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Literature summary for 3.1.3.11 extracted from

  • Rakus, D.; Gizak, A.; Kasprzak, A.A.; Zarzycki, M.; Maciaszczyk-Dziubinska, E.; Dzugaj, A.
    The mechanism of calcium-induced inhibition of muscle fructose 1,6-bisphosphatase and destabilization of glyconeogenic complex (2013), PLoS ONE, 8, e76669.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.3.11

Inhibitors

Inhibitors Comment Organism Structure
AMP
-
 Homo sapiens
Ca2+ Ca2+ affects conformation of the catalytic loop 52-72 of muscle FBPase and inhibits its activity by competing with activatory divalent cations, e.g. Mg2+ and Zn2+. Aldolase associates with FBPase in its active form, i.e. with loop 52-72 in the engaged conformation, while Ca2+ stabilizes the disengaged-like form of the loop Homo sapiens
D-fructose 1,6-bisphosphate
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
muscle
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-fructose 1,6-bisphosphate + H2O
-
 Homo sapiens D-fructose 6-phosphate + phosphate
-
 ?

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
21.7
-
 D-fructose 1,6-bisphosphate wild-type, pH 7.0, 37°C Homo sapiens
24.7
-
 D-fructose 1,6-bisphosphate mutant Y57W, pH 7.0, 37°C Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.000031
-
 AMP wild-type, pH 7.0, 37°C, Hill-coefficient 1.9 Homo sapiens
0.00081
-
 AMP mutant Y57W, pH 7.0, 37°C, Hill-coefficient 2.0 Homo sapiens
0.00098
-
 Ca2+ wild-type, pH 7.0, 37°C, Hill-coefficient 1.49 Homo sapiens
0.021
-
 Ca2+ mutant Y57W, pH 7.0, 37°C, Hill-coefficient 1.84 Homo sapiens
0.029
-
 D-fructose 1,6-bisphosphate mutant Y57W, pH 7.0, 37°C Homo sapiens
0.035
-
 D-fructose 1,6-bisphosphate wild-type, pH 7.0, 37°C Homo sapiens