Cloned (Comment) | Organism |
---|---|
expressed as GFP fusion protein in HEK293 cells | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | pChAT and cChAT | Rattus norvegicus | 5737 | - |
nucleus | cChAT but not pChAT, pChAT found in nucleus only after treatment with leptomycin B | Rattus norvegicus | 5634 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
49000 | - |
pChAT | Rattus norvegicus |
69000 | - |
cChAT | Rattus norvegicus |
76000 | - |
pChAT with GFP as fusion protein | Rattus norvegicus |
96000 | - |
cChAT with GFP as fusion protein | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + choline | Rattus norvegicus | synthesis of the neurotransmitter acetylcholine | acetylcholine + CoA | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
male Wistar rats | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
neuron | pChAT predominantly in peripheral neurons | Rattus norvegicus | - |
placenta | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + choline | - |
Rattus norvegicus | acetylcholine + CoA | - |
r | |
acetyl-CoA + choline | synthesis of the neurotransmitter acetylcholine | Rattus norvegicus | acetylcholine + CoA | - |
r |
Synonyms | Comment | Organism |
---|---|---|
cChAT | common choline O-acetyltransferase | Rattus norvegicus |
pChAT | peripheral choline O-acetyltransferase, predominantly found in peripheral neurons | Rattus norvegicus |