Information on EC 1.11.1.13 - manganese peroxidase

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The expected taxonomic range for this enzyme is: Eukaryota

EC NUMBER
COMMENTARY hide
1.11.1.13
-
RECOMMENDED NAME
GeneOntology No.
manganese peroxidase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
2 Mn(II) + 2 H+ + H2O2 = 2 Mn(III) + 2 H2O
show the reaction diagram
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
oxidation
redox reaction
-
-
-
-
reduction
PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
manganese oxidation I
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-
SYSTEMATIC NAME
IUBMB Comments
Mn(II):hydrogen-peroxide oxidoreductase
A hemoprotein. The enzyme from white rot basidiomycetes is involved in the oxidative degradation of lignin. The enzyme oxidizes a bound Mn2+ ion to Mn3+ in the presence of hydrogen peroxide. The product, Mn3+, is released from the active site in the presence of a chelator (mostly oxalate and malate) that stabilizes it against disproportionation to Mn2+ and insoluble Mn4+ [4]. The complexed Mn3+ ion can diffuse into the lignified cell wall, where it oxidizes phenolic components of lignin and other organic substrates [1]. It is inactive with veratryl alcohol or nonphenolic substrates.
CAS REGISTRY NUMBER
COMMENTARY hide
114995-15-2
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
strain ECN 100601
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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-
Manually annotated by BRENDA team
strain TM 70.84, 2 isoenzymes
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-
Manually annotated by BRENDA team
Agrocybe sp. 1
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-
Manually annotated by BRENDA team
Agrocybe sp. 2
-
-
-
Manually annotated by BRENDA team
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-
-
Manually annotated by BRENDA team
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-
-
Manually annotated by BRENDA team
Auricularia sp.
strain M37
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-
Manually annotated by BRENDA team
Auricularia sp. M37
strain M37
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-
Manually annotated by BRENDA team
strain 90-41, white rot fungus
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-
Manually annotated by BRENDA team
strain UAMH 8258
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-
Manually annotated by BRENDA team
Bjerkandera sp.
Bjerkandera sp. BOS55
-
-
-
Manually annotated by BRENDA team
Clitocybe sp.
-
-
-
Manually annotated by BRENDA team
Clitocybula dusenii
Clitocybula dusenii b11
strain b11, agaric white rot basidomycete
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-
Manually annotated by BRENDA team
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-
Manually annotated by BRENDA team
strain 146
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Manually annotated by BRENDA team
Coriolus pruinosum
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-
Manually annotated by BRENDA team
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-
-
Manually annotated by BRENDA team
strain ECN 100602
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Manually annotated by BRENDA team
Cortinarius sp. 2 ECN 100602
strain ECN 100602
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-
Manually annotated by BRENDA team
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-
-
Manually annotated by BRENDA team
Deuteromycotina sp.
strain CBS 432.34, 2 isoenzymes: MnP1 and MnP2, syn. Polyporus anceps
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-
Manually annotated by BRENDA team
syn. Irpex
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-
Manually annotated by BRENDA team
strain 845
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-
Manually annotated by BRENDA team
strain 845
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-
Manually annotated by BRENDA team
strain ECN 100603
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-
Manually annotated by BRENDA team
Ganoderma carnosum ECN 100603
strain ECN 100603
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-
Manually annotated by BRENDA team
strain 447
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-
Manually annotated by BRENDA team
strain FP-105752
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Manually annotated by BRENDA team
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-
Manually annotated by BRENDA team
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-
-
Manually annotated by BRENDA team
Inocybe longicystis
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-
Manually annotated by BRENDA team
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-
Manually annotated by BRENDA team
strain ECN 100604
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-
Manually annotated by BRENDA team
strain ECN 100604
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-
Manually annotated by BRENDA team
strain SR-1
UniProt
Manually annotated by BRENDA team
strain 577.79
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-
Manually annotated by BRENDA team
8/18
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Manually annotated by BRENDA team
Lentinus tigrinus CBS 577.79
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-
Manually annotated by BRENDA team
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Manually annotated by BRENDA team
Lepiota naucina
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Manually annotated by BRENDA team
Lepiota sp. 1
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-
Manually annotated by BRENDA team
Lepiota sp. 2
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Manually annotated by BRENDA team
strain ECN 100605
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Manually annotated by BRENDA team
Lepista nuda ECN 100605
strain ECN 100605
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Manually annotated by BRENDA team
Leptonia lazunila
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-
Manually annotated by BRENDA team
Lyophyllum subglobisporium
strain ECN 100606
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-
Manually annotated by BRENDA team
Lyophyllum subglobisporium ECN 100606
strain ECN 100606
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-
Manually annotated by BRENDA team
Merulius sp.
strain M15
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Manually annotated by BRENDA team
Merulius sp. M15
strain M15
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
Nematoloma frowardii
Nematoloma frowardii b19
precursor. Molecular characterization of the basidiomycete isolate Nematoloma frowardii b19 and its manganese peroxidase places the fungus in the corticioid genus Phlebia
SwissProt
Manually annotated by BRENDA team
strain 174
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-
Manually annotated by BRENDA team
strain 174
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
strain BKM-F 1767
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Manually annotated by BRENDA team
BKM-F-1767
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Manually annotated by BRENDA team
strain ME446
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Manually annotated by BRENDA team
MnP2
Uniprot
Manually annotated by BRENDA team
MZKI B-223
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-
Manually annotated by BRENDA team
strain VKM F-1767
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-
Manually annotated by BRENDA team
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Manually annotated by BRENDA team
strain 250
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-
Manually annotated by BRENDA team
strain 250
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Manually annotated by BRENDA team
Phellinus trivialis
-
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Manually annotated by BRENDA team
strain 511
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Manually annotated by BRENDA team
syn. Merulius
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Manually annotated by BRENDA team
strain CBS 411.71
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Manually annotated by BRENDA team
strain ECN 100607
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Manually annotated by BRENDA team
strain ECN 100608
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Manually annotated by BRENDA team
Ramaria stricta ECN 100608
strain ECN 100608
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
Schizophyllum sp.
strain F17
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Manually annotated by BRENDA team
strain F17
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Manually annotated by BRENDA team
strain TM 47-1, 3 isoenzymes: Mn2+-inducible MnP1 and MnP3, partly constitutive MnP2
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Manually annotated by BRENDA team
Stropharia cubensis
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
strain 681
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Manually annotated by BRENDA team
strain 1215
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
strain 235, 428 and 775
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Manually annotated by BRENDA team
strain ECN 100609
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Manually annotated by BRENDA team
Trametes zonata
strain 540
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-
Manually annotated by BRENDA team
Trametes zonata 540
strain 540
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Manually annotated by BRENDA team
strain 117
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Manually annotated by BRENDA team
LSK-27
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-
Manually annotated by BRENDA team
LSK-27
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Manually annotated by BRENDA team
Volvariella sp.
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Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
2 KBr + 2 H+ + H2O2
Br2 + 2 H2O + 2 K+
show the reaction diagram
-
-
-
-
?
2 KI + 2 H+ + H2O2
I2 + 2 H2O + 2 K+
show the reaction diagram
-
-
-
-
?
2 Mn(II) + 2 H+ + H2O2
2 Mn(III) + 2 H2O
show the reaction diagram
-
the kcat value for the reaction is dependent of the Mn(III) chelator molecules malonate, lactate and oxalate, indicating that the enzyme oxidizes chelated Mn(II) to Mn(III)
-
-
?
2 Mn2+ + 2 H+ + H2O2
2 Mn3+ + 2 H2O
show the reaction diagram
2 Mn2+ + H2O2 + aflatoxin B1
2 Mn3+ + aflatoxin B1-8,9-dihydrodiol
show the reaction diagram
2,2'-azino-bis(3-ethyl-benzothiazoline-6-sulfonic acid) + H2O2
?
show the reaction diagram
2,2'-azino-bis(3-ethylbenzothiazoline)-6-sulphonate + H2O2
?
show the reaction diagram
-
reaction with and without Mn2+
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-
?
2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonate) + H2O2
?
show the reaction diagram
2,2'-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) + Mn2+ + ?
?
show the reaction diagram
2,2'-azinobis(3-ethylbenzthiazoline)-6-sulfonic acid + H2O2
?
show the reaction diagram
-
-
-
-
?
2,2'-azinobis(3-ethylbenzthiazoline)-6-sulfonic acid + H2O2 + Mn2+
?
show the reaction diagram
-
-
-
-
?
2,4,6-trichlorophenol + H2O2
?
show the reaction diagram
2,6-dimethoxyphenol + H2O2
?
show the reaction diagram
2,6-dimethoxyphenol + H2O2 + Mn2+
?
show the reaction diagram
-
-
-
-
?
2,6-dimethoxyphenol + Mn2+ + ?
?
show the reaction diagram
-
-
-
-
?
2-bromonaphthalene + ?
?
show the reaction diagram
-
oxidation in presence of Tween 80
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-
?
4-(4-hydroxy-3-methoxy-phenyl)-2-butanone + H2O2
4-[6,2'-dihydroxy-5,3'-dimethoxy-5'-(3-oxo-butyl)-biphenyl]-butan-2-one + 4-(4-hydroxy-3-methoxyphenyl)-3-buten-2-one + 4-[6,2'-dihydroxy-5,3'-dimethoxy-5'-(3-oxo-butyl)-biphenyl]-3-buten-2-one + 3-(3-oxo-butyl)-hexa-2,4-dienedioic acid-1-methyl ester
show the reaction diagram
4-aminophenol + H2O2
?
show the reaction diagram
-
reaction in presence of Mn2+
-
-
?
4-methoxyphenol + H2O2
?
show the reaction diagram
-
reaction in presence of Mn2+
-
-
?
acenaphthene + ?
?
show the reaction diagram
-
oxidation in presence of Tween 80
-
-
?
acenaphthylene + ?
?
show the reaction diagram
-
oxidation in presence of Tween 80
-
-
?
alpha-naphthol + H2O2
?
show the reaction diagram
-
reaction in presence of Mn2+
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-
?
anthracene + ?
?
show the reaction diagram
-
oxidation in presence of Tween 80
-
-
?
benzo[a]anthracene + ?
?
show the reaction diagram
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oxidation in presence of Tween 80
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?
benzo[a]pyrene + ?
?
show the reaction diagram
-
key enzyme in degradation of benzo[a]pyrene and other polycyclic aromatic hydrocarbons
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?
benzo[a]pyrene + ?
benzo[a]pyrene-1,6-quinone + ?
show the reaction diagram
-
oxidation in presence of Tween 80
-
-
?
benzo[b]fluoroanthrene + ?
?
show the reaction diagram
-
oxidation in presence of Tween 80
-
-
?
benzo[g,h,i]perylene + H2O
?
show the reaction diagram
-
oxidation in presence of Tween 80
-
-
?
bromocresol green + H2O2
?
show the reaction diagram
-
-
-
-
?
bromocresol purple + H2O2
?
show the reaction diagram
-
-
-
-
?
bromophenol blue + H2O2
?
show the reaction diagram
-
-
-
-
?
bromophenol red + H2O2
?
show the reaction diagram
-
-
-
-
?
bromothymol blue + H2O2
?
show the reaction diagram
-
-
-
-
?
catechol + H2O2
?
show the reaction diagram
-
reaction in presence of Mn2+
-
-
?
chrysene + ?
?
show the reaction diagram
-
oxidation in presence of Tween 80
-
-
?
Co2+ + H+ + H2O2
Co3+ + H2O
show the reaction diagram
-
reduction of enzyme compound II, oxidation at 2% the rate of Mn2+ oxidation
-
?
dibenzo[a,h]anthracene + ?
?
show the reaction diagram
-
oxidation in presence of Tween 80
-
-
?
fluoranthene + ?
?
show the reaction diagram
-
oxidation in presence of Tween 80
-
-
?
fluorene + ?
?
show the reaction diagram
-
oxidation in presence of Tween 80
-
-
?
guaiacol + ?
?
show the reaction diagram
guaiacol + H2O2
?
show the reaction diagram
guaiacol + H2O2
tetraguaiacol + H2O
show the reaction diagram
-
-
-
-
?
guaiacol + H2O2 + Mn2+
?
show the reaction diagram
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-
-
-
?
guaiacol + Mn2+ + ?
?
show the reaction diagram
-
-
-
-
?
H2O2 + 2,2'-azino-bis(3-ethyl)-benzothiazoline-6-sulfonic acid
H2O + ?
show the reaction diagram
H2O2 + 2,6-dimethoxyphenol
H2O + ?
show the reaction diagram
H2O2 + guaiacol
H2O + ?
show the reaction diagram
H2O2 + Poly R-478
?
show the reaction diagram
hydroquinone + H2O2
?
show the reaction diagram
-
reaction in absence or in presence of Mn2+
-
-
?
indeno[1,2,3-c,d]pyrene + ?
?
show the reaction diagram
-
oxidation in presence of Tween 80
-
-
?
m-cresol purple + H2O2
?
show the reaction diagram
-
-
-
-
?
Mn2+ + 2,6-dimethoxyphenol + H2O2
?
show the reaction diagram
Mn2+ + di(2-methylpent-2-enyl) sulfide + H+
Mn3+ + 2,4-dimethylthiophene + 2-methyl-2-pentenal + H2O
show the reaction diagram
-
-
-
-
?
Mn2+ + guaiacol + H2O2
?
show the reaction diagram
Mn2+ + H+ + H2O2
Mn3+ + H2O
show the reaction diagram
Mn2+ + H2O2
Mn3+ + H2O
show the reaction diagram
Mn2+ + hydroquinone
?
show the reaction diagram
-
-
-
-
?
Mn2+ + methylhydroquinone
?
show the reaction diagram
-
-
-
-
?
NADH + acetate
NAD+ + ?
show the reaction diagram
-
-
-
-
?
NADH + lactate
NAD+ + ?
show the reaction diagram
-
-
-
-
?
NADH + malate
NAD+ + ?
show the reaction diagram
-
-
-
-
?
NADH + tartrate
NAD+ + ?
show the reaction diagram
-
-
-
-
?
naphthalene + ?
?
show the reaction diagram
-
oxidation in presence of Tween 80
-
-
?
o-cresol red + H2O2
?
show the reaction diagram
-
-
-
-
?
o-dianisidine + H2O2
?
show the reaction diagram
p-phenylenediamine + H2O2
?
show the reaction diagram
-
in absence or in presence of Mn2+
-
-
?
phenol red
?
show the reaction diagram
-
activity assay
-
-
?
phenol red + H2O2
?
show the reaction diagram
pyrene + ?
?
show the reaction diagram
-
oxidation in presence of Tween 80
-
-
?
pyrogallol + H2O2
?
show the reaction diagram
pyrogallol + H2O2 + Mn2+
?
show the reaction diagram
-
-
-
-
?
pyrogallol + Mn2+ + ?
?
show the reaction diagram
-
-
-
-
?
thymol blue + H2O2
?
show the reaction diagram
-
-
-
-
?
vanillylacetone + H2O2
?
show the reaction diagram
veratryl alcohol + H2O2
? + H2O
show the reaction diagram
veratryl alcohol + H2O2 + Mn2+
?
show the reaction diagram
-
veratryl alcohol oxidation requires the simultaneous presence of H2O2 and Mn2+
-
-
?
veratryl alcohol + Mn2+ + ?
?
show the reaction diagram
-
-
-
-
?
additional information
?
-