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Literature summary for 3.1.4.12 extracted from

  • Kornhuber, J.; Tripal, P.; Reichel, M.; Terfloth, L.; Bleich, S.; Wiltfang, J.; Gulbins, E.
    Identification of new functional inhibitors of acid sphingomyelinase using a structure-property-activity relation model (2008), J. Med. Chem., 51, 219-237.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
amlodipine
-
Homo sapiens
amlodipine
-
Rattus norvegicus
astemizole
-
Homo sapiens
astemizole
-
Rattus norvegicus
benztropine
-
Homo sapiens
benztropine
-
Rattus norvegicus
bepridil
-
Homo sapiens
bepridil
-
Rattus norvegicus
camylofin
-
Homo sapiens
camylofin
-
Rattus norvegicus
chlorprothixene
-
Homo sapiens
chlorprothixene
-
Rattus norvegicus
clomiphene
-
Homo sapiens
clomiphene
-
Rattus norvegicus
cloperastine
-
Homo sapiens
cloperastine
-
Rattus norvegicus
cyclobenzaprine
-
Homo sapiens
cyclobenzaprine
-
Rattus norvegicus
cyproheptadine
-
Homo sapiens
cyproheptadine
-
Rattus norvegicus
doxepine
-
Homo sapiens
doxepine
-
Rattus norvegicus
drofenine
-
Homo sapiens
drofenine
-
Rattus norvegicus
fendiline
-
Homo sapiens
fendiline
-
Rattus norvegicus
fluoxetine
-
Homo sapiens
fluoxetine
-
Rattus norvegicus
maprotiline
-
Homo sapiens
maprotiline
-
Rattus norvegicus
additional information ASM detachment from lysosomal membranes, caused by weak bases inhibit the enzyme, usage of structure-property-activity relation model in inhibitor screening, overview, no inhibition of ASM by dicyclomine, diphenhydramine, diphenylpyraline, donepezil, lercanidipine, mebeverine, memantine, oxymetazoline, oxyphencyclimine, pyrilamine, triprolidine, and xylometazoline Homo sapiens
additional information ASM detachment from lysosomal membranes caused by weak bases inhibit the enzyme, usage of structure-property-activity relation model in inhibitor screening, overview, no inhibition of ASM by dicyclomine, diphenhydramine, diphenylpyraline, donepezil, lercanidipine, mebeverine, memantine, oxymetazoline, oxyphencyclimine, pyrilamine, triprolidine, and xylometazoline Rattus norvegicus
norfluoxetine
-
Homo sapiens
norfluoxetine
-
Rattus norvegicus
nortriptyline
-
Homo sapiens
nortriptyline
-
Rattus norvegicus
paroxetine
-
Homo sapiens
paroxetine
-
Rattus norvegicus
pimethixene
-
Homo sapiens
pimethixene
-
Rattus norvegicus
promazine
-
Homo sapiens
promazine
-
Rattus norvegicus
Promethazine
-
Homo sapiens
Promethazine
-
Rattus norvegicus
protriptyline
-
Homo sapiens
protriptyline
-
Rattus norvegicus
sertraline
-
Homo sapiens
sertraline
-
Rattus norvegicus
suloctidil
-
Homo sapiens
suloctidil
-
Rattus norvegicus
terfenadine
-
Homo sapiens
terfenadine
-
Rattus norvegicus
triflupromazine
-
Homo sapiens
triflupromazine
-
Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
lysosomal membrane inner lysosomal membrane, detachment caused by weak bases inhibits the enzyme Homo sapiens 5765
-
lysosomal membrane inner lysosomal membrane, detachment caused by weak bases inhibits the enzyme Rattus norvegicus 5765
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
sphingomyelin + H2O Homo sapiens
-
N-acylsphingosine + choline phosphate
-
?
sphingomyelin + H2O Rattus norvegicus
-
N-acylsphingosine + choline phosphate
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Homo sapiens
-
H4 neuroglioma cell
-
Homo sapiens
-
neuroglioma cell
-
Homo sapiens
-
PC-12 cell
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
sphingomyelin + H2O
-
Homo sapiens N-acylsphingosine + choline phosphate
-
?
sphingomyelin + H2O
-
Rattus norvegicus N-acylsphingosine + choline phosphate
-
?

Synonyms

Synonyms Comment Organism
acid sphingomyelinase
-
Homo sapiens
acid sphingomyelinase
-
Rattus norvegicus
ASM
-
Homo sapiens
ASM
-
Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Homo sapiens
37
-
assay at Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
assay at Homo sapiens
7.5
-
assay at Rattus norvegicus