Reference on EC 1.1.1.270 - 3beta-hydroxysteroid 3-dehydrogenase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Billheimer, J.T.; Alcorn, M.; Gaylor, J.L.
Solubilization and partial purification of a microsomal 3-ketosteroid reductase of cholesterol biosynthesis
Arch. Biochem. Biophys.
211
430-438
1981
Rattus norvegicus
Appelkvist, E.L.; Reinhart, M.; Fischer, R.; Billheimer, J.; Dallner, G.
Presence of individual enzymes of cholesterol biosynthesis in rat liver peroxisomes
Arch. Biochem. Biophys.
282
318-325
1990
Rattus norvegicus
Pascal, S.; Taton, M.; Rahier, A.
Plant sterol biosynthesis: identification of a NADPH dependent sterone reductase involved in sterol-4 demethylation
Arch. Biochem. Biophys.
312
260-271
1994
Zea mays
Wieland, S.J.; Fox, T.O.
A DNA-binding of mouse kidney 3-ketosteroid reductase: comparison with androgen receptors
Steroids
37
527-538
1981
Mus musculus
Vanden Bossche, H.; Marichal, P.; Le Jeune, L.; Coene, M.C.; Gorrens, J.; Cools, W.
Effects of itraconazole on cytochrome P-450-dependent sterol 14alpha-demethylation and reduction of 3-ketosteroids in Cryptococcus neoformans
Antimicrob. Agents Chemother.
37
2101-2105
1993
Cryptococcus neoformans
Huang, X.F.; Luu-The, V.
Gene structure, chromosomal localization and analysis of 3-ketosteroid reductase activity of the human 3(alpha->beta)-hydroxysteroid epimerase
Biochim. Biophys. Acta
1520
124-130
2001
Homo sapiens
De Launoit, Y.; Zhao, H.F.; Belanger, A.; Labrie, F.; Simard, J.
Expression of liver-specific member of the 3beta-hydroxysteroid dehydrogenase family, an isoform possessing an almost exclusive 3-ketosteroid reductase activity
J. Biol. Chem.
267
4513-4517
1992
Rattus norvegicus
Abbaszade, I.G.; Arensburg, J.; Park, C.H.; Kasa-Vubu, J.Z.; Orly, J.; Payne, A.H.
Isolation of a new mouse 3beta-hydroxysteroid dehydrogenase isoform, 3beta-HSD VI, expressed during early pregnancy
Endocrinology
138
1392-1399
1997
Mus musculus
Huang, Y.W.; Lu, M.L.; Qi, H.; Lin, S.X.
Membrane-bound human 3beta-hydroxysteroid dehydrogenase: overexpression with his-tag using a baculvirus system and single-step purification
Protein Expr. Purif.
18
169-174
2000
Homo sapiens
Wong, C.K.; Keung, W.M.
Bovine adrenal 3beta-hydroxysteroid dehydrogenase (E.C. 1.1.1.145)/5-ene-4-ene isomerase (E.C. 5.3.3.1): characterization and its inhibition by isoflavones
J. Steroid Biochem. Mol. Biol.
71
191-202
1999
Bos taurus
Jin, Y.; Stayrook, S.E.; Albert, J.H.; Palackal, N.T.; Penning, T.M.; Lewis, M.
Crystal structure of human type III 3alpha-hydroxysteroid dehydrogenase/bile acid binding protein complexed with NADP(+) and ursodeoxycholate
Biochemistry
40
10161-10168
2001
Homo sapiens, Rattus
Fevold, H.R.; Wilson, P.L.; Slanina, S.M.
ACTH-stimulated rabbit adrenal 17alpha-hydroxylase. Kinetic properties and a comparison with those of 3beta-hydroxysteroid dehydrogenase
J. Steroid Biochem.
9
1033-1041
1978
Oryctolagus cuniculus
Qian, Y.M.; Song, W.C.
Regulation of estrogen sulfotransferase expression in Leydig cells by cyclic adenosine 3',5'-monophosphate and androgen
Endocrinology
140
1048-1053
1999
Mus musculus
Usami, N.; Yamamoto, T.; Shintani, S.; Ishikura, S.; Higaki, Y.; Katagiri, Y.; Hara, A.
Substrate specificity of human 3(20)alpha-hydroxysteroid dehydrogenase for neurosteroids and its inhibition by benzodiazepines
Biol. Pharm. Bull.
25
441-445
2002
Homo sapiens
Husen, B.; Adamski, J.; Bruns, A.; Deluca, D.; Fuhrmann, K.; Moller, G.; Schwabe, I.; Einspanier, A.
Characterization of 17beta-hydroxysteroid dehydrogenase type 7 in reproductive tissues of the marmoset monkey
Biol. Reprod.
68
2092-2099
2003
Platyrrhini, Primates, Rodentia
Higaki, Y.; Usami, N.; Shintani, S.; Ishikura, S.; El-Kabbani, O.; Hara, A.
Selective and potent inhibitors of human 20alpha-hydroxysteroid dehydrogenase (AKR1C1) that metabolizes neurosteroids derived from progesterone
Chem. Biol. Interact.
143-144
503-513
2003
Homo sapiens
Rizner, T.L.; Lin, H.K.; Peehl, D.M.; Steckelbroeck, S.; Bauman, D.R.; Penning, T.M.
Human type 3 3alpha-hydroxysteroid dehydrogenase (aldo-keto reductase 1C2) and androgen metabolism in prostate cells
Endocrinology
144
2922-2932
2003
Homo sapiens
Steckelbroeck, S.; Jin, Y.; Gopishetty, S.; Oyesanmi, B.; Penning, T.M.
Human cytosolic 3alpha-hydroxysteroid dehydrogenases of the aldo-keto reductase superfamily display significant 3beta-hydroxysteroid dehydrogenase activity: implications for steroid hormone metabolism and action
J. Biol. Chem.
279
10784-10795
2004
Homo sapiens (Q04828), Homo sapiens
Thomas, J.L.; Duax, W.L.; Addlagatta, A.; Scaccia, L.A.; Frizzell, K.A.; Carloni, S.B.
Serine 124 completes the Tyr, Lys and Ser triad responsible for the catalysis of human type 1 3beta-hydroxysteroid dehydrogenase
J. Mol. Endocrinol.
33
253-261
2004
Homo sapiens
Coirini, H.; Gouezou, M.; Delespierre, B.; Liere, P.; Pianos, A.; Eychenne, B.; Schumacher, M.; Guennoun, R.
Characterization and regulation of the 3beta-hydroxysteroid dehydrogenase isomerase enzyme in the rat sciatic nerve
J. Neurochem.
84
119-126
2003
Rattus
McVey, M.J.; Cooke, G.M.
Inhibition of rat testis microsomal 3b-hydroxysteroid dehydrogenase activity by tributyltin
J. Steroid Biochem. Mol. Biol.
86
99-105
2003
Rattus
Thomas, J.L.; Duax, W.L.; Addlagatta, A.; Kacsoh, B.; Brandt, S.E.; Norris, W.B.
Structure/function aspects of human 3beta-hydroxysteroid dehydrogenase
Mol. Cell. Endocrinol.
215
73-82
2004
Homo sapiens
Marijanovic, Z.; Laubner, D.; Moeller, G.; Gege, C.; Husen, B.; Adamski, J.; Breitling, R.
Closing the gap: Identification of human 3-ketosteroid reductase, the last unknown enzyme of mammalian cholesterol biosynthesis
Mol. Endocrinol.
17
1715-1725
2003
BRENDA: Homo sapiens, Mus musculus
Textmining: Saccharomyces cerevisiae
Steckelbroeck, S.; Jin, Y.; Oyesanmi, B.; Kloosterboer, H.J.; Penning, T.M.
Tibolone is metabolized by the 3alpha/3beta-hydroxysteroid dehydrogenase activities of the four human isozymes of the aldo-keto reductase 1C subfamily: Inversion of stereospecificity with a DELTA5(10)-3-ketosteroid
Mol. Pharmacol.
66
1702-1711
2004
Homo sapiens, Homo sapiens (Q04828)
Clementi, M.A.; Deis, R.P.; Telleria, C.M.
Luteal 3beta-hydroxysteroid dehydrogenase and 20alpha-hydroxysteroid dehydrogenase activities in the rat corpus luteum of pseudopregnancy: effect of the deciduoma reaction
Reprod. Biol. Endocrinol.
2
22
2004
Rattus
Thomas, J.L.; Boswell, E.L.; Scaccia, L.A.; Pletnev, V.; Umland, T.C.
Identification of key amino acids responsible for the substantially higher affinities of human type 1 3beta-hydroxysteroid dehydrogenase/isomerase (3b-HSD1) for substrates, coenzymes, and inhibitors relative to human 3b-HSD2
J. Biol. Chem.
280
21321-21328
2005
Homo sapiens (P14060), Homo sapiens (P26439), Homo sapiens
Sun, W.; Huang, Y.; Zhao, Z.; Gui, J.; Zhang, Q.
Characterization of the Rana grylio virus 3beta-hydroxysteroid dehydrogenase and its novel role in suppressing virus-induced cytopathic effect
Biochem. Biophys. Res. Commun.
351
44-50
2006
Rana grylio iridovirus (Q0G9Z6), Rana grylio iridovirus
Nakamura, Y.; Suzuki, T.; Inoue, T.; Tazawa, C.; Moriya, T.; Saito, H.; Ishibashi, T.; Takahashi, S.; Yamada, S.; Sasano, H.
3beta-hydroxysteroid dehydrogenase in human aorta
Endocr. J.
52
111-115
2005
Homo sapiens
Martin, L.J.; Tremblay, J.J.
The human 3beta-hydroxysteroid dehydrogenase/DELTA5-DELTA4 isomerase type 2 promoter is a novel target for the immediate early orphan nuclear receptor Nur77 in steroidogenic cells
Endocrinology
146
861-869
2005
Homo sapiens
Nakamura, I.; Evans, J.C.; Kusakabe, M.; Nagahama, Y.; Young, G.
Changes in steroidogenic enzyme and steroidogenic acute regulatory protein messenger RNAs in ovarian follicles during ovarian development of rainbow trout (Oncorhynchus mykiss)
Gen. Comp. Endocrinol.
144
224-231
2005
Oncorhynchus mykiss
Nicolau-Solano, S.I.; McGivan, J.D.; Whittington, F.M.; Nieuwhof, G.J.; Wood, J.D.; Doran, O.
Relationship between the expression of hepatic but not testicular 3beta-hydroxysteroid dehydrogenase with androstenone deposition in pig adipose tissue
J. Anim. Sci.
84
2809-2817
2006
Sus scrofa (Q9N119), Sus scrofa
Kowalewski, M.P.; Mason, J.I.; Howie, A.F.; Morley, S.D.; Schuler, G.; Hoffmann, B.
Characterization of the canine 3beta-hydroxysteroid dehydrogenase and its expression in the corpus luteum during diestrus
J. Steroid Biochem. Mol. Biol.
101
254-262
2006
Canis lupus familiaris
Lacey, M.; Bohday, J.; Fonseka, S.M.; Ullah, A.I.; Whitehead, S.A.
Dose-response effects of phytoestrogens on the activity and expression of 3beta-hydroxysteroid dehydrogenase and aromatase in human granulosa-luteal cells
J. Steroid Biochem. Mol. Biol.
96
279-286
2005
Homo sapiens
Jin, Y.; Penning, T.M.
Multiple steps determine the overall rate of the reduction of 5alpha-dihydrotestosterone catalyzed by human type 3 3alpha-hydroxysteroid dehydrogenase: implications for the elimination of androgens
Biochemistry
45
13054-13063
2006
Homo sapiens
Tam, H.; Schlinger, B.A.
Activities of 3beta-HSD and aromatase in slices of developing and adult zebra finch brain
Gen. Comp. Endocrinol.
150
26-33
2006
Taeniopygia guttata
Steckelbroeck, S.; Oyesanmi, B.; Jin, Y.; Lee, S.H.; Kloosterboer, H.J.; Penning, T.M.
Tibolone metabolism in human liver is catalyzed by 3alpha/3beta-hydroxysteroid dehydrogenase activities of the four isoforms of the aldo-keto reductase (AKR)1C subfamily
J. Pharmacol. Exp. Ther.
316
1300-1309
2006
Homo sapiens
Kazeto, Y.; Ijiri, S.; Adachi, S.; Yamauchi, K.
Cloning and characterization of a cDNA encoding cholesterol side-chain cleavage cytochrome P450 (CYP11A1): tissue-distribution and changes in the transcript abundance in ovarian tissue of Japanese eel, Anguilla japonica, during artificially induced sexual development
J. Steroid Biochem. Mol. Biol.
99
121-128
2006
Anguilla japonica, Anguilla japonica (Q4KYY5)
Yee, D.J.; Balsanek, V.; Bauman, D.R.; Penning, T.M.; Sames, D.
Fluorogenic metabolic probes for direct activity readout of redox enzymes: Selective measurement of human AKR1C2 in living cells
Proc. Natl. Acad. Sci. USA
103
13304-13309
2006
Homo sapiens
Couture, J.F.; de Jesus-Tran, K.P.; Roy, A.M.; Cantin, L.; Cote, P.L.; Legrand, P.; Luu-The, V.; Labrie, F.; Breton, R.
Comparison of crystal structures of human type 3 3alpha-hydroxysteroid dehydrogenase reveals an 'induced-fit' mechanism and a conserved basic motif involved in the binding of androgen
Protein Sci.
14
1485-1497
2005
Homo sapiens, Homo sapiens (P52895)
Jin, Y.; Penning, T.M.
Molecular docking simulations of steroid substrates into human cytosolic hydroxysteroid dehydrogenases (AKR1C1 and AKR1C2): insights into positional and stereochemical preferences
Steroids
71
380-391
2006
Homo sapiens (Q04828), Homo sapiens
Matsunaga, T.; Endo, S.; Maeda, S.; Ishikura, S.; Tajima, K.; Tanaka, N.; Nakamura, K.T.; Imamura, Y.; Hara, A.
Characterization of human DHRS4: An inducible short-chain dehydrogenase/reductase enzyme with 3beta-hydroxysteroid dehydrogenase activity
Arch. Biochem. Biophys.
477
339-347
2008
Homo sapiens
Yang, X.; Dubnau, E.; Smith, I.; Sampson, N.S.
Rv1106c from Mycobacterium tuberculosis is a 3beta-hydroxysteroid dehydrogenase
Biochemistry
46
9058-9067
2007
Mycobacterium tuberculosis
Arukwe, A.; Nordtug, T.; Kortner, T.M.; Mortensen, A.S.; Brakstad, O.G.
Modulation of steroidogenesis and xenobiotic biotransformation responses in zebrafish (Danio rerio) exposed to water-soluble fraction of crude oil
Environ. Res.
107
362-370
2008
Chondrichthyes
Knapczyk, K.; Duda, M.; Czaplicki, D.; Slomczynska, M.
The presence of 3beta-hydroxysteroid dehydrogenase in the ovarian follicles and corpora lutea of pregnant swine
Exp. Clin. Endocrinol. Diabetes
115
411-416
2007
Sus scrofa
Prisco, M.; Liguoro, A.; Ricchiari, L.; Del Giudice, G.; Angelini, F.; Andreuccetti, P.
Immunolocalization of 3beta-HSD and 17beta-HSD in the testis of the spotted ray Torpedo marmorata
Gen. Comp. Endocrinol.
155
157-163
2008
Torpedo marmorata
Chen, G.; Bourneuf, E.; Marklund, S.; Zamaratskaia, G.; Madej, A.; Lundstroem, K.
Gene expression of 3beta-hydroxysteroid dehydrogenase and 17beta-hydroxysteroid dehydrogenase in relation to androstenone, testosterone, and estrone sulphate in gonadally intact male and castrated pigs
J. Anim. Sci.
85
2457-2463
2007
Suidae
McCarthy, T.L.; Hochberg, R.B.; Labaree, D.C.; Centrella, M.
3-ketosteroid reductase activity and expression by fetal rat osteoblasts
J. Biol. Chem.
282
34003-34012
2007
Rattus
Azzarello, J.; Fung, K.M.; Lin, H.K.
Tissue distribution of human AKR1C3 and rat homolog in adult genitourinary system
J. Histochem. Cytochem.
56
853-861
2008
Homo sapiens, Rattus
Kim, H.H.; Kwak, D.H.; Yon, J.M.; Baek, I.J.; Lee, S.R.; Lee, J.E.; Nahm, S.S.; Jeong, J.H.; Lee, B.J.; Yun, Y.W.; Nam, S.Y.
Differential expression of 3beta-hydroxysteroid dehydrogenase mRNA in rat testes exposed to endocrine disruptors
J. Reprod. Dev.
53
465-471
2007
Rattus
Wang, L.; Salavaggione, E.; Pelleymounter, L.; Eckloff, B.; Wieben, E.; Weinshilboum, R.
Human 3beta-hydroxysteroid dehydrogenase types 1 and 2: Gene sequence variation and functional genomics
J. Steroid Biochem. Mol. Biol.
107
88-99
2007
Homo sapiens
Wang, S.; Yang, Q.; Fung, K.M.; Lin, H.K.
AKR1C2 and AKR1C3 mediated prostaglandin D2 metabolism augments the PI3K/Akt proliferative signaling pathway in human prostate cancer cells
Mol. Cell. Endocrinol.
289
60-66
2008
Homo sapiens
Szoltys, M.; Slomczynska, M.; Galas, J.; Duda, M.; Sakiewicz, A.
Expression of androgen receptor and 3beta-hydroxysteroid dehydrogenase in corpora lutea during pregnancy in the rat
Reprod. Fertil. Dev.
19
356-365
2007
Rattus
Dozier, B.L.; Watanabe, K.; Duffy, D.M.
Two pathways for prostaglandin F2 alpha synthesis by the primate periovulatory follicle
Reproduction
136
53-63
2008
Homo sapiens, Homo sapiens (P42330)
Teske, B.; Taramino, S.; Bhuiyan, M.S.; Kumaraswami, N.S.; Randall, S.K.; Barbuch, R.; Eckstein, J.; Balliano, G.; Bard, M.
Genetic analyses involving interactions between the ergosterol biosynthetic enzymes, lanosterol synthase (Erg7p) and 3-ketoreductase (Erg27p), in the yeast Saccharomyces cerevisiae
Biochim. Biophys. Acta
1781
359-366
2008
Saccharomyces cerevisiae
Thomas, J.L.; Mack, V.L.; Glow, J.A.; Moshkelani, D.; Terrell, J.R.; Bucholtz, K.M.
Structure/function of the inhibition of human 3beta-hydroxysteroid dehydrogenase type 1 and type 2 by trilostane
J. Steroid Biochem. Mol. Biol.
111
66-73
2008
Homo sapiens
Lysiak, J.J.; Kirby, J.L.; Tremblay, J.J.; Woodson, R.I.; Reardon, M.A.; Palmer, L.A.; Turner, T.T.
Hypoxia-inducible factor-1alpha is constitutively expressed in murine Leydig cells and regulates 3beta-hydroxysteroid dehydrogenase type 1 promoter activity
J. Androl.
30
146-156
2009
Mus musculus
Bruzzone, F.; Rego, J.L.; Luu-The, V.; Pelletier, G.; Vallarino, M.; Vaudry, H.
Immunohistochemical localization and biological activity of 3beta-hydroxysteroid dehydrogenase and 5alpha-reductase in the brain of the frog, Rana esculenta, during development
J. Chem. Neuroanat.
39
35-50
2010
Pelophylax lessonae, Pelophylax ridibundus
Breton, J.; Gage, M.C.; Hay, A.W.; Keen, J.N.; Wild, C.P.; Donnellan, C.; Findlay, J.B.; Hardie, L.J.
Proteomic screening of a cell line model of esophageal carcinogenesis identifies cathepsin D and aldo-keto reductase 1C2 and 1B10 dysregulation in Barretts esophagus and esophageal adenocarcinoma
J. Proteome Res.
7
1953-1962
2008
Homo sapiens, Homo sapiens (P07339)
Hu, G.X.; Zhou, H.Y.; Li, X.W.; Chen, B.B.; Xiao, Y.C.; Lian, Q.Q.; Liang, G.; Kim, H.H.; Zheng, Z.Q.; Hardy, D.O.; Ge, R.S.
The (+)- and (-)-gossypols potently inhibit both 3beta-hydroxysteroid dehydrogenase and 17beta-hydroxysteroid dehydrogenase 3 in human and rat testes
J. Steroid Biochem. Mol. Biol.
115
14-19
2009
Homo sapiens, Rattus
Thomas, J.L.; Bucholtz, K.M.; Sun, J.; Mack, V.L.; Kacsoh, B.
Structural basis for the selective inhibition of human 3beta-hydroxysteroid dehydrogenase 1 in human breast tumor MCF-7 cells
Mol. Cell. Endocrinol.
301
174-182
2009
Homo sapiens
Fernandez Presas, A.M.; Valdez, R.A.; Willms, K.; Romano, M.C.
The key steroidogenic enzyme 3beta-hydroxysteroid dehydrogenase in Taenia solium and Taenia crassiceps (WFU)
Parasitol. Res.
103
847-852
2008
Taenia solium, Taenia crassiceps
Faucher, F.; Cantin, L.; Luu-The, V.; Labrie, F.; Breton, R.
Crystal structures of human Delta4-3-ketosteroid 5beta-reductase (AKR1D1) reveal the presence of an alternative binding site responsible for substrate inhibition
Biochemistry
47
13537-13546
2008
Homo sapiens, Homo sapiens (P51857), Mus musculus
Taramino, S.; Valachovic, M.; Oliaro-Bosso, S.; Viola, F.; Teske, B.; Bard, M.; Balliano, G.
Interactions of oxidosqualene cyclase (Erg7p) with 3-keto reductase (Erg27p) and other enzymes of sterol biosynthesis in yeast
Biochim. Biophys. Acta
1801
156-162
2010
BRENDA: Saccharomyces cerevisiae
Textmining: Candida albicans
Taramino, S.; Teske, B.; Oliaro-Bosso, S.; Bard, M.; Balliano, G.
Divergent interactions involving the oxidosqualene cyclase and the steroid-3-ketoreductase in the sterol biosynthetic pathway of mammals and yeasts
Biochim. Biophys. Acta
1801
1232-1237
2010
BRENDA: Homo sapiens (P56937), Homo sapiens, Mus musculus (O88736), Mus musculus
Textmining: Mammalia, Saccharomyces cerevisiae, yeasts
Zhao, B.; Chu, Y.; Hardy, D.O.; Li, X.K.; Ge, R.S.
Inhibition of 3beta- and 17beta-hydroxysteroid dehydrogenase activities in rat Leydig cells by perfluorooctane acid
J. Steroid Biochem. Mol. Biol.
118
13-17
2010
Rattus
Han, G.; Gable, K.; Kohlwein, S.; Beaudoin, F.; Napier, J.; Dunn, T.
The Saccharomyces cerevisiae YBR159w gene encodes the 3-ketoreductase of the microsomal fatty acid elongase
J. Biol. Chem.
277
35440-35449
2002
Saccharomyces cerevisiae, Saccharomyces cerevisiae (P38286)
Mo, C.; Valachovic, M.; Randall, S.K.; Nickels, J.T.; Bard. M.
Protein-protein interactions among C-4 demethylation enzymes involved in yeast sterol biosynthesis
Proc. Natl. Acad. Sci. USA
99
39-44
2002
BRENDA: Saccharomyces cerevisiae
Textmining: Homo sapiens, Oryctolagus cuniculus
Endo, S.; Matsunaga, T.; Kumada, S.; Fujimoto, A.; Ohno, S.; El-Kabbani, O.; Hu, D.; Toyooka, N.; Mano, J.; Tajima, K.; Hara, A.
Characterization of rabbit aldose reductase-like protein with 3beta-hydroxysteroid dehydrogenase activity
Arch. Biochem. Biophys.
527
23-30
2012
Oryctolagus cuniculus
Rizner, T.; Lin, H.; Penning, T.
Role of human type 3 3alpha-hydroxysteroid dehydrogenase (AKR1C2) in androgen metabolism of prostate cancer cells
Chem. Biol. Interact.
143-144
401-409
2003
Homo sapiens
Nahoum, V.; Gangloff, A.; Legrand, P.; Zhu, D.W.; Cantin, L.; Zhorov, B.S.; Luu-The, V.; Labrie, F.; Breton, R.; Lin, S.X.
Structure of the human 3alpha-hydroxysteroid dehydrogenase type 3 in complex with testosterone and NADP at 1.25-A resolution
J. Biol. Chem.
276
42091-42098
2001
Homo sapiens, Homo sapiens (P52895)
Zhao, Y.; Xiao, J.
Homology modeling and molecular dynamics simulation studies of human type 1 3beta-hydroxysteroid dehydrogenase: Toward the understanding of cofactor specificity
J. Comput. Chem.
32
33-42
2011
Homo sapiens (P14060), Homo sapiens
Thomas, J.L.; Mack, V.L.; Sun, J.; Terrell, J.R.; Bucholtz, K.M.
The functions of key residues in the inhibitor, substrate and cofactor sites of human 3beta-hydroxysteroid dehydrogenase type 1 are validated by mutagenesis
J. Steroid Biochem. Mol. Biol.
120
192-199
2010
Homo sapiens
Debieu, D.; Bach, J.; Montesinos, E.; Fillinger, S.; Leroux, P.
Role of sterol 3-ketoreductase sensitivity in susceptibility to the fungicide fenhexamid in Botrytis cinerea and other phytopathogenic fungi
Pest Manag. Sci.
69
642-651
2013
BRENDA: Botrytis cinerea
Textmining: Fungi, Fusarium haematococcum, Botrytis pseudocinerea
Marschall, H.U.; Oppermann, U.C.; Svensson, S.; Nordling, E.; Persson, B.; Hoeoeg, J.O.; Joernvall, H.
Human liver class I alcohol dehydrogenase gammagamma isozyme: the sole cytosolic 3beta-hydroxysteroid dehydrogenase of iso bile acids
Hepatology
31
990-996
2000
Homo sapiens
Layer, J.; Barnes, B.; Yamasaki, Y.; Barbuch, R.; Li, L.; Taramino, S.; Balliano, G.; Bard, M.
Characterization of a mutation that results in independence of oxidosqualene cyclase (Erg7) activity from the downstream 3-ketoreductase (Erg27) in the yeast ergosterol biosynthetic pathway
Biochim. Biophys. Acta
1831
361-369
2013
BRENDA: Mus musculus (O88736), Mus musculus
Textmining: Saccharomyces cerevisiae, Fungi
Smolinska, N.; Dobrzyn, K.; Kiezun, M.; Szeszko, K.; Maleszka, A.; Kaminski, T.
Effect of adiponectin on the steroidogenic acute regulatory protein, P450 side chain cleavage enzyme and 3beta-hydroxysteroid dehydrogenase gene expression, progesterone and androstenedione production by the porcine uterus during early pregnancy
J. Physiol. Pharmacol.
67
443-456
2016
Sus scrofa
Ferrante, T.; Barge, A.; Taramino, S.; Oliaro-Bosso, S.; Balliano, G.
4-Methylzymosterone and other intermediates of sterol biosynthesis from yeast mutants engineered in the ERG27 gene encoding 3-ketosteroid reductase
Lipids
51
1103-1113
2016
Saccharomyces cerevisiae (Q12452), Saccharomyces cerevisiae
Ota, T.; Doi, M.; Yamazaki, F.; Yarimizu, D.; Okada, K.; Murai, I.; Hayashi, H.; Kunisue, S.; Nakagawa, Y.; Okamura, H.
Angiotensin II triggers expression of the adrenal gland zona glomerulosa-specific 3beta-hydroxysteroid dehydrogenase isoenzyme through de novo protein synthesis of the orphan nuclear receptors NGFIB and NURR1
Mol. Cell. Biol.
34
3880-3894
2014
Homo sapiens (P14060), Homo sapiens
Konosu-Fukaya, S.; Nakamura, Y.; Satoh, F.; Felizola, S.J.; Maekawa, T.; Ono, Y.; Morimoto, R.; Ise, K.; Takeda, K.; Katsu, K.; Fujishima, F.; Kasajima, A.; Watanabe, M.; Arai, Y.; Gomez-Sanchez, E.P.; Gomez-Sanchez, C.E.; Doi, M.; Okamura, H.; Sasano, H.
3beta-Hydroxysteroid dehydrogenase isoforms in human aldosterone-producing adenoma
Mol. Cell. Endocrinol.
408
205-212
2015
Homo sapiens, Homo sapiens (P26439)
Chen, G.; Bai, Y.; Ren, L.; Zhu, D.; Li, Y.; Fang, M.; Al-Kateb, H.; Doran, O.
Metabolism of androstenone, 17beta-estradiol and dihydrotestosterone in primary cultured pig hepatocytes and the role of 3beta-hydroxysteroid dehydrogenase in this process
PLoS ONE
10
e113194
2015
Sus scrofa
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Homo sapiens
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Bos taurus
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Homo sapiens
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Homo sapiens
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Homo sapiens
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Monilinia fructicola
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Bos taurus
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Bos taurus
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Bos taurus
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Homo sapiens
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Rattus
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Homo sapiens
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Homo sapiens, Rattus
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Homo sapiens, insertion sequences
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Homo sapiens
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Homo sapiens
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Homo sapiens
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Homo sapiens
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Homo sapiens, Mus musculus
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Homo sapiens
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Homo sapiens
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Homo sapiens
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Homo sapiens
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A mathematical analysis of the substrate effect observed in 3beta-hydroxysteroid dehydrogenase reactions of rat testicular microsomes.
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Gen Comp Endocrinol
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Galliformes
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On the intracellular localization of the 3beta-hydroxysteroid dehydrogenase isomerase in the rat adrenal cortex.
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Rattus
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The specificity of the 3beta-hydroxysteroid dehydrogenase activity of bovine ovaries toward dehydroepiandrosterone and pregnenolone: evidence for multiple enzymes.
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Bos taurus
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Modification of the kinetic properties of 5-ene, 3beta-hydroxysteroid dehydrogenase of human placental microsomes by hydrogen peroxide and 2-mercaptoethanol.
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Homo sapiens
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Electron
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Histochemistry of 3beta-hydroxysteroid dehydrogenase in rat ovary. I. Amethodological study.
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Rattus
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A simple procedure for solubilizing 3beta-hydroxysteroid dehydrogenase from microsomes of rat adrenals and testis interstitial cells.
Steroids
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Rattus
Sheth, K; Koszalka, TR; Brent, RL
delta 5, 3beta-Hydroxysteroid dehydrogenase activity in the rat parietal yolk sac during pregnancy.
Biol Reprod
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Bos taurus
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Ambystoma mexicanum
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Homo sapiens
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Human placental 3beta-hydroxysteroid dehydrogenase: delta5-isomerase. Demonstration of an intermediate in the conversion of 3beta-hydroxypregn-5-en-20-one to pregn-4-ene-3,20-dione.
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Homo sapiens
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Rattus, Metazoa
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Homo sapiens
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Sus scrofa
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Rattus
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In vitro androgen metabolism in mouse kidney: high 3-keto-reductase (3alpha-hydroxysteroid dehydrogenase) activity relative to 5alpha-reductase.
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Mus musculus
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Persistence of label in rat offspring after maternal administration of a 14C-labeled inhibitor of 3beta-hydroxysteroid dehydrogenase.
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Testicular endocrine function in a pubertal boy with 3beta-hydroxysteroid dehydrogenase deficiency.
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Homo sapiens
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The persistence of "steroid-synthesizing cell" antigen and 3beta-hydroxysteroid dehydrogenase in organ cultures of normal human placentas.
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Homo sapiens
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Elevation of level of 3beta-hydroxysteroid dehydrogenase in rats by extracts of DNA or RNA.
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Rattus
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Homo sapiens
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A novel mouse kidney 3 beta-hydroxysteroid dehydrogenase complementary DNA encodes a 3-ketosteroid reductase instead of a 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4-isomerase.
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Mus musculus
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Similarity in genome organization between Molluscum contagiosum virus (MCV) and vaccinia virus (VV): identification of MCV homologues of the VV genes for protein kinase 2, structural protein VP8, RNA polymerase 35 kDa subunit and 3beta-hydroxysteroid dehydrogenase.
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Vaccinia virus, Molluscum contagiosum virus
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Rattus
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Homo sapiens
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Variants of the type II 3beta-hydroxysteroid dehydrogenase gene in children with premature pubic hair and hyperandrogenic adolescents.
Mol Genet Metab
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Homo sapiens
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Ultracytochemistry of 3beta-hydroxysteroid dehydrogenase in Leydig cell precursors and vascular endothelial cells of the postnatal rat testis.
Anat Embryol (Berl)
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Rattus
Pignatelli, D; Bento, MJ; Maia, M; Magalhaes, MM; Magalhaes, MC; Mason, JI
Ontogeny of 3beta-hydroxysteroid dehydrogenase expression in the rat adrenal gland as studied by immunohistochemistry.
Endocr Res
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Human leukocyte antigen-DQB1* genotypes encoding aspartate at position 57 are associated with 3beta-hydroxysteroid dehydrogenase autoimmunity in premature ovarian failure.
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Homo sapiens
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Decrease in the expression of the 3beta-hydroxysteroid dehydrogenase gene in human adrenal tissue during prepuberty and early puberty: implications for the mechanism of adrenarche.
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Homo sapiens
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Mus musculus
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The gene mutated in bare patches and striated mice encodes a novel 3beta-hydroxysteroid dehydrogenase.
Nat Genet
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Mus sp.
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Metabolism of dihydrotestosterone in human liver: importance of 3alpha- and 3beta-hydroxysteroid dehydrogenase.
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Homo sapiens
Gachotte, D; Sen, SE; Eckstein, J; Barbuch, R; Krieger, M; Ray, BD; Bard, M
Characterization of the Saccharomyces cerevisiae ERG27 gene encoding the 3-keto reductase involved in C-4 sterol demethylation.
Proc Natl Acad Sci U S A
96
12655-60
1999
Saccharomyces cerevisiae
McBride, MW; McVie, AJ; Burridge, SM; Brintnell, B; Craig, N; Wallace, AM; Wilson, RH; Varley, J; Sutcliffe, RG
Cloning, expression, and physical mapping of the 3beta-hydroxysteroid dehydrogenase gene cluster (HSD3BP1-HSD3BP5) in human.
Genomics
61
277-84
1999
Homo sapiens
Moisan, AM; Ricketts, ML; Tardy, V; Desrochers, M; MĆ©barki, F; Chaussain, JL; Cabrol, S; Raux-Demay, MC; Forest, MG; Sippell, WG; Peter, M; Morel, Y; Simard, J
New insight into the molecular basis of 3beta-hydroxysteroid dehydrogenase deficiency: identification of eight mutations in the HSD3B2 gene eleven patients from seven new families and comparison of the functional properties of twenty-five mutant enzymes.
J Clin Endocrinol Metab
84
4410-25
1999
Homo sapiens
Marui, S; Castro, M; Latronico, AC; Elias, LL; Arnhold, IJ; Moreira, AC; Mendonca, BB
Mutations in the type II 3beta-hydroxysteroid dehydrogenase (HSD3B2) gene can cause premature pubarche in girls.
Clin Endocrinol (Oxf)
52
67-75
2000
Homo sapiens
Marui, S; Torrealba, IM; Russell, AJ; Latronico, AC; Sutcliffe, RG; Mendonca, BB
A novel homozygous nonsense mutations E135* in the type II 3beta-hydroxysteroid dehydrogenase gene in a girl with salt-losing congenital adrenal hyperplasia. Mutations in brief no. 168. Online.
Hum Mutat
12
139
1998
Homo sapiens
Gregorasczuk, EL; Kolodziejczyk, J; Rzysa, J
Triiodothyronine stimulates 3beta-hydroxysteroid dehydrogenase activity in the porcine corpus luteum.
Endocr Regul
33
155-60
1999
Sus scrofa
Port, CB; Bowen, JM; Keyes, PL; Townson, DH
Effects of a 3beta-hydroxysteroid dehydrogenase inhibitor on monocyte-macrophage infiltration into rat corpus luteum and on apoptosis: relationship to the luteolytic action of prolactin.
J Reprod Fertil
119
93-9
2000
Rattus
Marui, S; Russell, AJ; Paula, FJ; Dick-de-Paula, I; Marcondes, JA; Mendonca, BB
Genotyping of the type II 3beta-hydroxysteroid dehydrogenase gene (HSD3B2) in women with hirsutism and elevated ACTH-stimulated delta(5)-steroids.
Fertil Steril
74
553-7
2000
Homo sapiens
Peters, MA; Teerds, KJ; van der Gaag, I; de Rooij, DG; van Sluijs, FJ
Use of antibodies against LH receptor, 3beta-hydroxysteroid dehydrogenase and vimentin to characterize different types of testicular tumour in dogs.
Reproduction
121
287-96
2001
Canis lupus familiaris
Taniyama, H; Hirayama, K; Nakada, K; Numagami, K; Yaosaka, N; Kagawa, Y; Izumisawa, Y; Nakade, T; Tanaka, Y; Watanabe, G; Taya, K
Immunohistochemical detection of inhibin-alpha, -betaB, and -betaA chains and 3beta-hydroxysteroid dehydrogenase in canine testicular tumors and normal testes.
Vet Pathol
38
661-6
2001
Canis lupus familiaris
Madekurozwa, MC; Chabvepi, TS; Matema, S; Teerds, KJ
Relationship between seasonal changes in spermatogenesis in the juvenile ostrich (Stuthio camelus) and the presence of the LH receptor and 3beta-hydroxysteroid dehydrogenase.
Reproduction
123
735-42
2002
Struthio camelus
Kawai, M; Swan, KF; Green, AE; Edwards, DE; Anderson, MB; Henson, MC
Placental endocrine disruption induced by cadmium: effects on P450 cholesterol side-chain cleavage and 3beta-hydroxysteroid dehydrogenase enzymes in cultured human trophoblasts.
Biol Reprod
67
178-83
2002
Homo sapiens
Yarim, M; Kabakci, N
Distribution of 3beta-hydroxysteroid dehydrogenase in the cerebellum in canine distemper virus infection.
J Comp Pathol
127
290-6
2002
Canine morbillivirus, Canis lupus familiaris, Epicoccum
Tƶrn, S; Nokelainen, P; Kurkela, R; Pulkka, A; Menjivar, M; Ghosh, S; Coca-Prados, M; Peltoketo, H; Isomaa, V; Vihko, P
Production, purification, and functional analysis of recombinant human and mouse 17beta-hydroxysteroid dehydrogenase type 7.
Biochem Biophys Res Commun
305
37-45
2003
Homo sapiens, Mus musculus
Rhee, HS; Oh, SH; Ko, BJ; Han, DM; Jeon, BH; Park, H; Moon, HB; Kim, WS
Expression of 3beta-hydroxysteroid dehydrogenase and P450 side chain cleavage enzyme in the human uterine endometrium.
Exp Mol Med
35
160-6
2003
Homo sapiens
ARNOLD, A; BEYLER, AL; SCHAD, JS
Stimulatory effect of estrogen pretreatment on 3beta-hydroxysteroid dehydrogenase activity of rat testicular tissue.
Proc Soc Exp Biol Med
92
656-60
0
Rattus
Isobe, N; Nakao, T; Yoshimura, Y
Immunohistochemical localization of 3beta-hydroxysteroid dehydrogenase in the granulosa and theca interna layers of bovine cystic follicles.
J Reprod Dev
49
227-33
2003
Bos taurus
Peng, L; Huang, Y; Jin, F; Jiang, SW; Payne, AH
Transcription enhancer factor-5 and a GATA-like protein determine placental-specific expression of the Type I human 3beta-hydroxysteroid dehydrogenase gene, HSD3B1.
Mol Endocrinol
18
2049-60
2004
Homo sapiens
Yarim, M; Yildiz, K; Kabakci, N; Karahan, S
Immunohistochemical localisation of 3beta-hydroxysteroid dehydrogenase in Sarcocystis spp.
Parasitol Res
93
457-60
2004
Sarcocystis
Gomez-Sanchez, EP; Samuel, J; Vergara, G; Ahmad, N
Effect of 3beta-hydroxysteroid dehydrogenase inhibition by trilostane on blood pressure in the Dahl salt-sensitive rat.
Am J Physiol Regul Integr Comp Physiol
288
R389-93
2005
Rattus
Pierson, CA; Jia, N; Mo, C; Lees, ND; Sturm, AM; Eckstein, J; Barbuct, R; Bard, M
Isolation, characterization, and regulation of the Candida albicans ERG27 gene encoding the sterol 3-keto reductase.
Med Mycol
42
461-73
2004
Candida albicans, Saccharomyces cerevisiae
Mermejo, LM; Elias, LL; Marui, S; Moreira, AC; Mendonca, BB; de Castro, M
Refining hormonal diagnosis of type II 3beta-hydroxysteroid dehydrogenase deficiency in patients with premature pubarche and hirsutism based on HSD3B2 genotyping.
J Clin Endocrinol Metab
90
1287-93
2005
Homo sapiens
Thomas, JL; Umland, TC; Scaccia, LA; Boswell, EL; Kacsoh, B
The higher affinity of human type 1 3beta-hydroxysteroid dehydrogenase (3beta-HSD1) for substrate and inhibitor steroids relative to human 3beta-HSD2 is validated in MCF-7 tumor cells and related to subunit interactions.
Endocr Res
30
935-41
2004
Homo sapiens
Lu, DD
Growth factor NUN increased AKR1C2 expression by activated CDK2 related RB signal transduction pathway in human liver cancer cell line.
Hepatogastroenterology
52
567-70
0
Homo sapiens
Li, Y; Isomaa, V; Pulkka, A; Herva, R; Peltoketo, H; Vihko, P
Expression of 3beta-hydroxysteroid dehydrogenase type 1, P450 aromatase, and 17beta-hydroxysteroid dehydrogenase types 1, 2, 5 and 7 mRNAs in human early and mid-gestation placentas.
Placenta
26
387-92
2005
Homo sapiens
Ohnesorg, T; Adamski, J
Promoter analyses of human and mouse 17beta-hydroxysteroid dehydrogenase type 7.
J Steroid Biochem Mol Biol
94
259-61
2005
Homo sapiens, Mus musculus
Saredi, S; Patte-Mensah, C; Melcangi, RC; Mensah-Nyagan, AG
Effect of streptozotocin-induced diabetes on the gene expression and biological activity of 3beta-hydroxysteroid dehydrogenase in the rat spinal cord.
Neuroscience
135
869-77
2005
Rattus
Ohnesorg, T; Adamski, J
Analysis of the 5' flanking regions of human and murine HSD17B7: identification of a cholesterol dependent enhancer region.
Mol Cell Endocrinol
248
164-7
2006
Homo sapiens, Mus musculus, Mus sp.
Nakata, LC; Kata, SR; Womack, JE; Coutinho, LL; Amaral, ME
Assignment of the bovine PTGFR and HSD3B1 genes to bovine chromosome 3 with somatic and radiation hybrid panel mapping.
Cytogenet Genome Res
114
94E
2006
Bos taurus
Chen, W; Tsai, SJ; Liao, CY; Tsai, RY; Chen, YJ; Pan, BJ; Hung, CL; Zouboulis, CC
Higher levels of steroidogenic acute regulatory protein and type I 3beta-hydroxysteroid dehydrogenase in the scalp of men with androgenetic alopecia.
J Invest Dermatol
126
2332-5
2006
Homo sapiens
Scott Nunez, B; Evans, AN; Simpson, MA; Wong, WP; Ip, YK
Characterization of cDNAs encoding cholesterol side chain cleavage and 3beta-hydroxysteroid dehydrogenase in the freshwater stingray Potamotrygon motoro.
Comp Biochem Physiol B Biochem Mol Biol
145
306-17
0
Potamotrygon motoro
Cue, RA; Nicolau-Solano, SI; McGivan, JD; Wood, JD; Doran, O
Breed-associated variations in the sequence of the pig 3beta-hydroxysteroid dehydrogenase gene.
J Anim Sci
85
571-6
2007
Sus scrofa
Ji, Q; Chang, L; Stanczyk, FZ; Ookhtens, M; Sherrod, A; Stolz, A
Impaired dihydrotestosterone catabolism in human prostate cancer: critical role of AKR1C2 as a pre-receptor regulator of androgen receptor signaling.
Cancer Res
67
1361-9
2007
Homo sapiens
Moe, M; Grindflek, E; Doran, O
Expression of 3beta-hydroxysteroid dehydrogenase, cytochrome P450-c17, and sulfotransferase 2B1 proteins in liver and testis of pigs of two breeds: relationship with adipose tissue androstenone concentration.
J Anim Sci
85
2924-31
2007
Suidae
Lu, DD
AKR1C2 small interfering RNA (siRNA) inhibited beta-catenin expression and transcriptional activation in human liver cancer cell line QGY7701.
Hepatogastroenterology
54
2088-91
0
Homo sapiens, Maniola tithonus
Villeneuve, DL; Blake, LS; Brodin, JD; Cavallin, JE; Durhan, EJ; Jensen, KM; Kahl, MD; Makynen, EA; Martinovic, D; Mueller, ND; Ankley, GT
Effects of a 3beta-hydroxysteroid dehydrogenase inhibitor, trilostane, on the fathead minnow reproductive axis.
Toxicol Sci
104
113-23
2008
Pimephales promelas
Espallergues, J; Givalois, L; Temsamani, J; Laruelle, C; Maurice, T
The 3beta-hydroxysteroid dehydrogenase inhibitor trilostane shows antidepressant properties in mice.
Psychoneuroendocrinology
34
644-59
2009
Mus sp.
Szoke, D; Molnar, B; Solymosi, N; Racz, K; Gergics, P; Blasko, B; Vasarhelyi, B; Vannay, A; Mandy, Y; Klausz, G; Gyulai, Z; Galamb, O; Spisak, S; Hutkai, B; Somogyi, A; Berta, K; Szabo, A; Tulassay, T; Tulassay, Z
Polymorphisms of the ApoE, HSD3B1, IL-1beta and p53 genes are associated with the development of early uremic complications in diabetic patients: results of a DNA resequencing array study.
Int J Mol Med
23
217-27
2009
Homo sapiens
Papacleovoulou, G; Hogg, K; Fegan, KS; Critchley, HO; Hillier, SG; Mason, JI
Regulation of 3beta-hydroxysteroid dehydrogenase type 1 and type 2 gene expression and function in the human ovarian surface epithelium by cytokines.
Mol Hum Reprod
15
379-92
2009
Homo sapiens
Hu, GX; Zhao, BH; Chu, YH; Zhou, HY; Akingbemi, BT; Zheng, ZQ; Ge, RS
Effects of genistein and equol on human and rat testicular 3beta-hydroxysteroid dehydrogenase and 17beta-hydroxysteroid dehydrogenase 3 activities.
Asian J Androl
12
519-26
2010
Homo sapiens, Rattus
Hu, GX; Zhao, B; Chu, Y; Li, XH; Akingbemi, BT; Zheng, ZQ; Ge, RS
Effects of methoxychlor and 2,2-bis(p-hydroxyphenyl)-1,1,1-trichloroethane on 3beta-hydroxysteroid dehydrogenase and 17beta-hydroxysteroid dehydrogenase-3 activities in human and rat testes.
Int J Androl
2010
Homo sapiens, Rattus
Zhao, B; Hu, GX; Chu, Y; Jin, X; Gong, S; Akingbemi, BT; Zhang, Z; Zirkin, BR; Ge, RS
Inhibition of human and rat 3beta-hydroxysteroid dehydrogenase and 17beta-hydroxysteroid dehydrogenase 3 activities by perfluoroalkylated substances.
Chem Biol Interact
188
38-43
2010
Homo sapiens, Rattus
Steckelbroeck, S; Lütjohann, D; Bauman, DR; Ludwig, M; Friedl, A; Hans, VH; Penning, TM; Klingmüller, D
Non-stereo-selective cytosolic human brain tissue 3-ketosteroid reductase is refractory to inhibition by AKR1C inhibitors.
Biochim Biophys Acta
1801
1221-31
2010
Homo sapiens
Huang, KH; Chiou, SH; Chow, KC; Lin, TY; Chang, HW; Chiang, IP; Lee, MC
Overexpression of aldo-keto reductase 1C2 is associated with disease progression in patients with prostatic cancer.
Histopathology
57
384-94
2010
Homo sapiens
Berani?, N; Broi?, P; Brus, B; Sosi?, I; Gobec, S; Riner, TL
Expression of human aldo-keto reductase 1C2 in cell lines of peritoneal endometriosis: Potential implications in metabolism of progesterone and dydrogesterone and inhibition by progestins.
J Steroid Biochem Mol Biol
130
16-25
2012
Homo sapiens
Veilleux, A; Cōté, JA; Blouin, K; Nadeau, M; Pelletier, M; Marceau, P; Laberge, PY; Luu-The, V; Tchernof, A
Glucocorticoid-induced androgen inactivation by aldo-keto reductase 1C2 (AKR1C2) promotes adipogenesis in human preadipocytes.
Am J Physiol Endocrinol Metab
2012
Homo sapiens
Verwoert, GC; Hofland, J; Amin, N; Mattace-Raso, FU; Sijbrands, EJ; Hofman, A; van den Meiracker, AH; Uitterlinden, AG; van Duijn, CM; de Jong, FH; Danser, AH
Expression and Gene Variation Studies Deny Association of Human HSD3B1 Gene With Aldosterone Production or Blood Pressure.
Am J Hypertens
2014
Homo sapiens
Cohrs, KC; Burbank, J; Schumacher, J
A new transformant selection system for the gray mold fungus Botrytis cinerea based on the expression of fenhexamid-insensitive ERG27 variants.
Fungal Genet Biol
100
42-51
2017
Botrytis cinerea
Lai, TC; Li, HF; Li, YS; Hung, PY; Shyu, MK; Hu, MC
Proximal GATA-binding sites are essential for human HSD3B1 gene transcription in the placenta.
Sci Rep
7
4271
2017
Homo sapiens
Donadille, B; Houang, M; Netchine, I; Siffroi, JP; Christin-Maitre, S
Human 3beta-hydroxysteroid dehydrogenase deficiency associated with normal spermatic numeration despite a severe enzyme deficit.
Endocr Connect
7
395-402
2018
Homo sapiens
Samardzija Nenadov, D; Pogrmic-Majkic, K; Fa, S; Stanic, B; Tubic, A; Andric, N
Environmental mixture with estrogenic activity increases Hsd3b1 expression through estrogen receptors in immature rat granulosa cells.
J Appl Toxicol
2018
Rattus
Hahn, AW; Gill, DM; Nussenzveig, RH; Poole, A; Farnham, J; Cannon-Albright, L; Agarwal, N
Germline Variant in HSD3B1 (1245 A > C) and Response to Abiraterone Acetate Plus Prednisone in Men With New-Onset Metastatic Castration-Resistant Prostate Cancer.
Clin Genitourin Cancer
16
288-292
2018
Homo sapiens
Yang, C; Li, W; Li, C; Zhou, Z; Xiao, Y; Yan, X
Metabolism of ganoderic acids by a Ganoderma lucidum cytochrome P450 and the 3-keto sterol reductase ERG27 from yeast.
Phytochemistry
155
83-92
2018
Saccharomyces cerevisiae, Ganoderma lucidum
Amiri, A; Peres, NA
Diversity in the erg27 Gene of Botrytis cinerea Field Isolates from Strawberry Defines Different Levels of Resistance to the Hydroxyanilide Fenhexamid.
Plant Dis
98
1131-1137
2014
Fragaria x ananassa, Botrytis cinerea
Shiota, M; Narita, S; Akamatsu, S; Fujimoto, N; Sumiyoshi, T; Fujiwara, M; Uchiumi, T; Habuchi, T; Ogawa, O; Eto, M
Association of Missense Polymorphism in HSD3B1 With Outcomes Among Men With Prostate Cancer Treated With Androgen-Deprivation Therapy or Abiraterone.
JAMA Netw Open
2
e190115
2019
Homo sapiens
Tu, YA; Lin, SJ; Chen, PL; Chou, CH; Huang, CC; Ho, HN; Chen, MJ
HSD3B1 gene polymorphism and female pattern hair loss in women with polycystic ovary syndrome.
J Formos Med Assoc
118
1225-1231
2019
Homo sapiens
Sechman, A; Grzegorzewska, AK; Grzesiak, M; Kozubek, A; Katarzy?ska-Banasik, D; Kowalik, K; Hrabia, A
Nitrophenols suppress steroidogenesis in prehierarchical chicken ovarian follicles by targeting STAR, HSD3B1, and CYP19A1 and downregulating LH and estrogen receptor expression.
Domest Anim Endocrinol
70
106378
2019
Gallus gallus
Lu, C; Terbuch, A; Dolling, D; Yu, J; Wang, H; Chen, Y; Fountain, J; Bertan, C; Sharp, A; Carreira, S; Isaacs, WB; Antonarakis, ES; De Bono, JS; Luo, J
Treatment with abiraterone and enzalutamide does not overcome poor outcome from metastatic castration-resistant prostate cancer in men with the germline homozygous HSD3B1 c.1245C genotype.
Ann Oncol
31
1178-1185
2020
Homo sapiens
Khalaf, DJ; Aragón, IM; Annala, M; Lozano, R; Taavitsainen, S; Lorente, D; Finch, DL; Romero-Laorden, N; Vergidis, J; Cendón, Y; Oja, C; Pacheco, MI; Zulfiqar, M; , ; Gleave, ME; Wyatt, AW; Olmos, D; Chi, KN; Castro, E
HSD3B1 (1245A>C) germline variant and clinical outcomes in metastatic castration-resistant prostate cancer patients treated with abiraterone and enzalutamide: results from two prospective studies.
Ann Oncol
31
1186-1197
2020
Homo sapiens
Handy, WF; Schmidt, KT; Price, DK; Figg, WD
Examining HSD3B1 as a possible biomarker to detect prostate cancer patients who are likely to progress on ADT.
Cancer Biol Ther
21
782-784
2020
Homo sapiens
Albertini C;Leroux P
A Botrytis cinerea putative 3-keto reductase gene (ERG27) that is homologous to the mammalian 17beta-hydroxysteroid dehydrogenase type 7 gene (17beta-HSD7).
European journal of plant pathology
110
723-733
2004
Botrytis cinerea, Saccharomyces cerevisiae
Abbaszade, IG; Clarke, TR; Park, CH; Payne, AH
The mouse 3 beta-hydroxysteroid dehydrogenase multigene family includes two functionally distinct groups of proteins.
Mol Endocrinol
9
1214-22
1995
Mus musculus
Payne, AH; Clarke, TR; Bain, PA
The murine 3 beta-hydroxysteroid dehydrogenase multigene family: structure, function and tissue-specific expression.
J Steroid Biochem Mol Biol
53
111-8
1995
Mus musculus
Krazeisen, A; Breitling, R; Imai, K; Fritz, S; Mƶller, G; Adamski, J
Determination of cDNA, gene structure and chromosomal localization of the novel human 17beta-hydroxysteroid dehydrogenase type 7(1).
FEBS Lett
460
373-9
1999
Homo sapiens
Krusche, CA; Mƶller, G; Beier, HM; Adamski, J
Expression and regulation of 17beta-hydroxysteroid dehydrogenase 7 in the rabbit.
Mol Cell Endocrinol
171
169-77
2001
Oryctolagus cuniculus, Homo sapiens, Rodentia
Goosen, P; Swart, AC; Storbeck, KH; Swart, P
Hypocortisolism in the South African Angora goat: The role of 3betaHSD.
Mol Cell Endocrinol
2009
Capra hircus
Foti, DM; Reichardt, JK
YY1 binding within the human HSD3B2 gene intron 1 is required for maximal basal promoter activity: identification of YY1 as the 3beta1-A factor.
J Mol Endocrinol
33
99-119
2004
Homo sapiens
Doi, M; Takahashi, Y; Komatsu, R; Yamazaki, F; Yamada, H; Haraguchi, S; Emoto, N; Okuno, Y; Tsujimoto, G; Kanematsu, A; Ogawa, O; Todo, T; Tsutsui, K; van der Horst, GT; Okamura, H
Salt-sensitive hypertension in circadian clock-deficient Cry-null mice involves dysregulated adrenal Hsd3b6.
Nat Med
16
67-74
2010
Homo sapiens, Mus musculus
Lin, JC; Hu, S; Ho, PH; Hsu, HJ; Postlethwait, JH; Chung, BC
Two Zebrafish hsd3b Genes Are Distinct in Function, Expression, and Evolution.
Endocrinology
156
2854-62
2015
Danio rerio, Homo sapiens
Halim, M; Yee, DJ; Sames, D
Imaging Induction of Cytoprotective Enzymes in Intact Human Cells: Coumberone, a Metabolic Reporter for Human AKR1C Enzymes Reveals Activation by Panaxytriol, an Active Component of Red Ginseng.
J Am Chem Soc
130
14123-8
2008
Homo sapiens
Mack, SO; Garrett, WM; Guthrie, HD
Absence of correlation between in situ expression of cytochrome P450 17alpha hydroxylase/lyase and 3beta-hydroxysteroid dehydrogenase/(Delta5-4) isomerase messenger ribonucleic acids and steroidogenesis during pubertal development in the rat testis.
J Steroid Biochem Mol Biol
73
19-28
2000
Rattus
Lenz, S; Pƶhland, R; Becker, F; Vanselow, J
Expression of the bovine aromatase cytochrome P450 gene (Cyp19) is primarily regulated by promoter 2 in bovine follicles and by promoter 1.1 in corpora lutea.
Mol Reprod Dev
67
406-13
2004
Bos taurus
Degawa, M; Hanaki, K; Sekimoto, M
A hepatocarcinogenic tryptophan-pyrolyzate component, Trp-P-1, decreases serum total testosterone level and induces hepatic Cyp1a2 in male mice.
Cancer Sci
97
32-7
2006
Mus sp.
Hlavį?, V; Brynychovį, V; Vįclavķkovį, R; Ehrlichovį, M; Vrįna, D; Pecha, V; Trnkovį, M; Kodet, R; Mrhalovį, M; Kubį?kovį, K; Gat?k, J; Vįan, P; Sou?ek, P
The role of cytochromes p450 and aldo-keto reductases in prognosis of breast carcinoma patients.
Medicine (Baltimore)
93
e255
2014
Homo sapiens
BĆ©langer, A; Pelletier, G; Labrie, F; Barbier, O; Chouinard, S
Inactivation of androgens by UDP-glucuronosyltransferase enzymes in humans.
Trends Endocrinol Metab
14
473-9
2003
Homo sapiens
Chouinard, S; Pelletier, G; BĆ©langer, A; Barbier, O
Cellular specific expression of the androgen-conjugating enzymes UGT2B15 and UGT2B17 in the human prostate epithelium.
Endocr Res
30
717-25
2004
Homo sapiens
Wu, CH; Chen, YF; Wang, JY; Hsieh, MC; Yeh, CS; Lian, ST; Shin, SJ; Lin, SR
Mutant K-ras oncogene regulates steroidogenesis of normal human adrenocortical cells by the RAF-MEK-MAPK pathway.
Br J Cancer
87
1000-5
2002
Homo sapiens
Jokela, H; Rantakari, P; Lamminen, T; Strauss, L; Ola, R; Mutka, AL; Gylling, H; Miettinen, T; Pakarinen, P; Sainio, K; Poutanen, M
Hydroxysteroid (17beta) dehydrogenase 7 activity is essential for fetal de novo cholesterol synthesis and for neuroectodermal survival and cardiovascular differentiation in early mouse embryos.
Endocrinology
151
1884-92
2010
Mus musculus
Saloniemi, T; Jokela, H; Strauss, L; Pakarinen, P; Poutanen, M
The diversity of sex steroid action: novel functions of hydroxysteroid (17?) dehydrogenases as revealed by genetically modified mouse models.
J Endocrinol
212
27-40
2012
Mus musculus
Matsuoka, H; Uchino, Y; Choshi, M; Nakamura, T; Michihara, A
Stroke-prone spontaneously hypertensive rats have reduced hydroxysteroid 17-? dehydrogenase 7 levels for low cholesterol biosynthesis.
Clin Exp Pharmacol Physiol
47
255-262
2020
Rattus
Shirato, A; Kikugawa, T; Miura, N; Tanji, N; Takemori, N; Higashiyama, S; Yokoyama, M
Cisplatin resistance by induction of aldo-keto reductase family 1 member C2 in human bladder cancer cells.
Oncol Lett
7
674-678
2014
Homo sapiens
Ruksana, S; Pandit, NP; Nakamura, M
Efficacy of exemestane, a new generation of aromatase inhibitor, on sex differentiation in a gonochoristic fish.
Comp Biochem Physiol C Toxicol Pharmacol
152
69-74
2010
Chondrichthyes
Dong, Y; Mao, B; Li, L; Guan, H; Su, Y; Li, X; Lian, Q; Huang, P; Ge, RS
Gossypol enantiomers potently inhibit human placental 3?-hydroxysteroid dehydrogenase 1 and aromatase activities.
Fitoterapia
109
132-7
2016
Homo sapiens
Liu, S; Mao, B; Bai, Y; Liu, J; Li, H; Li, X; Lian, Q; Ge, RS
Effects of Methoxychlor and Its Metabolite Hydroxychlor on Human Placental 3?-Hydroxysteroid Dehydrogenase 1 and Aromatase in JEG-3 Cells.
Pharmacology
97
126-33
2016
Homo sapiens
Xu, RA; Mao, B; Li, S; Liu, J; Li, X; Li, H; Su, Y; Hu, G; Lian, QQ; Ge, RS
Structure-activity relationships of phthalates in inhibition of human placental 3?-hydroxysteroid dehydrogenase 1 and aromatase.
Reprod Toxicol
61
151-61
2016
Homo sapiens
Cao, S; Ye, L; Wu, Y; Mao, B; Chen, L; Wang, X; Huang, P; Su, Y; Ge, RS
The Effects of Fungicides on Human 3?-Hydroxysteroid Dehydrogenase 1 and Aromatase in Human Placental Cell Line JEG-3.
Pharmacology
100
139-147
2017
Homo sapiens
Chen, L; Chen, X; Chen, X; Hu, Z; Li, X; Su, Y; Li, X; Ge, RS
Ziram inhibits aromatase activity in human placenta and JEG-3 cell line.
Steroids
128
114-119
2017
Homo sapiens
Kim, ST; Moley, KH
Paternal effect on embryo quality in diabetic mice is related to poor sperm quality and associated with decreased glucose transporter expression.
Reproduction
136
313-22
2008
Mus sp.
MacLeod, AK; McMahon, M; Plummer, SM; Higgins, LG; Penning, TM; Igarashi, K; Hayes, JD
Characterization of the cancer chemopreventive NRF2-dependent gene battery in human keratinocytes: demonstration that the KEAP1-NRF2 pathway, and not the BACH1-NRF2 pathway, controls cytoprotection against electrophiles as well as redox-cycling compounds.
Carcinogenesis
30
1571-80
2009
Homo sapiens
Akao, T
Influence of various bile acids on the metabolism of glycyrrhizin and glycyrrhetic acid by Ruminococcus sp. PO1-3 of human intestinal bacteria.
Biol Pharm Bull
22
787-93
1999
Homo sapiens, bacterium
Akao, T
Competition in the metabolism of glycyrrhizin with glycyrrhetic acid mono-glucuronide by mixed Eubacterium sp. GLH and Ruminococcus sp. PO1-3.
Biol Pharm Bull
23
149-54
2000
Bacteria
Zhan, X; Zhang, J; Li, S; Zhang, X; Li, L; Song, T; Liu, Q; Lu, J; Xu, Y; Ge, RS
Monocyte Chemoattractant Protein-1 stimulates the differentiation of rat stem and progenitor Leydig cells during regeneration.
BMC Dev Biol
20
20
2020
Rattus
Young, KA; Stouffer, RL
Gonadotropin and steroid regulation of matrix metalloproteinases and their endogenous tissue inhibitors in the developed corpus luteum of the rhesus monkey during the menstrual cycle.
Biol Reprod
70
244-52
2004
Macaca mulatta
Keck, M; Romero-Aleshire, MJ; Cai, Q; Hoyer, PB; Brooks, HL
Hormonal status affects the progression of STZ-induced diabetes and diabetic renal damage in the VCD mouse model of menopause.
Am J Physiol Renal Physiol
293
F193-9
2007
Mus sp.
Aaronson, IA; Cakmak, MA; Key, LL
Defects of the testosterone biosynthetic pathway in boys with hypospadias.
J Urol
157
1884-8
1997
Homo sapiens
Sanders, SL; Stouffer, RL
Localization of steroidogenic enzymes in macaque luteal tissue during the menstrual cycle and simulated early pregnancy: immunohistochemical evidence supporting the two-cell model for estrogen production in the primate corpus luteum.
Biol Reprod
56
1077-87
1997
Macaca, Primates
O'Shaughnessy, PJ; Baker, P; Sohnius, U; Haavisto, AM; Charlton, HM; Huhtaniemi, I
Fetal development of Leydig cell activity in the mouse is independent of pituitary gonadotroph function.
Endocrinology
139
1141-6
1998
Mus sp.
Lebrethon, MC; Avallet, O; Reznik, Y; Archambeaud, F; Combes, J; Usdin, TB; Narboni, G; Mahoudeau, J; Saez, JM
Food-dependent Cushing's syndrome: characterization and functional role of gastric inhibitory polypeptide receptor in the adrenals of three patients.
J Clin Endocrinol Metab
83
4514-9
1998
Homo sapiens
Hombach-Klonisch, S; Tetens, F; Kauffold, J; Steger, K; Fischer, B; Klonisch, T
Molecular cloning and localization of caprine relaxin-like factor (RLF) mRNA within the goat testis.
Mol Reprod Dev
53
135-41
1999
Capra hircus
Klonisch, T; Hombach-Klonisch, S; Buchmann, J; Fischer, B; Bergmann, M; Steger, K
Relaxin-like factor expression in a human ovarian Sertoli-Leydig cell tumor.
Fertil Steril
72
546-8
1999
Homo sapiens
Chaffin, CL; Dissen, GA; Stouffer, RL
Hormonal regulation of steroidogenic enzyme expression in granulosa cells during the peri-ovulatory interval in monkeys.
Mol Hum Reprod
6
11-8
2000
Homo sapiens, Macaca
Tsubota, T; Taki, S; Nakayama, K; Mason, JI; Kominami, S; Harada, N; Kita, I
Immunolocalization of steroidogenic enzymes in the corpus luteum and placenta of the Japanese black bear, Ursus thibetanus japonicus, during pregnancy.
Reproduction
121
587-94
2001
Ursidae, Mammalia
Govoroun, M; McMeel, OM; Mecherouki, H; Smith, TJ; Guiguen, Y
17beta-estradiol treatment decreases steroidogenic enzyme messenger ribonucleic acid levels in the rainbow trout testis.
Endocrinology
142
1841-8
2001
Oncorhynchus mykiss
Manikkam, M; Calder, MD; Salfen, BE; Youngquist, RS; Keisler, DH; Garverick, HA
Concentrations of steroids and expression of messenger RNA for steroidogenic enzymes and gonadotropin receptors in bovine ovarian follicles of first and second waves and changes in second wave follicles after pulsatile LH infusion.
Anim Reprod Sci
67
189-203
2001
Bos taurus
Govoroun, M; McMeel, OM; D'Cotta, H; Ricordel, MJ; Smith, T; Fostier, A; Guiguen, Y
Steroid enzyme gene expressions during natural and androgen-induced gonadal differentiation in the rainbow trout, Oncorhynchus mykiss.
J Exp Zool
290
558-66
2001
Oncorhynchus mykiss
Qiang, W; Murase, T; Tsubota, T
Seasonal changes in spermatogenesis and testicular steroidogenesis in wild male raccoon dogs (Nyctereutes procynoides).
J Vet Med Sci
65
1087-92
2003
Homo sapiens, Sus scrofa, Bos taurus
Kubota, K; Ohsako, S; Kurosawa, S; Takeda, K; Qing, W; Sakaue, M; Kawakami, T; Ishimura, R; Tohyama, C
Effects of vinclozolin administration on sperm production and testosterone biosynthetic pathway in adult male rat.
J Reprod Dev
49
403-12
2003
Rattus
Warnes, KE; McMillen, IC; Robinson, JS; Coulter, CL
Differential actions of metyrapone on the fetal pituitary-adrenal axis in the sheep fetus in late gestation.
Biol Reprod
71
620-8
2004
Ovis aries
Weng, Q; Medan, MS; Ren, L; Watanabe, G; Tsubota, T; Taya, K
Immunolocalization of steroidogenic enzymes in the corpus luteum and placenta of the Japanese Shiba goat.
J Reprod Dev
51
247-52
2005
Capra hircus, Zoysia japonica
Ings, JS; Van Der Kraak, GJ
Characterization of the mRNA expression of StAR and steroidogenic enzymes in zebrafish ovarian follicles.
Mol Reprod Dev
73
943-54
2006
Chondrichthyes
Weng, Q; Tanaka, Y; Taniyama, H; Tsunoda, N; Nambo, Y; Watanabe, G; Taya, K
Immunolocalization of steroidogenic enzymes in equine fetal adrenal glands during mid-late gestation.
J Reprod Dev
53
1093-8
2007
Bos taurus, Homo sapiens, Sus scrofa
Tanaka, T; Gondo, S; Okabe, T; Ohe, K; Shirohzu, H; Morinaga, H; Nomura, M; Tani, K; Takayanagi, R; Nawata, H; Yanase, T
Steroidogenic factor 1/adrenal 4 binding protein transforms human bone marrow mesenchymal cells into steroidogenic cells.
J Mol Endocrinol
39
343-350
2007
Homo sapiens
Wu, XY; Wang, WY; Wang, RR; Xie, L; Fang, ZX; Chen, GR
[Ginkgo biloba extract enhances testosterone synthesis of Leydig cells in type 2 diabetic rats]
Zhonghua Nan Ke Xue
14
371-6
2008
Electron
Pogrmic, K; Fa, S; Dakic, V; Kaisarevic, S; Kovacevic, R
Atrazine oral exposure of peripubertal male rats downregulates steroidogenesis gene expression in Leydig cells.
Toxicol Sci
111
189-97
2009
Rattus
Moore, BC; Milnes, MR; Kohno, S; Katsu, Y; Iguchi, T; Guillette, LJ
Influences of Sex, Incubation Temperature, and Environmental Quality on Gonadal Estrogen and Androgen Receptor Messenger RNA Expression in Juvenile American Alligators (Alligator mississippiensis).
Biol Reprod
2009
Alligator
Sivils, JC; Gonzalez, I; Bain, LJ
Mice lacking Mrp1 have reduced testicular steroid hormone levels and alterations in steroid biosynthetic enzymes.
Gen Comp Endocrinol
167
51-9
2010
Mus sp.
Kaewmanee, S; Watanabe, G; Kishimoto, M; Jin, WZ; Yamamoto, Y; Yamamoto, T; Narushima, E; Komiya, T; Taya, K
Secretion of Inhibin during the Estrous Cycle in the Female Asian Elephant (Elephas maximus).
J Vet Med Sci
2010
Proboscidea
Miyado, M; Nakamura, M; Miyado, K; Morohashi, K; Sano, S; Nagata, E; Fukami, M; Ogata, T
Mamld1 deficiency significantly reduces mRNA expression levels of multiple genes expressed in mouse fetal Leydig cells but permits normal genital and reproductive development.
Endocrinology
153
6033-40
2012
Mus sp.
Taheri, S; Zararsiz, G; Karaburgu, S; Borlu, M; Ozgun, MT; Karaca, Z; Tanriverdi, F; Dundar, M; Kelestimur, F; Unluhizarci, K
Is idiopathic hirsutism (IH) really idiopathic? mRNA expressions of skin steroidogenic enzymes in women with IH.
Eur J Endocrinol
173
447-54
2015
Homo sapiens
Liu, HC; Zhu, D; Wang, C; Guan, H; Li, S; Hu, C; Chen, Z; Hu, Y; Lin, H; Lian, QQ; Ge, RS
Effects of Etomidate on the Steroidogenesis of Rat Immature Leydig Cells.
PLoS One
10
e0139311
2015
Rattus
Li, X; Cao, S; Mao, B; Bai, Y; Chen, X; Wang, X; Wu, Y; Li, L; Lin, H; Lian, Q; Huang, P; Ge, RS
Effects of butylated hydroxyanisole on the steroidogenesis of rat immature Leydig cells.
Toxicol Mech Methods
1-9
2016
Rattus
Wu, X; Guo, X; Wang, H; Zhou, S; Li, L; Chen, X; Wang, G; Liu, J; Ge, HS; Ge, RS
A brief exposure to cadmium impairs Leydig cell regeneration in the adult rat testis.
Sci Rep
7
6337
2017
Metazoa
Legacki, EL; Ball, BA; Corbin, CJ; Loux, SC; Scoggin, KE; Stanley, SD; Conley, AJ
Equine fetal adrenal, gonadal and placental steroidogenesis.
Reproduction
154
445-454
2017
Equus caballus
Buńay, J; Larriba, E; Patińo-Garcia, D; Cruz-Fernandes, L; Castańeda-Zegarra, S; Rodriguez-Fernandez, M; Del Mazo, J; Moreno, RD
Editor's Highlight: Differential Effects of Exposure to Single Versus a Mixture of Endocrine-Disrupting Chemicals on Steroidogenesis Pathway in Mouse Testes.
Toxicol Sci
161
76-86
2018
Mus sp.
Weger, M; Diotel, N; Weger, BD; Beil, T; Zaucker, A; Eachus, HL; Oakes, JA; do Rego, JL; Storbeck, KH; Gut, P; Straehle, U; Rastegar, S; Mueller, F; Krone, N
Expression and activity profiling of the steroidogenic enzymes of glucocorticoid biosynthesis and the fdx1 co-factors in zebrafish.
J Neuroendocrinol
2018
Danio rerio
Tian, M; Liu, F; Liu, H; Zhang, Q; Li, L; Hou, X; Zhao, J; Li, S; Chang, X; Sun, Y
Grape seed procyanidins extract attenuates Cisplatin-induced oxidative stress and testosterone synthase inhibition in rat testes.
Syst Biol Reprod Med
1-14
2018
Vitis vinifera
Zhu, Q; Ge, F; Li, X; Deng, HS; Xu, M; Bu, T; Li, J; Wang, Y; Shan, Y; Ge, RS; Yao, M
Dehydroepiandrosterone Antagonizes Pain Stress-Induced Suppression of Testosterone Production in Male Rats.
Front Pharmacol
9
322
2018
Rattus
Wang, Y; Chen, Y; Ni, C; Fang, Y; Wu, K; Zheng, W; Li, X; Lin, H; Fan, L; Ge, RS
Effects of dexmedetomidine on the steroidogenesis of rat immature Leydig cells.
Steroids
149
108423
2019
Rattus
Guo, Z; Chen, X; Feng, P; Yu, Q
Short-term rapamycin administration elevated testosterone levels and exacerbated reproductive disorder in dehydroepiandrosterone-induced polycystic ovary syndrome mice.
J Ovarian Res
14
64
2021
Mus sp.
Duncan, WC; Illingworth, PJ; Young, FM; Fraser, HM
Induced luteolysis in the primate: rapid loss of luteinizing hormone receptors.
Hum Reprod
13
2532-40
1998
Platyrrhini
Lo, YC; Brett, L; Kenyon, CJ; Morley, SD; Mason, JI; Williams, BC
StAR protein is expressed in both medulla and cortex of the bovine and rat adrenal gland.
Endocr Res
24
559-63
0
Bos taurus, Rattus, Homo sapiens
Engeland, WC; Levay-Young, BK
Changes in the glomerulosa cell phenotype during adrenal regeneration in rats.
Am J Physiol
276
R1374-82
1999
Rattus
Telleria, CM; Stocco, CO; Stati, AO; Deis, RP
Progesterone receptor is not required for progesterone action in the rat corpus luteum of pregnancy.
Steroids
64
760-6
1999
Rattus
Sato, Y; Terada, Y; Utsunomiya, H; Koyanagi, Y; Ito, M; Miyoshi, I; Suzuki, T; Sasano, H; Murakami, T; Yaegashi, N; Okamura, K
Immunohistochemical localization of steroidogenic enzymes in human follicle following xenotransplantation of the human ovarian cortex into NOD-SCID mice.
Mol Reprod Dev
65
67-72
2003
Homo sapiens, Mus sp.
Rosa-E-Silva, A; Guimaraes, MA; Padmanabhan, V; Lara, HE
Prepubertal administration of estradiol valerate disrupts cyclicity and leads to cystic ovarian morphology during adult life in the rat: role of sympathetic innervation.
Endocrinology
144
4289-97
2003
Rattus
Lai, KP; Wong, MH; Wong, CK
Inhibition of CYP450scc expression in dioxin-exposed rat Leydig cells.
J Endocrinol
185
519-27
2005
Rattus
Atanassova, N; Koeva, Y; Bakalska, M; Pavlova, E; Nikolov, B; Davidoff, M
Loss and recovery of androgen receptor protein expression in the adult rat testis following androgen withdrawal by ethane dimethanesulfonate.
Folia Histochem Cytobiol
44
81-6
2006
Rattus
Blom, MJ; Wassink, MG; De Gooyer, ME; Ederveen, AG; Kloosterboer, HJ; Lange, J; Lambert, JG; Goos, HJ
Metabolism of tibolone and its metabolites in uterine and vaginal tissue of rat and human origin.
J Steroid Biochem Mol Biol
101
42-9
2006
Homo sapiens
Raffalli-Mathieu, F; Persson, D; Mannervik, B
Differences between bovine and human steroid double-bond isomerase activities of Alpha-class glutathione transferases selectively expressed in steroidogenic tissues.
Biochim Biophys Acta
1770
130-6
2007
Bos taurus
Fecteau, KA; Mrkonjich, L; Mason, JI; Mendis-Handagama, SM
Detection of platelet-derived growth factor-alpha (PDGF-A) protein in cells of Leydig lineage in the postnatal rat testis.
Histol Histopathol
21
1295-302
2006
Indicator
Song, XF; Wei, GH; Deng, YJ; Chen, X; Liu, X; Zhang, DY
[Di(2-ethylhexyl) phthalate affects the testes and leydig cells of neonatal KM mice]
Zhonghua Nan Ke Xue
12
775-9
2006
Mus sp.
Blouin, K; Richard, C; Brochu, G; Hould, FS; Lebel, S; Marceau, S; Biron, S; Luu-The, V; Tchernof, A
Androgen inactivation and steroid-converting enzyme expression in abdominal adipose tissue in men.
J Endocrinol
191
637-49
2006
Homo sapiens
Kopera, I; Tuz, R; Kotula-Balak, M; Schwarz, T; Koczanowski, J; Bilinska, B
Morphofunctional alterations in testicular cells of deslorelin-treated boars: an immunohistochemical study.
J Exp Zool Part A Ecol Genet Physiol
309
117-26
2008
Suidae
Kumar, V; Chakraborty, A; Kural, MR; Roy, P
Alteration of testicular steroidogenesis and histopathology of reproductive system in male rats treated with triclosan.
Reprod Toxicol
27
177-85
2009
Rattus
Zurvarra, FM; Salvetti, NR; Mason, JI; Velazquez, MM; Alfaro, NS; Ortega, HH
Disruption in the expression and immunolocalisation of steroid receptors and steroidogenic enzymes in letrozole-induced polycystic ovaries in rat.
Reprod Fertil Dev
21
827-39
2009
Rattus
Victor-Costa, AB; Bandeira, SM; Oliveira, AG; Mahecha, GA; Oliveira, CA
Changes in testicular morphology and steroidogenesis in adult rats exposed to Atrazine.
Reprod Toxicol
29
323-31
2010
Rattus
Quintana, S; Venara, M; Rey, R; di Clemente, N; Chemes, HE
Origin and evolution of somatic cell testicular tumours in transgenic mice.
J Pathol
221
443-51
2010
Areas
Otis, M; Campbell, S; Payet, MD; Gallo-Payet, N
Expression of extracellular matrix proteins and integrins in rat adrenal gland: importance for ACTH-associated functions.
J Endocrinol
193
331-47
2007
Simian immunodeficiency virus
Ferrante, T; Viola, F; Balliano, G; Oliaro-Bosso, S
Difference in the late ergosterol biosynthesis between yeast spheroplasts and intact cells.
Acta Biochim Pol
2016
Saccharomyces cerevisiae
Zheng, L; Wu, S; Shen, J; Han, X; Jin, C; Chen, X; Zhao, S; Cao, Y; Yao, J
High rumen degradable starch decreased goat milk fat via trans-10, cis-12 conjugated linoleic acid-mediated downregulation of lipogenesis genes, particularly, INSIG1.
J Anim Sci Biotechnol
11
30
2020
Butyrivibrio fibrisolvens, Pseudobutyrivibrio
Gomez-Sanchez, CE; Lewis, M; Nanba, K; Rainey, WE; Kuppusamy, M; Gomez-Sanchez, EP
Development of monoclonal antibodies against the human 3?-hydroxysteroid dehydrogenase/isomerase isozymes.
Steroids
2017
Homo sapiens
Lo, MJ; Lee, SD
Direct effects of IL-15 on corticosterone secretion by rat adrenocortical cells.
Immunol Cell Biol
84
38-43
2006
Rattus
Yu, PL; Chao, HL; Wang, SW; Wang, PS
Effects of evodiamine and rutaecarpine on the secretion of corticosterone by Zona fasciculata-reticularis cells in male rats.
J Cell Biochem
108
469-75
2009
Rattus
Sangha, GK; Kaur, K; Khera, KS
Cypermethrin induced pathological and biochemical changes in reproductive organs of female rats.
J Environ Biol
34
99-105
2013
Rattus
Schirra, F; Suzuki, T; Dickinson, DP; Townsend, DJ; Gipson, IK; Sullivan, DA
Identification of steroidogenic enzyme mRNAs in the human lacrimal gland, meibomian gland, cornea, and conjunctiva.
Cornea
25
438-42
2006
Homo sapiens
Bernstein, RM; Sterner, KN; Wildman, DE
Adrenal androgen production in catarrhine primates and the evolution of adrenarche.
Am J Phys Anthropol
147
389-400
2012
Homo sapiens
Bai, R; Latifi, Z; Kusama, K; Nakamura, K; Shimada, M; Imakawa, K
Induction of immune-related gene expression by seminal exosomes in the porcine endometrium.
Biochem Biophys Res Commun
495
1094-1101
2018
Suidae
Ryzhavski?, BIa; Zadvornaia, OV
[3beta-Hydroxysteroid dehydrogenase in ependimocytes of brain lateral ventricle lining and vascular plexus villi in rats of different age].
Morfologiia
142
26-9
2012
Rattus
Nemoto, K; Ikeda, A; Ito, S; Miyata, M; Yoshida, C; Degawa, M
Comparison of constitutive gene expression levels of hepatic cholesterol biosynthetic enzymes between Wistar-Kyoto and stroke-prone spontaneously hypertensive rats.
Biol Pharm Bull
36
1216-20
2013
Rattus
Pazirandeh, A; Xue, Y; Rafter, I; Sjƶvall, J; Jondal, M; Okret, S
Paracrine glucocorticoid activity produced by mouse thymic epithelial cells.
FASEB J
13
893-901
1999
Rodentia
Yarimizu, D; Doi, M; Ota, T; Okamura, H
Stimulus-selective induction of the orphan nuclear receptor NGFIB underlies different influences of angiotensin II and potassium on the human adrenal gland zona glomerulosa-specific 3?-HSD isoform gene expression in adrenocortical H295R cells.
Endocr J
62
765-76
2015
Homo sapiens
Hofmann, A; Peitzsch, M; Brunssen, C; Mittag, J; Jannasch, A; Frenzel, A; Brown, N; Weldon, SM; Eisenhofer, G; Bornstein, SR; Morawietz, H
Elevated Steroid Hormone Production in the db/db Mouse Model of Obesity and Type 2 Diabetes.
Horm Metab Res
49
43-49
2017
Mus sp.
Chen, JJ; Wang, PS; Chien, EJ; Wang, SW
Direct inhibitory effect of digitalis on progesterone release from rat granulosa cells.
Br J Pharmacol
132
1761-8
2001
Rattus
Inoue, T; Akahira, J; Suzuki, T; Darnel, AD; Kaneko, C; Takahashi, K; Hatori, M; Shirane, R; Kumabe, T; Kurokawa, Y; Satomi, S; Sasano, H
Progesterone production and actions in the human central nervous system and neurogenic tumors.
J Clin Endocrinol Metab
87
5325-31
2002
Homo sapiens
Chen, JJ; Wang, SW; Chien, EJ; Wang, PS
Direct effect of propylthiouracil on progesterone release in rat granulosa cells.
Br J Pharmacol
139
1564-70
2003
Rattus
Hsia, SM; Chiang, W; Kuo, YH; Wang, PS
Downregulation of progesterone biosynthesis in rat granulosa cells by adlay (Coix lachryma-jobi L. var. ma-yuen Stapf.) bran extracts.
Int J Impot Res
18
264-74
0
Rattus
Yang, J; Zhang, Y; Wang, Y; Cui, S
Toxic effects of zearalenone and alpha-zearalenol on the regulation of steroidogenesis and testosterone production in mouse Leydig cells.
Toxicol In Vitro
21
558-65
2007
Mus musculus
Berensztein, EB; Baquedano, MS; Pepe, CM; Costanzo, M; Saraco, NI; Ponzio, R; Rivarola, MA; Belgorosky, A
Role of IGFs and insulin in the human testis during postnatal activation: differentiation of steroidogenic cells.
Pediatr Res
63
662-6
2008
Homo sapiens
Mani, AM; Fenwick, M; Cheng, Z; Sharma, M; Singh, D; Wathes, C
IGF1 induces up-regulation of steroidogenic and apoptotic regulatory genes via activation of phosphatidylinositol-dependent kinase/AKT in bovine granulosa cells.
Reproduction
2009
Bos taurus
Giganti, MG; Minella, D; Testa, B; Zenobi, R; Biancolella, M; Isidori, AM; Caprio, M; Novelli, G; Fabbri, A
A pilot study on the transcriptional response of androgen- and insulin-related genes in peripheral blood mononuclear cells induced by testosterone administration in hypogonadal men.
J Biol Regul Homeost Agents
25
291-4
0
Homo sapiens
Care, AS; Diener, KR; Jasper, MJ; Brown, HM; Ingman, WV; Robertson, SA
Macrophages regulate corpus luteum development during embryo implantation in mice.
J Clin Invest
123
3472-87
2013
Mus sp.
Falvo, S; Chieffi Baccaria, G; Spaziano, G; Rosati, L; Venditti, M; Di Flore, MM; Santillo, A
StAR protein and steroidogenic enzyme expressions in the rat Harderian gland.
C R Biol
341
160-166
2018
Rattus
Tu, X; Liu, M; Tang, J; Zhang, Y; Shi, Y; Yu, L; Sun, Z
The ovarian estrogen synthesis function was impaired in Y123F mouse and partly restored by exogenous FSH supplement.
Reprod Biol Endocrinol
16
44
2018
Mus sp.
Hasegawa, H; Nishimura, R; Yamashita, M; Yamaguchi, T; Hishinuma, M; Okuda, K
Effect of hypoxia on progesterone production by cultured bovine early and mid luteal cells.
J Reprod Dev
65
67-72
2019
Bos taurus
Herrera-Cogco, E; López-Bayghen, B; Hernandez-Melchor, D; López-Luna, A; Palafox, C; Ramķrez-Martķnez, L; López-Bello, E; Albores, A; López-Bayghen, E
Paraben concentrations found in human body fluids do not exert steroidogenic effects in human granulosa primary cell cultures.
Toxicol Mech Methods
1-34
2020
Homo sapiens
Liu, X; Wang, Z; Liu, F
Chronic exposure of BPA impairs male germ cell proliferation and induces lower sperm quality in male mice.
Chemosphere
262
127880
2020
Mus sp.
Hu, WP; Liu, MQ; Tian, ZL; Liu, QY; Zhang, ZB; Tang, JS; He, XY; Zhu, YY; Wang, YY; Chu, MX
Polymorphism, expression and structure analysis of key genes in the ovarian steroidogenesis pathway in sheep (Ovis aries).
Vet Med Sci
7
1303-1315
2021
Ovis aries
MaÅunowicz, EM; Mitkowska, Z; Bal, K; Nizankowska-BÅaz, T; MoszczyÅska, E; Iwanicka, Z; Romer, TE
Definitive diagnosis of enzymatic deficiencies of steroidogenesis in at-risk newborns and infants by urinary marker analysis using GC/MS-SIM.
Horm Res
48
243-51
1997
Homo sapiens
Ohno, S; Nakajima, Y; Inoue, K; Nakazawa, H; Nakajin, S
Genistein administration decreases serum corticosterone and testosterone levels in rats.
Life Sci
74
733-42
2003
Homo sapiens
Goto, M
Pituitary-adrenal axis during human development.
Clin Pediatr Endocrinol
16
37-44
2007
Homo sapiens
Bacila, I; Cunliffe, VT; Krone, NP
Interrenal development and function in zebrafish.
Mol Cell Endocrinol
535
111372
2021
Danio rerio
Atalla, A; Maser, E
Characterization of enzymes participating in carbonyl reduction of 4-methylnitrosamino-1-(3-pyridyl)-1-butanone (NNK) in human placenta.
Chem Biol Interact
130-132
737-48
2001
Homo sapiens
Rodway, RG; Rothchild, I
Effects of oestradiol on steroid dehydrogenase activities in rat corpora lutea.
J Endocrinol
84
391-5
1980
Rattus, Homo sapiens
Forneris, ML; Aguado, LI
Neonatal superior ovarian nerve transection disturbs the cyclic activity of the female rats.
J Steroid Biochem Mol Biol
82
75-82
2002
Rattus
Roberson, AE; Hyatt, K; Kenkel, C; Hanson, K; Myers, DA
Interleukin 1? regulates progesterone metabolism in human cervical fibroblasts.
Reprod Sci
19
271-81
2012
Homo sapiens
Su, H; Han, L; Ding, N; Guan, P; Hu, C; Huang, X
Bafilomycin C1 exert antifungal effect through disturbing sterol biosynthesis in Candida albicans.
J Antibiot (Tokyo)
71
467-476
2018
Candida albicans
KaiserovĆ”, H; KvasnickovĆ”, E
Inhibition study of rabbit liver cytosolic reductases involved in daunorubicin toxication.
J Enzyme Inhib Med Chem
20
477-83
2005
Oryctolagus cuniculus
Jana, K; Samanta, PK; Manna, I; Ghosh, P; Singh, N; Khetan, RP; Ray, BR
Protective effect of sodium selenite and zinc sulfate on intensive swimming-induced testicular gamatogenic and steroidogenic disorders in mature male rats.
Appl Physiol Nutr Metab
33
903-14
2008
Rattus
Di Cristo, C; Di Donato, P; Palumbo, A; d'Ischia, M; Paolucci, M; Di Cosmo, A
Steroidogenesis in the brain of Sepia officinalis and Octopus vulgaris.
Front Biosci (Elite Ed)
2
673-83
2010
Sepia, octopus
Sharp, F; Hay, JB; Hodgins, MB
Metabolism of androgens in vitro by human foetal skin.
J Endocrinol
70
491-9
1976
Homo sapiens
Kahri, AI; Huhtaniemi, I; SalmenperƤ, M
Steroid formation and differentiation of cortical cells in tissue culture of human fetal adrenals in the presence and absence of ACTH.
Endocrinology
98
33-41
1976
Homo sapiens
Marchut, M
In vitro metabolism of [4-14C] androstenedione and [4-14C] testosterone by rabbit placenta.
Endocrinol Exp
11
139-46
1977
Oryctolagus cuniculus
Lambert, F; Corcelle-Cerf, F; Lammerant, J; Kolanowski, J
On the specificity of the inhibitory effect of trilostane and aminoglutethimide on adrenocortical steroidogenesis in guinea pig.
Mol Cell Endocrinol
37
115-20
1984
Cavia porcellus
Sultan, C; Terraza, A; Devillier, C; Carilla, E; Briley, M; Loire, C; Descomps, B
Inhibition of androgen metabolism and binding by a liposterolic extract of "Serenoa repens B" in human foreskin fibroblasts.
J Steroid Biochem
20
515-9
1984
Homo sapiens
Haluska, GJ; Cook, MJ; Novy, MJ
Inhibition and augmentation of progesterone production during pregnancy: effects on parturition in rhesus monkeys.
Am J Obstet Gynecol
176
682-91
1997
Macaca mulatta, Primates
Hayashi, Y; Kiyono, T; Fujita, M; Ishibashi, M
Isolation of a novel cDNA whose corresponding mRNA is accumulated in growth-arrested confluent but not in growing sub-confluent rat 3Y1 cells.
Biochim Biophys Acta
1352
145-50
1997
Rattus
Duffy, DM; Stouffer, RL
Gonadotropin versus steroid regulation of the corpus luteum of the rhesus monkey during simulated early pregnancy.
Biol Reprod
57
1451-60
1997
Metazoa
Woolveridge, I; de Boer-Brouwer, M; Taylor, MF; Teerds, KJ; Wu, FC; Morris, ID
Apoptosis in the rat spermatogenic epithelium following androgen withdrawal: changes in apoptosis-related genes.
Biol Reprod
60
461-70
1999
Metazoa
Parker, CR
Dehydroepiandrosterone and dehydroepiandrosterone sulfate production in the human adrenal during development and aging.
Steroids
64
640-7
1999
Homo sapiens
Park, JI; Kim, WJ; Wang, L; Park, HJ; Lee, J; Park, JH; Kwon, HB; Tsafriri, A; Chun, SY
Involvement of progesterone in gonadotrophin-induced pituitary adenylate cyclase-activating polypeptide gene expression in pre-ovulatory follicles of rat ovary.
Mol Hum Reprod
6
238-45
2000
Rattus
Duffy, DM; Chaffin, CL; Stouffer, RL
Expression of estrogen receptor alpha and beta in the rhesus monkey corpus luteum during the menstrual cycle: regulation by luteinizing hormone and progesterone.
Endocrinology
141
1711-7
2000
Platyrrhini
Stuchi-Perez, EG; Lukas-Croisier, C; De Castro, M; Baptista, MT; Ribeiro Scolfaro, M; Marques-De-Faria, AP; Hackel, C; Maciel-Guerra, AT; Guerra JĆŗnior, G
Evaluation of the tubular and interstitial functions of the testis in 46,XY patients with ambiguous genitalia.
J Pediatr Endocrinol Metab
13
605-12
2000
Homo sapiens
Chaffin, CL; Stouffer, RL
Role of gonadotrophins and progesterone in the regulation of morphological remodelling and atresia in the monkey peri-ovulatory follicle.
Hum Reprod
15
2489-95
2000
Macaca, Homo sapiens
Ueno, M; Nakashima, J; Akita, M; Ban, SI; Nakanoma, T; Iida, M; Deguchi, N
Characterization of a newly established cell line derived from human adrenocortical carcinoma.
Int J Urol
8
17-22
2001
Homo sapiens
Di Cosmo, A; Di Cristo, C; Paolucci, M
Sex steroid hormone fluctuations and morphological changes of the reproductive system of the female of Octopus vulgaris throughout the annual cycle.
J Exp Zool
289
33-47
2001
Octopus vulgaris
Niiyama, S; Happle, R; Hoffmann, R
Influence of estrogens on the androgen metabolism in different subunits of human hair follicles.
Eur J Dermatol
11
195-8
0
Homo sapiens
Chaffin, CL; Schwinof, KM; Stouffer, RL
Gonadotropin and steroid control of granulosa cell proliferation during the periovulatory interval in rhesus monkeys.
Biol Reprod
65
755-62
2001
Macaca
Shanbhag, BA; Radder, RS; Saidapur, SK
Plasma progesterone levels and luteal activity during gestation and prolonged oviductal egg retention in a tropical lizard, Calotes versicolor.
Gen Comp Endocrinol
123
73-9
2001
Lepidosauria
Nwokoro, NA; Wassif, CA; Porter, FD
Genetic disorders of cholesterol biosynthesis in mice and humans.
Mol Genet Metab
74
105-19
0
Homo sapiens, Mus musculus
Debieu, D; Bach, J; Hugon, M; Malosse, C; Leroux, P
The hydroxyanilide fenhexamid, a new sterol biosynthesis inhibitor fungicide efficient against the plant pathogenic fungus Botryotinia fuckeliana (Botrytis cinerea).
Pest Manag Sci
57
1060-7
2001
Botrytis cinerea
Ruckstuhl, NS; Nett, CS; Reusch, CE
Results of clinical examinations, laboratory tests, and ultrasonography in dogs with pituitary-dependent hyperadrenocorticism treated with trilostane.
Am J Vet Res
63
506-12
2002
Canis lupus familiaris
Baker, PJ; Pakarinen, P; Huhtaniemi, IT; Abel, MH; Charlton, HM; Kumar, TR; O'Shaughnessy, PJ
Failure of normal Leydig cell development in follicle-stimulating hormone (FSH) receptor-deficient mice, but not FSHbeta-deficient mice: role for constitutive FSH receptor activity.
Endocrinology
144
138-45
2003
Mus sp.
Russell, AJ; Gilmore, DP; Mackay, S; Ullmann, SL; Baker, PJ; Payne, AP
The role of androgens in development of the scrotum of the grey short-tailed Brazilian opossum ( Monodelphis domestica).
Anat Embryol (Berl)
206
381-9
2003
Indicator
Klobucar, I; Kosec, M; Cebulj-Kadunc, N; Majdic, G
Postnatal hypothyroidism does not affect prepubertal testis development in boars.
Reprod Domest Anim
38
193-8
2003
Suidae
Micevych, P; Sinchak, K; Mills, RH; Tao, L; LaPolt, P; Lu, JK
The luteinizing hormone surge is preceded by an estrogen-induced increase of hypothalamic progesterone in ovariectomized and adrenalectomized rats.
Neuroendocrinology
78
29-35
2003
Rattus
Di Meo, GP; Perucatti, A; Gautier, M; Hayes, H; Incarnato, D; Eggen, A; Iannuzzi, L
Chromosome localization of the 31 type I Texas bovine markers in sheep and goat chromosomes by comparative FISH-mapping and R-banding.
Anim Genet
34
294-6
2003
Capra hircus, Ovis aries
Sandhyakumary, K; Boby, RG; Indira, M
Impact of feeding ethanolic extracts of Achyranthes aspera Linn. on reproductive functions in male rats.
Indian J Exp Biol
40
1307-9
2002
Rattus, Abacopteris aspera
Anbalagan, M; Sriraman, V; Jagannadha Rao, A
Isolation and characterization of Leydig cells from adult bonnet monkeys (Macaca radiata): evidence for low steroidogenic capacity in monkey Leydig cells in contrast to rat Leydig cells.
J Endocrinol
179
175-82
2003
Platyrrhini
Mantis, P; Lamb, CR; Witt, AL; Neiger, R
Changes in ultrasonographic appearance of adrenal glands in dogs with pituitary-dependent hyperadrenocorticism treated with trilostane.
Vet Radiol Ultrasound
44
682-5
0
Canis lupus familiaris
Froment, P; Staub, C; Hembert, S; Pisselet, C; Magistrini, M; Delaleu, B; Seurin, D; Levine, JE; Johnson, L; Binoux, M; Monget, P
Reproductive abnormalities in human insulin-like growth factor-binding protein-1 transgenic male mice.
Endocrinology
145
2080-91
2004
Mus sp.
Chaudhuri-Sengupta, S; Sarkar, R; Maiti, BR
Lithium action on adrenomedullary and adrenocortical functions and serum ionic balance in different age-groups of albino rats.
Arch Physiol Biochem
111
246-53
2003
Rattus
Doran, E; Whittington, FM; Wood, JD; McGivan, JD
Characterisation of androstenone metabolism in pig liver microsomes.
Chem Biol Interact
147
141-9
2004
Sus scrofa, Suidae
Chatterjee, S; Ray, A; Bagchi, P; Deb, C
Suppression of testicular steroidogenesis in rats by the organochlorine insecticide Aldrin.
Environ Pollut
51
87-94
1988
Rattus
McGowan, CM; Frost, R; Pfeiffer, DU; Neiger, R
Serum insulin concentrations in horses with equine Cushing's syndrome: response to a cortisol inhibitor and prognostic value.
Equine Vet J
36
295-8
2004
Equidae
Petrova-Souvandjieva, EI
Influence of oxytocin on the steroidogenic activity of rat adrenal cortex.
Folia Med (Plovdiv)
46
47-50
2004
Rattus
Frungieri, MB; Mayerhofer, A; Zitta, K; Pignataro, OP; Calandra, RS; Gonzalez-Calvar, SI
Direct effect of melatonin on Syrian hamster testes: melatonin subtype 1a receptors, inhibition of androgen production, and interaction with the local corticotropin-releasing hormone system.
Endocrinology
146
1541-52
2005
Homo sapiens, Cricetinae, Metazoa
Manna, I; Jana, K; Samanta, PK
Effect of different intensities of swimming exercise on testicular oxidative stress and reproductive dysfunction in mature male albino Wistar rats.
Indian J Exp Biol
42
816-22
2004
Rattus
Pushpalatha, T; Srinivas, M; Sreenivasula Reddy, P
Exposure to high fluoride concentration in drinking water will affect spermatogenesis and steroidogenesis in male albino rats.
Biometals
18
207-12
2005
Rattus
Bhandari, RK; Nakamura, M; Kobayashi, T; Nagahama, Y
Suppression of steroidogenic enzyme expression during androgen-induced sex reversal in Nile tilapia (Oreochromis niloticus).
Gen Comp Endocrinol
145
20-4
2006
Oreochromis niloticus, Tilapia
Izumi, S; Mitani, F
Gonadotropin stimuli increase adrenodoxin immunoreactivity in the mitochondria of rat ovarian cells.
Acta Histochem
107
269-77
2005
Rattus
Chertin, B; Koulikov, D; Hadas-Halpern, I; Farkas, A
Masculinizing genitoplasty in intersex patients.
J Urol
174
1683-6
2005
Homo sapiens
Lacombe, A; Lelievre, V; Roselli, CE; Salameh, W; Lue, YH; Lawson, G; Muller, JM; Waschek, JA; Vilain, E
Delayed testicular aging in pituitary adenylate cyclase-activating peptide (PACAP) null mice.
Proc Natl Acad Sci U S A
103
3793-8
2006
Mus sp.
Reddy, PS; Pushpalatha, T; Reddy, PS
Reduction of spermatogenesis and steroidogenesis in mice after fentin and fenbutatin administration.
Toxicol Lett
166
53-9
2006
Mus sp.
Ryzhavskii, BY; Matveeva, EP; Baranova, SN
Morphometric and statistical analysis of macro- and microscopic characteristics of the brain and their relationships with adrenocortical histophysiology in newborn rats.
Bull Exp Biol Med
140
736-9
2005
Rattus
Bell, R; Neiger, R; McGrotty, Y; Ramsey, IK
Study of the effects of once daily doses of trilostane on cortisol concentrations and responsiveness to adrenocorticotrophic hormone in hyperadrenocorticoid dogs.
Vet Rec
159
277-81
2006
Canis lupus familiaris
Teerds, KJ; Rijntjes, E; Veldhuizen-Tsoerkan, MB; Rommerts, FF; de Boer-Brouwer, M
The development of rat Leydig cell progenitors in vitro: how essential is luteinising hormone?
J Endocrinol
194
579-93
2007
Rattus
Dong-Dong, L
Small interfering RNA (siRNA) inhibited human liver cancer cell line SMMC7721 proliferation and tumorigenesis.
Hepatogastroenterology
54
1731-5
2007
Homo sapiens
Ryzhavskii, BY; Baranova, SN; Matveeva, EP
Effect of experimental litter reduction in female rats on parameters of brain and endocrine gland development in the progeny.
Bull Exp Biol Med
143
376-80
2007
Metazoa
Fillinger, S; Leroux, P; Auclair, C; Barreau, C; Al Hajj, C; Debieu, D
Genetic analysis of fenhexamid-resistant field isolates of the phytopathogenic fungus Botrytis cinerea.
Antimicrob Agents Chemother
52
3933-40
2008
Fungi
Aghajanova, L; Hamilton, A; Kwintkiewicz, J; Vo, KC; Giudice, LC
Steroidogenic enzyme and key decidualization marker dysregulation in endometrial stromal cells from women with versus without endometriosis.
Biol Reprod
80
105-14
2009
Homo sapiens
Bishop, CV; Hennebold, JD; Stouffer, RL
The effects of luteinizing hormone ablation/replacement versus steroid ablation/replacement on gene expression in the primate corpus luteum.
Mol Hum Reprod
15
181-93
2009
Macaca mulatta
London, SE; Clayton, DF
Genomic and neural analysis of the estradiol-synthetic pathway in the zebra finch.
BMC Neurosci
11
46
2010
Taeniopygia guttata, Mammalia
Singh, P; Krishna, A; Tsutsui, K
Effects of gonadotropin-inhibitory hormone on folliculogenesis and steroidogenesis of cyclic mice.
Fertil Steril
2010
Mus sp.
Hamden, K; Jaouadi, B; Carreau, S; Aouidet, A; El-Fazaa, S; Gharbi, N; Elfeki, A
Potential protective effect on key steroidogenesis and metabolic enzymes and sperm abnormalities by fenugreek steroids in testis and epididymis of surviving diabetic rats.
Arch Physiol Biochem
116
146-55
2010
Rattus
Flück, CE; Meyer-Böni, M; Pandey, AV; Kempnį, P; Miller, WL; Schoenle, EJ; Biason-Lauber, A
Why boys will be boys: two pathways of fetal testicular androgen biosynthesis are needed for male sexual differentiation.
Am J Hum Genet
89
201-18
2011
Homo sapiens, Bacteria
Chawengsaksophak, K; Svingen, T; Ng, ET; Epp, T; Spiller, CM; Clark, C; Cooper, H; Koopman, P
Loss of Wnt5a disrupts primordial germ cell migration and male sexual development in mice.
Biol Reprod
86
1-12
2012
Mus sp.
Billard, A; Fillinger, S; Leroux, P; Lachaise, H; Beffa, R; Debieu, D
Strong resistance to the fungicide fenhexamid entails a fitness cost in Botrytis cinerea, as shown by comparisons of isogenic strains.
Pest Manag Sci
2011
Botrytis
Siemieniuch, MJ; Jursza, E; Szostek, AZ; Skarzynski, DJ; Boos, A; Kowalewski, MP
Steroidogenic capacity of the placenta as a supplemental source of progesterone during pregnancy in domestic cats.
Reprod Biol Endocrinol
10
89
2012
Felis catus
Biason-Lauber, A; Miller, WL; Pandey, AV; Flück, CE
Of marsupials and men: "Backdoor" dihydrotestosterone synthesis in male sexual differentiation.
Mol Cell Endocrinol
2013
Homo sapiens
Biswas, NM; Biswas, R; Biswas, NM; Mandal, LH
Effect of continuous light on spermatogenesis and testicular steroidogenesis in rats: possible involvement of alpha 2u-globulin.
Nepal Med Coll J
15
62-4
2013
Rattus
Wu, Q; Kohli, M; Bergen, HR; Cheville, JC; Karnes, RJ; Cao, H; Young, CY; Tindall, DJ; McNiven, MA; Donkena, KV
Preclinical Evaluation of the Supercritical Extract of Azadirachta Indica (Neem) Leaves In Vitro and In Vivo on Inhibition of Prostate Cancer Tumor Growth.
Mol Cancer Ther
2014
Mus sp.
La Perle, KM; Green, MG; Niewiesk, S
Trophoblast deportation to the lungs of cotton rats (Sigmodon hispidus).
Comp Med
64
448-55
2014
Sigmodon
Moorman, GW; Walker, AS; May, S
First Report of Fenhexamid-Resistant Botrytis cinerea Causing Gray Mold on Heurchera in a North American Greenhouse.
Plant Dis
96
147
2012
Heuchera, Botrytis
Yokoyama, C; Chigi, Y; Baba, T; Ohshitanai, A; Harada, Y; Takahashi, F; Morohashi, KI
Three populations of adult Leydig cells in mouse testes revealed by a novel mouse HSD3B1-specific rat monoclonal antibody.
Biochem Biophys Res Commun
511
916-920
2019
Mus musculus, Rattus
Blaschka, C; Sįnchez-Guijo, A; Zimmer, B; Stöhr, J; Kotarski, F; Grothmann, H; Hartmann, MF; Wudy, SA; Wrenzycki, C
Temporal expression pattern of steroid-metabolizing enzymes in bovine COC during in vitro maturation employing different gonadotropin concentrations.
Theriogenology
131
182-192
2019
collection
Rebourcet, D; Monteiro, A; Cruickshanks, L; Jeffery, N; Smith, S; Milne, L; O'Shaughnessy, PJ; Smith, LB
Relationship of transcriptional markers to Leydig cell number in the mouse testis.
PLoS One
14
e0219524
2019
Indicator
Yang, H; Lee, YH; Lee, SR; Kaya, P; Hong, EJ; Lee, HW
Traditional Medicine (Mahuang-Tang) Improves Ovarian Dysfunction and the Regulation of Steroidogenic Genes in Letrozole-Induced PCOS Rats.
J Ethnopharmacol
248
112300
2020
Rattus
Wang, Y; Dong, Y; Wu, S; Zhu, Q; Li, X; Liu, S; Huang, T; Li, H; Ge, RS
Acephate interferes with androgen synthesis in rat immature Leydig cells.
Chemosphere
245
125597
2020
Rattus
Lohan, SB; Bühring, K; Lauer, AC; Friedrich, A; Lademann, J; Buss, A; Sabat, R; Wolk, K; Meinke, MC
Analysis of the Status of the Cutaneous Endogenous and Exogenous Antioxidative System of Smokers and the Short-Term Effect of Defined Smoking Thereon.
Antioxidants (Basel)
9
2020
Homo sapiens
Alzohairy, SA; Gillett, J; Saito, S; Naegele, RP; Xiao, CL; Miles, TD
Fungicide resistance profiles of Botrytis cinerea isolates from Michigan vineyards and development of a TaqMan assay for detection of fenhexamid resistance.
Plant Dis
2020
Botrytis cinerea
Zhang, M; Wei, H; Liu, T; Li, W; Li, Y; Wang, S; Xing, Q; Hu, X; Zhang, L; Bao, Z
Potential GnRH and steroidogenesis pathways in the scallop Patinopecten yessoensis.
J Steroid Biochem Mol Biol
105756
2020
Mizuhopecten yessoensis, Patinopecten sp.
Ni, C; Li, Y; Li, Z; Tian, L; Fu, J; Wu, K; Wang, Y; Yao, M; Ge, RS
Cisatracurium stimulates testosterone synthesis in rat and mouse Leydig cells via nicotinic acetylcholine receptor.
J Cell Mol Med
24
14184-14194
2020
Rattus
Lv, D; Wu, X; Chen, X; Yang, S; Chen, W; Wang, M; Liu, Y; Gu, D; Zeng, G
A novel immune-related gene-based prognostic signature to predict biochemical recurrence in patients with prostate cancer after radical prostatectomy.
Cancer Immunol Immunother
2021
Homo sapiens
Albrecht, BA; MacLeod, JN; Daels, PF
Expression of 3beta-hydroxysteroid dehydrogenase, cytochrome p450 17alpha-hydroxylase/17,20-lyase and cytochrome p450 aromatase enzymes in corpora lutea of diestrous and early pregnant mares.
Theriogenology
55
551-61
2001
Equus caballus
Almassi, N; Reichard, C; Li, J; Russell, C; Perry, J; Ryan, CJ; Friedlander, T; Sharifi, N
HSD3B1 and Response to a Nonsteroidal CYP17A1 Inhibitor in Castration-Resistant Prostate Cancer.
JAMA Oncol
2017
Homo sapiens
Pang, S; Wang, W; Rich, B; David, R; Chang, YT; Carbunaru, G; Myers, SE; Howie, AF; Smillie, KJ; Mason, JI
A novel nonstop mutation in the stop codon and a novel missense mutation in the type II 3beta-hydroxysteroid dehydrogenase (3beta-HSD) gene causing, respectively, nonclassic and classic 3beta-HSD deficiency congenital adrenal hyperplasia.
J Clin Endocrinol Metab
87
2556-63
2002
Homo sapiens
Chang, WC; Cheng, WC; Cheng, BH; Chen, L; Ju, LJ; Ou, YJ; Jeng, LB; Yang, MD; Hung, YC; Ma, WL
Mitochondrial Acetyl-CoA Synthetase 3 is Biosignature of Gastric Cancer Progression.
Cancer Med
2018
Homo sapiens
Okamura, H; Doi, M; Goto, K; Kojima, R
Clock genes and salt-sensitive hypertension: a new type of aldosterone-synthesizing enzyme controlled by the circadian clock and angiotensin II.
Hypertens Res
2016
Homo sapiens
Ji, Q; Aoyama, C; Nien, YD; Liu, PI; Chen, PK; Chang, L; Stanczyk, FZ; Stolz, A
Selective loss of AKR1C1 and AKR1C2 in breast cancer and their potential effect on progesterone signaling.
Cancer Res
64
7610-7
2004
mouse mammary tumor virus
Ostinelli, G; Vijay, J; Vohl, MC; Grundberg, E; Tchernof, A
AKR1C2 and AKR1C3 expression in adipose tissue: Association with body fat distribution and regulatory variants.
Mol Cell Endocrinol
527
111220
2021
Homo sapiens
Shiiba, M; Yamagami, H; Yamamoto, A; Minakawa, Y; Okamoto, A; Kasamatsu, A; Sakamoto, Y; Uzawa, K; Takiguchi, Y; Tanzawa, H
Mefenamic acid enhances anticancer drug sensitivity via inhibition of aldo-keto reductase 1C enzyme activity.
Oncol Rep
37
2025-2032
2017
Homo sapiens
Riner, TL
Enzymes of the AKR1B and AKR1C Subfamilies and Uterine Diseases.
Front Pharmacol
3
34
2012
Homo sapiens
Dauphin-Villemant, C; Bƶcking, D; Blais, C; Toullec, JY; Lafont, R
Involvement of a 3beta-hydroxysteroid dehydrogenase activity in ecdysteroid biosynthesis.
Mol Cell Endocrinol
128
139-49
1997
Arthropoda, vertebrata
Zhang, L; Mason, JI; Naiki, Y; Copeland, KC; Castro-Magana, M; Gordon-Walker, TT; Chang, YT; Pang, S
Characterization of two novel homozygous missense mutations involving codon 6 and 259 of type II 3beta-hydroxysteroid dehydrogenase (3betaHSD) gene causing, respectively, nonsalt-wasting and salt-wasting 3betaHSD deficiency disorder.
J Clin Endocrinol Metab
85
1678-85
2000
Homo sapiens, Microphallus
Breitling, R; Krazeisen, A; Mƶller, G; Adamski, J
17beta-hydroxysteroid dehydrogenase type 7--an ancient 3-ketosteroid reductase of cholesterogenesis.
Mol Cell Endocrinol
171
199-204
2001
Saccharomyces cerevisiae, Caenorhabditis elegans, Homo sapiens, Mammalia, Drosophila
Gasic, S; Nagamani, M; Green, A; Urban, RJ
Troglitazone is a competitive inhibitor of 3beta-hydroxysteroid dehydrogenase enzyme in the ovary.
Am J Obstet Gynecol
184
575-9
2001
Homo sapiens, Sus scrofa
Chang, BL; Zheng, SL; Hawkins, GA; Isaacs, SD; Wiley, KE; Turner, A; Carpten, JD; Bleecker, ER; Walsh, PC; Trent, JM; Meyers, DA; Isaacs, WB; Xu, J
Joint effect of HSD3B1 and HSD3B2 genes is associated with hereditary and sporadic prostate cancer susceptibility.
Cancer Res
62
1784-9
2002
Homo sapiens
Lutfallah, C; Wang, W; Mason, JI; Chang, YT; Haider, A; Rich, B; Castro-Magana, M; Copeland, KC; David, R; Pang, S
Newly proposed hormonal criteria via genotypic proof for type II 3beta-hydroxysteroid dehydrogenase deficiency.
J Clin Endocrinol Metab
87
2611-22
2002
Homo sapiens
Pang, S; Carbunaru, G; Haider, A; Copeland, KC; Chang, YT; Lutfallah, C; Mason, JI
Carriers for type II 3beta-hydroxysteroid dehydrogenase (HSD3B2) deficiency can only be identified by HSD3B2 genotype study and not by hormone test.
Clin Endocrinol (Oxf)
58
323-31
2003
Homo sapiens
le Roux, PA; van der Spuy, ZM
Labor induction abortion utilizing trilostane, a 3beta-hydroxysteroid dehydrogenase inhibitor.
Contraception
71
343-7
2005
Homo sapiens
Seth, G; McIvor, RS; Hu, WS
17Beta-hydroxysteroid dehydrogenase type 7 (Hsd17b7) reverts cholesterol auxotrophy in NS0 cells.
J Biotechnol
121
241-52
2006
Saccharomyces cerevisiae, Mammalia
Lou, H; Du, S; Ji, Q; Stolz, A
Induction of AKR1C2 by phase II inducers: identification of a distal consensus antioxidant response element regulated by NRF2.
Mol Pharmacol
69
1662-72
2006
Homo sapiens
Tai, HL; Lin, TS; Huang, HH; Lin, TY; Chou, MC; Chiou, SH; Chow, KC
Overexpression of aldo-keto reductase 1C2 as a high-risk factor in bladder cancer.
Oncol Rep
17
305-11
2007
Homo sapiens, Areas
Park, JY; Tanner, JP; Sellers, TA; Huang, Y; Stevens, CK; Dossett, N; Shankar, RA; Zachariah, B; Heysek, R; Pow-Sang, J
Association between polymorphisms in HSD3B1 and UGT2B17 and prostate cancer risk.
Urology
70
374-9
2007
Homo sapiens
Pang, S
The Molecular and Clinical Spectrum of 3beta-hydroxysteroid Dehydrogenase Deficiency Disorder.
Trends Endocrinol Metab
9
82-6
1998
Homo sapiens
Takahashi, RH; Grigliatti, TA; Reid, RE; Riggs, KW
The Effect of Allelic Variation in Aldo-Keto Reductase 1C2 on the In Vitro Metabolism of Dihydrotestosterone.
J Pharmacol Exp Ther
2009
Homo sapiens
Bellavance, E; Luu-The, V; Poirier, D
Potent and Selective Steroidal Inhibitors of 17beta-Hydroxysteroid Dehydrogenase Type 7, an Enzyme That Catalyzes the Reduction of the Key Hormones Estrone and Dihydrotestosterone.
J Med Chem
2009
Homo sapiens
Shimodaira, M; Nakayama, T; Sato, N; Aoi, N; Sato, M; Izumi, Y; Soma, M; Matsumoto, K
Association of HSD3B1 and HSD3B2 gene polymorphisms with essential hypertension, aldosterone level, and left ventricular structure.
Eur J Endocrinol
163
671-80
2010
Homo sapiens
Shehu, A; Albarracin, C; Sangeeta Devi, Y; Luther, K; Halperin, J; Le, J; Mao, J; Duan, RW; Frasor, J; Gibori, G
The Stimulation of HSD17B7 Expression by Estradiol Provides a Powerful Feed-Forward Mechanism for Estradiol Biosynthesis in Breast Cancer Cells.
Mol Endocrinol
2011
Homo sapiens, Mus musculus, Rattus
Ntostis, P; Peraki, O; Boulgari, A; Agiannitopoulos, K; Pantos, K; Lamnissou, K
Genetic variation in the HSD3B1 gene and recurrent spontaneous abortions.
J Matern Fetal Neonatal Med
2011
Homo sapiens
Shimodaira, M; Nakayama, T; Sato, I; Sato, N; Izawa, N; Mizutani, Y; Furuya, K; Yamamoto, T
Estrogen synthesis genes CYP19A1, HSD3B1, and HSD3B2 in hypertensive disorders of pregnancy.
Endocrine
2012
Homo sapiens
Yang, XY; Wu, WJ; Yang, C; Yang, T; He, JD; Yang, Z; He, L
Association of HSD17B3 and HSD3B1 polymorphisms with acne vulgaris in Southwestern Han Chinese.
Dermatology
227
202-8
2013
Homo sapiens
Bouwman, FG; Boer, JM; Imholz, S; Wang, P; Verschuren, WM; Dollé, ME; Mariman, EC
Gender-specific genetic associations of polymorphisms in ACE, AKR1C2, FTO and MMP2 with weight gain over a 10-year period.
Genes Nutr
9
434
2014
Homo sapiens
Hearn, JW; AbuAli, G; Reichard, CA; Reddy, CA; Magi-Galluzzi, C; Chang, KH; Carlson, R; Rangel, L; Reagan, K; Davis, BJ; Karnes, RJ; Kohli, M; Tindall, D; Klein, EA; Sharifi, N
HSD3B1 and resistance to androgen-deprivation therapy in prostate cancer: a retrospective, multicohort study.
Lancet Oncol
2016
Homo sapiens
Hearn, JWD; Xie, W; Nakabayashi, M; Almassi, N; Reichard, CA; Pomerantz, M; Kantoff, PW; Sharifi, N
Association of HSD3B1 Genotype With Response to Androgen-Deprivation Therapy for Biochemical Recurrence After Radiotherapy for Localized Prostate Cancer.
JAMA Oncol
2017
Homo sapiens
Hettel, D; Zhang, A; Alyamani, M; Berk, M; Sharifi, N
AR Signaling in Prostate Cancer Regulates a Feed-Forward Mechanism of Androgen Synthesis by Way of HSD3B1 Upregulation.
Endocrinology
159
2884-2890
2018
Mus musculus
Stangl-Kremser, J; Lemberger, U; Hassler, MR; Bruchbacher, A; Ilijazi, D; Garstka, N; Kramer, G; Haitel, A; Abufaraj, M; Shariat, SF
Prevalence and Prognostic Value of the Polymorphic Variant 1245A>C of HSD3B1 in Castration-resistant Prostate Cancer.
Clin Genitourin Cancer
2019
Homo sapiens
Hearn, JWD; Sweeney, CJ; Almassi, N; Reichard, CA; Reddy, CA; Li, H; Hobbs, B; Jarrard, DF; Chen, YH; Dreicer, R; Garcia, JA; Carducci, MA; DiPaola, RS; Sharifi, N
HSD3B1 Genotype and Clinical Outcomes in Metastatic Castration-Sensitive Prostate Cancer.
JAMA Oncol
e196496
2020
Homo sapiens
Han, FF; Ren, LL; Xuan, LL; Lv, YL; Liu, H; Gong, LL; An, ZL; Liu, LH
HSD3B1 variant and androgen-deprivation therapy outcome in prostate cancer.
Cancer Chemother Pharmacol
87
103-112
2021
Homo sapiens
He, XY; Wegiel, J; Yang, YZ; Pullarkat, R; Schulz, H; Yang, SY
Type 10 17beta-hydroxysteroid dehydrogenase catalyzing the oxidation of steroid modulators of gamma-aminobutyric acid type A receptors.
Mol Cell Endocrinol
229
111-7
2005
Homo sapiens
Simard, J; Sanchez, R; Durocher, F; RhƩaume, E; Turgeon, C; Labrie, Y; Luu-The, V; Mebarki, F; Morel, Y; de Launoit, Y
Structure-function relationships and molecular genetics of the 3 beta-hydroxysteroid dehydrogenase gene family.
J Steroid Biochem Mol Biol
55
489-505
1995
Mus musculus, Rattus
Donnerer, J; Liebmann, I; Schicho, R
Differential regulation of 3-beta-hydroxysteroid dehydrogenase and vanilloid receptor TRPV1 mRNA in sensory neurons by capsaicin and NGF.
Pharmacology
73
97-101
2005
Rattus
Sridaran, R; Philip, GH; Li, H; Culty, M; Liu, Z; Stocco, DM; Papadopoulos, V
GnRH agonist treatment decreases progesterone synthesis, luteal peripheral benzodiazepine receptor mRNA, ligand binding and steroidogenic acute regulatory protein expression during pregnancy.
J Mol Endocrinol
22
45-54
1999
Rattus
Yanase, T; Suzuki, S; Goto, K; Nomura, M; Okabe, T; Takayanagi, R; Nawata, H
Aromatase in bone: roles of Vitamin D3 and androgens.
J Steroid Biochem Mol Biol
86
393-7
2003
Homo sapiens
Barbieri, RL; Canick, JA; Makris, A; Todd, RB; Davies, IJ; Ryan, KJ
Danazol inhibits steroidogenesis.
Fertil Steril
28
809-13
1977
Rattus
Gautier, C; Levacher, C; Saez, JM; Habert, R
Transforming growth factor beta1 inhibits steroidogenesis in dispersed fetal testicular cells in culture.
Mol Cell Endocrinol
131
21-30
1997
Transformation
Kaaijk, EM; Sasano, H; Suzuki, T; Beek, JF; van Der Veen, F
Distribution of steroidogenic enzymes involved in androgen synthesis in polycystic ovaries: an immunohistochemical study.
Mol Hum Reprod
6
443-7
2000
Homo sapiens
Dooley, CA; Attia, GR; Rainey, WE; Moore, DR; Carr, BR
Bone morphogenetic protein inhibits ovarian androgen production.
J Clin Endocrinol Metab
85
3331-7
2000
Oryctolagus cuniculus
HeikkilƤ, M; Prunskaite, R; Naillat, F; ItƤranta, P; Vuoristo, J; LeppƤluoto, J; Peltoketo, H; Vainio, S
The partial female to male sex reversal in Wnt-4-deficient females involves induced expression of testosterone biosynthetic genes and testosterone production, and depends on androgen action.
Endocrinology
146
4016-23
2005
Mus musculus
Chang, WC; Huang, SF; Lee, YM; Lai, HC; Cheng, BH; Cheng, WC; Ho, JY; Jeng, LB; Ma, WL
Cholesterol import and steroidogenesis are biosignatures for gastric cancer patient survival.
Oncotarget
8
692-704
2017
Homo sapiens
Alyamani, M; Emamekhoo, H; Park, S; Taylor, J; Almassi, N; Upadhyay, S; Tyler, A; Berk, MP; Hu, B; Hwang, TH; Figg, WD; Peer, CJ; Chien, C; Koshkin, VS; Mendiratta, P; Grivas, P; Rini, B; Garcia, J; Auchus, RJ; Sharifi, N
HSD3B1(1245A>C) variant regulates dueling abiraterone metabolite effects in prostate cancer.
J Clin Invest
128
3333-3340
2018
Homo sapiens
Venara, M; Rey, R; BergadĆ”, I; Mendilaharzu, H; Campo, S; Chemes, H
Sertoli cell proliferations of the infantile testis: an intratubular form of Sertoli cell tumor?
Am J Surg Pathol
25
1237-44
2001
Homo sapiens, Electron
Simard, J; Moisan, AM; Morel, Y
Congenital adrenal hyperplasia due to 3beta-hydroxysteroid dehydrogenase/Delta(5)-Delta(4) isomerase deficiency.
Semin Reprod Med
20
255-76
2002
Homo sapiens
Liu, RH; Meng, Q; Shi, YP; Xu, HS
Regulatory role of microRNA-320a in the proliferation, migration, invasion, and apoptosis of trophoblasts and endothelial cells by targeting estrogen-related receptor ?.
J Cell Physiol
234
682-691
2018
Homo sapiens
Pau Ni, IB; Zakaria, Z; Muhammad, R; Abdullah, N; Ibrahim, N; Aina Emran, N; Hisham Abdullah, N; Syed Hussain, SN
Gene expression patterns distinguish breast carcinomas from normal breast tissues: the Malaysian context.
Pathol Res Pract
206
223-8
2010
Candida dubliniensis
Kumar, V; Majumdar, C; Roy, P
Effects of endocrine disrupting chemicals from leather industry effluents on male reproductive system.
J Steroid Biochem Mol Biol
111
208-16
2008
Rattus
Haynes, BP; Straume, AH; Geisler, J; A'Hern, R; Helle, H; Smith, IE; LĆønning, PE; Dowsett, M
Intratumoral estrogen disposition in breast cancer.
Clin Cancer Res
16
1790-801
2010
Homo sapiens
Le Bail, JC; Aubourg, L; Habrioux, G
Effects of pinostrobin on estrogen metabolism and estrogen receptor transactivation.
Cancer Lett
156
37-44
2000
Homo sapiens
Castro, M; Elias, LL
[Rare forms of female pseudohermaphroditism: when to investigate?]
Arq Bras Endocrinol Metabol
49
126-37
2005
Homo sapiens
Xu, Q; Chen, Q; Lin, L; Zhang, P; Li, Z; Yu, Y; Ma, F; Yingfen, Y; Li, X; Ge, RS
Triadimefon suppresses fetal adrenal gland development after in utero exposure.
Toxicology
152932
2021
Felis catus
Bauman, DR; Steckelbroeck, S; Penning, TM
The roles of aldo-keto reductases in steroid hormone action.
Drug News Perspect
17
563-78
2004
Homo sapiens
Roberts, RO; Bergstralh, EJ; Farmer, SA; Jacobson, DJ; Hebbring, SJ; Cunningham, JM; Thibodeau, SN; Lieber, MM; Jacobsen, SJ
Polymorphisms in genes involved in sex hormone metabolism may increase risk of benign prostatic hyperplasia.
Prostate
66
392-404
2006
Homo sapiens
Matsunaga, T; Haga, M; Watanabe, G; Shinoda, Y; Endo, S; Kajiwara, Y; Tanaka, H; Inagaki, N; El-Kabbani, O; Hara, A
9,10-Phenanthrenequinone promotes secretion of pulmonary aldo-keto reductases with surfactant.
Cell Tissue Res
347
407-17
2012
Homo sapiens
Söderhäll, C; Körberg, IB; Thai, HT; Cao, J; Chen, Y; Zhang, X; Shulu, Z; van der Zanden, LF; van Rooij, IA; Frisén, L; Roeleveld, N; Markljung, E; Kockum, I; Nordenskjöld, A
Fine mapping analysis confirms and strengthens linkage of four chromosomal regions in familial hypospadias.
Eur J Hum Genet
2014
Homo sapiens
Andrżs, R; Zemanovį, L; Len?o, J; Bķlkovį, Z; Wsól, V
Carbonyl-reducing enzymes as targets of a drug-immobilised affinity carrier.
Chem Biol Interact
2015
Escherichia coli, Homo sapiens
Platt, A; Xia, Z; Liu, Y; Chen, G; Lazarus, P
Impact of nonsynonymous single nucleotide polymorphisms on in-vitro metabolism of exemestane by hepatic cytosolic reductases.
Pharmacogenet Genomics
26
370-80
2016
Homo sapiens
Sheng, X; Parmentier, JH; Tucci, J; Pei, H; Cortez-Toledo, O; Dieli-Conwright, CM; Oberley, MJ; Neely, M; Orgel, E; Louie, SG; Mittelman, SD
Adipocytes Sequester and Metabolize the Chemotherapeutic Daunorubicin.
Mol Cancer Res
15
1704-1713
2017
Homo sapiens
Hellgren, C; Comasco, E; Skalkidou, A; Sundström-Poromaa, I
Allopregnanolone levels and depressive symptoms during pregnancy in relation to single nucleotide polymorphisms in the allopregnanolone synthesis pathway.
Horm Behav
94
106-113
2017
Homo sapiens
Zhou, J; Chao, G; Li, Y; Wu, M; Zhong, S; Feng, Z
Activation of NRF2/ARE by isosilybin alleviates A?25-35-induced oxidative stress injury in HT-22 cells.
Neurosci Lett
632
92-97
2016
plasmids
Gyƶry, G; Kiss, C; FehƩr, T; Poteczin, E
Concentration of unconjugated adrenogenic hormones and their precursors in normal and polycystic ovaries.
Endokrinologie
64
181-90
1975
Homo sapiens
Contet-Audonneau, JL
[Histoenzymologic study of the adrenal gland of the dormouse during the annual cycle]
Bull Assoc Anat (Nancy)
60
497-505
1976
Glis glis
Akobeng, AK; Clayton, PT; Miller, V; Super, M; Thomas, AG
An inborn error of bile acid synthesis (3beta-hydroxy-delta5-C27-steroid dehydrogenase deficiency) presenting as malabsorption leading to rickets.
Arch Dis Child
80
463-5
1999
Homo sapiens
GĆ³mez, Y; VelĆ”zquez, PN; Peralta-Delgado, I; MĆ©ndez, MC; Vilchis, F; JuĆ”rez-Oropeza, MA; Pedernera, E
Follicle-stimulating hormone regulates steroidogenic enzymes in cultured cells of the chick embryo ovary.
Gen Comp Endocrinol
121
305-15
2001
Transformation
Mo, Q; Lu, SF; Hu, S; Simon, NG
DHEA and DHEA sulfate differentially regulate neural androgen receptor and its transcriptional activity.
Brain Res Mol Brain Res
126
165-72
2004
Mus musculus
Huber, A; Keck, CC; Hefler, LA; Schneeberger, C; Huber, JC; Bentz, EK; Tempfer, CB
Ten estrogen-related polymorphisms and endometriosis: a study of multiple gene-gene interactions.
Obstet Gynecol
106
1025-31
2005
Homo sapiens
Steiner, AZ; Chang, L; Ji, Q; Ookhtens, M; Stolz, A; Paulson, RJ; Stanczyk, FZ
3{alpha}-Hydroxysteroid Dehydrogenase Type III Deficiency: A Novel Mechanism for Hirsutism.
J Clin Endocrinol Metab
93
1298-303
2008
Homo sapiens
Shehu, A; Mao, J; Gibori, GB; Halperin, J; Le, J; Devi, YS; Merrill, B; Kiyokawa, H; Gibori, G
Prolactin receptor-associated protein/17beta-hydroxysteroid dehydrogenase type 7 gene (Hsd17b7) plays a crucial role in embryonic development and fetal survival.
Mol Endocrinol
22
2268-77
2008
Mus musculus, Mus sp.
Ariel, I; Boldes, R; Weintraub, A; Reinus, C; Beller, U; Arbel, R
Chorangiocarcinoma: a case report and review of the literature.
Int J Gynecol Pathol
28
267-71
2009
Homo sapiens
Subramaniam, P; Clayton, PT; Portmann, BC; Mieli-Vergani, G; HadziÄ, N
Variable clinical spectrum of the most common inborn error of bile acid metabolism--3beta-hydroxy-Delta 5-C27-steroid dehydrogenase deficiency.
J Pediatr Gastroenterol Nutr
50
61-6
2010
Homo sapiens
Emter, R; Ellis, G; Natsch, A
Performance of a novel keratinocyte-based reporter cell line to screen skin sensitizers in vitro.
Toxicol Appl Pharmacol
2010
Homo sapiens
Andreas, N; Caroline, B; Leslie, F; Frank, G; Kimberly, N; Allison, H; Heather, I; Robert, L; Stefan, O; Hendrik, R; Andreas, S; Roger, E
The intra- and inter-laboratory reproducibility and predictivity of the KeratinoSens assay to predict skin sensitizers in vitro: Results of a ring-study in five laboratories.
Toxicol In Vitro
25
733-44
2011
Homo sapiens
Lisowski, P; Ko?ciuczuk, EM; Go?cik, J; Pierzcha?a, M; Rowi?ska, B; Zwierzchowski, L
Hepatic transcriptome profiling identifies differences in expression of genes associated with changes in metabolism and postnatal growth between Hereford and Holstein-Friesian bulls.
Anim Genet
45
288-92
2014
Felis catus
Huang, Q; Chen, Y; Chen, Q; Zhang, H; Lin, Y; Zhu, M; Dong, S
Dioxin-like rather than non-dioxin-like PCBs promote the development of endometriosis through stimulation of endocrine-inflammation interactions.
Arch Toxicol
91
1915-1924
2017
Homo sapiens
Chang, YC; Chen, CK; Chen, MJ; Lin, JC; Lin, CH; Huang, WC; Cheng, SP; Chen, SN; Liu, CL
Expression of 3?-Hydroxysteroid Dehydrogenase Type 1 in Breast Cancer is Associated with Poor Prognosis Independent of Estrogen Receptor Status.
Ann Surg Oncol
2017
Homo sapiens
Patel, R; Fleming, J; Mui, E; Loveridge, C; Repiscak, P; Blomme, A; Harle, V; Salji, M; Ahmad, I; Teo, K; Hamdy, FC; Hedley, A; van den Broek, N; Mackay, G; Edwards, J; Sansom, OJ; Leung, HY
Sprouty2 loss-induced IL6 drives castration-resistant prostate cancer through scavenger receptor B1.
EMBO Mol Med
2018
Homo sapiens, Mus musculus
Cervena, T; Vrbova, K; Rossnerova, A; Topinka, J; Rossner, P
Short-term and Long-term Exposure of the MucilAir Model to Polycyclic Aromatic Hydrocarbons.
Altern Lab Anim
47
9-18
2019
Felis catus
Cruickshank, T; Kaitu'u-Lino, TJ; Cannon, P; Harper, A; Nguyen, TV; Dane, KM; Middleton, AL; Kyritsis, VP; Hastie, R; Tong, S; Walker, SP; MacDonald, TM
Screening circulating proteins to identify biomarkers of fetal macrosomia.
BMC Res Notes
12
587
2019
Homo sapiens
Prizment, AE; McSweeney, S; Pankratz, N; Joshu, CE; Hwang, JH; Platz, EA; Ryan, CJ
Prostate Cancer Mortality Associated with Aggregate Polymorphisms in Androgen-Regulating Genes: The Atherosclerosis Risk in the Communities (ARIC) Study.
Cancers (Basel)
13
2021
Homo sapiens
Lin, JC; Liu, CL; Chang, YC; Cheng, SP; Huang, WC; Lin, CH; Wu, CY; Chen, MJ
Trilostane, a 3?-hydroxysteroid dehydrogenase inhibitor, suppresses growth of hepatocellular carcinoma and enhances anti-cancer effects of sorafenib.
Invest New Drugs
2021
Homo sapiens
Zhang, C; Chinnappan, M; Prestwood, CA; Edwards, M; Artami, M; Thompson, BM; Eckert, KM; Vale, G; Zouboulis, CC; McDonald, JG; Harris-Tryon, TA
Interleukins 4 and 13 drive lipid abnormalities in skin cells through regulation of sex steroid hormone synthesis.
Proc Natl Acad Sci U S A
118
2021
Homo sapiens
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