Application | Comment | Organism |
---|---|---|
medicine | ASM plays a complex and varied role in brain development, as well as in the pathogenesis of several common neurological diseases, ASM is particularly intriguing as an antioncogenic drug, ASM is associated with the type A Niemann-Pick disease, atherosclerosis, Wilson disease, hepatic autoimmune disease, alcohol-induced liver disease, cerebral ischemia, emphysema, cystic fibrosis, and cancer | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
expressed in CHO cells and in Mus musculus | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
D609 | nonspecific sphingomyelinase inhibitor | Homo sapiens | |
additional information | desipramine is a cationic amphiphile that triggers ASM proteolysis | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
lysosome | - |
Homo sapiens | 5764 | - |
membrane | phosphorylation of a specific serine residue on ASM (S508) by protein kinase C-delta is required for its translocation to the cell surface | Homo sapiens | 16020 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
72000 | - |
estimated molecular weight, SDS-PAGE | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | ASM is necessary for stress-induced cell death | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
glycoprotein | - |
Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
blood | - |
Homo sapiens | - |
blood plasma | a secreted, zinc-activated form of ASM is found in the plasma which plays an important role in the development of atherosclerosis | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | ASM is necessary for stress-induced cell death | Homo sapiens | ? | - |
? | |
sphingomyelin + H2O | - |
Homo sapiens | N-acylsphingosine + choline phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
acid sphingomyelinase | - |
Homo sapiens |
ASM | - |
Homo sapiens |