Information on EC 1.1.1.49 - glucose-6-phosphate dehydrogenase (NADP+)

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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria

EC NUMBER
COMMENTARY
1.1.1.49
-
RECOMMENDED NAME
GeneOntology No.
glucose-6-phosphate dehydrogenase (NADP+)
REACTION TYPE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
oxidation
-
-
-
-
oxidation
-
-
redox reaction
-
-
-
-
reduction
-
-
-
-
PATHWAY
KEGG Link
MetaCyc Link
Biosynthesis of secondary metabolites
-
formaldehyde oxidation I
-
Glutathione metabolism
-
heterolactic fermentation
-
Metabolic pathways
-
Microbial metabolism in diverse environments
-
NAD/NADP-NADH/NADPH cytosolic interconversion (yeast)
-
Pentose phosphate pathway
-
pentose phosphate pathway (oxidative branch) I
-
pentose phosphate pathway (oxidative branch) II
-
superpathway of glycolysis and Entner-Doudoroff
-
SYSTEMATIC NAME
IUBMB Comments
D-glucose-6-phosphate:NADP+ 1-oxidoreductase
The enzyme catalyses a step of the pentose phosphate pathway. The enzyme is specific for NADP+. cf. EC 1.1.1.363, glucose-6-phosphate dehydrogenase [NAD(P)+].
SYNONYMS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
6-phosphoglucose dehydrogenase
-
-
-
-
D-glucose 6-phosphate dehydrogenase
-
-
-
-
D-glucose 6-phosphate: NADP+ oxidoreductase
-
-
D-glucose-6-phosphate: NADP+ oxidoreductase
-
-
D-glucose-6-phosphate:NADP oxidoreductase
-
-
D-glucose-6-phosphate:NADP oxidoreductase
Bacillus megaterium QM Bl551
-
-
-
Entner-Doudoroff enzyme
-
-
-
-
G-6-PD
-
-
G6PD
-
-
-
-
G6PD
-
-
G6PD
-
-
G6PD
G1EHI3
-
G6PD
P11413
-
G6PD
Meyerozyma guilliermondii FTI 20037
-
-
-
G6PD1
-
-
-
-
G6PD1
Q43727
-
G6PD1
Arabidopsis thaliana T87
Q43727
-
-
G6PD2
-
-
-
-
G6PD2
Q9FY99
-
G6PD2
Arabidopsis thaliana T87
Q9FY99
-
-
G6PD3
-
-
-
-
G6PD3
Q8L743
-
G6PD3
Arabidopsis thaliana T87
Q8L743
-
-
G6PD4
-
-
-
-
G6PD4
Q93ZW0
-
G6PD4
Arabidopsis thaliana T87
Q93ZW0
-
-
G6PD5
-
-
-
-
G6PD5
Q9LK23
-
G6PD5
Arabidopsis thaliana T87
Q9LK23
-
-
G6PD6
-
-
-
-
G6PD6
Q9FJI5
-
G6PD6
Arabidopsis thaliana T87
Q9FJI5
-
-
G6PDH
Q43727
-
G6PDH
Q93ZW0, Q9FJI5, Q9FY99, Q9LK23
-
G6PDH
Arabidopsis thaliana T87
Q43727, Q8L743, Q93ZW0, Q9FJI5, Q9FY99, Q9LK23
-
-
G6PDH
-
-
G6PDH
-
-
G6PDH
Pseudomonas fluorescens 13525
-
-
-
G6PDH
Saccharomyces cerevisiae W303-181
-
-
-
G6PDH
-
-
G6PDH
Trichosporonoides megachiliensis
-
-
G6PDH
Trypanosoma brucei 427
-
-
-
G6PDH
Q1WBU6
-
G6PDH1
-
-
-
-
G6PDH1
Q43727
-
G6PDH2
-
-
-
-
G6PDH3
-
-
-
-
G6PDH4
-
-
-
-
G6PDH5
-
-
-
-
G6PDH6
-
-
-
-
Glc6PDH
-
-
glucose 6-phosphate dehydrogenase
-
-
glucose 6-phosphate dehydrogenase
-
-
glucose 6-phosphate dehydrogenase
-
-
glucose 6-phosphate dehydrogenase
-
-
glucose 6-phosphate dehydrogenase
-
-
glucose 6-phosphate dehydrogenase
-
-
glucose 6-phosphate dehydrogenase
Pseudomonas fluorescens 13525
-
-
-
glucose 6-phosphate dehydrogenase
-
-
glucose 6-phosphate dehydrogenase
-
-
glucose 6-phosphate dehydrogenase
Saccharomyces cerevisiae W303-181
-
-
-
glucose 6-phosphate dehydrogenase (NADP)
-
-
-
-
glucose-6-phosphate 1-dehydrogenase
-
-
-
-
glucose-6-phosphate dehydrogenase
-
-
-
-
glucose-6-phosphate dehydrogenase
-
-
glucose-6-phosphate dehydrogenase
-
-
glucose-6-phosphate dehydrogenase
-
-
glucose-6-phosphate dehydrogenase
-
-
glucose-6-phosphate dehydrogenase
-
-
glucose-6-phosphate dehydrogenase
-
-
glucose-6-phosphate dehydrogenase
-
-
glucose-6-phosphate dehydrogenase
-
-
glucose-6-phosphate dehydrogenase
-
-
glucose-6-phosphate dehydrogenase
-
-
glucose-6-phosphate dehydrogenase
Pseudomonas aeruginosa P4
-
-
-
glucose-6-phosphate dehydrogenase
-
-
glucose-6-phosphate dehydrogenase
-
-
glucose-6-phosphate dehydrogenase
-
-
glucose-6-phosphate dehydrogenase
-
-
glucose-6-phosphate dehydrogenase
-
-
glucose-6-phosphate dehydrogenase
Trichosporonoides megachiliensis
-
-
glucose-6-phosphate dehydrogenase
Trichosporonoides megachiliensis SN-G42
-
-
-
NADP-dependent glucose 6-phophate dehydrogenase
-
-
-
-
NADP-glucose-6-phosphate dehydrogenase
-
-
-
-
NADP-glucose-6-phosphate dehydrogenase
-
-
NADP-glucose-6-phosphate dehydrogenase
Bacillus megaterium QM Bl551
-
-
-
VEG11
-
-
-
-
Vegetative protein 11
-
-
-
-
Zwischenferment
-
-
-
-
CAS REGISTRY NUMBER
COMMENTARY
9001-40-5
-
ORGANISM
COMMENTARY
LITERATURE
SEQUENCE CODE
SEQUENCE DB
SOURCE
gene gsdA
-
-
Manually annotated by BRENDA team
Arabidopsis thaliana T87
strain T87
UniProt
Manually annotated by BRENDA team
filamentous fungus isolated from infected tongue of a human patient
-
-
Manually annotated by BRENDA team
strain ATCC 19213
-
-
Manually annotated by BRENDA team
strain QM Bl551
-
-
Manually annotated by BRENDA team
Bacillus megaterium QM Bl551
strain QM Bl551
-
-
Manually annotated by BRENDA team
Chalcalburnus tarischii
1811
-
-
Manually annotated by BRENDA team
Chalcalburnus tarischii 1811
1811
-
-
Manually annotated by BRENDA team
; high-level glucose-6-phosphate dehydrogenase strain
-
-
Manually annotated by BRENDA team
Escherichia coli DF82
high-level glucose-6-phosphate dehydrogenase strain
-
-
Manually annotated by BRENDA team
Escherichia coli K-10
-
-
-
Manually annotated by BRENDA team
2 isoenzymes
-
-
Manually annotated by BRENDA team
2 isoforms: A(+) and A(-), where A(-) is a mutant derivative of A(+) with V68M exchange
-
-
Manually annotated by BRENDA team
asymptomatic patient with high in vitro glucose-6-phosphate dehydrogenase deficiency, carrying a inherited mutation at A55T
-
-
Manually annotated by BRENDA team
wild-type and 3 enzyme-deficient children, i.e. mutants 1,2, and 3
-
-
Manually annotated by BRENDA team
wild-type and deficient mutant
-
-
Manually annotated by BRENDA team
X-linked house-keeping enzyme
-
-
Manually annotated by BRENDA team
var. Alfeo, root plastidic isozyme
-
-
Manually annotated by BRENDA team
isolated from a sea water sample collected at the Terra Nova Bay, Ross Sea, Antarctica
-
-
Manually annotated by BRENDA team
strain FTI 20037
-
-
Manually annotated by BRENDA team
Meyerozyma guilliermondii FTI 20037
strain FTI 20037
-
-
Manually annotated by BRENDA team
var. Samsun, resistant SNN cultivar and susceptible Xanthi cultivar
-
-
Manually annotated by BRENDA team
Penicillium duponti
-
-
-
Manually annotated by BRENDA team
L. cv. Lincoln
-
-
Manually annotated by BRENDA team
strain P4 (soil-isolate)
-
-
Manually annotated by BRENDA team
Pseudomonas aeruginosa P4
strain P4 (soil-isolate)
-
-
Manually annotated by BRENDA team
strain 13525
-
-
Manually annotated by BRENDA team
strain ATCC 13525
-
-
Manually annotated by BRENDA team
Pseudomonas fluorescens 13525
strain 13525
-
-
Manually annotated by BRENDA team
female Wistar rats
-
-
Manually annotated by BRENDA team
male sprague-dawley rats
-
-
Manually annotated by BRENDA team
male Wistar rats
-
-
Manually annotated by BRENDA team
male Wister strain albino rats
-
-
Manually annotated by BRENDA team
Sprague-Dawley rats
-
-
Manually annotated by BRENDA team
strain W303-181, constitutive enzyme
-
-
Manually annotated by BRENDA team
W303-181, having the plasmid YEpPGK-G6P (built by coupling the vector YEPLAC 181 with the promoter phosphoglycerate kinase 1)
-
-
Manually annotated by BRENDA team
Saccharomyces cerevisiae W303-181
strain W303-181, constitutive enzyme
-
-
Manually annotated by BRENDA team
4 weeks-old plants, isozymes in plastid, P1 and P2, and cytosol
-
-
Manually annotated by BRENDA team
2 isoenzymes
-
-
Manually annotated by BRENDA team
gene g6pd
-
-
Manually annotated by BRENDA team
Trichosporonoides megachiliensis
strain SN-G42 and 124A
-
-
Manually annotated by BRENDA team
Trichosporonoides megachiliensis SN-G42
strain SN-G42 and 124A
-
-
Manually annotated by BRENDA team
427 strain
-
-
Manually annotated by BRENDA team
Trypanosoma brucei 427
427 strain
-
-
Manually annotated by BRENDA team
strains Tulahuen 2 and Y
-
-
Manually annotated by BRENDA team
kcat/KM VALUE [1/mMs-1]
kcat/KM VALUE [1/mMs-1] Maximum
SUBSTRATE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
IMAGE
56
-
NAD+
-
25°C, pH 8.0
14330
23200
-
NADP+
-
25°C, pH 8.0
27497
Crystallization/COMMENTARY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
N-terminally truncated enzyme mutant DELTA37N, sitting drop vapour diffusion method, from 20 mMTris-HCl, pH 8.0, and 5 mM D-glucose 6-phosphate, mixing of 0.002 ml reservoir solution, containing 6% PEG 400, 1.6 M ammonium sulfate, 0.1 M HEPES pH 7.5 without D-glucose 6-phosphate and 4% PEG 400, 1.8 M ammonium sulfate, 0.1 M Na HEPES pH 7.5, with D-glucose 6-phosphate, with 0.002 ml of protein solution, containing 20 mg/ml and 33 mg/ml protein, respectively, followed by equilibration against 0.09 ml of reservoir solution, 4 days, X-ray diffraction structure determination and analysis at 2.85-3.35 A resolution, molecular replacement
Q1WBU6
ORGANIC SOLVENT
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
dimethylsulfoxide
-
substrate glucose and 40% DMSO (v/v): 10% remaining enzyme activity in HEPES buffer, 20% remaining enzyme activity in phosphate buffer