Reference on EC 2.4.2.4 - thymidine phosphorylase and Organism(s) Escherichia coli and UniProt Accession P07650
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AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Barbas, C.F.; Wong, C.H.
Overexpression and substrate specificity studies of phosphodeoxyribomutase and thymidine phosphorylase
Bioorg. Chem.
19
261-269
1991
Escherichia coli
-
Schwartz, M.
Thymidine phosphorylase from Escherichia coli
Methods Enzymol.
51
442-445
1978
Escherichia coli
Zimmerman, M.
Deoxyribosyl transfer. II. Nucleoside:pyrimidine deoxyribosyltransferase activity of three partially purified thymidine phosphorylases
J. Biol. Chem.
239
2622-2627
1964
Escherichia coli, Escherichia coli B / ATCC 11303, Homo sapiens, Rattus norvegicus
Cook, W.J.; Koszalka, G.W.; Hall, W.W.; Burns, C.L.; Ealick, S.E.
Crystallization and preliminary x-ray investigation of thymidine phosphorylase from Escherichia coli
J. Biol. Chem.
262
3788-3789
1987
Escherichia coli
Walter, M.R.; Cook, W.J.; Cole, L.B.; Short, S.A.; Koszalka, G.W.; Krenitsky, T.A.; Ealick, S.E.
Three-dimensional structure of thymidine phosphorylase from Escherichia coli at 2.8 A resolution
J. Biol. Chem.
265
14016-14022
1990
Escherichia coli
Krenitsky, T.A.; Tuttle, J.V.
Correlation of substrate-stabilization patterns with proposed mechanisms for three nucleoside phosphorylases
Biochim. Biophys. Acta
703
247-249
1982
Escherichia coli
Voytek, P.
Purification of thymidine phosphorylase from Escherichia coli and its photoinactivation in the presence of thymine, thymidine, and some halogenated analogs
J. Biol. Chem.
250
3660-3665
1975
Escherichia coli
Finnis, C.; Dodsworth, N.; Pollitt, C.E.; Carr, G.; Sleep, D.
Thymidine phosphorylase activity of platelet-derived endothelial cell growth factor is responsible for endothelial cell mitogenicity
Eur. J. Biochem.
212
201-210
1993
Escherichia coli, Homo sapiens
Rick, S.W.; Abashkin, Y.G.; Hilderbrandt, R.L.; Burt, S.K.
Computational studies of the domain movement and the catalytic mechanism of thymidine phosphorylase
Proteins
37
242-252
1999
Escherichia coli
Focher, F.; Spadari, S.
Thymidine phosphorylase: a two-face janus in anticancer chemotherapy
Curr. Cancer Drug Targets
1
141-153
2001
Escherichia coli, Homo sapiens
Mendieta, J.; Martin-Santamaria, S.; Priego, E.M.; Balzarini, J.; Camarasa, M.J.; Perez-Perez, M.J.; Gago, F.
Role of histidine-85 in the catalytic mechanism of thymidine phosphorylase as assessed by targeted molecular dynamics simulations and quantum mechanical calculations
Biochemistry
43
405-414
2004
Escherichia coli (P07650)
McNally, V.A.; Gbaj, A.; Douglas, K.T.; Stratford, I.J.; Jaffar, M.; Freeman, S.; Bryce, R.A.
Identification of a novel class of inhibitor of human and Escherichia coli thymidine phosphorylase by in silico screening
Bioorg. Med. Chem. Lett.
13
3705-3709
2003
Escherichia coli, Homo sapiens
Liekens, S.; Hernandez, A.I.; Ribatti, D.; De Clercq, E.; Camarasa, M.J.; Perez-Perez, M.J.; Balzarini, J.
The nucleoside derivative 5'-O-trityl-inosine (KIN59)suppresses thymidine phosphorylase-triggered angiogenesis via a noncompetitive mechanism of action
J. Biol. Chem.
279
29598-29605
2004
Escherichia coli, Homo sapiens
Reigan, P.; Edwards, P.N.; Gbaj, A.; Cole, C.; Barry, S.T.; Page, K.M.; Ashton, S.E.; Luke, R.W.; Douglas, K.T.; Stratford, I.J.; Jaffar, M.; Bryce, R.A.; Freeman, S.
Aminoimidazolylmethyluracil analogues as potent inhibitors of thymidine phosphorylase and their bioreductive nitroimidazolyl prodrugs
J. Med. Chem.
48
392-402
2005
Escherichia coli, Homo sapiens (P19971), Homo sapiens
Panova, N.G.; Shcheveleva, E.V.; Alexeev, C.S.; Mukhortov, V.G.; Zuev, A.N.; Mikhailov, S.N.; Esipov, R.S.; Chuvikovsky, D.V.; Miroshnikov, A.I.
Use of 4-thiouridine and 4-thiothymidine in studies on pyrimidine nucleoside phosphorylases
Mol. Biol.
38
770-776
2004
Escherichia coli
-
Panova, N.G.; Alexeev, C.S.; Kuzmichov, A.S.; Shcheveleva, E.V.; Gavryushov, S.A.; Polyakov, K.M.; Kritzyn, A.M.; Mikhailov, S.N.; Esipov, R.S.; Miroshnikov, A.I.
Substrate specificity of Escherichia coli thymidine phosphorylase
Biochemistry
72
21-28
2007
Escherichia coli, Escherichia coli (P07650)
Gbaj, A.; Edwards, P.N.; Reigan, P.; Freeman, S.; Jaffar, M.; Douglas, K.T.
Thymidine phosphorylase from Escherichia coli: tight-binding inhibitors as enzyme active-site titrants
J. Enzyme Inhib. Med. Chem.
21
69-73
2006
Escherichia coli
Kalman, T.I.; Lai, L.
6-Substituted 5-fluorouracil derivatives as transition state analogue inhibitors of thymidine phosphorylase
Nucleosides Nucleotides Nucleic Acids
24
367-373
2005
Escherichia coli
Liekens, S.; Balzarini, J.; Hernandez, A.I.; De Clercq, E.; Priego, E.M.; Camarasa, M.J.; Perez-Perez, M.J.
Thymidine phosphorylase is noncompetitively inhibited by 5-O-trityl-inosine (KIN59) and related compounds
Nucleosides Nucleotides Nucleic Acids
25
975-980
2006
Escherichia coli, Homo sapiens (P19971), Homo sapiens
Hatano, A.; Harano, A.; Takigawa, Y.; Naramoto, Y.; Toda, K.; Nakagomi, Y.; Yamada, H.
Kinetic parameters and recognition of thymidine analogues with varying functional groups by thymidine phosphorylase
Bioorg. Med. Chem.
16
3866-3870
2008
Escherichia coli
Pomeisl, K.; Holy, A.; Votruba, I.; Pohl, R.
Syntheses of N3-substituted thymine acyclic nucleoside phosphonates and a comparison of their inhibitory effect towards thymidine phosphorylase
Bioorg. Med. Chem. Lett.
18
1364-1367
2008
Escherichia coli, Homo sapiens
Reigan, P.; Gbaj, A.; Stratford, I.J.; Bryce, R.A.; Freeman, S.
Xanthine oxidase-activated prodrugs of thymidine phosphorylase inhibitors
Eur. J. Med. Chem.
43
1248-1260
2008
Escherichia coli, Homo sapiens (P19971), Homo sapiens
Pomeisl, K.; Votruba, I.; Holy, A.; Pohl, R.
Syntheses of pyrimidine acyclic nucleoside phosphonates as potent inhibitors of thymidine phosphorylase (PD-ECGF) from SD-lymphoma
Nucleosides Nucleotides Nucleic Acids
26
1025-1028
2007
Escherichia coli, Homo sapiens
Jain, H.V.; Rasheed, R.; Kalman, T.I.
The role of phosphate in the action of thymidine phosphorylase inhibitors: implications for the catalytic mechanism
Bioorg. Med. Chem. Lett.
20
1648-1651
2010
Escherichia coli, Homo sapiens (P19971)
Khan, K.M.; Ambreen, N.; Hussain, S.; Perveen, S.; Choudhary, M.I.
Schiff bases of 3-formylchromone as thymidine phosphorylase inhibitors
Bioorg. Med. Chem.
17
2983-2988
2009
Escherichia coli
Bronckaers, A.; Gago, F.; Balzarini, J.; Liekens, S.
The dual role of thymidine phosphorylase in cancer development and chemotherapy
Med. Res. Rev.
29
903-953
2009
Geobacillus stearothermophilus, Escherichia coli, Homo sapiens, Mus musculus, Rattus norvegicus, Salmonella enterica subsp. enterica serovar Typhimurium
Panova, N.; Alexeev, C.; Polyakov, K.; Gavryushov, S.; Kritzyn, A.; Mikhailov, S.
Substrate specificity of thymidine phosphorylase of E. coli: role of hydroxyl groups
Nucleosides Nucleotides Nucleic Acids
27
1211-1214
2008
Escherichia coli
Marak, D.; Otmar, M.; Votruba, I.; Dracinsky, M.; Krecmerova, M.
8-Aza-7,9-dideazaxanthine acyclic nucleoside phosphonate inhibitors of thymidine phosphorylase
Bioorg. Med. Chem. Lett.
21
652-654
2011
Escherichia coli, Homo sapiens
Serra, I.; Serra, C.D.; Rocchietti, S.; Ubiali, D.; Terreni, M.
Stabilization of thymidine phosphorylase from Escherichia coli by immobilization and post immobilization techniques
Enzyme Microb. Technol.
49
52-58
2011
Escherichia coli
Rajabi, M.; Mansell, D.; Freeman, S.; Bryce, R.A.
Structure-activity relationship of 2,4,5-trioxoimidazolidines as inhibitors of thymidine phosphorylase
Eur. J. Med. Chem.
46
1165-1171
2011
Escherichia coli
Ding, Q.; Ou, L.; Wei, D.; Wei, X.
Optimum induction of recombinant thymidine phosphorylase and its application
Nucleosides Nucleotides Nucleic Acids
30
360-368
2011
Escherichia coli
Javaid, S.; Saad, S.M.; Perveen, S.; Khan, K.M.; Choudhary, M.I.
2-Arylquinazolin-4(3H)-ones: A novel class of thymidine phosphorylase inhibitors
Bioorg. Chem.
63
142-151
2015
Escherichia coli
Shahzad, S.A.; Yar, M.; Bajda, M.; Jadoon, B.; Khan, Z.A.; Naqvi, S.A.; Shaikh, A.J.; Hayat, K.; Mahmmod, A.; Mahmood, N.; Filipek, S.
Synthesis and biological evaluation of novel oxadiazole derivatives: a new class of thymidine phosphorylase inhibitors as potential anti-tumor agents
Bioorg. Med. Chem.
22
1008-1015
2014
Escherichia coli
Petaccia, M.; Gentili, P.; Besker, N.; DAbramo, M.; Giansanti, L.; Leonelli, F.; La Bella, A.; Gradella Villalva, D.; Mancini, G.
Kinetics and mechanistic study of competitive inhibition of thymidine phosphorylase by 5-fluoruracil derivatives
Colloids Surf. B Biointerfaces
140
121-127
2016
Escherichia coli (P07650), Escherichia coli
Xiong, S.; Wang, Y.; Wang, X.; Wang, J.; Li, J.; Zhang, G.; Zhang, R.; Xie, L.; Wang, H.
Enzymatic synthesis of 2-deoxyuridine by whole cell catalyst co-expressing uridine phosphorylase and thymidine phosphorylase through auto-induction system
J. Biosci. Bioeng.
118
723-727
2014
Escherichia coli
Serra, I.; Bavaro, T.; Cecchini, D.; Daly, S.; Albertini, A.; Terreni, M.; Ubiali, D.
A comparison between immobilized pyrimidine nucleoside phosphorylase from Bacillus subtilis and thymidine phosphorylase from Escherichia coli in the synthesis of 5-substituted pyrimidine 2'-deoxyribonucleosides
J. Mol. Catal. B
95
16-22
2013
Escherichia coli
-
Taha, M.; Ismail, N.H.; Imran, S.; Rahim, F.; Wadood, A.; Al Muqarrabun, L.M.; Khan, K.M.; Ghufran, M.; Ali, M.
In silico binding analysis and SAR elucidations of newly designed benzopyrazine analogs as potent inhibitors of thymidine phosphorylase
Bioorg. Chem.
68
80-89
2016
Escherichia coli
Javaid, S.; Ishtiaq, M.; Shaikh, M.; Hameed, A.; Choudhary, M.I.
Thymidine esters as substrate analogue inhibitors of angiogenic enzyme thymidine phosphorylase in vitro
Bioorg. Chem.
70
44-56
2017
Escherichia coli (P0C037)
Uddin, I.; Taha, M.; Rahim, F.; Wadood, A.
Synthesis and molecular docking study of piperazine derivatives as potent inhibitor of thymidine phosphorylase
Bioorg. Chem.
78
324-331
2018
Escherichia coli (P0C037)
Iftikhar, F.; Yaqoob, F.; Tabassum, N.; Jan, M.S.; Sadiq, A.; Tahir, S.; Batool, T.; Niaz, B.; Ansari, F.L.; Choudhary, M.I.; Rashid, U.
Design, synthesis, in-vitro thymidine phosphorylase inhibition, in-vivo antiangiogenic and in-silico studies of C-6 substituted dihydropyrimidines
Bioorg. Chem.
80
99-111
2018
Escherichia coli (P0C037)
Shahzad, S.A.; Yar, M.; Khan, Z.A.; Shahzadi, L.; Naqvi, S.A.R.; Mahmood, A.; Ullah, S.; Shaikh, A.J.; Sherazi, T.A.; Bale, A.T.; Kukulowicz, J.; Bajda, M.
Identification of 1,2,4-triazoles as new thymidine phosphorylase inhibitors future anti-tumor drugs
Bioorg. Chem.
85
209-220
2019
Escherichia coli (P0C037)
Zaman, K.; Rahim, F.; Taha, M.; Wadood, A.; Adnan Ali Shah, S.; Gollapalli, M.; Ullah, F.; Ahmed, A.
Synthesis, thymidine phosphorylase, angiogenic inhibition and molecular docking study of isoquinoline derivatives
Bioorg. Chem.
89
102999
2019
Escherichia coli (P0C037), Escherichia coli
Taha, M.; Aldhamin, E.A.J.; Almandil, N.B.; Anouar, E.H.; Uddin, N.; Alomari, M.; Rahim, F.; Adalat, B.; Ibrahim, M.; Nawaz, F.; Iqbal, N.; Alghanem, B.; Altolayyan, A.; Khan, K.M.
Synthesis of indole based acetohydrazide analogs Their in vitro and in silico thymidine phosphorylase studies
Bioorg. Chem.
98
103745
2020
Escherichia coli (P0C037)
Bera, H.; Chigurupati, S.
Recent discovery of non-nucleobase thymidine phosphorylase inhibitors targeting cancer
Eur. J. Med. Chem.
124
992-1003
2016
Escherichia coli (P0C037), Homo sapiens (P19971)
