6.3.4.18: 5-(carboxyamino)imidazole ribonucleotide synthase

This is an abbreviated version!
For detailed information about 5-(carboxyamino)imidazole ribonucleotide synthase, go to the full flat file.

Reaction

Synonyms

More, N5-CAIR synthetase, N5-carboxyaminoimidazole ribonucleotide synthetase, N5-carboxylaminoimidazole ribonucleotide synthetase, N5CAIR synthetase, PurK

ECTree

     6 Ligases

         6.3 Forming carbon-nitrogen bonds

             6.3.4 Other carbon-nitrogen ligases

                6.3.4.18 5-(carboxyamino)imidazole ribonucleotide synthase

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Results	in table
27228	AA Sequence
2	Application
7	Cloned(Commentary)
4	Cofactor
3	Crystallization (Commentary)
3	General Information
14	IC50 Value
21	Inhibitors
19	kcat/KM [mM/s]
5	Ki Value [mM]
22	KM Value [mM]
1	Metals/Ions
3	Molecular Weight [Da]
7	Natural Substrates/ Products (Substrates)
21	Organism
7	Pathway
7	PDB ID
3	pH Optimum
27	Protein Variants
4	Purification (Commentary)
1	Reaction
3	Reaction Type
17	Reference
1	Specific Activity [micromol/min/mg]
13	Substrates and Products (Substrate)
4	Subunits
33	Synonyms
1	Systematic Name
4	Temperature Optimum [°C]
12	Turnover Number [1/s]

Substrates Products

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Substrates Products on EC 6.3.4.18 - 5-(carboxyamino)imidazole ribonucleotide synthase

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SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

ATP + 5-amino-1(5-phospho-D-ribosyl)imidazole + HCO3-

ADP + phosphate + 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole

2 entries

ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole + HCO3-

ADP + 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + phosphate

2 entries

ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole + HCO3-

ADP + phosphate + 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole

Escherichia coli

-

-

661050, 702643

-

-

?

ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole + HCO3- + H+

ADP + phosphate + 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole

4 entries

additional information

?

-

2 entries

ATP + 5-amino-1(5-phospho-D-ribosyl)imidazole + HCO3-

ADP + phosphate + 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole

Escherichia coli

-

-

702643, 706630

-

-

?

ATP + 5-amino-1(5-phospho-D-ribosyl)imidazole + HCO3-

ADP + phosphate + 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole

Escherichia coli

-

catalytic steps are the formation of an acyl phosphate intermediate upon ATP cleavage, followed by the nucleophilic attack on the carboxyl carbon of the intermediates by the amino nitrogen of the mononucleotides, formation of acyl phosphate intermediates

706630

-

-

?

ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole + HCO3-

ADP + 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + phosphate

Aspergillus clavatus

-

assay at pH 7.5, 37°C

702382

-

-

?

ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole + HCO3-

ADP + 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + phosphate

Escherichia coli

-

assay at pH 7.5, 37°C

702643

-

-

?

ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole + HCO3- + H+

ADP + phosphate + 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole

Aspergillus clavatus

A1CII2

-

727030

-

-

?

ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole + HCO3- + H+

ADP + phosphate + 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole

Aspergillus clavatus DSM 816

A1CII2

-

727030

-

-

?

ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole + HCO3- + H+

ADP + phosphate + 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole

Staphylococcus aureus

A0A0H3KFM7

-

726578

-

-

?

ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole + HCO3- + H+

ADP + phosphate + 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole

Staphylococcus aureus Newman

A0A0H3KFM7

-

726578

-

-

?

additional information

?

-

Escherichia coli

-

the purEK operon is regulated by the purR gene product

661978

-

-

?

additional information

?

-

Escherichia coli

-

comparison of active site organization and reaction mechanism to purT-encoded glycinamide ribonucleotide formyltransferase, overview

706630

-

-

?