Reference on EC 3.1.4.12 - sphingomyelin phosphodiesterase and Organism(s) Homo sapiens and UniProt Accession O60906
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AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Spence, M.W.; Byers, D.M.; Palmer, F.B.St.C.; Cook, H.W.
A new Zn2+-stimulated sphingomyelinase in fetal bovine serum
J. Biol. Chem.
264
5358-5363
1989
Bos taurus, Equus caballus, Homo sapiens
Zou, L.; Kojima, N.; Kito, M.; Yagi, K.
Purification to homogeneity of human placental acid sphingomyelinase
Biotechnol. Appl. Biochem.
11
217-225
1989
Homo sapiens
Vanha-Perttula, T.
Sphingomyelinases in human, bovine and porcine seminal plasma
FEBS Lett.
233
263-267
1988
Bos taurus, Homo sapiens, Sus scrofa
Quintern, L.E.; Weitz, G.; Nehrkorn, H.; Tager, J.M.; Schram, A.W.; Sandhoff, K.
Acid sphingomyelinase from human urine: purification and characterization
Biochim. Biophys. Acta
922
323-336
1987
Homo sapiens
Rousson, R.; Bonnet, J.; Louisot, P.; Vanier, M.T.
Presence of immunoreactive material in Niemann-Pick type A placenta using anti-sphingomyelinase rabbit gammaglobulins
Biochim. Biophys. Acta
924
502-508
1987
Homo sapiens
Christomanou, H.; Aignesberger, A.; Linke, R.P.
Immunochemical characterization of two activator proteins stimulating enzymic sphingomyelin degradation in vitro. Absence of one of them in a human Gaucher disease variant
Biol. Chem. Hoppe-Seyler
367
879-890
1986
Homo sapiens
Christmanou, H.; Kleinschmidt, T.
Isolation of two forms of an activator protein for the enzymic sphingomyelin degradation from human Gaucher spleen
Biol. Chem. Hoppe-Seyler
366
245-256
1985
Homo sapiens
Schram, A.W.; Weitz, G.; Driessen, M.; Brouwer-Kelder, E.M.; Sandhoff, K.; Barranger, J.A.; Tager, J.M.
Immunological properties of urinary sphingomyelinase
Biochem. Soc. Trans.
12
1027-1028
1984
Homo sapiens
-
Weitz, G.; Lindl, T.; Hinrichs, U.; Sandhoff, K.
Release of sphingomyelin phosphodiesterase (acid sphingomyelinase) by ammonium chloride from CL 1D mouse L-cells and human fibroblasts. Partial purification and characterization of the exported enzymes
Hoppe-Seyler's Z. Physiol. Chem.
364
863-871
1983
Homo sapiens, Mus musculus
Sakuragawa, N.
Acid sphingomyelinase of human placenta: purification, properties, and 125iodine labeling
J. Biochem.
92
637-646
1982
Homo sapiens
Jones, C.S.; Shankaran, P.; Callahan, J.W.
Purification of sphingomyelinase to apparent homogeneity by using hydrophobic chromatography
Biochem. J.
195
373-382
1981
Homo sapiens
Yamanaka, T.; Hanada, E.; Suzuki, K.
Acid sphingomyelinase of human brain. Improved purification procedures and characterization
J. Biol. Chem.
256
3884-3889
1981
Homo sapiens
Callahan, J.W.; Gerrie, J.; Jones, C.S.; Shankaran, P.
Studies on the hydrophobic properties of sphingomyelinase
Biochem. J.
193
275-283
1981
Homo sapiens
Callahan, J.W.; Shankaran, P.; Khalil, M.; Gerrie, J.
Sphingomyelinases in human tissues. IV. Purification of sphingomyelinase from human placenta and effect of Triton X-100
Can. J. Biochem.
56
885-891
1978
Homo sapiens
Pentchev, P.G.; Brady, R.O.; Gal, A.E.; Hibbert, S.R.
The isolation and characterization of sphingomyelinase from human placental tissue
Biochim. Biophys. Acta
488
312-321
1977
Homo sapiens
Yamaguchi, S.; Suzuki, K.
Purification and characterization of sphingomyelinase from human brain
J. Biol. Chem.
252
3805-3813
1977
Homo sapiens
Okazaki, T.; Bielawska, A.; Domae, N.; Bell, R.M.; Hannun, Y.A.
Characteristics and partial purification of a novel cytosolic, magnesium-independent, neutral sphingomyelinase activated in the early signal transduction of 1alpha,25-dihydroxyvitamin D3-induced HL-60 cell differentiation
J. Biol. Chem.
269
4070-4077
1994
Homo sapiens
Lansmann, S.; Ferlinz, K.; Hurwitz, R.; Bartelsen, O.; Glombitza, G.; Sandhoff, K.
Purification of acid sphingomyelinase from human placenta: Characterization and N-terminal sequence
FEBS Lett.
399
227-231
1996
Homo sapiens
Duan, R.D.; Nilsson, A.
Purification of a newly identified alkaline sphingomyelinase in human bile and effects of bile salts and phosphatidylcholine on enzyme activity
Hepatology
26
823-830
1997
Homo sapiens
Mansat, V.; Bettaieb, A.; Levade, T.; Laurent, G.; Jaffrezou, J.P.
Serine protease inhibitors block neutral sphingomyelinase activation, ceramide generation, and apoptosis triggered by daunorubicin
FASEB J.
11
695-702
1997
Homo sapiens
Chatterjee, S.; Han, H.; Rollins, S.; Cleveland, T.
Molecular cloning, characterization, and expression of a novel human neutral sphingomyelinase
J. Biol. Chem.
274
37407-37412
1999
Homo sapiens
Bartelsen, O.; Lansmann, S.; Nettersheim, M.; Le mM, T.; Ferlinz, K.; Sandhoff, K.
Expression of recombinant human acid sphingomyelinase in insect Sf21 cells: purification, processing and enzymatic characterization
J. Biotechnol.
63
29-40
1998
Homo sapiens
He, X.; Miranda, S.R.P.; Xiong, X.; Dagan, A.; Gatt, S.; Schuchman, E.H.
Characterization of human acid sphingomyelinase purified from the media of overexpressing chinese hamster ovary cells
Biochim. Biophys. Acta
1432
251-264
1999
Homo sapiens
Samet, D.; Barenholz, Y.
Characterization of acidic and neutral sphingomyelinase activities in crude extracts of HL-60 cells
Chem. Phys. Lipids
102
65-77
1999
Homo sapiens
Tepper, A.D.; Ruurs, P.; Borst, J.; van Blitterswijk, W.J.
Effect of overexpression of a neutral sphingomyelinase on CD95-induced ceramide production and apoptosis
Biochem. Biophys. Res. Commun.
280
634-639
2001
Homo sapiens (O60906), Homo sapiens
Lansmann, S.; Schuette, C.G.; Bartelsen, O.; Hoernschemeyer, J.; Linke, T.; Weisgerber, J.; Sandhoff, K.
Human acid sphingomyelinase: Assignment of the disulfide bond pattern
Eur. J. Biochem.
270
1076-1088
2003
Homo sapiens
Miura, Y.; Gotoh, E.; Nara, F.; Nishijima, M.; Hanada, K.
Hydrolysis of sphingosylphosphocholine by neutral sphingomyelinases
FEBS Lett.
557
288-292
2004
Bacillus cereus, Homo sapiens
Tomiuk, S.; Zumbansen, M.; Stoffel, W.
Characterization and subcellular localization of murine and human magnesium-dependent neutral sphingomyelinase
J. Biol. Chem.
275
5710-5717
2000
Homo sapiens, Mus musculus
Qiu, H.; Edmunds, T.; Baker-Malcolm, J.; Karey, K.P.; Estes, S.; Schwarz, C.; Hughes, H.; Van Patten, S.M.
Activation of human acid sphingomyelinase through modification or deletion of C-terminal cysteine
J. Biol. Chem.
278
32744-32752
2003
Homo sapiens
Duan, R.D.; Bergman, T.; Xu, N.; Wu, J.; Cheng, Y.; Duan, J.; Nelander, S.; Palmberg, C.; Nilsson, A.
Identification of human intestinal alkaline sphingomyelinase as a novel ecto-enzyme related to the nucleotide phosphodiesterase family
J. Biol. Chem.
278
38528-38536
2003
Homo sapiens (Q6UWV6), Homo sapiens
Marchesini, N.; Osta, W.; Bielawski, J.; Luberto, C.; Obeid, L.M.; Hannun, Y.A.
Role for mammalian neutral sphingomyelinase 2 in confluence-induced growth arrest of MCF7 cells
J. Biol. Chem.
279
25101-25111
2004
Homo sapiens
Lansmann, S.; Bartelsen, O.; Sandhoff, K.
Purification and characterization of recombinant human acid sphingomyelinase expressed in insect Sf21 cells
Methods Enzymol.
311
149-156
2000
Homo sapiens
Hofmann, K.; Tomiuk, S.; Wolff, G.; Stoffel, W.
Cloning and characterization of the mammalian brain-specific, Mg2+-dependent neutral sphingomyelinase
Proc. Natl. Acad. Sci. USA
97
5895-5900
2000
Homo sapiens (Q9NY59)
Oeoerni, K.; Posio, P.; Ala-Korpela, M.; Jauhiainen, M.; Kovanen, P.T.
Sphingomyelinase induces aggregation and fusion of small very low-density lipoprotein and intermediate-density lipoprotein particles and increases their retention to human arterial proteoglycans
Arterioscler. Thromb. Vasc. Biol.
25
1678-1683
2005
Homo sapiens
Wu, J.; Hansen, G.H.; Nilsson, A.; Duan, R.D.
Functional studies of human intestinal alkaline sphingomyelinase by deglycosylation and mutagenesis
Biochem. J.
386
153-160
2005
Homo sapiens
Wu, J.; Nilsson, A.; Jonsson, B.A.; Stenstad, H.; Agace, W.; Cheng, Y.; Duan, R.D.
Intestinal alkaline sphingomyelinase hydrolyses and inactivates platelet-activating factor by a phospholipase C activity
Biochem. J.
394
299-308
2006
Homo sapiens, Rattus norvegicus
Duan, R.D.
Alkaline sphingomyelinase: An old enzyme with novel implications
Biochim. Biophys. Acta
1761
281-291
2006
Homo sapiens
Koelzer, M.; Ferlinz, K.; Bartelsen, O.; Hoops, S.L.; Lang, F.; Sandhoff, K.
Functional characterization of the postulated intramolecular sphingolipid activator protein domain of human acid sphingomyelinase
Biol. Chem.
385
1193-1195
2004
Homo sapiens
Di Marzio, L.; Di Leo, A.; Cinque, B.; Fanini, D.; Agnifili, A.; Berloco, P.; Linsalata, M.; Lorusso, D.; Barone, M.; De Simone, C.; Cifone, M.G.
Detection of alkaline sphingomyelinase activity in human stool: Proposed role as a new diagnostic and prognostic marker of colorectal cancer
Cancer Epidemiol. Biomarkers Prev.
14
856-862
2005
Homo sapiens
Liu, F.; Cheng, Y.; Wu, J.; Tauschel, H.D.; Duan, R.D.
Ursodeoxycholic acid differentially affects three types of sphingomyelinase in human colon cancer Caco 2 cells
Cancer Lett.
235
141-146
2006
Homo sapiens
Wu, J.; Cheng, Y.; Nilsson, A.; Duan, R.D.
Identification of one exon deletion of intestinal alkaline sphingomyelinase in colon cancer HT-29 cells and a differentiation-related expression of the wild-type enzyme in Caco-2 cells
Carcinogenesis
25
1327-1333
2004
Homo sapiens
Koelzer, M.; Werth, N.; Sandhoff, K.
Interactions of acid sphingomyelinase and lipid bilayers in the presence of the tricyclic antidepressant desipramine
FEBS Lett.
559
96-98
2004
Homo sapiens
Knapp, P.; Dobrzyn, A.; Gorski, J.
Ceramides, sphinganine, sphingosine and acid sphingomyelinases in the human umbilical cord blood
Horm. Metab. Res.
37
433-437
2005
Homo sapiens
Pittis, M.G.; Ricci, V.; Guerci, V.I.; Marcais, C.; Ciana, G.; Dardis, A.; Gerin, F.; Stroppiano, M.; Vanier, M.T.; Filocamo, M.; Bembi, B.
Acid sphingomyelinase: identification of nine novel mutations among Italian Niemann pick type B patients and characterization of in vivo functional in-frame start codon
Hum. Mutat.
24
186-187
2004
Homo sapiens
Kashkar, H.; Wiegmann, K.; Yazdanpanah, B.; Haubert, D.; Kroenke, M.
Acid sphingomyelinase is indispensable for UV light-induced Bax conformational change at the mitochondrial membrane
J. Biol. Chem.
280
20804-20813
2005
Homo sapiens
Krut, O.; Wiegmann, K.; Kashkar, H.; Yazdanpanah, B.; Kronke, M.
Novel tumor necrosis factor-responsive mammalian neutral sphingomyelinase-3 is a C-tail-anchored protein
J. Biol. Chem.
281
13784-13793
2006
Homo sapiens (Q9NXE4), Homo sapiens
Mari, M.; Colell, A.; Morales, A.; Paneda, C.; Varela-Nieto, I.; Garcia-Ruiz, C.; Fernandez-Checa, J.C.
Acidic sphingomyelinase downregulates the liver-specific methionine adenosyltransferase 1A, contributing to tumor necrosis factor-induced lethal hepatitis
J. Clin. Invest.
113
895-904
2004
Homo sapiens
Jensen, J.M.; Folster-Holst, R.; Baranowsky, A.; Schunck, M.; Winoto-Morbach, S.; Neumann, C.; Schutze, S.; Proksch, E.
Impaired sphingomyelinase activity and epidermal differentiation in atopic dermatitis
J. Invest. Dermatol.
122
1423-1431
2004
Homo sapiens
Testai, F.D.; Landek, M.A.; Goswami, R.; Ahmed, M.; Dawson, G.
Acid sphingomyelinase and inhibition by phosphate ion: role of inhibition by phosphatidyl-myo-inositol 3,4,5-triphosphate in oligodendrocyte cell signaling
J. Neurochem.
89
636-644
2004
Homo sapiens
Testai, F.D.; Landek, M.A.; Dawson, G.
Regulation of sphingomyelinases in cells of the oligodendrocyte lineage
J. Neurosci. Res.
75
66-74
2004
Homo sapiens, Rattus norvegicus
Zhou, Q.; Band, M.R.; Hernandez, A.; Liu, Z.L.; Kummerow, F.A.
27-Hydroxycholesterol inhibits neutral sphingomyelinase in cultured human endothelial cells
Life Sci.
75
1567-1577
2004
Homo sapiens (O60906), Homo sapiens
Takahashi, I.; Takahashi, T.; Mikami, T.; Komatsu, M.; Ohura, T.; Schuchman, E.H.; Takada, G.
Acid sphingomyelinase: Relation of 93Lysine residue on the ratio of intracellular to secreted enzyme activity
Tohoku J. Exp. Med.
206
333-340
2005
Homo sapiens
Grammatikos, G.; Teichgraeber, V.; Carpinteiro, A.; Trarbach, T.; Weller, M.; Hengge, U.R.; Gulbins, E.
Overexpression of acid sphingomyelinase sensitizes glioma cells to chemotherapy
Antioxid. Redox Signal.
9
1449-1456
2007
Homo sapiens
Martin, S.F.; Sawai, H.; Villalba, J.M.; Hannun, Y.A.
Redox regulation of neutral sphingomyelinase-1 activity in HEK293 cells through a GSH-dependent mechanism
Arch. Biochem. Biophys.
459
295-300
2007
Homo sapiens
De Palma, C.; Meacci, E.; Perrotta, C.; Bruni, P.; Clementi, E.
Endothelial nitric oxide synthase activation by tumor necrosis factor alpha through neutral sphingomyelinase 2, sphingosine kinase 1, and sphingosine 1 phosphate receptors
Arterioscler. Thromb. Vasc. Biol.
26
99-105
2006
Homo sapiens
Clarke, C.J.; Snook, C.F.; Tani, M.; Matmati, N.; Marchesini, N.; Hannun, Y.A.
The extended family of neutral sphingomyelinases
Biochemistry
45
11247-11256
2006
Helicobacter pylori, Staphylococcus aureus, Rattus norvegicus, Homo sapiens (O60906), Homo sapiens (Q9NY59), Bacillus cereus (P09599), Listeria ivanovii (Q9RLV9), Listeria ivanovii nSMase (Q9RLV9), Helicobacter pylori nSMase, Bacillus cereus nSMase (P09599)
Lee, C.Y.; Tamura, T.; Rabah, N.; Lee, D.Y.; Ruel, I.; Hafiane, A.; Iatan, I.; Nyholt, D.; Laporte, F.; Lazure, C.; Wada, I.; Krimbou, L.; Genest, J.
Carboxyl-terminal disulfide bond of acid sphingomyelinase is critical for its secretion and enzymatic function
Biochemistry
46
14969-14978
2007
Homo sapiens
Clarke, C.J.; Hannun, Y.A.
Neutral sphingomyelinases and nSMase2: bridging the gaps
Biochim. Biophys. Acta
1758
1893-1901
2006
Bos taurus, Homo sapiens, Mus musculus, Rattus norvegicus
Dastani, Z.; Ruel, I.L.; Engert, J.C.; Genest, J.; Marcil, M.
Sphingomyelin phosphodiesterase-1 (SMPD1) coding variants do not contribute to low levels of high-density lipoprotein cholesterol
BMC Med. genet.
8
79
2007
Homo sapiens
Cheng, Y.; Wu, J.; Hertervig, E.; Lindgren, S.; Duan, D.; Nilsson, A.; Duan, R.D.
Identification of aberrant forms of alkaline sphingomyelinase (NPP7) associated with human liver tumorigenesis
Br. J. Cancer
97
1441-1448
2007
Homo sapiens (Q6UWV6), Homo sapiens
Ion, G.; Fajka-Boja, R.; Kovacs, F.; Szebeni, G.; Gombos, I.; Czibula, A.; Matko, J.; Monostori, E.
Acid sphingomyelinase mediated release of ceramide is essential to trigger the mitochondrial pathway of apoptosis by galectin-1
Cell. Signal.
18
1887-1896
2006
Homo sapiens
Doehner, W.; Bunck, A.C.; Rauchhaus, M.; von Haehling, S.; Brunkhorst, F.M.; Cicoira, M.; Tschope, C.; Ponikowski, P.; Claus, R.A.; Anker, S.D.
Secretory sphingomyelinase is upregulated in chronic heart failure: a second messenger system of immune activation relates to body composition, muscular functional capacity, and peripheral blood flow
Eur. Heart J.
28
821-828
2007
Homo sapiens
Duan, R.
Sphingomyelinase and ceramidase in the intestinal tract
Eur. J. Lipid Sci. Technol.
109
987-993
2007
Homo sapiens, Mus musculus, Rattus norvegicus
-
Castillo, S.S.; Levy, M.; Thaikoottathil, J.V.; Goldkorn, T.
Reactive nitrogen and oxygen species activate different sphingomyelinases to induce apoptosis in airway epithelial cells
Exp. Cell Res.
313
2680-2686
2007
Homo sapiens
Castillo, S.S.; Levy, M.; Wang, C.; Thaikoottathil, J.V.; Khan, E.; Goldkorn, T.
Nitric oxide-enhanced caspase-3 and acidic sphingomyelinase interaction: a novel mechanism by which airway epithelial cells escape ceramide-induced apoptosis
Exp. Cell Res.
313
816-823
2007
Homo sapiens
Tani, M.; Hannun, Y.A.
Neutral sphingomyelinase 2 is palmitoylated on multiple cysteine residues. Role of palmitoylation in subcellular localization
J. Biol. Chem.
282
10047-10056
2007
Homo sapiens
Zeidan, Y.H.; Hannun, Y.A.
Activation of acid sphingomyelinase by protein kinase Cdelta-mediated phosphorylation
J. Biol. Chem.
282
11549-11561
2007
Homo sapiens
Clarke, C.J.; Truong, T.G.; Hannun, Y.A.
Role for neutral sphingomyelinase-2 in tumor necrosis factor alpha-stimulated expression of vascular cell adhesion molecule-1 (VCAM) and intercellular adhesion molecule-1 (ICAM) in lung epithelial cells: p38 MAPK is an upstream regulator of nSMase2
J. Biol. Chem.
282
1384-1396
2007
Homo sapiens
Walton, K.A.; Gugiu, B.G.; Thomas, M.; Basseri, R.J.; Eliav, D.R.; Salomon, R.G.; Berliner, J.A.
A role for neutral sphingomyelinase activation in the inhibition of LPS action by phospholipid oxidation products
J. Lipid Res.
47
1967-1974
2006
Homo sapiens
Coll, O.; Morales, A.; Fernandez-Checa, J.C.; Garcia-Ruiz, C.
Neutral sphingomyelinase-induced ceramide triggers germinal vesicle breakdown and oxidant-dependent apoptosis in Xenopus laevis oocytes
J. Lipid Res.
48
1924-1935
2007
Bacillus cereus, Homo sapiens
Kornhuber, J.; Tripal, P.; Reichel, M.; Terfloth, L.; Bleich, S.; Wiltfang, J.; Gulbins, E.
Identification of new functional inhibitors of acid sphingomyelinase using a structure-property-activity relation model
J. Med. Chem.
51
219-237
2008
Homo sapiens, Rattus norvegicus
Adamy, C.; Mulder, P.; Khouzami, L.; Andrieu-abadie, N.; Defer, N.; Candiani, G.; Pavoine, C.; Caramelle, P.; Souktani, R.; Le Corvoisier, P.; Perier, M.; Kirsch, M.; Damy, T.; Berdeaux, A.; Levade, T.; Thuillez, C.; Hittinger, L.; Pecker, F.
Neutral sphingomyelinase inhibition participates to the benefits of N-acetylcysteine treatment in post-myocardial infarction failing heart rats
J. Mol. Cell. Cardiol.
43
344-353
2007
Homo sapiens, Rattus norvegicus
Duan, R.; Cheng, Y.; Joensson, B.A.; Ohlsson, L.; Herbst, A.; Hellstroem-Westas, L.; Nilsson, A.
Human meconium contains significant amounts of alkaline sphingomyelinase, neutral ceramidase, and sphingolipid metabolites
Pediatr. Res.
61
61-66
2006
Homo sapiens
Cheng, Y.; Kozubek, A.; Ohlsson, L.; Sternby, B.; Duan, R.D.
Curcumin decreases acid sphingomyelinase activity in colon cancer Caco-2 cells
Planta Med.
73
725-730
2007
Homo sapiens
Bock, J.; Liebisch, G.; Schweimer, J.; Schmitz, G.; Rogler, G.
Exogenous sphingomyelinase causes impaired intestinal epithelial barrier function
World J. Gastroenterol.
13
5217-5225
2007
Homo sapiens
Jafurulla, M.; Pucadyil, T.J.; Chattopadhyay, A.
Effect of sphingomyelinase treatment on ligand binding activity of human serotonin1A receptors
Biochim. Biophys. Acta
1778
2022-2025
2008
Homo sapiens
Kim, W.J.; Okimoto, R.A.; Purton, L.E.; Goodwin, M.; Haserlat, S.M.; Dayyani, F.; Sweetser, D.A.; McClatchey, A.I.; Bernard, O.A.; Look, A.T.; Bell, D.W.; Scadden, D.T.; Haber, D.A.
Mutations in the neutral sphingomyelinase gene SMPD3 implicate the ceramide pathway in human leukemias
Blood
111
4716-4722
2008
Homo sapiens
Andersson, D.; Kotarsky, K.; Wu, J.; Agace, W.; Duan, R.D.
Expression of alkaline sphingomyelinase in yeast cells and anti-inflammatory effects of the expressed enzyme in a rat colitis model
Digest. Dis. Sci.
54
1440-1448
2008
Homo sapiens
Dodge, J.C.; Clarke, J.; Treleaven, C.M.; Taksir, T.V.; Griffiths, D.A.; Yang, W.; Fidler, J.A.; Passini, M.A.; Karey, K.P.; Schuchman, E.H.; Cheng, S.H.; Shihabuddin, L.S.
Intracerebroventricular infusion of acid sphingomyelinase corrects CNS manifestations in a mouse model of Niemann-Pick A disease
Exp. Neurol.
215
349-357
2009
Homo sapiens
Smith, E.L.; Schuchman, E.H.
The unexpected role of acid sphingomyelinase in cell death and the pathophysiology of common diseases
FASEB J.
22
3419-3431
2008
Homo sapiens
Corcoran, C.A.; He, Q.; Ponnusamy, S.; Ogretmen, B.; Huang, Y.; Sheikh, M.S.
Neutral sphingomyelinase-3 is a DNA damage and nongenotoxic stress-regulated gene that is deregulated in human malignancies
Mol. Cancer Res.
6
795-807
2008
Homo sapiens
Ziegler, R.J.; Brown, C.; Barbon, C.M.; DAngona, A.M.; Schuchman, E.H.; Andrews, L.; Thurberg, B.L.; McPherson, J.M.; Karey, K.P.; Cheng, S.H.
Pulmonary delivery of recombinant acid sphingomyelinase improves clearance of lysosomal sphingomyelin from the lungs of a murine model of Niemann-Pick disease
Mol. Genet. Metab.
97
35-42
2009
Homo sapiens
Clarke, C.J.; Guthrie, J.M.; Hannun, Y.A.
Regulation of neutral sphingomyelinase-2 (nSMase2) by tumor necrosis factor-alpha involves protein kinase C-delta in lung epithelial cells
Mol. Pharmacol.
74
1022-1032
2008
Homo sapiens
Smith, E.L.; Schuchman, E.H.
Acid sphingomyelinase overexpression enhances the antineoplastic effects of irradiation in vitro and in vivo
Mol. Ther.
16
1565-1571
2008
Homo sapiens
Zhang, Y.; Duan, R.D.
Boswellic acid inhibits expression of acid sphingomyelinase in intestinal cells
Lipids Health Dis.
8
51
2009
Homo sapiens
Cheng, Y.; Liu, F.; Wu, J.; Zhang, Y.; Nilsson, A.; Duan, R.D.
Ezetimibe inhibits expression of acid sphingomyelinase in liver and intestine
Lipids
44
897-906
2009
Homo sapiens, Rattus norvegicus
Arenz, C.
Small molecule inhibitors of acid sphingomyelinase
Cell. Physiol. Biochem.
26
1-8
2010
Homo sapiens
Clarke, C.J.; Mediwala, K.; Jenkins, R.W.; Sutton, C.A.; Tholanikunnel, B.G.; Hannun, Y.A.
Neutral sphingomyelinase-2 mediates growth arrest by retinoic acid through modulation of ribosomal S6 kinase
J. Biol. Chem.
286
21565-21576
2011
Homo sapiens
Jenkins, R.W.; Idkowiak-Baldys, J.; Simbari, F.; Canals, D.; Roddy, P.; Riner, C.D.; Clarke, C.J.; Hannun, Y.A.
A novel mechanism of lysosomal acid sphingomyelinase maturation: requirement for carboxyl-terminal proteolytic processing
J. Biol. Chem.
286
3777-3788
2011
Homo sapiens
Perrotta, C.; Clementi, E.
Biological roles of Acid and neutral sphingomyelinases and their regulation by nitric oxide
Physiology
25
64-71
2010
Homo sapiens
Kumagai, T.; Ishino, T.; Nakagawa, Y.
Acidic sphingomyelinase induced by electrophiles promotes proinflammatory cytokine production in human bladder carcinoma ECV-304 cells
Arch. Biochem. Biophys.
519
8-16
2012
Homo sapiens
Traini, M.; Quinn, C.M.; Sandoval, C.; Johansson, E.; Schroder, K.; Kockx, M.; Meikle, P.J.; Jessup, W.; Kritharides, L.
Sphingomyelin phosphodiesterase-like 3A (SMPDL3A) is a novel nucleotide phosphodiesterase regulated by cholesterol in human macrophages
J. Biol. Chem.
289
32895-32913
2014
Homo sapiens (Q8IUN0), Homo sapiens
Miller, M.E.; Adhikary, S.; Kolokoltsov, A.A.; Davey, R.A.
Ebolavirus requires acid sphingomyelinase activity and plasma membrane sphingomyelin for infection
J. Virol.
86
7473-7483
2012
Homo sapiens
Toth, B.; Erdoes, M.; Szekely, A.; Ritli, L.; Bagossi, P.; Suemegi, J.; Marodi, L.
Molecular genetic characterization of novel sphingomyelin phosphodiesterase 1 mutations causing Niemann-Pick disease
JIMD Rep.
3
125-129
2012
Homo sapiens (P17405), Homo sapiens
He, Q.; Wang, G.; Wakade, S.; Dasgupta, S.; Dinkins, M.; Kong, J.N.; Spassieva, S.D.; Bieberich, E.
Primary cilia in stem cells and neural progenitors are regulated by neutral sphingomyelinase 2 and ceramide
Mol. Biol. Cell
25
1715-1729
2014
Homo sapiens
Rhein, C.; Tripal, P.; Seebahn, A.; Konrad, A.; Kramer, M.; Nagel, C.; Kemper, J.; Bode, J.; Muehle, C.; Gulbins, E.; Reichel, M.; Becker, C.M.; Kornhuber, J.
Functional implications of novel human acid sphingomyelinase splice variants
PLoS ONE
7
e35467
2012
Homo sapiens (E9LUE7), Homo sapiens (E9LUE8), Homo sapiens (E9LUE9), Homo sapiens (P17405), Homo sapiens
Muehle, C.; Huttner, H.B.; Walter, S.; Reichel, M.; Canneva, F.; Lewczuk, P.; Gulbins, E.; Kornhuber, J.
Characterization of acid sphingomyelinase activity in human cerebrospinal fluid
PLoS ONE
8
e62912
2013
Homo sapiens, Mus musculus
Bai, A.; Kokkotou, E.; Zheng, Y.; Robson, S.C.
Role of acid sphingomyelinase bioactivity in human CD4+ T-cell activation and immune responses
Cell Death Dis.
6
e1828
2015
Homo sapiens
Klutzny, S.; Lesche, R.; Keck, M.; Kaulfuss, S.; Schlicker, A.; Christian, S.; Sperl, C.; Neuhaus, R.; Mowat, J.; Steckel, M.; Riefke, B.; Prechtl, S.; Parczyk, K.; Steigemann, P.
Functional inhibition of acid sphingomyelinase by fluphenazine triggers hypoxia-specific tumor cell death
Cell Death Dis.
8
e2709
2017
Homo sapiens
Lim, S.M.; Yeung, K.; Tresaugues, L.; Ling, T.H.; Nordlund, P.
The structure and catalytic mechanism of human sphingomyelin phosphodiesterase like 3a--an acid sphingomyelinase homologue with a novel nucleotide hydrolase activity
FEBS J.
283
1107-1123
2016
Homo sapiens (Q92484), Homo sapiens
Collenburg, L.; Beyersdorf, N.; Wiese, T.; Arenz, C.; Saied, E.M.; Becker-Flegler, K.A.; Schneider-Schaulies, S.; Avota, E.
The activity of the neutral sphingomyelinase is important in T cell recruitment and directional migration
Front. Immunol.
8
1007
2017
Homo sapiens
Gorelik, A.; Liu, F.; Illes, K.; Nagar, B.
Crystal structure of the human alkaline sphingomyelinase provides insights into substrate recognition
J. Biol. Chem.
292
7087-7094
2017
Homo sapiens (Q6UWV6), Homo sapiens
