6.3.5.9: hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolysing)

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For detailed information about hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolysing), go to the full flat file.

Reaction

2 ATP +

Synonyms

CbiA, cobalamin biosynthesis aminotransferase, CobB, cobyric acid synthase, cobyrinic acid a,c-diamide synthase, new NaMN:Me2Bza phosphoribosyltransferase enzyme

ECTree

     6 Ligases

         6.3 Forming carbon-nitrogen bonds

             6.3.5 Carbon-nitrogen ligases with glutamine as amido-N-donor

                6.3.5.9 hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolysing)

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Results	in table
6116	AA Sequence
1	CAS Registry Number
5	Cloned(Commentary)
1	General Stability
28	KM Value [mM]
2	Metals/Ions
10	Molecular Weight [Da]
7	Natural Substrates/ Products (Substrates)
9	Organism
5	Pathway
4	pH Optimum
1	pI Value
6	Protein Variants
3	Purification (Commentary)
1	Reaction
9	Reference
2	Specific Activity [micromol/min/mg]
3	Storage Stability
36	Substrates and Products (Substrate)
7	Subunits
15	Synonyms
1	Systematic Name
8	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 6.3.5.9 - hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolysing)

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SYSTEMATIC NAME

IUBMB Comments

hydrogenobyrinic-acid:L-glutamine amido-ligase (AMP-forming)

This enzyme, which participates in the aerobic (late cobalt insertion) cobalamin biosynthesis pathway, generates hydrogenobyrinate a,c-diamide, the substrate required by EC 6.6.1.2, cobaltochelatase, which adds cobalt to the macrocycle. The equivalent reaction in the anaerobic cobalamin biosynthesis pathway is catalysed by EC 6.3.5.11, cobyrinate a,c-diamide synthase.