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6.3.4.18: 5-(carboxyamino)imidazole ribonucleotide synthase

This is an abbreviated version!
For detailed information about 5-(carboxyamino)imidazole ribonucleotide synthase, go to the full flat file.

Reaction

ATP
+
5-amino-1-(5-phospho-D-ribosyl)imidazole
 +
HCO3-
 +
H+
=
ADP
 +
phosphate
 +
5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole

Synonyms

More, N5-CAIR synthetase, N5-carboxyaminoimidazole ribonucleotide synthetase, N5-carboxylaminoimidazole ribonucleotide synthetase, N5CAIR synthetase, PurK

ECTree

     6 Ligases
         6.3 Forming carbon-nitrogen bonds
             6.3.4 Other carbon-nitrogen ligases
                6.3.4.18 5-(carboxyamino)imidazole ribonucleotide synthase

Inhibitors

Inhibitors on EC 6.3.4.18 - 5-(carboxyamino)imidazole ribonucleotide synthase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1,1'-(imidazolidine-1,3-diyldimethanediyl)bis(1H-indole-2,3-dione)
-
class II inhibitor
1-deoxy-1-(7,8-dimethyl-2,4-dioxo-3,4-dihydrobenzo[g]pteridin-10(2H)-yl)pentitol
-
noncompetitive, class III inhibitor
1-[(4-methylpiperazin-1-yl)methyl]-1H-indole-2,3-dione
-
class II inhibitor
2-(2,3-dioxo-2,3-dihydro-1H-indol-1-yl)-N,N-diethylacetamide
-
noncompetitive, class II inhibitor
2-hydroxy-2-[(4-methyl-1,2,5-oxadiazol-3-yl)amino]-1H-indene-1,3(2H)-dione
-
class I inhibitor
5-(trifluoromethoxy)-1H-indole-2,3-dione
-
class II inhibitor
5-bromo-1-(morpholin-4-ylmethyl)-1H-indole-2,3-dione
-
class II inhibitor
5-bromo-1-([3-[(2,3-dioxo-2,3-dihydro-1H-indol-1-yl)methyl]imidazolidin-1-yl]methyl)-1H-indole-2,3-dione
-
-
-
5-[(2-hydroxy-1,3-dioxo-2,3-dihydro-1H-inden-2-yl)carbamoyl]-4-(trifluoromethyl)pyridin-2-olate
-
class I inhibitor
ATP
substrate inhibition
ethyl 1-[(2,3-dioxo-2,3-dihydro-1H-indol-1-yl)methyl]piperidine-4-carboxylate
-
class II inhibitor
ethyl 4-(2-[[(4-chlorophenyl)sulfonyl]methyl]-1,3-thiazol-4-yl)-1,2-oxazole-3-carboxylate
-
-
ethyl 4-(2-[[(4-chlorophenyl)sulfonyl]methyl]-1,3-thiazol-4-yl)-5-methyl-1,2-oxazole-3-carboxylate
-
class III inhibitor
N-(2-hydroxy-1,3-dioxo-2,3-dihydro-1H-inden-2-yl)-1,3-dimethyl-1H-pyrazole-5-carboxamide
-
-
N-(2-hydroxy-1,3-dioxo-2,3-dihydro-1H-inden-2-yl)-1-methyl-1H-pyrazole-5-carboxamide
-
class I inhibitor
N-(2-hydroxy-1,3-dioxo-2,3-dihydro-1H-inden-2-yl)-2-methyl-1,3-thiazole-4-carboxamide
-
class I inhibitor
N-(2-hydroxy-1,3-dioxo-2,3-dihydro-1H-inden-2-yl)-4-methoxythiophene-3-carboxamide
-
class I inhibitor
N-(2-hydroxy-1,3-dioxo-2,3-dihydro-1H-inden-2-yl)-6-methoxy-4-(trifluoromethyl)pyridine-3-carboxamide
-
-
N-(2-hydroxy-1,3-dioxo-2,3-dihydro-1H-inden-2-yl)-9-oxo-9H-fluorene-4-carboxamide
-
class I inhibitor
riboflavin
-
-
additional information
-
high-throughput screening for enzyme inhibitors, identification of inhibitor separated into three classes: class I contains compounds with an indenedione core. Class II contains an indolinedione group, and class III contains compounds that are structurally unrelated to other inhibitors in the group, overview
-