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Literature summary for 3.1.3.11 extracted from

  • Kebede, M.; Favaloro, J.; Gunton, J.E.; Laybutt, D.R.; Shaw, M.; Wong, N.; Fam, B.C.; Aston-Mourney, K.; Rantzau, C.; Zulli, A.; Proietto, J.; Andrikopoulos, S.
    Fructose-1,6-bisphosphatase overexpression in pancreatic beta-cells results in reduced insulin secretion: a new mechanism for fat-induced impairment of beta-cell function (2008), Diabetes, 57, 1887-1895.
    View publication on PubMedView publication on EuropePMC
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Application

Application Comment Organism
medicine upregulation of FBPase in pancreatic islet beta-cells, as occurs in states of lipid oversupply and type 2 diabetes, contributes to insulin secretory dysfunction Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information transgenic mouse lines overexpressing huFBPase gene specifically in pancreatic islet beta-cells are generated to determine whether a specific increase in islet beta-cell FBPase can result in reduced glucose-mediated insulin secretion. FBPase transgenic mice show reduced insulin secretion in response to an intravenous glucose bolus. Pancreatic beta-cell lines (MIN6) stably overexpressing huFBPase show a decreased cell proliferation rate and significantly depressed glucose-induced insulin secretion. These defects are associated with a decrease in the rate of glucose utilization, resulting in reduced cellular ATP levels Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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Synonyms

Synonyms Comment Organism
fructose 1,6-bisphosphatase
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 Homo sapiens
huFBPase
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 Homo sapiens