Information on EC 2.3.1.6 - choline O-acetyltransferase

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The expected taxonomic range for this enzyme is: Eukaryota

EC NUMBER
COMMENTARY
2.3.1.6
-
RECOMMENDED NAME
GeneOntology No.
choline O-acetyltransferase
REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
acetyl-CoA + choline = CoA + O-acetylcholine
show the reaction diagram
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-
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REACTION TYPE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
Acyl group transfer
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-
-
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PATHWAY
KEGG Link
MetaCyc Link
Glycerophospholipid metabolism
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SYSTEMATIC NAME
IUBMB Comments
acetyl-CoA:choline O-acetyltransferase
Propanoyl-CoA can act, more slowly, in place of acetyl-CoA.
SYNONYMS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
acetyl CoA:choline-O-acetyltransferase
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-
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acetyl-CoA:choline-O-acetyltransferase
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-
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acetyltransferase, choline
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cChAT
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common choline O-acetyltransferase
cChAT
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common choline O-acetyltransferase
cChAT
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common type choline acetyltransferase
chAcT
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-
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ChAT
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ChAT
Oenanthe siolonifera, Oryza sativa, Paeonia suffruticosa
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-
ChAT
Paeonia suffruticosa Andrews
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-
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ChAT
Polygonatum sibiricum Red.
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-
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ChAT
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ChAT
Poria cocos Wolf.
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-
-
ChAT
Rosa laevigata Michx
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-
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ChAT
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choline acetyl transferase
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-
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choline acetylase
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-
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choline acetyltransferase
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-
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choline acetyltransferase
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choline acetyltransferase
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choline acetyltransferase
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choline acetyltransferase
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choline acetyltransferase
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choline acetyltransferase
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choline acetyltransferase
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choline acetyltransferase
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choline acetyltransferase
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choline acetyltransferase
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choline acetyltransferase
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choline acetyltransferase
Oenanthe siolonifera, Oryza sativa, Paeonia suffruticosa
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choline acetyltransferase
Paeonia suffruticosa Andrews
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-
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choline acetyltransferase
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-
choline acetyltransferase
-
-
choline acetyltransferase
Polygonatum sibiricum Red.
-
-
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choline acetyltransferase
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choline acetyltransferase
Poria cocos Wolf.
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-
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choline acetyltransferase
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choline acetyltransferase
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choline acetyltransferase
-
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choline acetyltransferase
Rosa laevigata Michx
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-
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choline acetyltransferase
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choline acetyltransferase
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pChAT
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peripheral choline O-acetyltransferase, predominantly found in peripheral neurons
pChAT
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a variant form of choline acetyltransferase
pChAT
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peripheral choline O-acetyltransferase, predominantly found in peripheral neurons
pChAT
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splice variant of choline acetyltransferase
CAS REGISTRY NUMBER
COMMENTARY
9012-78-6
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ORGANISM
COMMENTARY
LITERATURE
SEQUENCE CODE
SEQUENCE DB
SOURCE
2 enzyme forms
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-
Manually annotated by BRENDA team
colocalization of calbindin-D28k and calretinin with ChAT
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-
Manually annotated by BRENDA team
goldfish
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-
Manually annotated by BRENDA team
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-
Manually annotated by BRENDA team
var. ma-yuen
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-
Manually annotated by BRENDA team
zebrafish mutant line, bajan, in which compromised motility and fatigue result from a point mutation in the gene coding choline acetyltransferase
Uniprot
Manually annotated by BRENDA team
snail
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-
Manually annotated by BRENDA team
horseshoe crab
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-
Manually annotated by BRENDA team
Lepidoptera: Spingidae
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-
Manually annotated by BRENDA team
3 enzyme forms
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-
Manually annotated by BRENDA team
B6 CBA wild type mice
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-
Manually annotated by BRENDA team
Musa domestica
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-
-
Manually annotated by BRENDA team
Oenanthe siolonifera
-
-
-
Manually annotated by BRENDA team
Paeonia suffruticosa Andrews
Andrews
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-
Manually annotated by BRENDA team
3 enzyme forms
-
-
Manually annotated by BRENDA team
Polygonatum sibiricum Red.
Red.
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-
Manually annotated by BRENDA team
Wolf.
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-
Manually annotated by BRENDA team
Poria cocos Wolf.
Wolf.
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-
Manually annotated by BRENDA team
var. ansu
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-
Manually annotated by BRENDA team
Sprague Dawley rats
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-
Manually annotated by BRENDA team
two splicing variants, peripheral-type pChAT and common-type cChAT
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-
Manually annotated by BRENDA team
Rosa laevigata Michx
Michx
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-
Manually annotated by BRENDA team
Sasamorpha purpurascens
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-
-
Manually annotated by BRENDA team
ChAT/calretinin colocalization
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-
Manually annotated by BRENDA team
IC50 VALUE [mM]
IC50 VALUE [mM] Maximum
INHIBITOR
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
IMAGE
0.0025
-
Hg2+
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noncompetitive with respect to choline, IC50: 0.0004 mM, mixed type inhibition with respect to acetyl-CoA, IC50: 0.0025 mM, activity can be recovered using 2,3-dimercapto-propanol
TEMPERATURE RANGE
TEMPERATURE MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE