Inhibitors | Comment | Organism | Structure |
---|---|---|---|
5-fluoro-6-[(2-aminoimidazol-1-yl)methyl]uracil | i.e. AIFU, synthesis, overview, uncompetitive with respect to phosphate, acts as transition state analogs, mimicking the anionic thymine leaving group anchored by their protonated side chains to the enzyme-bound phosphate by electrostatic and H-bonding interactions, modeling of ligand binding at the active site, overview | Escherichia coli | |
5-fluoro-6-[(2-aminoimidazol-1-yl)methyl]uracil | i.e. AIFU, synthesis, overview, uncompetitive with respect to phosphate, acts as transition state analogs, mimicking the anionic thymine leaving group anchored by their protonated side chains to the enzyme-bound phosphate by electrostatic and H-bonding interactions, modeling of ligand binding at the active site, overview | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
thymidine + phosphate | Escherichia coli | - |
thymine + 2-deoxy-alpha-D-ribose 1-phosphate | - |
? | |
thymidine + phosphate | Homo sapiens | - |
thymine + 2-deoxy-alpha-D-ribose 1-phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
- |
- |
Homo sapiens | P19971 | - |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate | SN2-type catalytic mechanism | Escherichia coli | |
thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate | SN2-type catalytic mechanism | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
thymidine + phosphate | - |
Escherichia coli | thymine + 2-deoxy-alpha-D-ribose 1-phosphate | - |
? | |
thymidine + phosphate | - |
Homo sapiens | thymine + 2-deoxy-alpha-D-ribose 1-phosphate | - |
? |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | inhibition kinetics, overview | Escherichia coli | |
additional information | - |
additional information | inhibition kinetics, overview | Homo sapiens | |
0.000011 | - |
5-fluoro-6-[(2-aminoimidazol-1-yl)methyl]uracil | - |
Escherichia coli | |
0.000017 | - |
5-fluoro-6-[(2-aminoimidazol-1-yl)methyl]uracil | - |
Homo sapiens |