Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P14060 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
breast cancer cell | expression of 3beta-hydroxysteroid dehydrogenase type 1 (HSD3B1) in breast cancer is associated with shorter recurrence-free survival, and genetic or pharmacologic inhibition of HSD3B1 reduced colony formation and xenograft growth | Homo sapiens | - |
MDA-MB-231 cell | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
3beta-hydroxysteroid dehydrogenase type 1 | - |
Homo sapiens |
HSD3B1 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
drug target | inhibition of 3beta-hydroxysteroid dehydrogenase type 1 suppresses interleukin-6 in breast cancer. The therapeutic potential of targeting HSD3B1 is in part mediated by IL-6 suppression | Homo sapiens |
malfunction | interleukin-6 treatment partially reduces the cytotoxicity augmented by the HSD3B1 knockdown | Homo sapiens |
metabolism | expression of 3beta-hydroxysteroid dehydrogenase type 1 (HSD3B1) in breast cancer is associated with shorter recurrence-free survival, and genetic or pharmacologic inhibition of HSD3B1 reduced colony formation and xenograft growth | Homo sapiens |