Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + choline | Homo sapiens | - |
CoA + O-acetylcholine | acetylcholine is the primary parasympathetic neurotransmitter in the airways | ? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
fibroblast | lung, fetal lung fibroblasts, HFL-1 | Homo sapiens | - |
HFL-1 cell | - |
Homo sapiens | - |
lung | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + choline | - |
Homo sapiens | CoA + O-acetylcholine | - |
? | |
acetyl-CoA + choline | - |
Homo sapiens | CoA + O-acetylcholine | acetylcholine is the primary parasympathetic neurotransmitter in the airways | ? |
Synonyms | Comment | Organism |
---|---|---|
ChAT | - |
Homo sapiens |
choline acetyltransferase | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
acetyl-CoA | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | interleukin-1beta induces the enzyme in HFL-1 cells | up |
General Information | Comment | Organism |
---|---|---|
malfunction | in cigarette smokers and patients with chronic obstructive pulmonary disease, acetylcholine activation in lung fibroblasts causes increased cell proliferation involving muscarinic M1, M2, and M3 receptors, and ERK1/2 and NFkappaB pathways, overview | Homo sapiens |
physiological function | acetylcholine, synthesized by ChAT, and muscarinic M1, M2, and M3 receptors are involved in fibroblast proliferation | Homo sapiens |