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(2-amino-4,5-dihydronaphtho[1,2-d][1,3]thiazol-7-yl)methyl dihydrogen phosphate
-
(2-amino-4,5-dihydronaphtho[1,2-d][1,3]thiazol-7-yl)phosphonic acid
-
(2-amino-4,5-dihydronaphtho[1,2-d][1,3]thiazol-8-yl)methyl dihydrogen phosphate
-
(2-amino-4,5-dihydronaphtho[1,2-d][1,3]thiazol-8-yl)phosphonic acid
-
(2-amino-4,5-dihydronaphtho[1,2-d][1,3]thiazol-9-yl)methyl dihydrogen phosphate
-
(2-amino-4,5-dihydronaphtho[1,2-d][1,3]thiazol-9-yl)phosphonic acid
-
(2-amino-5,6-dihydro-4H-benzo[6,7]cyclohepta[1,2-d][1,3]thiazol-9-yl)methyl dihydrogen phosphate
-
(2-amino-5,6-dihydro-4H-benzo[6,7]cyclohepta[1,2-d][1,3]thiazol-9-yl)phosphonic acid
-
(2-amino-8H-indeno[1,2-d][1,3]thiazol-4-yl)methyl dihydrogen phosphate
-
(2-amino-8H-indeno[1,2-d][1,3]thiazol-4-yl)phosphonic acid
-
(2-amino-8H-indeno[1,2-d][1,3]thiazol-5-yl)methyl dihydrogen phosphate
-
(2-amino-8H-indeno[1,2-d][1,3]thiazol-5-yl)phosphonic acid
-
(2-amino-8H-indeno[1,2-d][1,3]thiazol-6-yl)methyl dihydrogen phosphate
-
(2-amino-8H-indeno[1,2-d][1,3]thiazol-6-yl)phosphonic acid
-
(2E)-3-(5-bromo-4-hydroxy-2-methoxyphenyl)-1-[4-[(3-methylbut-2-en-1-yl)oxy]phenyl]prop-2-en-1-one
-
-
(3-Bromo-phenyl)-(6,7-diethoxy-quinazolin-4-yl)-amine
-
IC50: 0.0017 mM
(3-Bromo-phenyl)-(6,7-dimethoxy-2-methyl-quinazolin-4-yl)-amine
-
IC50: 0.0045 mM
(3-Bromo-phenyl)-(6,7-dimethoxy-quinazolin-4-yl)-amine
-
IC50: 0.001 mM
(3-Bromo-phenyl)-(7-ethoxy-6-nitro-quinazolin-4-yl)-amine
-
IC50: 0.0039 mM
(3-Bromo-phenyl)-[6-(2-methoxy-ethoxy)-quinazolin-4-yl]-amine
-
IC50: 0.0029 mM
(3-Bromo-phenyl)-[7-methoxy-6-(2-methoxy-ethoxy)-quinazolin-4-yl]-amine
-
IC50: 0.0055 mM
(3-Chloro-4-fluoro-phenyl)-(6,7-diethoxy-quinazolin-4-yl)-amine
-
IC50: 0.00053 mM
(3-Chloro-phenyl)-(6,7-diethoxy-quinazolin-4-yl)-amine
-
IC50: 0.0016 mM
(3-Chloro-phenyl)-(6,7-dimethoxy-quinazolin-4-yl)-amine
-
IC50: 0.0013 mM
(4-[3-(6,7-diethoxy-quinazolin-4-ylamino)-phenyl]-thiazol-2-yl)-methanol
i.e. PFE, allosteric inhibitor
(5-[2-amino-5-[(propylsulfanyl)carbonyl]-1,3-thiazol-4-yl]furan-2-yl)phosphonic acid
-
-
(5-[4-amino-7-[3-(dimethylamino)propyl]-5-fluoro-1-(2-methylpropyl)-1H-benzimidazol-2-yl]furan-2-yl)phosphonic acid
-
-
(6,7-Diethoxy-quinazolin-4-yl)-(3-ethynyl-phenyl)-amine
-
IC50: 0.0024 mM
(6,7-Diethoxy-quinazolin-4-yl)-(3-fluoro-phenyl)-amine
-
IC50: 0.0092 mM
(6,7-Diethoxy-quinazolin-4-yl)-(3-iodo-phenyl)-amine
-
IC50: 0.0021 mM
(6,7-Dimethoxy-quinazolin-4-yl)-(3-ethynyl-phenyl)-amine
-
IC50: 0.0009 mM
1-(cyclopropyl)methyl-3-(2-carboxyethyl)-7-nitro-1H-indole-2-carboxylic acid
-
1-benzyl-3-(2-carboxyethyl)-7-nitro-1H-indole-2-carboxylic acid
-
2',3'-O-(2,4,6-trinitrophenyl)adenosine 5'-monophosphate
2,5-dichloro-N-(4-methyl-1,3-benzoxazol-2-yl)benzenesulfonamide
-
-
2,5-dichloro-N-(5-chloro-1,3-benzoxazol-2-yl)benzenesulfonamide
2,5-dichloro-N-(5-methyl-1,3-benzoxazol-2-yl)benzenesulfonamide
-
-
2,5-dichloro-N-(6-chloro-1,3-benzoxazol-2-yl)benzenesulfonamide
-
-
2,5-dichloro-N-(6-methoxy-1,3-benzoxazol-2-yl)benzenesulfonamide
-
-
2,5-dichloro-N-(6-methyl-1,3-benzoxazol-2-yl)benzenesulfonamide
-
-
2,5-dichloro-N-[5-(3-furyl)-1,3-benzoxazol-2-yl]benzenesulfonamide
-
-
2,5-dichloro-N-[5-methoxy-7-(4-methoxypyridin-3-yl)-1,3-benzoxazol-2-yl]benzenesulfonamide
-
-
2,5-dichloro-N-[7-(3-hydroxyphenyl)-5-methoxy-1,3-benzoxazol-2-yl]benzenesulfonamide
-
-
2,5-dichloro-N-[7-(4-hydroxyphenyl)-5-methoxy-1,3-benzoxazol-2-yl]benzenesulfonamide
-
-
2-(2-aminoethyl)-6,7-diethoxy-N-[3-(2-methyl-1,3-thiazol-4-yl)phenyl]quinazolin-4-amine
-
uncompetitive
2-(2-thienyl)-5-isobutyl-4-[2-(5-phosphono)furanyl]thiazole
-
-
2-(3-pyridyl)-5-isobutyl-4-[2-(5-phosphono)furanyl]thiazole
-
-
2-acetamido-5-isobutyl-4-[2-(5-phosphono)furanyl]thiazole
-
-
2-amino-4,5-dihydronaphtho[1,2-d][1,3]thiazol-7-yl dihydrogen phosphate
-
2-amino-4,5-dihydronaphtho[1,2-d][1,3]thiazol-8-yl dihydrogen phosphate
-
2-amino-4,5-dihydronaphtho[1,2-d][1,3]thiazol-9-yl dihydrogen phosphate
-
2-amino-4-[1-(3-phosphono)phenyl]thiazole
-
-
2-amino-4-[2-(5-(1-(3-bromophenyl)-1,3-propyl)phosphono)-furanyl]-5-isobutyl-thiazole
-
-
2-amino-4-[2-(5-(O-phenyl)-(N-((S)-1-ethoxycarbonyl)ethyl)-phosphonamido)-furanyl]-5-isobutylthiazole
-
-
2-amino-4-[2-(5-bis(p-acetoxybenzyl)phosphono)furanyl]-5-isobutylthiazole
-
-
2-amino-4-[2-(5-diphenylphosphono)furanyl]-5-isobutylthiazole
-
-
2-amino-4-[2-(5-monophenyl-monoamino-phosphono)furanyl]-5-isobutylthiazole
-
-
2-amino-4-[2-(5-monophenylphosphono)furanyl]-5-isobutylthiazole
-
-
2-amino-4-[2-(5-N,N'-bis((S)-1-(1-ethoxycarbonyl)ethyl)phosphonoamido)furanyl]-5-isobutylthiazole
-
optimization of the diamide prodrugs of phosphonic acid leads to the identification of a new diamide, the first reported orally efficacious FBPase inhibitor
2-amino-4-[2-(5-phosphono)furanyl]-5-ethoxycarbonylthiazole
-
potent FBPase inhibitor
2-amino-4-[2-(5-phosphono)furanyl]-5-isobutylthiazole
-
potent FBPase inhibitor
2-amino-4-[2-(5-phosphono)furanyl]-5-phenylthiazole
-
potent FBPase inhibitor
2-amino-4-[2-(5-phosphono)furanyl]-5-propylsulfanylthiazole
-
potent FBPase inhibitor
2-amino-4-[2-(6-phosphono)pyridyl]thiazole
-
-
2-amino-4-[2-[5-(1-(4-pyridyl)-1,3-propyl)phosphono]furanyl]-5-isobutylthiazole
-
-
2-amino-4-[2-[5-bis(1-(1-ethoxycarbonyloxy)ethyl)phosphono]-furanyl]-5-isobutyl-thiazole
-
-
2-amino-4-[2-[5-bis(ethoxycarbonyloxymethyl)phosphono]-furanyl]-5-isobutyl-thiazole
-
-
2-amino-4-[2-[5-bis(phenoxycarbonyloxymethyl)phosphono]-furanyl]-5-isobutyl-thiazole
-
-
2-amino-5,6-dihydro-4H-benzo[6,7]cyclohepta[1,2-d][1,3]thiazol-9-yl dihydrogen phosphate
-
2-amino-5-(2,2,2-trifluoroethyl)-4-[2-(5-phosphono)furanyl]-thiazole
-
-
2-amino-5-(2-furanyl)-4-[2-(5-phosphono)furanyl]thiazole
-
-
2-amino-5-(2-methoxyphenyl)-4-[2-(5-phosphono)furanyl]-thiazole
-
-
2-amino-5-(2-naphthyl)-4-[2-(5-phosphono)furanyl]thiazole
-
-
2-amino-5-(2-thienyl)-4-[(N-phosphonomethyl)carbamoyl]-thiazole
-
-
2-amino-5-(2-thienyl)-4-[2-(5-phosphono)furanyl]thiazole
-
-
2-amino-5-(3-methoxyphenyl)-4-[2-(5-phosphono)furanyl]-thiazole
-
-
2-amino-5-(4-acetylphenyl)-4-[2-(5-phosphono)furanyl]thiazole
-
-
2-amino-5-(4-chlorophenyl)-4-[2-(5-phosphono)furanyl]thiazole
-
-
2-amino-5-(4-fluorophenyl)-4-[2-(5-phosphono)furanyl]thiazole
-
-
2-amino-5-(4-methanesulfonyl)-4-[2-(5-phosphono)furanyl]thiazole
-
-
2-amino-5-(4-methoxycarbonylphenyl)-4-[2-(5-phosphono)-furanyl]thiazole
-
-
2-amino-5-(4-methoxyphenyl)-4-[2-(5-phosphono)furanyl]-thiazole
-
-
2-amino-5-(4-methylthiophenyl)-4-[2-(5-phosphono)furanyl]-thiazole
-
-
2-amino-5-(4-phenylphenyl)-4-[2-(5-phosphono)furanyl]thiazole
-
-
2-amino-5-(4-tert-butylphenyl)-4-[2-(5-phosphono)furanyl]-thiazole
-
-
2-amino-5-(N-morpholinyl)-4-[2-(5-phosphono)furanyl]thiazole
-
-
2-amino-5-benzyl-4-[2-(5-phosphono)furanyl]thiazole
-
-
2-amino-5-benzyloxycarbonyl-4-[2-(5-phosphono)furanyl]-thiazole
-
-
2-amino-5-bromo-4-[2-(5-phosphono)furanyl]thiazole
-
-
2-amino-5-chloro-4-[2-(5-phosphono)furanyl]thiazole
-
-
2-amino-5-cyclobutyl-4-[2-(5-phosphono)furanyl]thiazole
-
-
2-amino-5-cyclohexyl-4-[2-(5-phosphono)furanyl]thiazole
-
-
2-amino-5-cyclohexylmethyl-4-[2-(5-phosphono)furanyl]-thiazole
-
-
2-amino-5-cyclopentyl-4-[2-(5-phosphono)furanyl]thiazole
-
-
2-amino-5-cyclopentylmethyl-4-[2-(5-phosphono)furanyl]-thiazole
-
-
2-amino-5-cyclopropylmethyl-4-[2-(5-phosphono)furanyl]-thiazole
-
-
2-amino-5-ethylthio-4-[2-(5-phosphono)furanyl]thiazole
-
-
2-amino-5-hydroxymethyl-4-[2-(5-phosphono)furanyl]thiazole
-
-
2-amino-5-iodo-4-[2-(5-phosphono)furanyl]thiazole
-
-
2-amino-5-isobutyl-4-[2-(5-phosphono)furanyl]thiazole
-
poor oral bioavailability
2-amino-5-isopropyl- 4-[1-(4-methoxy-3-phosphono)phenyl]-thiazole
-
-
2-amino-5-isopropyl-4-[2-(5-phosphono)furanyl]thiazole
-
-
2-amino-5-isopropylthio-4-[2-(5-phosphono)furanyl]thiazole hydrobromide
-
-
2-amino-5-methyl-4-[2-(5-phosphono)furanyl]thiazole
-
-
2-amino-5-methylsulfanyl-4-[2-(5-diethylphosphono)furanyl]thiazole
-
potent FBPase inhibitor
2-amino-5-neopentyl-4-[2-(5-phosphono)furanyl]thiazole
-
-
2-amino-5-phenyl- 4-[1-(4-fluoro-3-phosphono)phenyl]thiazole
-
-
2-amino-5-phenyl-4-[2-(5-methyl-4-phosphono)oxazolyl]-thiazole
-
-
2-amino-5-phenyl-4-[3-(1-phosphono)pyrrolyl]thiazole
-
-
2-amino-5-phenylthio-4-[2-(5-phosphono)furanyl]thiazole
-
-
2-amino-5-propyl- 4-[1-(4-methyl-3-phosphono)phenyl]thiazole
-
-
2-amino-5-propyl-4-phosphonomethoxycarbonylthiazole
-
-
2-amino-5-propyl-4-[1-(3-phosphono)phenyl]thiazole
-
-
2-amino-5-propyl-4-[2-(5-phosphono)furanyl]thiazole
-
-
2-amino-5-tert-butylthio-4-[2-(5-phosphono)furanyl]thiazole
-
-
2-amino-5-[(4-morpholinyl)methyl]-4-[2-(5-phosphono)furanyl]-thiazole dihydrobromide
-
-
2-amino-5-[(N,N-dimethyl)carbamoyl]-4-[2-(5-phosphono)-furanyl]thiazole
-
-
2-amino-8H-indeno[1,2-d][1,3]thiazol-4-yl dihydrogen phosphate
-
2-amino-8H-indeno[1,2-d][1,3]thiazol-5-yl dihydrogen phosphate
-
2-amino-8H-indeno[1,2-d][1,3]thiazol-6-yl dihydrogen phosphate
-
2-bromo-5-isobutyl-4-[2-(5-phosphono)furanyl]thiazole
-
-
2-bromo-N-(5-chloro-1,3-benzoxazol-2-yl)benzenesulfonamide
-
-
2-carbamoyl-5-isobutyl-4-[2-(5-phosphono)furanyl]thiazole
-
-
2-chloro-5-isobutyl-4-[2-(5-phosphono)furanyl]thiazole
-
-
2-cyano-5-isobutyl-4-[2-(5-phosphono)furanyl]thiazole
-
-
2-ethyl-5-isobutyl-4-[2-(5-phosphono)furanyl]thiazole
-
-
2-hydroxymethyl-5-isobutyl-4-[2-(5-phosphono)furanyl]thiazole
-
-
2-methyl-5-isobutyl-4-[2-(5-phosphono)furanyl]-thiazole
-
-
2-methylamino-5-isobutyl-4-[2-(5-hosphono)furanyl]thiazole
-
-
2-methylthio-5-isobutyl-4-[2-(5-phosphono)furanyl]thiazole
-
-
2-phenyl-5-isobutyl-4-[2-(5-phosphono)furanyl]thiazole
-
-
2-thiocarbamoyl-5-isobutyl-4-[2-(5-phosphono)furanyl]thiazole
-
-
2-vinyl-5-isobutyl-4-[2-(5-phosphono)furanyl]thiazole
-
-
2-[(3S,11aS)-3-(4-hydroxybenzyl)-1,4-dioxo-1,3,4,6,11,11a-hexahydro-2H-pyrazino[1,2-b]isoquinolin-2-yl]-N-[2-(4-hydroxyphenyl)ethyl]pentanamide
-
uncompetitive
2-[3-methyl-5-([[6-methyl-4-(trifluoromethyl)pyridin-2-yl]carbamoyl]sulfamoyl)thiophen-2-yl]ethyl acetate
-
-
2-[5-([[6-amino-5-fluoro-4-(trifluoromethyl)pyridin-2-yl]carbamoyl]sulfamoyl)-3-methylthiophen-2-yl]ethyl acetate
-
-
3-(2-(ethoxycarbonyl)-7-nitro-1H-indol-3-yl)propanoic acid
-
3-(2-carboxyethyl)-4,6-dichloro-1H-indole-2-carboxylic acid
3-(2-carboxyethyl)-4-(2-fluorophenyl)-7-nitro-1H-indole-2-carboxylic acid
-
3-(2-carboxyethyl)-4-(2-methylpropyl)-7-nitro-1H-indole-2-carboxylic acid
-
-
3-(2-carboxyethyl)-4-(3-fluorophenyl)-7-nitro-1H-indole-2-carboxylic acid
-
3-(2-carboxyethyl)-4-(3-methoxyanilino)-7-nitro-1H-indole-2-carboxylic acid
-
-
3-(2-carboxyethyl)-4-(3-methoxyphenyl)-7-nitro-1H-indole-2-carboxylic acid
-
3-(2-carboxyethyl)-4-(4-fluorophenyl)-7-nitro-1H-indole-2-carboxylic acid
-
3-(2-carboxyethyl)-4-(4-methoxyanilino)-7-nitro-1H-indole-2-carboxylic acid
-
-
3-(2-carboxyethyl)-4-(4-methoxyphenyl)-7-nitro-1H-indole-2-carboxylic acid
-
3-(2-carboxyethyl)-4-chloro-7-nitro-1H-indole-2-carboxylic acid
-
3-(2-carboxyethyl)-4-ethyl-7-nitro-1H-indole-2-carboxylic acid
-
3-(2-carboxyethyl)-4-isobutyl-7-nitro-1H-indole-2-carboxylic acid
-
3-(2-carboxyethyl)-5-(2-methylpropyl)-7-nitro-1H-indole-2-carboxylic acid
-
-
3-(2-carboxyethyl)-5-bromo-7-nitro-1H-indole-2-carboxylic acid
-
3-(2-carboxyethyl)-5-chloro-7-nitro-1H-indole-2-carboxylic acid
-
3-(2-carboxyethyl)-5-ethyl-7-nitro-1H-indole-2-carboxylic acid
-
3-(2-carboxyethyl)-5-ethyl-7-nitro-1H-indole-2-carboxylicacid
-
3-(2-carboxyethyl)-5-isobutyl-7-nitro-1H-indole-2-carboxylic acid
-
3-(2-carboxyethyl)-5-nitro-1H-indole-2-carboxylic acid
-
3-(2-carboxyethyl)-5-phenylamino-7-nitro-1H-indole-2-carboxylic acid
-
3-(2-carboxyethyl)-7-nitro-1H-indole-2-carboxylic acid
-
3-(2-carboxyethyl)-7-nitro-4-(3-methoxyphenylamino)-1H-indole-2-carboxylic acid
-
3-(2-carboxyethyl)-7-nitro-4-(3-nitrophenyl)-1H-indole-2-carboxylic acid
-
3-(2-carboxyethyl)-7-nitro-4-(4-methoxyphenylamino)-1H-indole-2-carboxylic acid
-
3-(2-carboxyethyl)-7-nitro-4-(4-nitrophenyl)-1H-indole-2-carboxylic acid
-
3-(2-carboxyethyl)-7-nitro-4-phenyl-1H-indole-2-carboxylic acid
-
3-(2-carboxyethyl)-7-nitro-4-phenylamino-1H-indole-2-carboxylic acid
-
3-(2-carboxyethyl)-7-nitro-5-phenyl-1H-indole-2-carboxylic acid
-
3-chloro-N-(5-chloro-1,3-benzoxazol-2-yl)benzenesulfonamide
-
-
3-chloro-N-[(3,5-dichlorophenyl)carbamoyl]benzenesulfonamide
-
-
3-ethyl-5-isobutyl-7-nitro-1H-indole-2-carboxylic acid
-
molecular modeling of binding mode. The key hydrogen bonding interactions are observed between the carboxylate and residues Thr 27, Lys 112 and Arg 140, which are also recognized by the phosphate group in AMP. This hydrogen bonding network may make crucial contributions to the binding affinity. The indole ring is situated in a hydrophobic pocket involved in residues Leu30 and Leu34. The 7-nitro group interacted with the hydroxyl group of Thr31 via a hydrogen bond
4-anilino-3-(2-carboxyethyl)-7-nitro-1H-indole-2-carboxylic acid
-
-
4-anilinoquinazoline
-
low molecular weight inhibitors of enzyme that are not substrate mimics or AMP analogues
4-tert-butyl-N-(5-chloro-1,3-benzoxazol-2-yl)benzenesulfonamide
-
-
5-(1H-tetrazol-5-yl)-N-(3-(5-p-tolyl-1,3,4-oxadiazol-2-yl)phenyl)pentanamide
-
-
5-(2-hydroxyethyl)-4-methyl-N-[[6-methyl-4-(trifluoromethyl)pyridin-2-yl]carbamoyl]thiophene-2-sulfonamide
-
-
5-(2-methoxyethyl)-4-methyl-N-([6-[(methylcarbamoyl)amino]-4-(methylsulfanyl)pyridin-2-yl]carbamoyl)thiophene-2-sulfonamide
-
-
5-(2-methoxyethyl)-4-methyl-N-[[4-(trifluoromethyl)pyridin-2-yl]carbamoyl]thiophene-2-sulfonamide
-
-
5-(2-methoxyethyl)-4-methyl-N-[[6-methyl-4-(trifluoromethyl)pyridin-2-yl]carbamoyl]thiophene-2-sulfonamide
-
-
5-(2-methoxyethyl)-N-([4-methoxy-6-[(methylcarbamoyl)amino]pyridin-2-yl]carbamoyl)-4-methylthiophene-2-sulfonamide
-
-
5-anilino-3-(2-carboxyethyl)-7-nitro-1H-indole-2-carboxylic acid
-
-
5-bromo-3-(2-carboxyethyl)-7-nitro-1H-indole-2-carboxylic acid
-
-
5-isobutyl-4-[2-(5-phosphono)furanyl]thiazole
-
-
6-hydroxy-N-(3-(5-p-tolyl-1,3,4-oxadiazol-2-yl)phenyl)hexanamide
-
-
6-oxo-6-(3-(5-p-tolyl-1,3,4-oxadiazol-2-yl)phenylamino)hexanoic acid
-
-
7-amino-3-(2-carboxyethyl)-1H-indole-2-carboxylic acid
-
D-fructose 1,6-bisphosphate
D-fructose 2,6-bisphosphate
diethyl (5-[4-amino-1-[(1R,2R)-bicyclo[2.2.1]hept-2-ylamino]-1H-benzimidazol-2-yl]furan-2-yl)phosphonate
-
-
diethyl (5-[4-amino-1-[3-(thiophen-3-ylmethyl)benzyl]-1H-benzimidazol-2-yl]furan-2-yl)phosphonate
-
-
diethyl (5-[4-amino-1-[4-(furan-3-ylmethyl)benzyl]-1H-benzimidazol-2-yl]furan-2-yl)phosphonate
-
-
diethyl (5-[4-amino-1-[4-(trifluoromethyl)benzyl]-1H-benzimidazol-2-yl]furan-2-yl)phosphonate
-
-
diethyl [5-(4-amino-1-benzyl-1H-benzimidazol-2-yl)furan-2-yl]phosphonate
-
-
diethyl [5-(4-amino-1-ethyl-1H-benzimidazol-2-yl)furan-2-yl]phosphonate
-
-
diethyl [5-(4-amino-1-methyl-1H-benzimidazol-2-yl)furan-2-yl]phosphonate
-
-
diethyl [5-(4-amino-1-propyl-1H-benzimidazol-2-yl)furan-2-yl]phosphonate
-
-
diethyl [5-[4-amino-1-(2-methylpropyl)-1H-benzimidazol-2-yl]furan-2-yl]phosphonate
-
-
diethyl [5-[4-amino-1-(3-hydroxybenzyl)-1H-benzimidazol-2-yl]furan-2-yl]phosphonate
-
-
diethyl [5-[4-amino-1-(4-tert-butylbenzyl)-1H-benzimidazol-2-yl]furan-2-yl]phosphonate
-
-
diethyl [5-[4-amino-1-(biphenyl-4-ylmethyl)-1H-benzimidazol-2-yl]furan-2-yl]phosphonate
-
-
diethyl [5-[4-amino-1-(cyclobutylmethyl)-1H-benzimidazol-2-yl]furan-2-yl]phosphonate
-
-
diethyl [5-[4-amino-1-(cycloheptylmethyl)-1H-benzimidazol-2-yl]furan-2-yl]phosphonate
-
-
diethyl [5-[4-amino-1-(cyclohexylmethyl)-1H-benzimidazol-2-yl]furan-2-yl]phosphonate
-
-
diethyl [5-[4-amino-1-(cyclopentylmethyl)-1H-benzimidazol-2-yl]furan-2-yl]phosphonate
-
-
diethyl [5-[4-amino-1-(cyclopropylmethyl)-1H-benzimidazol-2-yl]furan-2-yl]phosphonate
-
-
diphenyl [5-[2-amino-5-(2-methylpropyl)-1,3-thiazol-4-yl]furan-2-yl]phosphonate
-
non-competitive
ethyl (2S,6S)-4-[5-[2-amino-5-(2-methylpropyl)-1,3-thiazol-4-yl]furan-2-yl]-2,6-dimethyl-7-oxo-8-oxa-3,5-diaza-4-phosphadecan-1-oate 4-oxide
-
-
ethyl 2-[((5-[2-amino-5-(2,2-dimethylpropanoyl)-1,3-thiazol-4-yl]furan-2-yl)[(1-ethoxy-2-methyl-1-oxopropan-2-yl)amino]phosphoryl)amino]-2-methylpropanoate
MB07803
ethyl 4-[5-[2-amino-5-(2-methylpropyl)-1,3-thiazol-4-yl]furan-2-yl]-2,2,6,6-tetramethyl-7-oxo-8-oxa-3,5-diaza-4-phosphadecan-1-oate 4-oxide (non-preferred name)
-
-
ethyl 4-[5-[2-amino-5-(2-methylpropyl)-1,3-thiazol-4-yl]furan-2-yl]-2,6-dimethyl-7-oxo-8-oxa-3,5-diaza-4-phosphadecan-1-oate 4-oxide (non-preferred name)
-
-
ethyl 4-[5-[2-amino-5-(2-methylpropyl)-1,3-thiazol-4-yl]furan-2-yl]-7-oxo-8-oxa-3,5-diaza-4-phosphadecan-1-oate 4-oxide (non-preferred name)
-
-
fructose 1,6-diphosphate
-
-
fructose-2,6-bisphosphate
-
-
K+
-
at 5 mM Mg2+, increasing K+ up to 140 mM are progressively inhibitory for neutral and alkaline isoenzyme from liver, muscle neutral isoenzyme is activated, 10% at 5 mM Mg2+ but inhibited at 1 mM Mg2+
N,N'-bis(6,7-diethoxy-2,3-dihydro-1H-cyclopenta[b]quinolin-9-yl)pentane-1,5-diamine
-
uncompetitive
N-(5-bromo-1,3-benzoxazol-2-yl)-2,5-dichlorobenzenesulfonamide
-
-
N-(5-chloro-1,3-benzoxazol-2-yl)-1-methyl-1H-imidazole-4-sulfonamide
-
-
N-(5-chloro-1,3-benzoxazol-2-yl)-2-(1H-imidazol-1-yl)benzenesulfonamide
-
-
N-(5-chloro-1,3-benzoxazol-2-yl)-2-cyanobenzenesulfonamide
-
-
N-(5-chloro-1,3-benzoxazol-2-yl)-3-nitrobenzenesulfonamide
-
-
N-(5-chloro-1,3-benzoxazol-2-yl)-4-(3-furyl)benzenesulfonamide
-
-
N-(5-chloro-1,3-benzoxazol-2-yl)-4-(trifluoromethoxy)benzenesulfonamide
-
-
N-(5-chloro-1,3-benzoxazol-2-yl)-4-fluorobenzenesulfonamide
-
-
N-(5-chloro-1,3-benzoxazol-2-yl)-4-methylbenzenesulfonamide
-
-
N-(5-chloro-1,3-benzoxazol-2-yl)anthracene-2-sulfonamide
-
-
N-(5-chloro-1,3-benzoxazol-2-yl)benzenesulfonamide
-
-
N-(5-chloro-1,3-benzoxazol-2-yl)biphenyl-2-sulfonamide
-
-
N-(5-chloro-1,3-benzoxazol-2-yl)biphenyl-3-sulfonamide
-
-
N-(5-chloro-1,3-benzoxazol-2-yl)biphenyl-4-sulfonamide
-
-
N-(5-chloro-1,3-benzoxazol-2-yl)naphthalene-2-sulfonamide
N-(5-chloro-1,3-benzoxazol-2-yl)thiophene-2-sulfonamide
-
-
N-(5-tert-butyl-1,3-benzoxazol-2-yl)-2,5-dichlorobenzenesulfonamide
-
-
N-([4-bromo-6-[(2,2,2-trifluoroethyl)amino]pyridin-2-yl]carbamoyl)-5-(2-methoxyethyl)-4-methylthiophene-2-sulfonamide
-
-
N-([4-bromo-6-[(methylcarbamoyl)amino]pyridin-2-yl]carbamoyl)-5-(2-methoxyethyl)-4-methylthiophene-2-sulfonamide
-
-
N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-3-chlorobenzenesulfonamide
-
-
N-[(6-amino-4-bromopyridin-2-yl)carbamoyl]-5-(2-methoxyethyl)-4-methylthiophene-2-sulfonamide
-
-
N-[(6-amino-4-methoxypyridin-2-yl)carbamoyl]-5-(2-methoxyethyl)-4-methylthiophene-2-sulfonamide
-
-
N-[(6-bromo-1H-indazol-4-yl)carbamoyl]-3-chlorobenzenesulfonamide
-
-
N-[(6-bromo-1H-indazol-4-yl)carbamoyl]-5-(2-methoxyethyl)-4-methylthiophene-2-sulfonamide
-
-
N-[(6-bromo-1H-indol-4-yl)carbamoyl]-3-chlorobenzenesulfonamide
-
-
N-[(7-bromoimidazo[1,2-a]pyridin-5-yl)carbamoyl]-5-(2-methoxyethyl)-4-methylthiophene-2-sulfonamide
-
-
N-[4-[[(5-chloro-1,3-benzoxazol-2-yl)amino]sulfonyl]phenyl]butanamide
-
-
N-[6-(4-aminophenyl)-5-methoxy-1,3-benzoxazol-2-yl]-2,5-dichlorobenzenesulfonamide
-
non-competitive
N-[7-(3-aminophenyl)-5-methoxy-1,3-benzoxazol-2-yl]-2,5-dichlorobenzenesulfonamide
-
-
N-[7-(4-aminophenyl)-5-methoxy-1,3-benzoxazol-2-yl]-2,5-dichlorobenzenesulfonamide
-
-
N-[7-[3-(aminomethyl)phenyl]-5-methoxy-1,3-benzoxazol-2-yl]-2,5-dichlorobenzenesulfonamide
-
-
N-[[6-amino-4-(methylsulfanyl)pyridin-2-yl]carbamoyl]-5-(2-methoxyethyl)-4-methylthiophene-2-sulfonamide
-
-
N-[[6-amino-4-(trifluoromethyl)pyridin-2-yl]carbamoyl]-5-(2-methoxyethyl)-4-methylthiophene-2-sulfonamide
-
-
N-[[6-amino-5-fluoro-4-(trifluoromethyl)pyridin-2-yl]carbamoyl]-5-(2-hydroxyethyl)-4-methylthiophene-2-sulfonamide
-
-
N-[[6-amino-5-fluoro-4-(trifluoromethyl)pyridin-2-yl]carbamoyl]-5-(2-methoxyethyl)-4-methylthiophene-2-sulfonamide
-
-
N4-(3-Bromo-phenyl)-7-chloro-quinazoline-4,6-diamine
-
IC50: 0.0119 mM
NH4+
-
0.01-0.02 mM, slight activation of neutral and alkaline isoenzyme, progressive inhibition at increasing concentration
propan-2-yl 4-[5-[2-amino-5-(2-methylpropyl)-1,3-thiazol-4-yl]furan-2-yl]-9-methyl-7-oxo-3,5,8-trioxa-4-phosphadecan-1-oate 4-oxide
-
-
tert-butyl 4-[5-[2-amino-5-(2-methylpropyl)-1,3-thiazol-4-yl]furan-2-yl]-9,9-dimethyl-7-oxo-3,5,8-trioxa-4-phosphadecan-1-oate 4-oxide
-
-
TNP-AMP
-
a fluorescent AMP analogue, 2',3'-O-(2,4,6-trinitrophenyl)adenosine 5'-monophosphate (TNP-AMP), is used as a fluorescent probe as it is able to competitively inhibit AMP binding to the AMP allosteric site. AMP and fructose 1,6-bisphosphate both can reduce the fluorescence from the bound TNP-AMP through competition for FBPase, suggesting that TNP-AMP binds not only to the AMP allosteric site but also to the FBP active site. The residue K274 is very important for TNP-AMP to bind to the active site of FBPase. When the residue K274 is mutated to L274, TNP-AMP cannot bind to the active site, but can bind to the allosteric site
Zn2+
-
0.001-0.010 mM has no significant effect, with 0.002-0.0035 mM Zn2+, in absence of EDTA, 50% inhibition, 80% inhibition by 0.01 mM Zn2+
[(2-amino-4,5-dihydronaphtho[1,2-d][1,3]thiazol-8-yl)(difluoro)methyl]phosphonic acid
-
[(2-amino-4,5-dihydronaphtho[1,2-d][1,3]thiazol-8-yl)methyl]phosphonic acid
-
[(2R,3S,4R,5R)-5-[4-(aminocarbonyl)-1H-imidazol-1-yl]-3,4-dihydroxytetrahydrofuran-2-yl]methyl dihydrogen phosphate
-
-
[2-[(6-amino-8,9-dihydro-7H-purin-8-yl)amino]ethyl]phosphonate
-
[2-[[6-amino-9-(2-cyclohexylethyl)-8,9-dihydro-7H-purin-8-yl]amino]ethyl]phosphonate
-
[3-[6-amino-9-(2-cyclohexylethyl)-8,9-dihydro-7H-purin-8-yl]propyl]phosphonate
-
[5-(1,3-thiazol-4-yl)-2-furyl]phosphonic acid
-
-
[5-(2-amino-1,3-thiazol-4-yl)-2-furyl]phosphonic acid
-
-
[5-(2-amino-5-isobutyl-1,3-oxazol-4-yl)-2-furyl]phosphonic acid
-
-
[5-(2-amino-5-isobutyl-1,3-thiazol-4-yl)-2-furyl]phosphonic acid
-
non-competitive
[5-(2-amino-5-isobutyl-1H-imidazol-4-yl)-2-furyl]phosphonic acid
-
-
[5-(2-amino-5-phenyl-1,3-thiazol-4-yl)-2-furyl]phosphonic acid
-
-
[5-(2-amino-5-phenyl-1,3-thiazol-4-yl)furan-2-yl]phosphonic acid
-
-
[5-(2-amino-5-propyl-1,3-thiazol-4-yl)-2-furyl]phosphonic acid
-
-
[5-(2-amino-5-propyl-1,3-thiazol-4-yl)thiophen-2-yl]phosphonic acid
-
-
[5-(4-amino-1-tert-butyl-2,3-dihydro-1H-benzimidazol-2-yl)-2-furyl]phosphonate
-
[5-(4-amino-1-tert-butyl-7-ethyl-5-fluoro-2,3-dihydro-1H-benzimidazol-2-yl)-2-furyl]phosphonate
-
[5-(4-amino-5-bromo-1-cyclopropyl-1H-benzimidazol-2-yl)furan-2-yl]phosphonic acid
-
-
[5-(5-isobutyl-1,3-thiazol-4-yl)-2-furyl]phosphonic acid
-
-
[5-(6-amino-3-phenylpyridin-2-yl)-2-furyl]phosphonic acid
-
-
[5-(6-amino-9-tert-butyl-8,9-dihydro-7H-purin-8-yl)-2-furyl]phosphonate
-
[5-[2-amino-5-(2-methylpropyl)-1,3-selenazol-4-yl]furan-2-yl]phosphonic acid
-
-
[5-[2-amino-5-(2-methylpropyl)-1,3-thiazol-4-yl]furan-2-yl]phosphonic acid
[5-[2-amino-5-(ethoxycarbonyl)-1,3-thiazol-4-yl]furan-2-yl]phosphonic acid
-
-
[5-[2-amino-5-(propylsulfanyl)-1,3-thiazol-4-yl]furan-2-yl]phosphonic acid
-
-
[5-[4-amino-1-(2-ethylbutyl)-5-fluoro-1H-benzimidazol-2-yl]furan-2-yl]phosphonic acid
-
-
[5-[4-amino-5,7-dibromo-1-(2-methylpropyl)-1H-benzimidazol-2-yl]furan-2-yl]phosphonic acid
-
-
[5-[4-amino-5,7-dichloro-1-(2-methylpropyl)-1H-benzimidazol-2-yl]furan-2-yl]phosphonic acid
-
-
[5-[4-amino-5-bromo-1-(2-methylpropyl)-1H-benzimidazol-2-yl]furan-2-yl]phosphonic acid
-
-
[5-[4-amino-5-bromo-6,7-dichloro-1-(2-methylpropyl)-1H-benzimidazol-2-yl]furan-2-yl]phosphonic acid
-
-
[5-[4-amino-5-chloro-1-(2-methylpropyl)-1H-benzimidazol-2-yl]furan-2-yl]phosphonic acid
-
-
[5-[4-amino-5-ethyl-1-(2-methylpropyl)-1H-benzimidazol-2-yl]furan-2-yl]phosphonic acid
-
-
[5-[4-amino-5-fluoro-1-(2-methylpropyl)-1H-benzimidazol-2-yl]furan-2-yl]phosphonic acid
-
-
[5-[4-amino-5-fluoro-1-(2-methylpropyl)-7-phenyl-1H-benzimidazol-2-yl]furan-2-yl]phosphonic acid
-
-
[5-[4-amino-5-fluoro-1-(2-methylpropyl)-7-propyl-1H-benzimidazol-2-yl]furan-2-yl]phosphonic acid
-
-
[5-[4-amino-5-fluoro-1-(pentan-3-yl)-1H-benzimidazol-2-yl]furan-2-yl]phosphonic acid
-
-
[5-[4-amino-5-fluoro-7-(2-methoxyethyl)-1-(2-methylpropyl)-1H-benzimidazol-2-yl]furan-2-yl]phosphonic acid
-
-
[5-[4-amino-5-fluoro-7-(3-methylbutyl)-1-(2-methylpropyl)-1H-benzimidazol-2-yl]furan-2-yl]phosphonic acid
-
-
[5-[4-amino-5-fluoro-7-(4-fluorophenyl)-1-(2-methylpropyl)-1H-benzimidazol-2-yl]furan-2-yl]phosphonic acid
-
-
[5-[4-amino-5-hydroxy-1-(2-methylpropyl)-1H-benzimidazol-2-yl]furan-2-yl]phosphonic acid
-
-
[5-[4-amino-5-methoxy-1-(2-methylpropyl)-1H-benzimidazol-2-yl]furan-2-yl]phosphonic acid
-
-
[5-[4-amino-6-chloro-5-fluoro-1-(2-methylpropyl)-1H-benzimidazol-2-yl]furan-2-yl]phosphonic acid
-
-
[5-[4-amino-7-(3,3-dimethylbutyl)-5-fluoro-1-(2-methylpropyl)-1H-benzimidazol-2-yl]furan-2-yl]phosphonic acid
-
-
[5-[4-amino-7-(4-chlorophenyl)-5-fluoro-1-(2-methylpropyl)-1H-benzimidazol-2-yl]furan-2-yl]phosphonic acid
-
-
[5-[4-amino-7-(6-chlorohexyl)-5-fluoro-1-(2-methylpropyl)-1H-benzimidazol-2-yl]furan-2-yl]phosphonic acid
-
-
[5-[4-amino-7-bromo-1-(2-methylpropyl)-1H-benzimidazol-2-yl]furan-2-yl]phosphonic acid
-
-
[5-[4-amino-7-bromo-5-fluoro-1-(2-methylpropyl)-1H-benzimidazol-2-yl]furan-2-yl]phosphonic acid
-
-
[5-[4-amino-7-chloro-1-(2-methylpropyl)-1H-benzimidazol-2-yl]furan-2-yl]phosphonic acid
-
-
[5-[4-amino-7-chloro-5-fluoro-1-(2-methylpropyl)-1H-benzimidazol-2-yl]furan-2-yl]phosphonic acid
-
-
[5-[4-amino-7-cyclopropyl-5-fluoro-1-(2-methylpropyl)-1H-benzimidazol-2-yl]furan-2-yl]phosphonic acid
-
-
[5-[4-amino-7-ethenyl-5-fluoro-1-(2-methylpropyl)-1H-benzimidazol-2-yl]furan-2-yl]phosphonic acid
-
-
[5-[4-amino-7-ethyl-5-fluoro-1-(2-methylpropyl)-1H-benzimidazol-2-yl]furan-2-yl]phosphonic acid
-
-
[5-[5-(2-methylpropyl)-2-phenyl-1,3-thiazol-4-yl]furan-2-yl]phosphonic acid
-
-
[5-[6-amino-9-(2,2-dimethylpropyl)-8,9-dihydro-7H-purin-8-yl]-2-furyl]phosphonate
-
[5-[6-amino-9-(2-cyclohexylethyl)-8,9-dihydro-7H-purin-8-yl]-2-furyl]phosphonate
-
[5-[6-amino-9-(2-phenylethyl)-8,9-dihydro-7H-purin-8-yl]-2-furyl]phosphonate
-
AMP
-
AMP
inactive, AMP-associated T state of the enzyme, AMP binding results in improved thermal stability of muscle FBPase
2',3'-O-(2,4,6-trinitrophenyl)adenosine 5'-monophosphate
wild-type muscle enzyme, 50% inhibition at 0.00022 mM, wild-type liver enzyme, 50% inhibition at 0.0046 mM
2',3'-O-(2,4,6-trinitrophenyl)adenosine 5'-monophosphate
-
able to bind not only to the AMP allosteric site but also to the fructose-1,6-bisphosphate active site
2,5-dichloro-N-(5-chloro-1,3-benzoxazol-2-yl)benzenesulfonamide
-
-
2,5-dichloro-N-(5-chloro-1,3-benzoxazol-2-yl)benzenesulfonamide
-
non-competitive
2,5-dichloro-N-(5-chloro-1,3-benzoxazol-2-yl)benzenesulfonamide
-
50% inhibition at 0.0034 mM
3-(2-carboxyethyl)-4,6-dichloro-1H-indole-2-carboxylic acid
-
non-competitive
3-(2-carboxyethyl)-4,6-dichloro-1H-indole-2-carboxylic acid
MDL-29951
AMP
-
-
AMP
-
muscle enzyme is more strongly inhibited than the liver isoenzyme
AMP
lung enzyme is significantly less inhibited than the muscle enzyme
AMP
wild-type muscle enzyme, 50% inhibition at 0.0001 mM, Hill coefficient 1.78, wild-type liver enzyme, 50% inhibition at 0.0044 mM, Hill coefficient 2.08
AMP
-
113Tyr and 31Thr play an mportant role, each via two hydrogen bonds affecting the binding affinity of inhibitor AMP to FBPase
AMP
-
allosteric inhibition. The fluorescent AMP analogue, 2',3'-O-(2,4,6-trinitrophenyl)adenosine 5'-monophosphate (TNP-AMP), is used as a fluorescent probe as it is able to competitively inhibit AMP binding to the AMP allosteric site
Ca2+
-
-
Ca2+
-
Ca2+ affects conformation of the catalytic loop 52-72 of muscle FBPase and inhibits its activity by competing with activatory divalent cations, e.g. Mg2+ and Zn2+. Aldolase associates with FBPase in its active form, i.e. with loop 52-72 in the engaged conformation, while Ca2+ stabilizes the disengaged-like form of the loop
D-fructose 1,6-bisphosphate
-
-
D-fructose 1,6-bisphosphate
-
D-fructose 2,6-bisphosphate
-
D-fructose 2,6-bisphosphate
a natural heterotropic inhibitor
fructose 2,6-diphosphate
-
-
fructose 2,6-diphosphate
lung enzyme is slightly more sensitive to inhibition than the liver enzyme. Synergistic effect of AMP and fructose 2,6-diphosphate on lung and liver enzyme
N-(5-chloro-1,3-benzoxazol-2-yl)naphthalene-2-sulfonamide
-
-
N-(5-chloro-1,3-benzoxazol-2-yl)naphthalene-2-sulfonamide
-
non-competitive
[5-[2-amino-5-(2-methylpropyl)-1,3-thiazol-4-yl]furan-2-yl]phosphonic acid
-
-
[5-[2-amino-5-(2-methylpropyl)-1,3-thiazol-4-yl]furan-2-yl]phosphonic acid
-
additional information
mammalian muscle FBPase is about 100times more susceptible to the allosteric inhibitors AMP and NAD+ and about 1000times more sensitive to inhibition by Ca2+ than the liver isozyme
-
additional information
-
mammalian muscle FBPase is about 100times more susceptible to the allosteric inhibitors AMP and NAD+ and about 1000times more sensitive to inhibition by Ca2+ than the liver isozyme
-
additional information
-
design, synthesis, and structure-activity relationship of a series of phosphonic acid containing benzimidazoles that function as fructose-1,6-bisphosphatase inhibitors and AMP mimics
-
additional information
-
inhibitor design, synthesis and molecular modeling, overview
-
additional information
-
synthesis and evaluation of a series of phosphonic acid-containing thiazoles as enzyme inhibitors, structure-guided drug design approach, optimization of both the thiazole FBPase inhibitors and their prodrugs, overview
-
additional information
-
a series of novel indole derivatives is designed and synthesized as inhibitors of fructose-1,6-bisphosphatase (FBPase), structure-activity relationships, molecular docking, overview. No inhibition by 3-(2-carboxyethyl)-4-nitro-1H-indole-2-carboxylic acid and 3-(2-carboxyethyl)-6-nitro-1H-indole-2-carboxylic acid
-
additional information
a series of novel indole derivatives is designed and synthesized as inhibitors of fructose-1,6-bisphosphatase (FBPase), structure-activity relationships, molecular docking, overview. No inhibition by 3-(2-carboxyethyl)-4-nitro-1H-indole-2-carboxylic acid and 3-(2-carboxyethyl)-6-nitro-1H-indole-2-carboxylic acid
-
additional information
-
the FBP active site works by stabilizing the FBPase, and the allosteric site impairs the activity of FBPase through its binding of a nonsubstrate molecule. Competitive inhibition of AMP, fructose 1,6-bisphosphate, or fructose 6-phosphate binding to FBPase with fluorescent AMP analogue, 2',3'-O-(2,4,6-trinitrophenyl)adenosine 5'-monophosphate (TNP-AMP)-binding FBPase
-
additional information
the FBPase pig kidney tetramer overlay of human and pig kidney (PDB IDs 1FTA and 1KZ8, respectively) show nearly identical orientation and conformation in the active site, AMP allosteric binding site, and inhibitor (4-[3-(6,7-diethoxy-quinazolin-4-ylamino)-phenyl]-thiazol-2-yl)-methanol allosteric binding site architecture
-
additional information
-
the FBPase pig kidney tetramer overlay of human and pig kidney (PDB IDs 1FTA and 1KZ8, respectively) show nearly identical orientation and conformation in the active site, AMP allosteric binding site, and inhibitor (4-[3-(6,7-diethoxy-quinazolin-4-ylamino)-phenyl]-thiazol-2-yl)-methanol allosteric binding site architecture
-
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6-phosphofructokinase deficiency
Pyrophosphate-dependent phosphofructo-1-kinase complements fructose 1,6-bisphosphatase but not phosphofructokinase deficiency in Escherichia coli.
Acidosis
Carbohydrate metabolism in rat kidney: heterogeneous distribution of glycolytic and gluconeogenic key enzymes.
Acidosis
Distribution along the rat nephron of three enzymes of gluconeogenesis in acidosis and starvation.
Acidosis
Fructose-1,6-bisphosphatase deficiency as a cause of recurrent hypoglycemia and metabolic acidosis: Clinical and molecular findings in Malaysian patients.
Acidosis
Fructose-1,6-bisphosphatase deficiency with confirmed molecular diagnosis. An important cause of hypoglycemia in children.
Acidosis
Human fructose-1,6-bisphosphatase gene (FBP1): exon-intron organization, localization to chromosome bands 9q22.2-q22.3, and mutation screening in subjects with fructose-1,6-bisphosphatase deficiency.
Acidosis
Intravenous glycerol therapy should not be used in patients with unrecognized fructose-1,6-bisphosphatase deficiency.
Acidosis
Status epilepticus due to fructose-1,6-bisphosphatase deficiency caused by FBP1 gene mutation.
Acidosis, Lactic
Fructose-1,6-bisphosphatase deficiency with confirmed molecular diagnosis. An important cause of hypoglycemia in children.
Acidosis, Lactic
Fructose-1,6-Bisphosphatase Deficiency: A Case of a Successful Pregnancy by Closely Monitoring Metabolic Control.
Acidosis, Lactic
Genetic analysis of fructose-1,6-bisphosphatase (FBPase) deficiency in nine consanguineous Pakistani families.
Acidosis, Lactic
Infantile lactic acidosis due to hereditary fructose 1,6-diphosphatase deficiency.
Acidosis, Lactic
Novel compound heterozygous mutations in the fructose-1,6-bisphosphatase gene cause hypoglycemia and lactic acidosis.
Acidosis, Lactic
Novel FBP1 gene mutations in Arab patients with fructose-1,6-bisphosphatase deficiency.
Acidosis, Lactic
Problems in the congenital lactic acidoses.
Apnea
Novel FBP1 gene mutations in Arab patients with fructose-1,6-bisphosphatase deficiency.
Asthma
Fructose-1,6-bisphosphatase aggravates oxidative stress-induced apoptosis in asthma by suppressing the Nrf2 pathway.
Brain Ischemia
Hyperglycemia is associated with enhanced gluconeogenesis in a rat model of permanent cerebral ischemia.
Breast Neoplasms
Aberrant methylation of human L- and M-fructose 1,6-bisphosphatase genes in cancer.
Breast Neoplasms
Fructose-1,6-bisphosphatase is a novel regulator of Wnt/?-Catenin pathway in breast cancer.
Breast Neoplasms
Invalidation of mitophagy by FBP1-mediated repression promotes apoptosis in breast cancer.
Carcinogenesis
Fructose?1,6?bisphosphatase?1 decrease may promote carcinogenesis and chemoresistance in cervical cancer.
Carcinogenesis
Loss of fructose-1,6-bisphosphatase induces glycolysis and promotes apoptosis resistance of cancer stem-like cells: an important role in hexavalent chromium-induced carcinogenesis.
Carcinoma
Fructose 1,6-Bisphosphatase 1 Expression Reduces 18F-FDG Uptake in Clear Cell Renal Cell Carcinoma.
Carcinoma, Embryonal
One of the retinoic acid-inducible cDNA clones in mouse embryonal carcinoma F9 cells encodes a novel isoenzyme of fructose 1,6-bisphosphatase.
Carcinoma, Hepatocellular
A case of minimal deviation hepatoma in man with elevated liver-type pyruvate kinase isozyme.
Carcinoma, Hepatocellular
A selective system for hepatoma cells producing gluconeogenic enzymes.
Carcinoma, Hepatocellular
CCAAT-enhancer binding protein-? (C/EBP?) and hepatocyte nuclear factor 4? (HNF4?) regulate expression of the human fructose-1,6-bisphosphatase 1 (FBP1) gene in human hepatocellular carcinoma HepG2 cells.
Carcinoma, Hepatocellular
Decreased Expression of Fructose-1,6-bisphosphatase Associates with Glucose Metabolism and Tumor Progression in Hepatocellular Carcinoma.
Carcinoma, Hepatocellular
Enzyme deviation patterns in primary rat hepatomas induced by sequential administration of two chemically different carcinogens.
Carcinoma, Hepatocellular
Fructose 1,6-diphosphatase of rat tissues and transplantable rat hepatomas.
Carcinoma, Hepatocellular
Fructose-1,6-Bisphosphatase 1 Reduces (18)F FDG Uptake in Hepatocellular Carcinoma.
Carcinoma, Hepatocellular
Profiles of carbohydrate-metabolizing enzymes in human hepatocellular carcinomas and preneoplastic livers.
Carcinoma, Hepatocellular
Rev-erb? activation down-regulates hepatic Pck1 enzyme to lower plasma glucose in mice.
Carcinoma, Renal Cell
Fructose 1,6-Bisphosphatase 1 Expression Reduces 18F-FDG Uptake in Clear Cell Renal Cell Carcinoma.
Carcinoma, Renal Cell
Fructose-1,6-bisphosphatase opposes renal carcinoma progression.
Carcinoma, Renal Cell
Re: Fructose-1,6-bisphosphatase opposes renal carcinoma progression.
Cholangiocarcinoma
Forced overexpression of FBP1 inhibits proliferation and metastasis in cholangiocarcinoma cells via Wnt/?-catenin pathway.
Cholestasis
Evaluation of key gluconeogenic enzymes in experimental biliary obstruction.
Dehydration
Antioxidative defense system, pigment composition, and photosynthetic efficiency in two wheat cultivars subjected to drought
Dehydration
Mild Water Stress of Phaseolus vulgaris Plants Leads to Reduced Starch Synthesis and Extractable Sucrose Phosphate Synthase Activity.
Diabetes Mellitus
Fructose-1,6-bisphosphatase inhibitors: A new valid approach for management of type 2 diabetes mellitus.
Diabetes Mellitus
Impaired regulation of hepatic fructose-1,6-biphosphatase in the New Zealand Obese mouse: an acquired defect.
Diabetes Mellitus
In silico identification of structure requirement for novel thiazole and oxazole derivatives as potent fructose 1,6-bisphosphatase inhibitors.
Diabetes Mellitus
Mononuclear and polymorphonuclear leukocytes show increased fructose-1,6-bisphosphatase activity in patients with type 1 diabetes mellitus.
Diabetes Mellitus
The GID ubiquitin ligase complex is a regulator of AMPK activity and organismal lifespan.
Diabetes Mellitus
Toward the Prediction of FBPase Inhibitory Activity Using Chemoinformatic Methods.
Diabetes Mellitus, Experimental
Hormonal effects on structure and catalytic properties of fructose 1,6-bisphosphatase.
Diabetes Mellitus, Experimental
[Level of fructose-2,6-bisphosphate and activity of fructose-1,6-bisphosphatase in hepatocyte suspensions in streptozotocin diabetes]
Diabetes Mellitus, Type 1
Mononuclear and polymorphonuclear leukocytes show increased fructose-1,6-bisphosphatase activity in patients with type 1 diabetes mellitus.
Diabetes Mellitus, Type 2
Contributions of Hepatic Gluconeogenesis Suppression and Compensative Glycogenolysis on the Glucose-Lowering Effect of CS-917, a Fructose 1,6-Bisphosphatase Inhibitor, in Non-obese Type 2 Diabetes Goto-Kakizaki Rats.
Diabetes Mellitus, Type 2
Determination of protein-ligand binding constants of a cooperatively regulated tetrameric enzyme using electrospray mass spectrometry.
Diabetes Mellitus, Type 2
Development of disulfide-derived fructose-1,6-bisphosphatase (FBPase) covalent inhibitors for the treatment of type 2 diabetes.
Diabetes Mellitus, Type 2
Discovery of fructose-1,6-bisphosphatase inhibitors for the treatment of type 2 diabetes.
Diabetes Mellitus, Type 2
Discovery of potent and specific fructose-1,6-bisphosphatase inhibitors and a series of orally-bioavailable phosphoramidase-sensitive prodrugs for the treatment of type 2 diabetes.
Diabetes Mellitus, Type 2
Enzymes involved in l-lactate metabolism in humans.
Diabetes Mellitus, Type 2
Expression of human fructose-1,6-bisphosphatase in the liver of transgenic mice results in increased glycerol gluconeogenesis.
Diabetes Mellitus, Type 2
Fructose-1, 6-bisphosphatase inhibitors for reducing excessive endogenous glucose production in type 2 diabetes.
Diabetes Mellitus, Type 2
Fructose-1,6-bisphosphatase inhibitors: A new valid approach for management of type 2 diabetes mellitus.
Diabetes Mellitus, Type 2
Fructose-1,6-bisphosphatase: genetic and physical mapping to human chromosome 9q22.3 and evaluation in non-insulin-dependent diabetes mellitus.
Diabetes Mellitus, Type 2
Identification of activating enzymes of a novel FBPase inhibitor prodrug, CS-917.
Diabetes Mellitus, Type 2
Identification of the New Covalent Allosteric Binding Site of Fructose-1,6-bisphosphatase with Disulfiram Derivatives toward Glucose Reduction.
Diabetes Mellitus, Type 2
Impaired regulation of hepatic fructose-1,6-bisphosphatase in the New Zealand obese mouse model of NIDDM.
Diabetes Mellitus, Type 2
In silico identification of structure requirement for novel thiazole and oxazole derivatives as potent fructose 1,6-bisphosphatase inhibitors.
Diabetes Mellitus, Type 2
Managlinat dialanetil, a fructose-1,6-bisphosphatase inhibitor for the treatment of type 2 diabetes.
Diabetes Mellitus, Type 2
MB06322 (CS-917): A potent and selective inhibitor of fructose 1,6-bisphosphatase for controlling gluconeogenesis in type 2 diabetes.
Diabetes Mellitus, Type 2
Quadruple space-group ambiguity owing to rotational and translational noncrystallographic symmetry in human liver fructose-1,6-bisphosphatase.
Diabetes Mellitus, Type 2
The GID ubiquitin ligase complex is a regulator of AMPK activity and organismal lifespan.
Diabetes Mellitus, Type 2
Toward the Prediction of FBPase Inhibitory Activity Using Chemoinformatic Methods.
Diabetes Mellitus, Type 2
Use of Graph Based Descriptors for Determination of Structural Features Causing Modulation of Fructose-1,6-Bisphosphatase.
fructokinase deficiency
Inborn Errors of Fructose Metabolism. What Can We Learn from Them?
Fructose Intolerance
Inborn Errors of Fructose Metabolism. What Can We Learn from Them?
fructose-2,6-bisphosphate 2-phosphatase deficiency
Diagnosis of fructose-1,6-bisphosphatase deficiency using cultured lymphocyte fraction: a secure and noninvasive alternative to liver biopsy.
fructose-2,6-bisphosphate 2-phosphatase deficiency
Fructose-1,6-bisphosphatase deficiency with confirmed molecular diagnosis. An important cause of hypoglycemia in children.
fructose-2,6-bisphosphate 2-phosphatase deficiency
Two newly identified genomic mutations in a Japanese female patient with fructose-1,6-bisphosphatase (FBPase) deficiency.
fructose-bisphosphatase deficiency
A Chinese Adult Patient with Fructose 1,6-bisphosphatase Deficiency.
fructose-bisphosphatase deficiency
A Japanese boy with fructose-1,6-bisphosphatase deficiency who had a novel
fructose-bisphosphatase deficiency
A potential role for muscle in glucose homeostasis: in vivo kinetic studies in glycogen storage disease type 1a and fructose-1,6-bisphosphatase deficiency.
fructose-bisphosphatase deficiency
A summary of molecular genetic findings in fructose-1,6-bisphosphatase deficiency with a focus on a common long-range deletion and the role of MLPA analysis.
fructose-bisphosphatase deficiency
cDNA sequences encoding human fructose 1,6-bisphosphatase from monocytes, liver and kidney: application of monocytes to molecular analysis of human fructose 1,6-bisphosphatase deficiency.
fructose-bisphosphatase deficiency
Clinical and Molecular Characterization of Patients with Fructose 1,6-Bisphosphatase Deficiency.
fructose-bisphosphatase deficiency
Detection of heterozygotes for fructose 1,6-diphosphatase deficiency by measuring fructose 1,6-diphosphatase activity in their cultured peripheral lymphocytes.
fructose-bisphosphatase deficiency
Diagnosis of fructose-1,6-bisphosphatase deficiency using cultured lymphocyte fraction: a secure and noninvasive alternative to liver biopsy.
fructose-bisphosphatase deficiency
Diagnosis of fructose-1,6-bisphosphatase deficiency using leukocytes: normal leukocyte enzyme activity in three female patients.
fructose-bisphosphatase deficiency
Diagnosis of inborn errors of metabolism using filter paper urine, urease treatment, isotope dilution and gas chromatography-mass spectrometry.
fructose-bisphosphatase deficiency
Effect of phosphoglycerate mutase and fructose 1,6-bisphosphatase deficiency on symbiotic Burkholderia phymatum.
fructose-bisphosphatase deficiency
Exon 2 deletion represents a common mutation in Turkish patients with fructose-1,6-bisphosphatase deficiency.
fructose-bisphosphatase deficiency
False positive fructose loading: a pitfall in the diagnosis of fructose-1,6-bisphosphatase deficiency.
fructose-bisphosphatase deficiency
Fructose 1,6-bisphosphatase deficiency as a cause of childhood interstitial lung disease.
fructose-bisphosphatase deficiency
Fructose 1,6-bisphosphatase deficiency: clinical, biochemical and genetic features in French patients.
fructose-bisphosphatase deficiency
Fructose 1,6-bisphosphatase deficiency: enzyme and mutation analysis performed on calcitriol-stimulated monocytes with a note on long-term prognosis.
fructose-bisphosphatase deficiency
Fructose-1,6-bisphosphatase deficiency as a cause of recurrent hypoglycemia and metabolic acidosis: Clinical and molecular findings in Malaysian patients.
fructose-bisphosphatase deficiency
Fructose-1,6-bisphosphatase deficiency caused by a novel homozygous Alu element insertion in the FBP1 gene and delayed diagnosis.
fructose-bisphosphatase deficiency
Fructose-1,6-bisphosphatase deficiency presented with complex febrile convulsion.
fructose-bisphosphatase deficiency
Fructose-1,6-bisphosphatase deficiency with confirmed molecular diagnosis. An important cause of hypoglycemia in children.
fructose-bisphosphatase deficiency
Fructose-1,6-Bisphosphatase Deficiency: A Case of a Successful Pregnancy by Closely Monitoring Metabolic Control.
fructose-bisphosphatase deficiency
Fructose-1,6-bisphosphatase deficiency: severe phenotype with normal leukocyte enzyme activity.
fructose-bisphosphatase deficiency
Genetic analysis of patients with fructose-1,6-bisphosphatase deficiency.
fructose-bisphosphatase deficiency
Genetic Analysis of Tyrosinemia Type 1 and Fructose-1, 6 Bisphosphatase Deficiency Affected Pakistani Cohorts.
fructose-bisphosphatase deficiency
Human fructose-1,6-bisphosphatase gene (FBP1): exon-intron organization, localization to chromosome bands 9q22.2-q22.3, and mutation screening in subjects with fructose-1,6-bisphosphatase deficiency.
fructose-bisphosphatase deficiency
Identification of a genetic mutation in a family with fructose-1,6- bisphosphatase deficiency.
fructose-bisphosphatase deficiency
Identification of genetic mutations in Japanese patients with fructose-1,6-bisphosphatase deficiency.
fructose-bisphosphatase deficiency
Impaired ketogenesis in fructose-1,6-bisphosphatase deficiency: a pitfall in the investigation of hypoglycaemia.
fructose-bisphosphatase deficiency
Inborn Errors of Fructose Metabolism. What Can We Learn from Them?
fructose-bisphosphatase deficiency
Infantile lactic acidosis due to hereditary fructose 1,6-diphosphatase deficiency.
fructose-bisphosphatase deficiency
Inherited metabolic disorders in Thailand.
fructose-bisphosphatase deficiency
Intravenous glycerol therapy should not be used in patients with unrecognized fructose-1,6-bisphosphatase deficiency.
fructose-bisphosphatase deficiency
Lactic acidosis in childhood.
fructose-bisphosphatase deficiency
Metabolic and biochemical studies in fructose 1,6-diphosphatase deficiency.
fructose-bisphosphatase deficiency
Muscle fructose 1,6-diphosphatase deficiency associated with an atypical central core disease.
fructose-bisphosphatase deficiency
Mutation spectrum in patients with fructose-1,6-bisphosphatase deficiency.
fructose-bisphosphatase deficiency
Novel FBP1 gene mutations in Arab patients with fructose-1,6-bisphosphatase deficiency.
fructose-bisphosphatase deficiency
Novel Mutation with Fructose-1,6-Bisphosphatase Deficiency.
fructose-bisphosphatase deficiency
Novel mutations in patients with fructose-1,6-bisphosphatase deficiency.
fructose-bisphosphatase deficiency
Pitfall in the Diagnosis of Fructose-1,6-Bisphosphatase Deficiency: Difficulty in Detecting Glycerol-3-Phosphate with Solvent Extraction in Urinary GC/MS Analysis.
fructose-bisphosphatase deficiency
Status epilepticus due to fructose-1,6-bisphosphatase deficiency caused by FBP1 gene mutation.
fructose-bisphosphatase deficiency
The fructose-1,6-bisphosphatase deficiency and the p.(Lys204ArgfsTer72) variant.
fructose-bisphosphatase deficiency
Three successful pregnancies through dietary management of fructose-1,6-bisphosphatase deficiency.
fructose-bisphosphatase deficiency
Transient pseudo-hypertriglyceridemia: a useful biochemical marker of fructose-1,6-bisphosphatase deficiency.
fructose-bisphosphatase deficiency
[Congenital fructose 1,6 diphosphatase deficiency. Description of a case]
fructose-bisphosphatase deficiency
[Fructose 1,6-bisphosphatase deficiency as a cause of recessive serious hypoglycaemia]
fructose-bisphosphatase deficiency
[Fructose 1,6-diphosphatase deficiency in 2 sisters]
fructose-bisphosphatase deficiency
[Fructose-1,6-bisphosphatase deficiency]
Glycogen Storage Disease
A potential role for muscle in glucose homeostasis: in vivo kinetic studies in glycogen storage disease type 1a and fructose-1,6-bisphosphatase deficiency.
Glycogen Storage Disease
Lactic acidosis in childhood.
Hepatitis
Fructose 1,6-bisphosphatase in the diagnosis of chronic hepatitis. II. Classification of chronic hepatitis based on fructose 1,6-bisphosphatase and other laboratory data.
Hepatitis
Science letters: Proteomic analysis of differentially expressed proteins in mice with concanavalin A-induced hepatitis.
Hepatitis, Chronic
Fructose 1,6-bisphosphatase in the diagnosis of chronic hepatitis. I. Activity measurements of fructose 1,6-bisphosphatase in human serum.
Hepatitis, Chronic
Fructose 1,6-bisphosphatase in the diagnosis of chronic hepatitis. II. Classification of chronic hepatitis based on fructose 1,6-bisphosphatase and other laboratory data.
Hepatitis, Chronic
Profiles of carbohydrate-metabolizing enzymes in human hepatocellular carcinomas and preneoplastic livers.
Hepatomegaly
Problems in the congenital lactic acidoses.
Homocystinuria
Inherited metabolic disorders in Thailand.
Hyperglycemia
CS-917, a fructose 1,6-bisphosphatase inhibitor, improves postprandial hyperglycemia after meal loading in non-obese type 2 diabetic Goto-Kakizaki rats.
Hyperglycemia
Developmental aspects of transcription of fructose-1,6-bisphosphatase in newborn dogs.
Hyperglycemia
Fructose-1, 6-bisphosphatase inhibitors for reducing excessive endogenous glucose production in type 2 diabetes.
Hyperglycemia
Inhibition of fructose 1,6-bisphosphatase reduces excessive endogenous glucose production and attenuates hyperglycemia in zucker diabetic Fatty rats.
Hyperglycemia
Nuclear accumulation of fructose 1,6-bisphosphatase is impaired in diabetic rat liver.
Hyperglycemia
SirT1 knockdown in liver decreases basal hepatic glucose production and increases hepatic insulin responsiveness in diabetic rats.
Hyperglycinemia, Nonketotic
Inherited metabolic disorders in Thailand.
Hyperinsulinism
Dehydroepiandrosterone suppresses the elevated hepatic glucose-6-phosphatase and fructose-1,6-bisphosphatase activities in C57BL/Ksj-db/db mice: comparison with troglitazone.
Hyperinsulinism
Developmental aspects of transcription of fructose-1,6-bisphosphatase in newborn dogs.
Hyperinsulinism
Nuclear accumulation of fructose 1,6-bisphosphatase is impaired in diabetic rat liver.
Hyperthyroidism
The rate of substrate cycling between fructose 6-phosphate and fructose 1,6-bisphosphate in skeletal muscle from cold-exposed, hyperthyroid or acutely exercised rats.
Hyperventilation
Novel FBP1 gene mutations in Arab patients with fructose-1,6-bisphosphatase deficiency.
Hypoglycemia
A central role of RLIP76 in regulation of glycemic control.
Hypoglycemia
Fructose-1,6-bisphosphatase deficiency as a cause of recurrent hypoglycemia and metabolic acidosis: Clinical and molecular findings in Malaysian patients.
Hypoglycemia
Fructose-1,6-bisphosphatase deficiency with confirmed molecular diagnosis. An important cause of hypoglycemia in children.
Hypoglycemia
Fructose-1,6-Bisphosphatase Deficiency: A Case of a Successful Pregnancy by Closely Monitoring Metabolic Control.
Hypoglycemia
Genetic analysis of fructose-1,6-bisphosphatase (FBPase) deficiency in nine consanguineous Pakistani families.
Hypoglycemia
Human fructose-1,6-bisphosphatase gene (FBP1): exon-intron organization, localization to chromosome bands 9q22.2-q22.3, and mutation screening in subjects with fructose-1,6-bisphosphatase deficiency.
Hypoglycemia
Intravenous glycerol therapy should not be used in patients with unrecognized fructose-1,6-bisphosphatase deficiency.
Hypoglycemia
Novel compound heterozygous mutations in the fructose-1,6-bisphosphatase gene cause hypoglycemia and lactic acidosis.
Hypoglycemia
Novel FBP1 gene mutations in Arab patients with fructose-1,6-bisphosphatase deficiency.
Hypoglycemia
Novel Fructose-1,6-bisphosphatase Gene Mutation in Two Siblings.
Hypoglycemia
Status epilepticus due to fructose-1,6-bisphosphatase deficiency caused by FBP1 gene mutation.
Insulin Resistance
Developmental aspects of transcription of fructose-1,6-bisphosphatase in newborn dogs.
Insulin Resistance
Increased glucose production in mice overexpressing human fructose-1,6-bisphosphatase in the liver.
Insulin Resistance
Mitigating Perspectives of Asiatic acid in the Renal derangements of Streptozotocin-Nicotinamide induced Diabetic Rats.
Ketosis
Genetic analysis of fructose-1,6-bisphosphatase (FBPase) deficiency in nine consanguineous Pakistani families.
Ketosis
Status epilepticus due to fructose-1,6-bisphosphatase deficiency caused by FBP1 gene mutation.
Leigh Disease
Lactic acidosis in childhood.
Leukemia
Induction and turnover of fructose 1,6-bisphosphatase in HL-60 leukemia cells by calcitriol.
Leukemia
Induction of fructose 1,6-bisphosphatase in HL-60 leukemia cells by retinoic acid.
Lissencephaly
Armadillo Repeat Containing 8alpha Binds to HRS and Promotes HRS Interaction with Ubiquitinated Proteins.
Liver Cirrhosis
Profiles of carbohydrate-metabolizing enzymes in human hepatocellular carcinomas and preneoplastic livers.
Liver Diseases
Proteomic signature of acute liver failure: from discovery and verification in a pig model to confirmation in humans.
Liver Neoplasms
LIX1-like protein promotes liver cancer progression via miR-21-3p-mediated inhibition of fructose-1,6-bisphosphatase.
Liver Neoplasms
Overexpression of far upstream element binding proteins: a mechanism regulating proliferation and migration in liver cancer cells.
Lung Diseases, Interstitial
Fructose 1,6-bisphosphatase deficiency as a cause of childhood interstitial lung disease.
Lymphoma
Mouse thymoma cell line expresses a gluconeogenic enzyme, fructose 1,6-bisphosphatase.
Magnesium Deficiency
Hepatic gluconeogenic enzymes, plasma insulin and glucagon response to magnesium deficiency and fasting.
Menkes Kinky Hair Syndrome
Inherited metabolic disorders in Thailand.
Mucopolysaccharidoses
Inherited metabolic disorders in Thailand.
Myopathy, Central Core
Muscle fructose 1,6-diphosphatase deficiency associated with an atypical central core disease.
Nasopharyngeal Carcinoma
FBP1 enhances the radiosensitivity by suppressing glycolysis via the FBXW7/mTOR axis in nasopharyngeal carcinoma cells.
Neoplasms
Aberrant methylation of human L- and M-fructose 1,6-bisphosphatase genes in cancer.
Neoplasms
Abnormal muscle fructose bisphosphatase activity in malnourished cancer patients.
Neoplasms
Biochemical alterations in 7,12-dimethylbenz[a]anthracene-induced mammary tumors from rats subjected to caloric restriction.
Neoplasms
Breast Cancer Subtypes Underlying EMT-Mediated Catabolic Metabolism.
Neoplasms
Coordinated expression of stathmin family members by far upstream sequence element-binding protein-1 increases motility in non-small cell lung cancer.
Neoplasms
Decreased Expression of Fructose-1,6-bisphosphatase Associates with Glucose Metabolism and Tumor Progression in Hepatocellular Carcinoma.
Neoplasms
Dual targeting of histone methyltransferase G9a and DNA-methyltransferase 1 for the treatment of experimental hepatocellular carcinoma.
Neoplasms
E3 ubiquitin ligase UBR5 promotes pancreatic cancer growth and aerobic glycolysis by downregulating FBP1 via destabilization of C/EBP?.
Neoplasms
Effect of tumor necrosis factor on enzymes of gluconeogenesis in the rat.
Neoplasms
Enzyme deviation patterns in primary rat hepatomas induced by sequential administration of two chemically different carcinogens.
Neoplasms
Epigenetic Marks Repressing Gluconeogenesis in Liver and Kidney Cancer.
Neoplasms
FBP1 enhances the radiosensitivity by suppressing glycolysis via the FBXW7/mTOR axis in nasopharyngeal carcinoma cells.
Neoplasms
FBP1 loss disrupts liver metabolism and promotes tumorigenesis through a hepatic stellate cell senescence secretome.
Neoplasms
FBP1 regulates proliferation, metastasis, and chemoresistance by participating in C-MYC/STAT3 signaling axis in ovarian cancer.
Neoplasms
Fructose 1,6-Bisphosphatase 1 Expression Reduces 18F-FDG Uptake in Clear Cell Renal Cell Carcinoma.
Neoplasms
Fructose-1,6-Bisphosphatase 1 Reduces (18)F FDG Uptake in Hepatocellular Carcinoma.
Neoplasms
Fructose-1,6-bisphosphatase aggravates oxidative stress-induced apoptosis in asthma by suppressing the Nrf2 pathway.
Neoplasms
Fructose-1,6-bisphosphatase Inhibits ERK Activation and Bypasses Gemcitabine Resistance in Pancreatic Cancer by Blocking IQGAP1-MAPK Interaction.
Neoplasms
Fructose-1,6-bisphosphatase is a novel regulator of Wnt/?-Catenin pathway in breast cancer.
Neoplasms
Fructose-1,6-bisphosphatase loss modulates STAT3-dependent expression of PD-L1 and cancer immunity.
Neoplasms
Fructose-1,6-bisphosphatase opposes renal carcinoma progression.
Neoplasms
Fructose?1,6?bisphosphatase?1 decrease may promote carcinogenesis and chemoresistance in cervical cancer.
Neoplasms
Gluconeogenesis in cancer cells - Repurposing of a starvation-induced metabolic pathway?
Neoplasms
Gluconeogenesis in Cancer: Function and Regulation of PEPCK, FBPase, and G6Pase.
Neoplasms
HSF2 regulates aerobic glycolysis by suppression of FBP1 in hepatocellular carcinoma.
Neoplasms
Identification of the New Covalent Allosteric Binding Site of Fructose-1,6-bisphosphatase with Disulfiram Derivatives toward Glucose Reduction.
Neoplasms
Inhibiting histone deacetylases suppresses glucose metabolism and hepatocellular carcinoma growth by restoring FBP1 expression.
Neoplasms
Invalidation of mitophagy by FBP1-mediated repression promotes apoptosis in breast cancer.
Neoplasms
Knockdown of FBP1 enhances radiosensitivity in prostate cancer cells by activating autophagy.
Neoplasms
Loss of fructose-1,6-bisphosphatase induces glycolysis and promotes apoptosis resistance of cancer stem-like cells: an important role in hexavalent chromium-induced carcinogenesis.
Neoplasms
Monocyte fructose 1,6-bisphosphatase and cytidine deaminase enzyme activities: potential pharmacodynamic measures of calcitriol effects in cancer patients.
Neoplasms
Non-canonical functions of enzymes facilitate cross-talk between cell metabolic and regulatory pathways.
Neoplasms
Overexpression of far upstream element binding proteins: a mechanism regulating proliferation and migration in liver cancer cells.
Neoplasms
Phenolic glycosides and other constituents from the bark of Magnolia officinalis.
Neoplasms
Prenatal alcohol exposure alters phosphorylation and glycosylation of proteins in rat offspring liver.
Neoplasms
Profiles of carbohydrate-metabolizing enzymes in human hepatocellular carcinomas and preneoplastic livers.
Neoplasms
Restoration of FBP1 suppressed Snail-induced epithelial to mesenchymal transition in hepatocellular carcinoma.
Neoplasms
The expression of glyceraldehyde-3-phosphate dehydrogenase associated cell cycle (GACC) genes correlates with cancer stage and poor survival in patients with solid tumors.
Neoplasms
The Glycogen Shunt Maintains Glycolytic Homeostasis and the Warburg Effect in Cancer.
Neoplasms
The Reverse Warburg Effect is Associated with Fbp2-Dependent Hif1? Regulation in Cancer Cells Stimulated by Fibroblasts.
Nephrotic Syndrome
Urinary fructose-1,6-bisphosphatase activity as a marker of the damage to the renal proximal tubules in children with idiopathic nephrotic syndrome.
Obesity
Increased glucose production in mice overexpressing human fructose-1,6-bisphosphatase in the liver.
Obesity
The liver: Key in regulating appetite and body weight.
Obesity
The role of liver fructose-1,6-bisphosphatase in regulating appetite and adiposity.
Obesity, Morbid
The GID ubiquitin ligase complex is a regulator of AMPK activity and organismal lifespan.
Pancreatic Neoplasms
Fructose-1,6-bisphosphatase Inhibits ERK Activation and Bypasses Gemcitabine Resistance in Pancreatic Cancer by Blocking IQGAP1-MAPK Interaction.
Periodontitis
Acid-base status and fructose diphosphatase activity in rats exposed to fluoride and induced periodontitis.
Phenylketonurias
Inherited metabolic disorders in Thailand.
Propionic Acidemia
Inherited metabolic disorders in Thailand.
Propionic Acidemia
Lactic acidosis in childhood.
Proteinuria
Urinary fructose-1,6-bisphosphatase activity as a marker of the damage to the renal proximal tubules in children with idiopathic nephrotic syndrome.
Pyelonephritis
[Assessment of fructose-1,6-biphosphatase in urine of children with acute pyelonephritis]
Sarcoma
Fructose-1,6-Bisphosphatase 2 Inhibits Sarcoma Progression by Restraining Mitochondrial Biogenesis.
Sarcoma
High-performance liquid chromatography/nano-electrospray ionization tandem mass spectrometry, two-dimensional difference in-gel electrophoresis and gene microarray identification of lymphatic metastasis-associated biomarkers.
Seizures
Status epilepticus due to fructose-1,6-bisphosphatase deficiency caused by FBP1 gene mutation.
Seizures, Febrile
Fructose-1,6-bisphosphatase deficiency presented with complex febrile convulsion.
Starvation
A selective autophagy pathway that degrades gluconeogenic enzymes during catabolite inactivation.
Starvation
Carbohydrate metabolism in rat kidney: heterogeneous distribution of glycolytic and gluconeogenic key enzymes.
Starvation
Comparison between starvation and consumption of a high protein diet: plasma insulin and glucagon and hepatic activities of gluconeogenic enzymes during the first 24 hours.
Starvation
Cyclophilin A mediates Vid22p function in the import of fructose-1,6-bisphosphatase into Vid vesicles.
Starvation
Degradation of the Gluconeogenic Enzyme Fructose-1, 6-Bisphosphatase is Dependent on the Vacuolar ATPase.
Starvation
Distribution along the rat nephron of three enzymes of gluconeogenesis in acidosis and starvation.
Starvation
Effect of starvation on fructose diphosphatase, glucose-6-phosphatase and phosphoglucomutase activities in organs of Pseudemys (Chrysemys) scripta elegans.
Starvation
Fuel utilization in colonocytes of the rat.
Starvation
Metabolic adaptation of the renal carbohydrate metabolism. I. Effects of starvation on the gluconeogenic and glycolytic fluxes in the proximal and distal renal tubules.
Starvation
Predominant periportal expression of the fructose 1,6-bisphosphatase gene in rat liver: dynamics during the daily feeding rhythm and starvation-refeeding cycle.
Starvation
Stress-induced lncRNAs evade nuclear degradation and enter the translational machinery.
Starvation
The key gluconeogenic enzyme fructose-1,6-bisphosphatase is secreted during prolonged glucose starvation and is internalized following glucose re-feeding via the non-classical secretory and internalizing pathways in Saccharomyces cerevisiae.
Status Epilepticus
Status epilepticus due to fructose-1,6-bisphosphatase deficiency caused by FBP1 gene mutation.
Stroke
Hyperglycemia is associated with enhanced gluconeogenesis in a rat model of permanent cerebral ischemia.
succinate-semialdehyde dehydrogenase [nad(p)+] deficiency
Diagnosis of inborn errors of metabolism using filter paper urine, urease treatment, isotope dilution and gas chromatography-mass spectrometry.
Teratocarcinoma
Various fructose-1,6-bisphosphatase mRNAs in mouse brain, liver, kidney and heart.
Thymoma
Mouse thymoma cell line expresses a gluconeogenic enzyme, fructose 1,6-bisphosphatase.
Tuberculosis
Crystallization and preliminary X-ray characterization of the glpX-encoded class II fructose-1,6-bisphosphatase from Mycobacterium tuberculosis.
Tuberculosis
glpX Gene of Mycobacterium tuberculosis: Heterologous Expression, Purification, and Enzymatic Characterization of the Encoded Fructose 1,6-bisphosphatase II.
Tuberculosis
Mutagenesis of threonine to serine in the active site of Mycobacterium tuberculosis fructose-1,6-bisphosphatase (Class II) retains partial enzyme activity.
Tuberculosis
Rv2131c gene product: an unconventional enzyme that is both inositol monophosphatase and fructose-1,6-bisphosphatase.
Tuberculosis
Structures of the Mycobacterium tuberculosis GlpX protein (class II fructose-1,6-bisphosphatase): implications for the active oligomeric state, catalytic mechanism and citrate inhibition.
Tuberculosis
The Mycobacterium tuberculosis Rv1099c gene encodes a GlpX-like class II fructose 1,6-bisphosphatase.
Tuberculosis
Two enzymes with redundant fructose bisphosphatase activity sustain gluconeogenesis and virulence in Mycobacterium tuberculosis.
Tuberous Sclerosis
The GID ubiquitin ligase complex is a regulator of AMPK activity and organismal lifespan.
Tyrosinemias
Genetic Analysis of Tyrosinemia Type 1 and Fructose-1, 6 Bisphosphatase Deficiency Affected Pakistani Cohorts.
Uterine Cervical Neoplasms
Fructose-1,6-bisphosphatase 2 represses cervical cancer progression via inhibiting aerobic glycolysis through promoting pyruvate kinase isozyme type M2 ubiquitination.
Virus Diseases
Viral infection enables phloem loading of GFP and long-distance trafficking of the protein.
Vitamin A Deficiency
Vitamin A regulates genes involved in hepatic gluconeogenesis in mice: phosphoenolpyruvate carboxykinase, fructose-1,6-bisphosphatase and 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase.
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0.0164
(2-amino-4,5-dihydronaphtho[1,2-d][1,3]thiazol-7-yl)methyl dihydrogen phosphate
Homo sapiens
-
0.354
(2-amino-4,5-dihydronaphtho[1,2-d][1,3]thiazol-7-yl)phosphonic acid
Homo sapiens
-
0.0191
(2-amino-4,5-dihydronaphtho[1,2-d][1,3]thiazol-8-yl)methyl dihydrogen phosphate
Homo sapiens
-
0.00932
(2-amino-4,5-dihydronaphtho[1,2-d][1,3]thiazol-8-yl)phosphonic acid
Homo sapiens
-
0.0215
(2-amino-4,5-dihydronaphtho[1,2-d][1,3]thiazol-9-yl)methyl dihydrogen phosphate
Homo sapiens
-
0.354
(2-amino-4,5-dihydronaphtho[1,2-d][1,3]thiazol-9-yl)phosphonic acid
Homo sapiens
-
0.0417
(2-amino-5,6-dihydro-4H-benzo[6,7]cyclohepta[1,2-d][1,3]thiazol-9-yl)methyl dihydrogen phosphate
Homo sapiens
-
0.000169
(2-amino-5,6-dihydro-4H-benzo[6,7]cyclohepta[1,2-d][1,3]thiazol-9-yl)phosphonic acid
Homo sapiens
-
0.000124
(2-amino-8H-indeno[1,2-d][1,3]thiazol-4-yl)methyl dihydrogen phosphate
Homo sapiens
-
0.0284
(2-amino-8H-indeno[1,2-d][1,3]thiazol-4-yl)phosphonic acid
Homo sapiens
-
0.112
(2-amino-8H-indeno[1,2-d][1,3]thiazol-5-yl)methyl dihydrogen phosphate
Homo sapiens
-
0.0187
(2-amino-8H-indeno[1,2-d][1,3]thiazol-5-yl)phosphonic acid
Homo sapiens
-
0.112
(2-amino-8H-indeno[1,2-d][1,3]thiazol-6-yl)methyl dihydrogen phosphate
Homo sapiens
-
0.0919
(2-amino-8H-indeno[1,2-d][1,3]thiazol-6-yl)phosphonic acid
Homo sapiens
-
0.00029
(2E)-3-(5-bromo-4-hydroxy-2-methoxyphenyl)-1-[4-[(3-methylbut-2-en-1-yl)oxy]phenyl]prop-2-en-1-one
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.0017
(3-Bromo-phenyl)-(6,7-diethoxy-quinazolin-4-yl)-amine
Homo sapiens
-
IC50: 0.0017 mM
0.0045
(3-Bromo-phenyl)-(6,7-dimethoxy-2-methyl-quinazolin-4-yl)-amine
Homo sapiens
-
IC50: 0.0045 mM
0.001
(3-Bromo-phenyl)-(6,7-dimethoxy-quinazolin-4-yl)-amine
Homo sapiens
-
IC50: 0.001 mM
0.0039
(3-Bromo-phenyl)-(7-ethoxy-6-nitro-quinazolin-4-yl)-amine
Homo sapiens
-
IC50: 0.0039 mM
0.0029
(3-Bromo-phenyl)-[6-(2-methoxy-ethoxy)-quinazolin-4-yl]-amine
Homo sapiens
-
IC50: 0.0029 mM
0.0055
(3-Bromo-phenyl)-[7-methoxy-6-(2-methoxy-ethoxy)-quinazolin-4-yl]-amine
Homo sapiens
-
IC50: 0.0055 mM
0.00053
(3-Chloro-4-fluoro-phenyl)-(6,7-diethoxy-quinazolin-4-yl)-amine
Homo sapiens
-
IC50: 0.00053 mM
0.0016
(3-Chloro-phenyl)-(6,7-diethoxy-quinazolin-4-yl)-amine
Homo sapiens
-
IC50: 0.0016 mM
0.0013
(3-Chloro-phenyl)-(6,7-dimethoxy-quinazolin-4-yl)-amine
Homo sapiens
-
IC50: 0.0013 mM
0.000858
(5-[2-amino-5-[(propylsulfanyl)carbonyl]-1,3-thiazol-4-yl]furan-2-yl)phosphonic acid
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.000055
(5-[4-amino-7-[3-(dimethylamino)propyl]-5-fluoro-1-(2-methylpropyl)-1H-benzimidazol-2-yl]furan-2-yl)phosphonic acid
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.0024
(6,7-Diethoxy-quinazolin-4-yl)-(3-ethynyl-phenyl)-amine
Homo sapiens
-
IC50: 0.0024 mM
0.0092
(6,7-Diethoxy-quinazolin-4-yl)-(3-fluoro-phenyl)-amine
Homo sapiens
-
IC50: 0.0092 mM
0.0021
(6,7-Diethoxy-quinazolin-4-yl)-(3-iodo-phenyl)-amine
Homo sapiens
-
IC50: 0.0021 mM
0.0009
(6,7-Dimethoxy-quinazolin-4-yl)-(3-ethynyl-phenyl)-amine
Homo sapiens
-
IC50: 0.0009 mM
0.05
1-(cyclopropyl)methyl-3-(2-carboxyethyl)-7-nitro-1H-indole-2-carboxylic acid
Homo sapiens
above, pH 7.5, 37°C, recombinant His-tagged enzyme
0.05
1-benzyl-3-(2-carboxyethyl)-7-nitro-1H-indole-2-carboxylic acid
Homo sapiens
above, pH 7.5, 37°C, recombinant His-tagged enzyme
0.055
2,5-dichloro-N-(4-methyl-1,3-benzoxazol-2-yl)benzenesulfonamide
Homo sapiens
-
-
0.0034
2,5-dichloro-N-(5-chloro-1,3-benzoxazol-2-yl)benzenesulfonamide
0.0064
2,5-dichloro-N-(5-methyl-1,3-benzoxazol-2-yl)benzenesulfonamide
Homo sapiens
-
-
0.0081
2,5-dichloro-N-(6-chloro-1,3-benzoxazol-2-yl)benzenesulfonamide
Homo sapiens
-
-
0.008
2,5-dichloro-N-(6-methoxy-1,3-benzoxazol-2-yl)benzenesulfonamide
Homo sapiens
-
-
0.01
2,5-dichloro-N-(6-methyl-1,3-benzoxazol-2-yl)benzenesulfonamide
Homo sapiens
-
-
0.004
2,5-dichloro-N-[5-(3-furyl)-1,3-benzoxazol-2-yl]benzenesulfonamide
Homo sapiens
-
-
0.0035
2,5-dichloro-N-[5-methoxy-7-(4-methoxypyridin-3-yl)-1,3-benzoxazol-2-yl]benzenesulfonamide
Homo sapiens
-
-
0.0017
2,5-dichloro-N-[7-(3-hydroxyphenyl)-5-methoxy-1,3-benzoxazol-2-yl]benzenesulfonamide
Homo sapiens
-
-
0.0018
2,5-dichloro-N-[7-(4-hydroxyphenyl)-5-methoxy-1,3-benzoxazol-2-yl]benzenesulfonamide
Homo sapiens
-
-
0.00022
2-(2-aminoethyl)-6,7-diethoxy-N-[3-(2-methyl-1,3-thiazol-4-yl)phenyl]quinazolin-4-amine
Homo sapiens
-
uncompetitive
0.008
2-(2-thienyl)-5-isobutyl-4-[2-(5-phosphono)furanyl]thiazole
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.005
2-(3-pyridyl)-5-isobutyl-4-[2-(5-phosphono)furanyl]thiazole
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.01
2-acetamido-5-isobutyl-4-[2-(5-phosphono)furanyl]thiazole
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.112
2-amino-4,5-dihydronaphtho[1,2-d][1,3]thiazol-7-yl dihydrogen phosphate
Homo sapiens
-
0.000013
2-amino-4,5-dihydronaphtho[1,2-d][1,3]thiazol-8-yl dihydrogen phosphate
Homo sapiens
-
0.335
2-amino-4,5-dihydronaphtho[1,2-d][1,3]thiazol-9-yl dihydrogen phosphate
Homo sapiens
-
0.0013
2-amino-4-[1-(3-phosphono)phenyl]thiazole
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.002
2-amino-4-[2-(6-phosphono)pyridyl]thiazole
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.000022
2-amino-5,6-dihydro-4H-benzo[6,7]cyclohepta[1,2-d][1,3]thiazol-9-yl dihydrogen phosphate
Homo sapiens
-
0.000028
2-amino-5-(2,2,2-trifluoroethyl)-4-[2-(5-phosphono)furanyl]-thiazole
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.00004
2-amino-5-(2-furanyl)-4-[2-(5-phosphono)furanyl]thiazole
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.000043
2-amino-5-(2-methoxyphenyl)-4-[2-(5-phosphono)furanyl]-thiazole
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.000012
2-amino-5-(2-naphthyl)-4-[2-(5-phosphono)furanyl]thiazole
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.95
2-amino-5-(2-thienyl)-4-[(N-phosphonomethyl)carbamoyl]-thiazole
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.000044
2-amino-5-(2-thienyl)-4-[2-(5-phosphono)furanyl]thiazole
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.000021
2-amino-5-(3-methoxyphenyl)-4-[2-(5-phosphono)furanyl]-thiazole
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.000032
2-amino-5-(4-acetylphenyl)-4-[2-(5-phosphono)furanyl]thiazole
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.000013
2-amino-5-(4-chlorophenyl)-4-[2-(5-phosphono)furanyl]thiazole
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.000016
2-amino-5-(4-fluorophenyl)-4-[2-(5-phosphono)furanyl]thiazole
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.000041
2-amino-5-(4-methanesulfonyl)-4-[2-(5-phosphono)furanyl]thiazole
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.000014
2-amino-5-(4-methoxycarbonylphenyl)-4-[2-(5-phosphono)-furanyl]thiazole
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.000022
2-amino-5-(4-methoxyphenyl)-4-[2-(5-phosphono)furanyl]-thiazole
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.000021
2-amino-5-(4-methylthiophenyl)-4-[2-(5-phosphono)furanyl]-thiazole
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.000034
2-amino-5-(4-phenylphenyl)-4-[2-(5-phosphono)furanyl]thiazole
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.000088
2-amino-5-(4-tert-butylphenyl)-4-[2-(5-phosphono)furanyl]-thiazole
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.000016
2-amino-5-(N-morpholinyl)-4-[2-(5-phosphono)furanyl]thiazole
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.000059
2-amino-5-benzyl-4-[2-(5-phosphono)furanyl]thiazole
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.000015
2-amino-5-benzyloxycarbonyl-4-[2-(5-phosphono)furanyl]-thiazole
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.00005
2-amino-5-bromo-4-[2-(5-phosphono)furanyl]thiazole
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.00007
2-amino-5-chloro-4-[2-(5-phosphono)furanyl]thiazole
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.000012
2-amino-5-cyclobutyl-4-[2-(5-phosphono)furanyl]thiazole
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.000021
2-amino-5-cyclohexyl-4-[2-(5-phosphono)furanyl]thiazole
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.000018
2-amino-5-cyclohexylmethyl-4-[2-(5-phosphono)furanyl]-thiazole
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.000019
2-amino-5-cyclopentyl-4-[2-(5-phosphono)furanyl]thiazole
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.00002
2-amino-5-cyclopentylmethyl-4-[2-(5-phosphono)furanyl]-thiazole
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.00001
2-amino-5-cyclopropylmethyl-4-[2-(5-phosphono)furanyl]-thiazole
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.000033
2-amino-5-ethylthio-4-[2-(5-phosphono)furanyl]thiazole
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.00012
2-amino-5-hydroxymethyl-4-[2-(5-phosphono)furanyl]thiazole
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.0001
2-amino-5-iodo-4-[2-(5-phosphono)furanyl]thiazole
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.016
2-amino-5-isobutyl-4-[2-(5-phosphono)furanyl]thiazole
Homo sapiens
-
-
0.21
2-amino-5-isopropyl- 4-[1-(4-methoxy-3-phosphono)phenyl]-thiazole
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.00003
2-amino-5-isopropyl-4-[2-(5-phosphono)furanyl]thiazole
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.000024
2-amino-5-isopropylthio-4-[2-(5-phosphono)furanyl]thiazole hydrobromide
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.00045
2-amino-5-methyl-4-[2-(5-phosphono)furanyl]thiazole
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.000057
2-amino-5-neopentyl-4-[2-(5-phosphono)furanyl]thiazole
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.08
2-amino-5-phenyl- 4-[1-(4-fluoro-3-phosphono)phenyl]thiazole
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.01
2-amino-5-phenyl-4-[2-(5-methyl-4-phosphono)oxazolyl]-thiazole
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.01
2-amino-5-phenyl-4-[3-(1-phosphono)pyrrolyl]thiazole
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.0003
2-amino-5-phenylthio-4-[2-(5-phosphono)furanyl]thiazole
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.135
2-amino-5-propyl- 4-[1-(4-methyl-3-phosphono)phenyl]thiazole
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.05
2-amino-5-propyl-4-phosphonomethoxycarbonylthiazole
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.25
2-amino-5-propyl-4-[1-(3-phosphono)phenyl]thiazole
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.0005
2-amino-5-propyl-4-[2-(5-phosphono)furanyl]thiazole
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.000024
2-amino-5-tert-butylthio-4-[2-(5-phosphono)furanyl]thiazole
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.00015
2-amino-5-[(4-morpholinyl)methyl]-4-[2-(5-phosphono)furanyl]-thiazole dihydrobromide
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.0017
2-amino-5-[(N,N-dimethyl)carbamoyl]-4-[2-(5-phosphono)-furanyl]thiazole
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.00007
2-amino-8H-indeno[1,2-d][1,3]thiazol-4-yl dihydrogen phosphate
Homo sapiens
-
0.307
2-amino-8H-indeno[1,2-d][1,3]thiazol-5-yl dihydrogen phosphate
Homo sapiens
-
0.146
2-amino-8H-indeno[1,2-d][1,3]thiazol-6-yl dihydrogen phosphate
Homo sapiens
-
0.00008
2-bromo-5-isobutyl-4-[2-(5-phosphono)furanyl]thiazole
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.0065
2-bromo-N-(5-chloro-1,3-benzoxazol-2-yl)benzenesulfonamide
Homo sapiens
-
-
0.00275
2-carbamoyl-5-isobutyl-4-[2-(5-phosphono)furanyl]thiazole
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.00018
2-chloro-5-isobutyl-4-[2-(5-phosphono)furanyl]thiazole
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.002
2-cyano-5-isobutyl-4-[2-(5-phosphono)furanyl]thiazole
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.0004
2-ethyl-5-isobutyl-4-[2-(5-phosphono)furanyl]thiazole
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.00022
2-hydroxymethyl-5-isobutyl-4-[2-(5-phosphono)furanyl]thiazole
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.0001
2-methyl-5-isobutyl-4-[2-(5-phosphono)furanyl]-thiazole
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.001
2-methylamino-5-isobutyl-4-[2-(5-hosphono)furanyl]thiazole
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.00089
2-methylthio-5-isobutyl-4-[2-(5-phosphono)furanyl]thiazole
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.0135
2-phenyl-5-isobutyl-4-[2-(5-phosphono)furanyl]thiazole
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.0005
2-thiocarbamoyl-5-isobutyl-4-[2-(5-phosphono)furanyl]thiazole
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.0012
2-vinyl-5-isobutyl-4-[2-(5-phosphono)furanyl]thiazole
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.00187
2-[(3S,11aS)-3-(4-hydroxybenzyl)-1,4-dioxo-1,3,4,6,11,11a-hexahydro-2H-pyrazino[1,2-b]isoquinolin-2-yl]-N-[2-(4-hydroxyphenyl)ethyl]pentanamide
Homo sapiens
-
uncompetitive
0.00052
2-[3-methyl-5-([[6-methyl-4-(trifluoromethyl)pyridin-2-yl]carbamoyl]sulfamoyl)thiophen-2-yl]ethyl acetate
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.00067
2-[5-([[6-amino-5-fluoro-4-(trifluoromethyl)pyridin-2-yl]carbamoyl]sulfamoyl)-3-methylthiophen-2-yl]ethyl acetate
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.05
3-(2-(ethoxycarbonyl)-7-nitro-1H-indol-3-yl)propanoic acid
Homo sapiens
above, pH 7.5, 37°C, recombinant His-tagged enzyme
0.0025
3-(2-carboxyethyl)-4,6-dichloro-1H-indole-2-carboxylic acid
Homo sapiens
-
non-competitive
0.0024
3-(2-carboxyethyl)-4-(2-fluorophenyl)-7-nitro-1H-indole-2-carboxylic acid
0.00069
3-(2-carboxyethyl)-4-(2-methylpropyl)-7-nitro-1H-indole-2-carboxylic acid
Homo sapiens
37°C, pH 7.5
-
0.00527
3-(2-carboxyethyl)-4-(3-fluorophenyl)-7-nitro-1H-indole-2-carboxylic acid
0.00131
3-(2-carboxyethyl)-4-(3-methoxyanilino)-7-nitro-1H-indole-2-carboxylic acid
Homo sapiens
37°C, pH 7.5
-
0.00522
3-(2-carboxyethyl)-4-(3-methoxyphenyl)-7-nitro-1H-indole-2-carboxylic acid
0.0024
3-(2-carboxyethyl)-4-(4-fluorophenyl)-7-nitro-1H-indole-2-carboxylic acid
0.0017
3-(2-carboxyethyl)-4-(4-methoxyanilino)-7-nitro-1H-indole-2-carboxylic acid
Homo sapiens
37°C, pH 7.5
-
0.0018
3-(2-carboxyethyl)-4-(4-methoxyphenyl)-7-nitro-1H-indole-2-carboxylic acid
0.00088
3-(2-carboxyethyl)-4-chloro-7-nitro-1H-indole-2-carboxylic acid
0.00276
3-(2-carboxyethyl)-4-ethyl-7-nitro-1H-indole-2-carboxylic acid
0.00069
3-(2-carboxyethyl)-4-isobutyl-7-nitro-1H-indole-2-carboxylic acid
Homo sapiens
pH 7.5, 37°C, recombinant His-tagged enzyme
0.00045
3-(2-carboxyethyl)-5-(2-methylpropyl)-7-nitro-1H-indole-2-carboxylic acid
Homo sapiens
37°C, pH 7.5
-
0.00129
3-(2-carboxyethyl)-5-bromo-7-nitro-1H-indole-2-carboxylic acid
Homo sapiens
pH 7.5, 37°C, recombinant His-tagged enzyme
0.00207
3-(2-carboxyethyl)-5-chloro-7-nitro-1H-indole-2-carboxylic acid
0.0001
3-(2-carboxyethyl)-5-ethyl-7-nitro-1H-indole-2-carboxylic acid
Homo sapiens
37°C, pH 7.5
0.0001
3-(2-carboxyethyl)-5-ethyl-7-nitro-1H-indole-2-carboxylicacid
Homo sapiens
pH 7.5, 37°C, recombinant His-tagged enzyme
0.00045
3-(2-carboxyethyl)-5-isobutyl-7-nitro-1H-indole-2-carboxylic acid
Homo sapiens
pH 7.5, 37°C, recombinant His-tagged enzyme
0.05
3-(2-carboxyethyl)-5-nitro-1H-indole-2-carboxylic acid
Homo sapiens
above, pH 7.5, 37°C, recombinant His-tagged enzyme
0.0016
3-(2-carboxyethyl)-5-phenylamino-7-nitro-1H-indole-2-carboxylic acid
Homo sapiens
pH 7.5, 37°C, recombinant His-tagged enzyme
0.00517
3-(2-carboxyethyl)-7-nitro-1H-indole-2-carboxylic acid
0.00131
3-(2-carboxyethyl)-7-nitro-4-(3-methoxyphenylamino)-1H-indole-2-carboxylic acid
Homo sapiens
pH 7.5, 37°C, recombinant His-tagged enzyme
0.0011
3-(2-carboxyethyl)-7-nitro-4-(3-nitrophenyl)-1H-indole-2-carboxylic acid
0.0017
3-(2-carboxyethyl)-7-nitro-4-(4-methoxyphenylamino)-1H-indole-2-carboxylic acid
Homo sapiens
pH 7.5, 37°C, recombinant His-tagged enzyme
0.002
3-(2-carboxyethyl)-7-nitro-4-(4-nitrophenyl)-1H-indole-2-carboxylic acid
0.0014
3-(2-carboxyethyl)-7-nitro-4-phenyl-1H-indole-2-carboxylic acid
0.00069
3-(2-carboxyethyl)-7-nitro-4-phenylamino-1H-indole-2-carboxylic acid
Homo sapiens
pH 7.5, 37°C, recombinant His-tagged enzyme
0.00643
3-(2-carboxyethyl)-7-nitro-5-phenyl-1H-indole-2-carboxylic acid
0.0013
3-chloro-N-(5-chloro-1,3-benzoxazol-2-yl)benzenesulfonamide
Homo sapiens
-
-
0.00064
3-chloro-N-[(3,5-dichlorophenyl)carbamoyl]benzenesulfonamide
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.00099
3-ethyl-5-isobutyl-7-nitro-1H-indole-2-carboxylic acid
Homo sapiens
-
pH 7.5, 37°C
0.00069
4-anilino-3-(2-carboxyethyl)-7-nitro-1H-indole-2-carboxylic acid
Homo sapiens
37°C, pH 7.5
-
0.024
4-tert-butyl-N-(5-chloro-1,3-benzoxazol-2-yl)benzenesulfonamide
Homo sapiens
-
-
0.00298
5-(1H-tetrazol-5-yl)-N-(3-(5-p-tolyl-1,3,4-oxadiazol-2-yl)phenyl)pentanamide
Homo sapiens
-
pH 7.5, temperature not specified in the publication
0.00035
5-(2-hydroxyethyl)-4-methyl-N-[[6-methyl-4-(trifluoromethyl)pyridin-2-yl]carbamoyl]thiophene-2-sulfonamide
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.00017
5-(2-methoxyethyl)-4-methyl-N-([6-[(methylcarbamoyl)amino]-4-(methylsulfanyl)pyridin-2-yl]carbamoyl)thiophene-2-sulfonamide
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.0017
5-(2-methoxyethyl)-4-methyl-N-[[4-(trifluoromethyl)pyridin-2-yl]carbamoyl]thiophene-2-sulfonamide
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.00053
5-(2-methoxyethyl)-4-methyl-N-[[6-methyl-4-(trifluoromethyl)pyridin-2-yl]carbamoyl]thiophene-2-sulfonamide
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.00022
5-(2-methoxyethyl)-N-([4-methoxy-6-[(methylcarbamoyl)amino]pyridin-2-yl]carbamoyl)-4-methylthiophene-2-sulfonamide
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.0016
5-anilino-3-(2-carboxyethyl)-7-nitro-1H-indole-2-carboxylic acid
Homo sapiens
37°C, pH 7.5
-
0.00129
5-bromo-3-(2-carboxyethyl)-7-nitro-1H-indole-2-carboxylic acid
Homo sapiens
37°C, pH 7.5
-
0.0005
5-isobutyl-4-[2-(5-phosphono)furanyl]thiazole
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.00132
6-hydroxy-N-(3-(5-p-tolyl-1,3,4-oxadiazol-2-yl)phenyl)hexanamide
Homo sapiens
-
pH 7.5, temperature not specified in the publication
0.00532
6-oxo-6-(3-(5-p-tolyl-1,3,4-oxadiazol-2-yl)phenylamino)hexanoic acid
Homo sapiens
-
pH 7.5, temperature not specified in the publication
0.05
7-amino-3-(2-carboxyethyl)-1H-indole-2-carboxylic acid
Homo sapiens
above, pH 7.5, 37°C, recombinant His-tagged enzyme
0.002
diethyl (5-[4-amino-1-[(1R,2R)-bicyclo[2.2.1]hept-2-ylamino]-1H-benzimidazol-2-yl]furan-2-yl)phosphonate
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.004
diethyl (5-[4-amino-1-[3-(thiophen-3-ylmethyl)benzyl]-1H-benzimidazol-2-yl]furan-2-yl)phosphonate
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.0042
diethyl (5-[4-amino-1-[4-(furan-3-ylmethyl)benzyl]-1H-benzimidazol-2-yl]furan-2-yl)phosphonate
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.007
diethyl (5-[4-amino-1-[4-(trifluoromethyl)benzyl]-1H-benzimidazol-2-yl]furan-2-yl)phosphonate
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.005
diethyl [5-(4-amino-1-benzyl-1H-benzimidazol-2-yl)furan-2-yl]phosphonate
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.00225
diethyl [5-(4-amino-1-ethyl-1H-benzimidazol-2-yl)furan-2-yl]phosphonate
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.006
diethyl [5-(4-amino-1-methyl-1H-benzimidazol-2-yl)furan-2-yl]phosphonate
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.0011
diethyl [5-(4-amino-1-propyl-1H-benzimidazol-2-yl)furan-2-yl]phosphonate
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.0015
diethyl [5-[4-amino-1-(2-methylpropyl)-1H-benzimidazol-2-yl]furan-2-yl]phosphonate
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.00185
diethyl [5-[4-amino-1-(3-hydroxybenzyl)-1H-benzimidazol-2-yl]furan-2-yl]phosphonate
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.0095
diethyl [5-[4-amino-1-(4-tert-butylbenzyl)-1H-benzimidazol-2-yl]furan-2-yl]phosphonate
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.0025
diethyl [5-[4-amino-1-(biphenyl-4-ylmethyl)-1H-benzimidazol-2-yl]furan-2-yl]phosphonate
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.0008
diethyl [5-[4-amino-1-(cyclobutylmethyl)-1H-benzimidazol-2-yl]furan-2-yl]phosphonate
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.00325
diethyl [5-[4-amino-1-(cycloheptylmethyl)-1H-benzimidazol-2-yl]furan-2-yl]phosphonate
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.0025
diethyl [5-[4-amino-1-(cyclohexylmethyl)-1H-benzimidazol-2-yl]furan-2-yl]phosphonate
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.0015
diethyl [5-[4-amino-1-(cyclopentylmethyl)-1H-benzimidazol-2-yl]furan-2-yl]phosphonate
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.0008
diethyl [5-[4-amino-1-(cyclopropylmethyl)-1H-benzimidazol-2-yl]furan-2-yl]phosphonate
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.0026
N,N'-bis(6,7-diethoxy-2,3-dihydro-1H-cyclopenta[b]quinolin-9-yl)pentane-1,5-diamine
Homo sapiens
-
uncompetitive
0.0019
N-(5-bromo-1,3-benzoxazol-2-yl)-2,5-dichlorobenzenesulfonamide
Homo sapiens
-
-
0.0094
N-(5-chloro-1,3-benzoxazol-2-yl)-1-methyl-1H-imidazole-4-sulfonamide
Homo sapiens
-
-
0.023
N-(5-chloro-1,3-benzoxazol-2-yl)-2-(1H-imidazol-1-yl)benzenesulfonamide
Homo sapiens
-
-
0.006
N-(5-chloro-1,3-benzoxazol-2-yl)-2-cyanobenzenesulfonamide
Homo sapiens
-
-
0.0018
N-(5-chloro-1,3-benzoxazol-2-yl)-3-nitrobenzenesulfonamide
Homo sapiens
-
-
0.0067
N-(5-chloro-1,3-benzoxazol-2-yl)-4-(3-furyl)benzenesulfonamide
Homo sapiens
-
-
0.0078
N-(5-chloro-1,3-benzoxazol-2-yl)-4-(trifluoromethoxy)benzenesulfonamide
Homo sapiens
-
-
0.0028
N-(5-chloro-1,3-benzoxazol-2-yl)-4-fluorobenzenesulfonamide
Homo sapiens
-
-
0.0062
N-(5-chloro-1,3-benzoxazol-2-yl)-4-methylbenzenesulfonamide
Homo sapiens
-
-
0.0034
N-(5-chloro-1,3-benzoxazol-2-yl)anthracene-2-sulfonamide
Homo sapiens
-
-
0.0077
N-(5-chloro-1,3-benzoxazol-2-yl)benzenesulfonamide
Homo sapiens
-
-
0.0038
N-(5-chloro-1,3-benzoxazol-2-yl)biphenyl-2-sulfonamide
Homo sapiens
-
-
0.0098
N-(5-chloro-1,3-benzoxazol-2-yl)biphenyl-3-sulfonamide
Homo sapiens
-
-
0.004
N-(5-chloro-1,3-benzoxazol-2-yl)biphenyl-4-sulfonamide
Homo sapiens
-
-
0.0025
N-(5-chloro-1,3-benzoxazol-2-yl)naphthalene-2-sulfonamide
0.013
N-(5-chloro-1,3-benzoxazol-2-yl)thiophene-2-sulfonamide
Homo sapiens
-
-
0.032
N-(5-tert-butyl-1,3-benzoxazol-2-yl)-2,5-dichlorobenzenesulfonamide
Homo sapiens
-
-
0.0002
N-([4-bromo-6-[(2,2,2-trifluoroethyl)amino]pyridin-2-yl]carbamoyl)-5-(2-methoxyethyl)-4-methylthiophene-2-sulfonamide
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.00008
N-([4-bromo-6-[(methylcarbamoyl)amino]pyridin-2-yl]carbamoyl)-5-(2-methoxyethyl)-4-methylthiophene-2-sulfonamide
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.00033
N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-3-chlorobenzenesulfonamide
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.00013
N-[(6-amino-4-bromopyridin-2-yl)carbamoyl]-5-(2-methoxyethyl)-4-methylthiophene-2-sulfonamide
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.0004
N-[(6-amino-4-methoxypyridin-2-yl)carbamoyl]-5-(2-methoxyethyl)-4-methylthiophene-2-sulfonamide
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.00033
N-[(6-bromo-1H-indazol-4-yl)carbamoyl]-3-chlorobenzenesulfonamide
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.00014
N-[(6-bromo-1H-indazol-4-yl)carbamoyl]-5-(2-methoxyethyl)-4-methylthiophene-2-sulfonamide
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.00035
N-[(6-bromo-1H-indol-4-yl)carbamoyl]-3-chlorobenzenesulfonamide
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.00082
N-[(7-bromoimidazo[1,2-a]pyridin-5-yl)carbamoyl]-5-(2-methoxyethyl)-4-methylthiophene-2-sulfonamide
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.012
N-[4-[[(5-chloro-1,3-benzoxazol-2-yl)amino]sulfonyl]phenyl]butanamide
Homo sapiens
-
-
0.00057
N-[6-(4-aminophenyl)-5-methoxy-1,3-benzoxazol-2-yl]-2,5-dichlorobenzenesulfonamide
Homo sapiens
-
non-competitive
0.00057
N-[7-(3-aminophenyl)-5-methoxy-1,3-benzoxazol-2-yl]-2,5-dichlorobenzenesulfonamide
Homo sapiens
-
-
0.0013
N-[7-(4-aminophenyl)-5-methoxy-1,3-benzoxazol-2-yl]-2,5-dichlorobenzenesulfonamide
Homo sapiens
-
-
0.0026
N-[7-[3-(aminomethyl)phenyl]-5-methoxy-1,3-benzoxazol-2-yl]-2,5-dichlorobenzenesulfonamide
Homo sapiens
-
-
0.0018
N-[[6-amino-4-(methylsulfanyl)pyridin-2-yl]carbamoyl]-5-(2-methoxyethyl)-4-methylthiophene-2-sulfonamide
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.00076
N-[[6-amino-4-(trifluoromethyl)pyridin-2-yl]carbamoyl]-5-(2-methoxyethyl)-4-methylthiophene-2-sulfonamide
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.00042
N-[[6-amino-5-fluoro-4-(trifluoromethyl)pyridin-2-yl]carbamoyl]-5-(2-hydroxyethyl)-4-methylthiophene-2-sulfonamide
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.0006
N-[[6-amino-5-fluoro-4-(trifluoromethyl)pyridin-2-yl]carbamoyl]-5-(2-methoxyethyl)-4-methylthiophene-2-sulfonamide
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.0119
N4-(3-Bromo-phenyl)-7-chloro-quinazoline-4,6-diamine
Homo sapiens
-
IC50: 0.0119 mM
0.000047
[(2-amino-4,5-dihydronaphtho[1,2-d][1,3]thiazol-8-yl)(difluoro)methyl]phosphonic acid
Homo sapiens
-
0.00084
[(2-amino-4,5-dihydronaphtho[1,2-d][1,3]thiazol-8-yl)methyl]phosphonic acid
Homo sapiens
-
0.012
[(2R,3S,4R,5R)-5-[4-(aminocarbonyl)-1H-imidazol-1-yl]-3,4-dihydroxytetrahydrofuran-2-yl]methyl dihydrogen phosphate
Homo sapiens
-
-
0.5
[2-[(6-amino-8,9-dihydro-7H-purin-8-yl)amino]ethyl]phosphonate
Homo sapiens
-
0.097
[2-[[6-amino-9-(2-cyclohexylethyl)-8,9-dihydro-7H-purin-8-yl]amino]ethyl]phosphonate
Homo sapiens
-
0.026
[3-[6-amino-9-(2-cyclohexylethyl)-8,9-dihydro-7H-purin-8-yl]propyl]phosphonate
Homo sapiens
-
0.005
[5-(1,3-thiazol-4-yl)-2-furyl]phosphonic acid
Homo sapiens
-
-
0.00045
[5-(2-amino-1,3-thiazol-4-yl)-2-furyl]phosphonic acid
Homo sapiens
-
-
0.00012
[5-(2-amino-5-isobutyl-1,3-oxazol-4-yl)-2-furyl]phosphonic acid
Homo sapiens
-
-
0.000016
[5-(2-amino-5-isobutyl-1,3-thiazol-4-yl)-2-furyl]phosphonic acid
Homo sapiens
-
non-competitive
0.005
[5-(2-amino-5-isobutyl-1H-imidazol-4-yl)-2-furyl]phosphonic acid
Homo sapiens
-
-
0.000014
[5-(2-amino-5-phenyl-1,3-thiazol-4-yl)-2-furyl]phosphonic acid
Homo sapiens
-
-
0.000014
[5-(2-amino-5-phenyl-1,3-thiazol-4-yl)furan-2-yl]phosphonic acid
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.00003
[5-(2-amino-5-propyl-1,3-thiazol-4-yl)-2-furyl]phosphonic acid
Homo sapiens
-
-
0.01
[5-(2-amino-5-propyl-1,3-thiazol-4-yl)thiophen-2-yl]phosphonic acid
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.0016
[5-(4-amino-1-tert-butyl-2,3-dihydro-1H-benzimidazol-2-yl)-2-furyl]phosphonate
Homo sapiens
-
0.00009
[5-(4-amino-1-tert-butyl-7-ethyl-5-fluoro-2,3-dihydro-1H-benzimidazol-2-yl)-2-furyl]phosphonate
Homo sapiens
-
0.000055
[5-(4-amino-5-bromo-1-cyclopropyl-1H-benzimidazol-2-yl)furan-2-yl]phosphonic acid
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.0005
[5-(5-isobutyl-1,3-thiazol-4-yl)-2-furyl]phosphonic acid
Homo sapiens
-
-
0.000042
[5-(6-amino-3-phenylpyridin-2-yl)-2-furyl]phosphonic acid
Homo sapiens
-
-
0.0022
[5-(6-amino-9-tert-butyl-8,9-dihydro-7H-purin-8-yl)-2-furyl]phosphonate
Homo sapiens
-
0.000039
[5-[2-amino-5-(2-methylpropyl)-1,3-selenazol-4-yl]furan-2-yl]phosphonic acid
Homo sapiens
-
-
0.000001 - 0.000025
[5-[2-amino-5-(2-methylpropyl)-1,3-thiazol-4-yl]furan-2-yl]phosphonic acid
0.000014
[5-[2-amino-5-(ethoxycarbonyl)-1,3-thiazol-4-yl]furan-2-yl]phosphonic acid
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.000016
[5-[2-amino-5-(propylsulfanyl)-1,3-thiazol-4-yl]furan-2-yl]phosphonic acid
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.00015
[5-[4-amino-1-(2-ethylbutyl)-5-fluoro-1H-benzimidazol-2-yl]furan-2-yl]phosphonic acid
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.001
[5-[4-amino-5,7-dibromo-1-(2-methylpropyl)-1H-benzimidazol-2-yl]furan-2-yl]phosphonic acid
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.00045
[5-[4-amino-5,7-dichloro-1-(2-methylpropyl)-1H-benzimidazol-2-yl]furan-2-yl]phosphonic acid
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.0004
[5-[4-amino-5-bromo-1-(2-methylpropyl)-1H-benzimidazol-2-yl]furan-2-yl]phosphonic acid
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.01
[5-[4-amino-5-bromo-6,7-dichloro-1-(2-methylpropyl)-1H-benzimidazol-2-yl]furan-2-yl]phosphonic acid
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.0002
[5-[4-amino-5-chloro-1-(2-methylpropyl)-1H-benzimidazol-2-yl]furan-2-yl]phosphonic acid
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.0025
[5-[4-amino-5-ethyl-1-(2-methylpropyl)-1H-benzimidazol-2-yl]furan-2-yl]phosphonic acid
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.0001
[5-[4-amino-5-fluoro-1-(2-methylpropyl)-1H-benzimidazol-2-yl]furan-2-yl]phosphonic acid
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.00009
[5-[4-amino-5-fluoro-1-(2-methylpropyl)-7-phenyl-1H-benzimidazol-2-yl]furan-2-yl]phosphonic acid
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.0001
[5-[4-amino-5-fluoro-1-(2-methylpropyl)-7-propyl-1H-benzimidazol-2-yl]furan-2-yl]phosphonic acid
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.00085
[5-[4-amino-5-fluoro-1-(pentan-3-yl)-1H-benzimidazol-2-yl]furan-2-yl]phosphonic acid
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.00008
[5-[4-amino-5-fluoro-7-(2-methoxyethyl)-1-(2-methylpropyl)-1H-benzimidazol-2-yl]furan-2-yl]phosphonic acid
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.0001
[5-[4-amino-5-fluoro-7-(3-methylbutyl)-1-(2-methylpropyl)-1H-benzimidazol-2-yl]furan-2-yl]phosphonic acid
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.00018
[5-[4-amino-5-fluoro-7-(4-fluorophenyl)-1-(2-methylpropyl)-1H-benzimidazol-2-yl]furan-2-yl]phosphonic acid
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.0005
[5-[4-amino-5-hydroxy-1-(2-methylpropyl)-1H-benzimidazol-2-yl]furan-2-yl]phosphonic acid
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.0007 - 0.003
[5-[4-amino-5-methoxy-1-(2-methylpropyl)-1H-benzimidazol-2-yl]furan-2-yl]phosphonic acid
0.000225
[5-[4-amino-6-chloro-5-fluoro-1-(2-methylpropyl)-1H-benzimidazol-2-yl]furan-2-yl]phosphonic acid
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.00021
[5-[4-amino-7-(3,3-dimethylbutyl)-5-fluoro-1-(2-methylpropyl)-1H-benzimidazol-2-yl]furan-2-yl]phosphonic acid
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.00009
[5-[4-amino-7-(4-chlorophenyl)-5-fluoro-1-(2-methylpropyl)-1H-benzimidazol-2-yl]furan-2-yl]phosphonic acid
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.00007
[5-[4-amino-7-(6-chlorohexyl)-5-fluoro-1-(2-methylpropyl)-1H-benzimidazol-2-yl]furan-2-yl]phosphonic acid
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.0004
[5-[4-amino-7-bromo-1-(2-methylpropyl)-1H-benzimidazol-2-yl]furan-2-yl]phosphonic acid
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.00013
[5-[4-amino-7-bromo-5-fluoro-1-(2-methylpropyl)-1H-benzimidazol-2-yl]furan-2-yl]phosphonic acid
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.0009
[5-[4-amino-7-chloro-1-(2-methylpropyl)-1H-benzimidazol-2-yl]furan-2-yl]phosphonic acid
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.0001
[5-[4-amino-7-chloro-5-fluoro-1-(2-methylpropyl)-1H-benzimidazol-2-yl]furan-2-yl]phosphonic acid
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.00006
[5-[4-amino-7-cyclopropyl-5-fluoro-1-(2-methylpropyl)-1H-benzimidazol-2-yl]furan-2-yl]phosphonic acid
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.00028
[5-[4-amino-7-ethenyl-5-fluoro-1-(2-methylpropyl)-1H-benzimidazol-2-yl]furan-2-yl]phosphonic acid
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.000055
[5-[4-amino-7-ethyl-5-fluoro-1-(2-methylpropyl)-1H-benzimidazol-2-yl]furan-2-yl]phosphonic acid
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.00056
[5-[5-(2-methylpropyl)-2-phenyl-1,3-thiazol-4-yl]furan-2-yl]phosphonic acid
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.0011
[5-[6-amino-9-(2,2-dimethylpropyl)-8,9-dihydro-7H-purin-8-yl]-2-furyl]phosphonate
Homo sapiens
-
0.0012
[5-[6-amino-9-(2-cyclohexylethyl)-8,9-dihydro-7H-purin-8-yl]-2-furyl]phosphonate
Homo sapiens
-
0.005 - 0.015
[5-[6-amino-9-(2-phenylethyl)-8,9-dihydro-7H-purin-8-yl]-2-furyl]phosphonate
0.00019
AMP
Homo sapiens
wild-type, pH 7.4, 25°C, Hill-coefficient 1.34
0.00365
AMP
Homo sapiens
mutant Q32R, pH 7.4, 25°C, Hill-coefficient 0.59
0.0034
2,5-dichloro-N-(5-chloro-1,3-benzoxazol-2-yl)benzenesulfonamide
Homo sapiens
-
-
0.0034
2,5-dichloro-N-(5-chloro-1,3-benzoxazol-2-yl)benzenesulfonamide
Homo sapiens
-
non-competitive
0.0024
3-(2-carboxyethyl)-4-(2-fluorophenyl)-7-nitro-1H-indole-2-carboxylic acid
Homo sapiens
37°C, pH 7.5
0.0024
3-(2-carboxyethyl)-4-(2-fluorophenyl)-7-nitro-1H-indole-2-carboxylic acid
Homo sapiens
pH 7.5, 37°C, recombinant His-tagged enzyme
0.00527
3-(2-carboxyethyl)-4-(3-fluorophenyl)-7-nitro-1H-indole-2-carboxylic acid
Homo sapiens
37°C, pH 7.5
0.00527
3-(2-carboxyethyl)-4-(3-fluorophenyl)-7-nitro-1H-indole-2-carboxylic acid
Homo sapiens
pH 7.5, 37°C, recombinant His-tagged enzyme
0.00522
3-(2-carboxyethyl)-4-(3-methoxyphenyl)-7-nitro-1H-indole-2-carboxylic acid
Homo sapiens
37°C, pH 7.5
0.00522
3-(2-carboxyethyl)-4-(3-methoxyphenyl)-7-nitro-1H-indole-2-carboxylic acid
Homo sapiens
pH 7.5, 37°C, recombinant His-tagged enzyme
0.0024
3-(2-carboxyethyl)-4-(4-fluorophenyl)-7-nitro-1H-indole-2-carboxylic acid
Homo sapiens
37°C, pH 7.5
0.0024
3-(2-carboxyethyl)-4-(4-fluorophenyl)-7-nitro-1H-indole-2-carboxylic acid
Homo sapiens
pH 7.5, 37°C, recombinant His-tagged enzyme
0.0018
3-(2-carboxyethyl)-4-(4-methoxyphenyl)-7-nitro-1H-indole-2-carboxylic acid
Homo sapiens
37°C, pH 7.5
0.0018
3-(2-carboxyethyl)-4-(4-methoxyphenyl)-7-nitro-1H-indole-2-carboxylic acid
Homo sapiens
pH 7.5, 37°C, recombinant His-tagged enzyme
0.00088
3-(2-carboxyethyl)-4-chloro-7-nitro-1H-indole-2-carboxylic acid
Homo sapiens
37°C, pH 7.5
0.00088
3-(2-carboxyethyl)-4-chloro-7-nitro-1H-indole-2-carboxylic acid
Homo sapiens
pH 7.5, 37°C, recombinant His-tagged enzyme
0.00276
3-(2-carboxyethyl)-4-ethyl-7-nitro-1H-indole-2-carboxylic acid
Homo sapiens
37°C, pH 7.5
0.00276
3-(2-carboxyethyl)-4-ethyl-7-nitro-1H-indole-2-carboxylic acid
Homo sapiens
pH 7.5, 37°C, recombinant His-tagged enzyme
0.00207
3-(2-carboxyethyl)-5-chloro-7-nitro-1H-indole-2-carboxylic acid
Homo sapiens
37°C, pH 7.5
0.00207
3-(2-carboxyethyl)-5-chloro-7-nitro-1H-indole-2-carboxylic acid
Homo sapiens
pH 7.5, 37°C, recombinant His-tagged enzyme
0.00517
3-(2-carboxyethyl)-7-nitro-1H-indole-2-carboxylic acid
Homo sapiens
37°C, pH 7.5
0.00517
3-(2-carboxyethyl)-7-nitro-1H-indole-2-carboxylic acid
Homo sapiens
pH 7.5, 37°C, recombinant His-tagged enzyme
0.0011
3-(2-carboxyethyl)-7-nitro-4-(3-nitrophenyl)-1H-indole-2-carboxylic acid
Homo sapiens
37°C, pH 7.5
0.0011
3-(2-carboxyethyl)-7-nitro-4-(3-nitrophenyl)-1H-indole-2-carboxylic acid
Homo sapiens
pH 7.5, 37°C, recombinant His-tagged enzyme
0.002
3-(2-carboxyethyl)-7-nitro-4-(4-nitrophenyl)-1H-indole-2-carboxylic acid
Homo sapiens
37°C, pH 7.5
0.002
3-(2-carboxyethyl)-7-nitro-4-(4-nitrophenyl)-1H-indole-2-carboxylic acid
Homo sapiens
pH 7.5, 37°C, recombinant His-tagged enzyme
0.0014
3-(2-carboxyethyl)-7-nitro-4-phenyl-1H-indole-2-carboxylic acid
Homo sapiens
37°C, pH 7.5
0.0014
3-(2-carboxyethyl)-7-nitro-4-phenyl-1H-indole-2-carboxylic acid
Homo sapiens
pH 7.5, 37°C, recombinant His-tagged enzyme
0.00643
3-(2-carboxyethyl)-7-nitro-5-phenyl-1H-indole-2-carboxylic acid
Homo sapiens
37°C, pH 7.5
0.00643
3-(2-carboxyethyl)-7-nitro-5-phenyl-1H-indole-2-carboxylic acid
Homo sapiens
pH 7.5, 37°C, recombinant His-tagged enzyme
0.00014
AMP
Homo sapiens
-
mutant DELTA3
0.00016
AMP
Homo sapiens
-
wild-type enzyme
0.00016
AMP
Homo sapiens
-
wild-type muscle enzyme
0.00033
AMP
Homo sapiens
-
mutant DELTA4
0.00081
AMP
Homo sapiens
-
mutant DELTA5
0.001
AMP
Homo sapiens
-
-
0.00139
AMP
Homo sapiens
-
mutant DELTA6
0.00197
AMP
Homo sapiens
-
mutant DELTA10
0.00393
AMP
Homo sapiens
-
mutant DELTA7
0.00425
AMP
Homo sapiens
-
mutant DELTA8
0.00506
AMP
Homo sapiens
-
wild-type liver enzyme
0.00077
Ca2+
Homo sapiens
-
mutant DELTA4
0.00091
Ca2+
Homo sapiens
-
wild-type muscle enzyme
0.00099
Ca2+
Homo sapiens
-
mutant DELTA3
0.00131
Ca2+
Homo sapiens
-
mutant DELTA6
0.00137
Ca2+
Homo sapiens
-
mutant DELTA5
0.00218
Ca2+
Homo sapiens
-
mutant DELTA7
0.00689
Ca2+
Homo sapiens
-
wild-type liver enzyme, biphasic inhibition by Ca2+
0.00731
Ca2+
Homo sapiens
-
mutant DELTA10
0.934
Ca2+
Homo sapiens
-
wild-type liver enzyme, biphasic inhibition by Ca2+
0.0025
N-(5-chloro-1,3-benzoxazol-2-yl)naphthalene-2-sulfonamide
Homo sapiens
-
-
0.0025
N-(5-chloro-1,3-benzoxazol-2-yl)naphthalene-2-sulfonamide
Homo sapiens
-
non-competitive
0.000001
[5-[2-amino-5-(2-methylpropyl)-1,3-thiazol-4-yl]furan-2-yl]phosphonic acid
Homo sapiens
-
0.000025
[5-[2-amino-5-(2-methylpropyl)-1,3-thiazol-4-yl]furan-2-yl]phosphonic acid
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.0007
[5-[4-amino-5-methoxy-1-(2-methylpropyl)-1H-benzimidazol-2-yl]furan-2-yl]phosphonic acid
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.003
[5-[4-amino-5-methoxy-1-(2-methylpropyl)-1H-benzimidazol-2-yl]furan-2-yl]phosphonic acid
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.005
[5-[6-amino-9-(2-phenylethyl)-8,9-dihydro-7H-purin-8-yl]-2-furyl]phosphonate
Homo sapiens
-
0.015
[5-[6-amino-9-(2-phenylethyl)-8,9-dihydro-7H-purin-8-yl]-2-furyl]phosphonate
Homo sapiens
-
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Dzugaj, A.; Kochman, M.
Purification of human liver fructose-1,6-bisphosphatase
Biochim. Biophys. Acta
614
407-412
1980
Homo sapiens
brenda
Skalecki, K.; Rakus, D.; Wisniewski, J.R.; Kolodziej, J.; Dzugaj, A.
cDNA sequence and kinetic properties of human lung fructose(1,6)bisphosphatase
Arch. Biochem. Biophys.
365
1-9
1999
Homo sapiens (P09467)
brenda
Iversen, L.F.; Brzozowski, M.; Hastrup, S.; Hubbard, R.; Kastrup, J.S.; Larsen, I.K.; Naerum, L.; Norskov-Lauridsen, L.; Rasmussen, P.B.; Thim, L.; Wiberg, F.C.; Lundgren, K.
Characterization of the allosteric binding pocket of human liver fructose-1,6-bisphosphatase by protein crystallography and inhibitor activity studies
Protein Sci.
6
971-982
1997
Homo sapiens
brenda
Skalecki, K.; Mularczyk, W.; Dzugaj, A.
Kinetic properties of D-fructose-1,6-bisphosphate 1-phosphohydrolase isolated from human muscle
Biochem. J.
310
1029-1035
1995
Homo sapiens
brenda
Adams, A.; Redden, C.; Menahem, S.
Characterization of human fructose 1,6-bisphosphatase in control and deficient tissues
J. Inherit. Metab. Dis.
13
829-848
1990
Homo sapiens
brenda
Koekemoer, T.C.; Stanton, L.A.; Oelofsen, W.
Kinetic properties of ovine adipose tissue fructose-1,6-bisphosphatase
Comp. Biochem. Physiol. B
109
443-450
1994
Oryctolagus cuniculus, Ovis aries, Homo sapiens, Rattus norvegicus
-
brenda
Zhu, D.W.; Xu, G.J.; Rehse, P.H.; Shi, R.; Zhao, F.K.; Lin, S.X.
Crystallization and preliminary crystallographic data of fructose-1,6-bisphosphatase from human muscle
Acta Crystallogr. Sect. D
57
847-849
2001
Homo sapiens
brenda
Zhang, F.W.; Zhao, F.K.; Xu, G.J.
Molecular cloning, expression and purification of muscle fructose-1,6-bisphosphatase from Zaocys dhumnades: the role of the N-terminal sequence in AMP activation at alkaline pH
Biol. Chem.
381
561-566
2000
Homo sapiens, Rattus norvegicus, Sus scrofa, Ptyas dhumnades
brenda
Wright, S.W.; Hageman, D.L.; McClure, L.D.; Carlo, A.A.; Treadway, J.L.; Mathiowetz, A.M.; Withka, J.M.; Bauer, P.H.
Allosteric inhibition of fructose-1,6-bisphosphatase by anilinoquinazolines
Bioorg. Med. Chem. Lett.
11
17-21
2001
Oryctolagus cuniculus, Homo sapiens, Rattus norvegicus
brenda
Rakus, D.; Skalecki, K.; Dzugaj, A.
Kinetic properties of pig (Sus scrofa domestica) and bovine (Bos taurus) D-fructose-1,6-bisphosphate 1-phosphohydrolase (F1,6BPase): liver-like isozymes in mammalian lung tissue
Comp. Biochem. Physiol. B
127
123-134
2000
Bos taurus, Oryctolagus cuniculus, Homo sapiens, Sus scrofa domesticus
brenda
Gizak, A.; Rakus, D.; Kolodziej, J.; Zabel, M.; Ogorzalek, A.; Dzugaj, A.
Human lung fructose-1,6-bisphosphatase is localized in pneumocytes II
Histol. Histopathol.
16
53-55
2001
Homo sapiens
brenda
Gizak, A.; Rakus, D.; Dzugaj, A.
Immunohistochemical localization of human fructose-1,6-bisphosphatase in subcellular structures of myocytes
Histol. Histopathol.
18
135-142
2003
Homo sapiens
brenda
von Geldern, T.W.; Lai, C.; Gum, R.J.; Daly, M.; Sun, C.; Fry, E.H.; Abad-Zapatero, C.
Benzoxazole benzenesulfonamides are novel allosteric inhibitors of fructose-1,6-bisphosphatase with a distinct binding mode
Bioorg. Med. Chem. Lett.
16
1811-1815
2006
Homo sapiens
brenda
Muindi, J.R.; Peng, Y.; Wilson, J.W.; Johnson, C.S.; Branch, R.A.; Trump, D.L.
Monocyte fructose 1,6-bisphosphatase and cytidine deaminase enzyme activities: potential pharmacodynamic measures of calcitriol effects in cancer patients
Cancer Chemother. Pharmacol.
59
97-104
2006
Homo sapiens
brenda
Rakus, D.; Maciaszczyk, E.; Wawrzycka, D.; Ulaszewski, S.; Eschrich, K.; Dzugaj, A.
The origin of the high sensitivity of muscle fructose 1,6-bisphosphatase towards AMP
FEBS Lett.
579
5577-5581
2005
Homo sapiens (P09467)
brenda
Yanez, A.J.; Bertinat, R.; Spichiger, C.; Carcamo, J.G.; de Los Angeles Garcia, M.; Concha, II; Nualart, F.; Slebe, J.C.
Novel expression of liver FBPase in Langerhans islets of human and rat pancreas
J. Cell. Physiol.
205
19-24
2005
Homo sapiens, Rattus norvegicus
brenda
Cazalis, R.; Chueca, A.; Sahrawy, M.; Lopez-Gorge, J.
Construction of chimeric cytosolic fructose-1,6-bisphosphatases by insertion of a chloroplastic redox regulatory cluster
J. Physiol. Biochem.
60
7-22
2004
Beta vulgaris, Homo sapiens
brenda
Lai, C.; Gum, R.J.; Daly, M.; Fry, E.H.; Hutchins, C.; Abad-Zapatero, C.; von Geldern, T.W.
Benzoxazole benzenesulfonamides as allosteric inhibitors of fructose-1,6-bisphosphatase
Bioorg. Med. Chem. Lett.
16
1807-1810
2006
Homo sapiens, Rattus norvegicus
brenda
Sybirna, N.; Dziewulska-Szwajkowska, D.; Barska, M.; Dzugaj, A.
Mononuclear and polymorphonuclear leukocytes show increased fructose-1,6-bisphosphatase activity in patients with type 1 diabetes mellitus
Cell Biol. Int.
30
624-630
2006
Homo sapiens
brenda
van Poelje, P.D.; Dang, Q.; Erion, M.D.
Discovery of fructose-1,6-bisphosphatase inhibitors for the treatment of type 2 diabetes
Curr. Opin. Drug Discov. Devel.
10
430-437
2007
Homo sapiens
brenda
Lamont, B.J.; Visinoni, S.; Fam, B.C.; Kebede, M.; Weinrich, B.; Papapostolou, S.; Massinet, H.; Proietto, J.; Favaloro, J.; Andrikopoulos, S.
Expression of human fructose-1,6-bisphosphatase in the liver of transgenic mice results in increased glycerol gluconeogenesis
Endocrinology
147
2764-2772
2006
Homo sapiens
brenda
Erion, M.D.; Dang, Q.; Reddy, M.R.; Kasibhatla, S.R.; Huang, J.; Lipscomb, W.N.; van Poelje, P.D.
Structure-guided design of AMP mimics that inhibit fructose-1,6-bisphosphatase with high affinity and specificity
J. Am. Chem. Soc.
129
15480-15490
2007
Homo sapiens (P09467), Homo sapiens
brenda
Dang, Q.; Kasibhatla, S.R.; Reddy, K.R.; Jiang, T.; Reddy, M.R.; Potter, S.C.; Fujitaki, J.M.; van Poelje, P.D.; Huang, J.; Lipscomb, W.N.; Erion, M.D.
Discovery of potent and specific fructose-1,6-bisphosphatase inhibitors and a series of orally-bioavailable phosphoramidase-sensitive prodrugs for the treatment of type 2 diabetes
J. Am. Chem. Soc.
129
15491-15502
2007
Homo sapiens, Rattus norvegicus
brenda
Mutyala, R.; Reddy, R.N.; Sumakanth, M.; Reddanna, P.; Reddy, M.R.
Calculation of relative binding affinities of fructose 1,6-bisphosphatase mutants with adenosine monophosphate using free energy perturbation method
J. Comput. Chem.
28
932-937
2007
Homo sapiens
brenda
Gizak, A.; Maciaszczyk, E.; Dzugaj, A.; Eschrich, K.; Rakus, D.
Evolutionary conserved N-terminal region of human muscle fructose 1,6-bisphosphatase regulates its activity and the interaction with aldolase
Proteins
72
209-216
2008
Homo sapiens
brenda
Visinoni, S.; Fam, B.C.; Blair, A.; Rantzau, C.; Lamont, B.J.; Bouwman, R.; Watt, M.J.; Proietto, J.; Favaloro, J.M.; Andrikopoulos, S.
Increased glucose production in mice overexpressing human fructose-1,6-bisphosphatase in the liver
Am. J. Physiol. Endocrinol. Metab.
295
E1132-E1141
2008
Homo sapiens
brenda
Bigl, M.; Jandrig, B.; Horn, L.C.; Eschrich, K.
Aberrant methylation of human L- and M-fructose 1,6-bisphosphatase genes in cancer
Biochem. Biophys. Res. Commun.
377
720-724
2008
Homo sapiens
brenda
Kepka, A.; Dariusz Szajda, S.; Stypu?kowska, A.; Waszkiewicz, N.; Jankowska, A.; Chojnowska, S.; Zwierz, K.
Urinary fructose-1,6-bisphosphatase activity as a marker of the damage to the renal proximal tubules in children with idiopathic nephrotic syndrome
Clin. Chem. Lab. Med.
46
831-835
2008
Homo sapiens
brenda
Kebede, M.; Favaloro, J.; Gunton, J.E.; Laybutt, D.R.; Shaw, M.; Wong, N.; Fam, B.C.; Aston-Mourney, K.; Rantzau, C.; Zulli, A.; Proietto, J.; Andrikopoulos, S.
Fructose-1,6-bisphosphatase overexpression in pancreatic beta-cells results in reduced insulin secretion: a new mechanism for fat-induced impairment of beta-cell function
Diabetes
57
1887-1895
2008
Homo sapiens
brenda
Dang, Q.; Kasibhatla, S.R.; Jiang, T.; Fan, K.; Liu, Y.; Taplin, F.; Schulz, W.; Cashion, D.K.; Reddy, K.R.; van Poelje, P.D.; Fujitaki, J.M.; Potter, S.C.; Erion, M.D.
Discovery of phosphonic diamide prodrugs and their use for the oral delivery of a series of fructose 1,6-bisphosphatase inhibitors
J. Med. Chem.
51
4331-4339
2008
Homo sapiens, Rattus norvegicus
brenda
Tsukada, T.; Takahashi, M.; Takemoto, T.; Kanno, O.; Yamane, T.; Kawamura, S.; Nishi, T.
Synthesis, SAR, and X-ray structure of tricyclic compounds as potent FBPase inhibitors
Bioorg. Med. Chem. Lett.
19
5909-5912
2009
Homo sapiens (P09467), Homo sapiens
brenda
Gizak, A.; Maciaszczyk-Dziubinska, E.; Jurowicz, M.; Rakus, D.
Muscle FBPase is targeted to nucleus by its 203KKKGK207 sequence
Proteins
77
262-267
2009
Homo sapiens
brenda
Hebeisen, P.; Haap, W.; Kuhn, B.; Mohr, P.; Wessel, H.P.; Zutter, U.; Kirchner, S.; Ruf, A.; Benz, J.; Joseph, C.; Alvarez-Sanchez, R.; Gubler, M.; Schott, B.; Benardeau, A.; Tozzo, E.; Kitas, E.
Orally active aminopyridines as inhibitors of tetrameric fructose-1,6-bisphosphatase
Bioorg. Med. Chem. Lett.
21
3237-3242
2011
Homo sapiens, Mus musculus
brenda
Dang, Q.; Kasibhatla, S.R.; Xiao, W.; Liu, Y.; Dare, J.; Taplin, F.; Reddy, K.R.; Scarlato, G.R.; Gibson, T.; van Poelje, P.D.; Potter, S.C.; Erion, M.D.
Fructose-1,6-bisphosphatase Inhibitors. 2. Design, synthesis, and structure-activity relationship of a series of phosphonic acid containing benzimidazoles that function as 5-adenosinemonophosphate (AMP) mimics
J. Med. Chem.
53
441-451
2010
Homo sapiens, Rattus norvegicus
brenda
Dang, Q.; Liu, Y.; Cashion, D.K.; Kasibhatla, S.R.; Jiang, T.; Taplin, F.; Jacintho, J.D.; Li, H.; Sun, Z.; Fan, Y.; Dare, J.; Tian, F.; Li, W.; Gibson, T.; Lemus, R.; van Poelje, P.D.; Potter, S.C.; Erion, M.D.
Discovery of a series of phosphonic Acid-containing thiazoles and orally bioavailable diamide prodrugs that lower glucose in diabetic animals through inhibition of fructose-1,6-bisphosphatase
J. Med. Chem.
54
153-165
2011
Homo sapiens
brenda
Bie, J.; Liu, S.; Zhou, J.; Xu, B.; Shen, Z.
Design, synthesis and biological evaluation of 7-nitro-1H-indole-2-carboxylic acid derivatives as allosteric inhibitors of fructose-1,6-bisphosphatase
Bioorg. Med. Chem.
22
1850-1862
2014
Homo sapiens
brenda
Visinoni, S.; Khalid, N.F.; Joannides, C.N.; Shulkes, A.; Yim, M.; Whitehead, J.; Tiganis, T.; Lamont, B.J.; Favaloro, J.M.; Proietto, J.; Andrikopoulos, S.; Fam, B.C.
The role of liver fructose-1,6-bisphosphatase in regulating appetite and adiposity
Diabetes
61
1122-1132
2012
Homo sapiens (P09467)
brenda
Liao, B.R.; He, H.B.; Yang, L.L.; Gao, L.X.; Chang, L.; Tang, J.; Li, J.Y.; Li, J.; Yang, F.
Synthesis and structure-activity relationship of non-phosphorus-based fructose-1,6-bisphosphatase inhibitors: 2,5-diphenyl-1,3,4-oxadiazoles
Eur. J. Med. Chem.
83
15-25
2014
Homo sapiens
brenda
Pirog, M.; Gizak, A.; Rakus, D.
Changes in quaternary structure of muscle fructose-1,6-bisphosphatase regulate affinity of the enzyme to mitochondria
Int. J. Biochem. Cell Biol.
48
55-59
2014
Homo sapiens (O00757)
brenda
Li, B.; Qiu, B.; Lee, D.S.; Walton, Z.E.; Ochocki, J.D.; Mathew, L.K.; Mancuso, A.; Gade, T.P.; Keith, B.; Nissim, I.; Simon, M.C.
Fructose-1,6-bisphosphatase opposes renal carcinoma progression
Nature
513
251-255
2014
Homo sapiens
brenda
Shi, R.; Chen, Z.Y.; Zhu, D.W.; Li, C.; Shan, Y.; Xu, G.; Lin, S.X.
Crystal structures of human muscle fructose-1,6-bisphosphatase: novel quaternary states, enhanced AMP affinity, and allosteric signal transmission pathway
PLoS ONE
8
e71242
2013
Homo sapiens (O00757), Homo sapiens
brenda
Rakus, D.; Gizak, A.; Kasprzak, A.A.; Zarzycki, M.; Maciaszczyk-Dziubinska, E.; Dzugaj, A.
The mechanism of calcium-induced inhibition of muscle fructose 1,6-bisphosphatase and destabilization of glyconeogenic complex
PLoS ONE
8
e76669
2013
Homo sapiens
brenda
Ruf, A.; Tetaz, T.; Schott, B.; Joseph, C.; Rudolph, M.
Quadruple space-group ambiguity owing to rotational and translational noncrystallographic symmetry in human liver fructose-1,6-bisphosphatase
Acta Crystallogr. Sect. D
72
1212-1224
2016
Homo sapiens (P09467), Homo sapiens
brenda
Barciszewski, J.; Wisniewski, J.; Kolodziejczyk, R.; Jaskolski, M.; Rakus, D.; Dzugaj, A.
T-to-R switch of muscle fructose-1,6-bisphosphatase involves fundamental changes of secondary and quaternary structure
Acta Crystallogr. Sect. D
72
536-550
2016
Homo sapiens (O00757), Homo sapiens
brenda
Li, K.; Ying, M.; Feng, D.; Du, J.; Chen, S.; Dan, B.; Wang, C.; Wang, Y.
Fructose-1,6-bisphosphatase is a novel regulator of Wnt/beta-catenin pathway in breast cancer
Biomed. Pharmacother.
84
1144-1149
2016
Homo sapiens (O00757), Homo sapiens (P09467)
brenda
Topaz, G.R.; Epiter-Smith, V.; Robolo, C.; Emad, M.; Ford, V.; Daley, J.; Byron, J.; Stieglitz, K.A.
Characterization of recombinant fructose 1,6-bisphosphatase (FBPase) gene mutations evidence of inhibition/activation of FBPase protein by gene mutation
Biosci. Rep.
39
BSR20180960
2019
Sus scrofa (P00636), Homo sapiens (P09467), Homo sapiens
brenda
Bie, J.; Liu, S.; Li, Z.; Mu, Y.; Xu, B.; Shen, Z.
Discovery of novel indole derivatives as allosteric inhibitors of fructose-1,6-bisphosphatase
Eur. J. Med. Chem.
90
394-405
2015
Homo sapiens, Homo sapiens (P09467)
brenda
Han, X.; Huang, Y.; Zhang, R.; Xiao, S.; Zhu, S.; Qin, N.; Hong, Z.; Wei, L.; Feng, J.; Ren, Y.; Feng, L.; Wan, J.
New insight into the binding modes of TNP-AMP to human liver fructose-1,6-bisphosphatase
Spectrochim. Acta A. Mol. Biomol. Spectrosc.
165
155-160
2016
Homo sapiens
brenda