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Literature summary for 3.1.3.11 extracted from

  • Wright, S.W.; Hageman, D.L.; McClure, L.D.; Carlo, A.A.; Treadway, J.L.; Mathiowetz, A.M.; Withka, J.M.; Bauer, P.H.
    Allosteric inhibition of fructose-1,6-bisphosphatase by anilinoquinazolines (2001), Bioorg. Med. Chem. Lett., 11, 17-21.
    View publication on PubMed
Search for more literature for 3.1.3.11

Inhibitors

Inhibitors Comment Organism Structure
(3-Bromo-phenyl)-(6,7-diethoxy-quinazolin-4-yl)-amine IC50: 0.0017 mM Homo sapiens
(3-Bromo-phenyl)-(6,7-dimethoxy-2-methyl-quinazolin-4-yl)-amine IC50: 0.0045 mM Homo sapiens
(3-Bromo-phenyl)-(6,7-dimethoxy-quinazolin-4-yl)-amine IC50: 0.001 mM Homo sapiens
(3-Bromo-phenyl)-(7-ethoxy-6-nitro-quinazolin-4-yl)-amine IC50: 0.0039 mM Homo sapiens
(3-Bromo-phenyl)-[6-(2-methoxy-ethoxy)-quinazolin-4-yl]-amine IC50: 0.0029 mM Homo sapiens
(3-Bromo-phenyl)-[7-methoxy-6-(2-methoxy-ethoxy)-quinazolin-4-yl]-amine IC50: 0.0055 mM Homo sapiens
(3-Chloro-4-fluoro-phenyl)-(6,7-diethoxy-quinazolin-4-yl)-amine IC50: 0.00053 mM Homo sapiens
(3-Chloro-phenyl)-(6,7-diethoxy-quinazolin-4-yl)-amine IC50: 0.0016 mM Homo sapiens
(3-Chloro-phenyl)-(6,7-dimethoxy-quinazolin-4-yl)-amine IC50: 0.0013 mM Homo sapiens
(6,7-Diethoxy-quinazolin-4-yl)-(3-ethynyl-phenyl)-amine IC50: 0.0024 mM Homo sapiens
(6,7-Diethoxy-quinazolin-4-yl)-(3-fluoro-phenyl)-amine IC50: 0.0092 mM Homo sapiens
(6,7-Diethoxy-quinazolin-4-yl)-(3-iodo-phenyl)-amine IC50: 0.0021 mM Homo sapiens
(6,7-Dimethoxy-quinazolin-4-yl)-(3-ethynyl-phenyl)-amine IC50: 0.0009 mM Homo sapiens
4-anilinoquinazoline low molecular weight inhibitors of enzyme that are not substrate mimics or AMP analogues Homo sapiens
N4-(3-Bromo-phenyl)-7-chloro-quinazoline-4,6-diamine IC50: 0.0119 mM Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
D-fructose 1,6-bisphosphate + H2O Homo sapiens enzyme is usually regarded as a regulatory enzyme of gluconeogenesis D-fructose 6-phosphate + phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Oryctolagus cuniculus
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-
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Rattus norvegicus
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-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-fructose 1,6-bisphosphate + H2O
-
 Homo sapiens D-fructose 6-phosphate + phosphate
-
 ?
D-fructose 1,6-bisphosphate + H2O enzyme is usually regarded as a regulatory enzyme of gluconeogenesis Homo sapiens D-fructose 6-phosphate + phosphate
-
 ?

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00053
-
 IC50: 0.00053 mM Homo sapiens (3-Chloro-4-fluoro-phenyl)-(6,7-diethoxy-quinazolin-4-yl)-amine
0.0009
-
 IC50: 0.0009 mM Homo sapiens (6,7-Dimethoxy-quinazolin-4-yl)-(3-ethynyl-phenyl)-amine
0.001
-
 IC50: 0.001 mM Homo sapiens (3-Bromo-phenyl)-(6,7-dimethoxy-quinazolin-4-yl)-amine
0.0013
-
 IC50: 0.0013 mM Homo sapiens (3-Chloro-phenyl)-(6,7-dimethoxy-quinazolin-4-yl)-amine
0.0016
-
 IC50: 0.0016 mM Homo sapiens (3-Chloro-phenyl)-(6,7-diethoxy-quinazolin-4-yl)-amine
0.0017
-
 IC50: 0.0017 mM Homo sapiens (3-Bromo-phenyl)-(6,7-diethoxy-quinazolin-4-yl)-amine
0.0021
-
 IC50: 0.0021 mM Homo sapiens (6,7-Diethoxy-quinazolin-4-yl)-(3-iodo-phenyl)-amine
0.0024
-
 IC50: 0.0024 mM Homo sapiens (6,7-Diethoxy-quinazolin-4-yl)-(3-ethynyl-phenyl)-amine
0.0029
-
 IC50: 0.0029 mM Homo sapiens (3-Bromo-phenyl)-[6-(2-methoxy-ethoxy)-quinazolin-4-yl]-amine
0.0039
-
 IC50: 0.0039 mM Homo sapiens (3-Bromo-phenyl)-(7-ethoxy-6-nitro-quinazolin-4-yl)-amine
0.0045
-
 IC50: 0.0045 mM Homo sapiens (3-Bromo-phenyl)-(6,7-dimethoxy-2-methyl-quinazolin-4-yl)-amine
0.0055
-
 IC50: 0.0055 mM Homo sapiens (3-Bromo-phenyl)-[7-methoxy-6-(2-methoxy-ethoxy)-quinazolin-4-yl]-amine
0.0092
-
 IC50: 0.0092 mM Homo sapiens (6,7-Diethoxy-quinazolin-4-yl)-(3-fluoro-phenyl)-amine
0.0119
-
 IC50: 0.0119 mM Homo sapiens N4-(3-Bromo-phenyl)-7-chloro-quinazoline-4,6-diamine