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Literature summary for 1.1.1.270 extracted from

  • Huang, X.F.; Luu-The, V.
    Gene structure, chromosomal localization and analysis of 3-ketosteroid reductase activity of the human 3(alpha->beta)-hydroxysteroid epimerase (2001), Biochim. Biophys. Acta, 1520, 124-130.
    View publication on PubMed
Search for more literature for 1.1.1.270

Cloned(Commentary)

Cloned (Comment) Organism
3-ketosteroid reductase activity of the human 3(alpha-beta)-hydroxysteroid epimerase, stable expression Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Homo sapiens
-
-
additional information 3-keto reductase activity in both microsomal fractions and intact cells Homo sapiens
-
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 human
-
Homo sapiens
-
 3-ketosteroid reductase activity of the human 3(alpha-beta)-hydroxysteroid epimerase
-

Reaction

Reaction Comment Organism Reaction ID
a 3beta-hydroxysteroid + NADP+ = a 3-oxosteroid + NADPH + H+ stereoselectivity : #1,4,5# catalyzes reduction of the 3-keto group to a 3beta-hydroxyl group <5,6,7> Homo sapiens
a

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5alpha-androstane-3,17-dione + NADPH 3-ketosteroid reductase activity of the human 3(alpha-beta)-hydroxysteroid epimerase, stereoselective reduction Homo sapiens epi-androsterone + NADP+ epi-ADT ?
5alpha-androstane-3,17-dione + NADPH 5alpha-dione Homo sapiens epi-androsterone + NADP+ epi-ADT ?
additional information 3-ketosteroid reductase activity of the human 3(alpha-beta)-hydroxysteroid epimerase catalyzes reduction of 3-ketosteroids to form 3beta-hydroxysteroids Homo sapiens ?
-
 ?

Cofactor

Cofactor Comment Organism Structure
NADPH
-
 Homo sapiens