease and colorectal cancer: Diagnostic and therapeutic potential.
Clin Exp Immunol
181
39-50
2015
Homo sapiens
Romero, R; Xu, Y; Plazyo, O; Chaemsaithong, P; Chaiworapongsa, T; Unkel, R; Than, NG; Chiang, PJ; Dong, Z; Xu, Z; Tarca, AL; Abrahams, VM; Hassan, SS; Yeo, L; Gomez-Lopez, N
A Role for the Inflammasome in Spontaneous Labor at Term.
Am J Reprod Immunol
2016
Homo sapiens
Gomez-Lopez, N; Romero, R; Xu, Y; Plazyo, O; Unkel, R; Than, NG; Chaemsaithong, P; Chaiworapongsa, T; Dong, Z; Tarca, AL; Abrahams, VM; Yeo, L; Hassan, SS
A Role for the Inflammasome in Spontaneous Labor at Term with Acute Histologic Chorioamnionitis.
Reprod Sci
1933719116675058
2016
Homo sapiens
Crowley, SM; Vallance, BA; Knodler, LA
Noncanonical inflammasomes: Antimicrobial defense that does not play by the rules.
Cell Microbiol
19
2017
Homo sapiens, Mus sp.
Gomez-Lopez, N; Romero, R; Xu, Y; Plazyo, O; Unkel, R; Leng, Y; Than, NG; Chaiworapongsa, T; Panaitescu, B; Dong, Z; Tarca, AL; Abrahams, VM; Yeo, L; Hassan, SS
A Role for the Inflammasome in Spontaneous Preterm Labor With Acute Histologic Chorioamnionitis.
Reprod Sci
24
1382-1401
2017
Homo sapiens
Russo, AJ; Behl, B; Banerjee, I; Rathinam, VAK
Emerging Insights into Noncanonical Inflammasome Recognition of Microbes.
J Mol Biol
430
207-216
2018
Bacteria
De Falco, G; Colarusso, C; Terlizzi, M; Popolo, A; Pecoraro, M; Commodo, M; Minutolo, P; Sirignano, M; D'Anna, A; Aquino, RP; Pinto, A; Molino, A; Sorrentino, R
Chronic Obstructive Pulmonary Disease-Derived Circulating Cells Release IL-18 and IL-33 under Ultrafine Particulate Matter Exposure in a Caspase-1/8-Independent Manner.
Front Immunol
8
1415
2017
Homo sapiens
Awad, F; Assrawi, E; Louvrier, C; Jumeau, C; Georgin-Lavialle, S; Grateau, G; Amselem, S; Giurgea, I; Karabina, SA
Inflammasome biology, molecular pathology and therapeutic implications.
Pharmacol Ther
2018
Homo sapiens
Gonzalez-Juarbe, N; Bradley, KM; Riegler, AN; Reyes, LF; Brissac, T; Park, SS; Restrepo, MI; Orihuela, CJ
Bacterial Pore-Forming Toxins Promote the Activation of Caspases in Parallel to Necroptosis to Enhance Alarmin Release and Inflammation During Pneumonia.
Sci Rep
8
5846
2018
Mus musculus
Thygesen, SJ; Stacey, KJ
IRF1 and IRF2 regulate the non-canonical inflammasome.
EMBO Rep
20
e48891
2019
Homo sapiens
Qiao, L; Wu, X; Zhang, J; Liu, L; Sui, X; Zhang, R; Liu, W; Shen, F; Sun, Y; Xi, X
?-NETA induces pyroptosis of epithelial ovarian cancer cells through the GSDMD/caspase-4 pathway.
FASEB J
fj201900483RR
2019
Electron
Kutsch, M; Sistemich, L; Lesser, CF; Goldberg, MB; Herrmann, C; Coers, J
Direct binding of polymeric GBP1 to LPS disrupts bacterial cell envelope functions.
EMBO J
39
e104926
2020
Shigella, Homo sapiens
Chen, Q; Liu, X; Wang, D; Zheng, J; Chen, L; Xie, Q; Liu, X; Niu, S; Qu, G; Lan, J; Li, J; Yang, C; Zou, D
Periodontal Inflammation-Triggered by Periodontal Ligament Stem Cell Pyroptosis Exacerbates Periodontitis.
Front Cell Dev Biol
9
663037
2021
Rattus
Ni, D; Tang, T; Lu, Y; Xu, K; Shao, Y; Saaoud, F; Saredy, J; Liu, L; Drummer, C; Sun, Y; Hu, W; Lopez-Pastrana, J; Luo, JJ; Jiang, X; Choi, ET; Wang, H; Yang, X
Canonical Secretomes, Innate Immune Caspase-1-, 4/11-Gasdermin D Non-Canonical Secretomes and Exosomes May Contribute to Maintain Treg-Ness for Treg Immunosuppression, Tissue Repair and Modulate Anti-Tumor Immunity via ROS Pathways.
Front Immunol
12
678201
2021
Mus sp.
html completed
