6.3.4.18: 5-(carboxyamino)imidazole ribonucleotide synthase

This is an abbreviated version!
For detailed information about 5-(carboxyamino)imidazole ribonucleotide synthase, go to the full flat file.

Reaction

Synonyms

More, N5-CAIR synthetase, N5-carboxyaminoimidazole ribonucleotide synthetase, N5-carboxylaminoimidazole ribonucleotide synthetase, N5CAIR synthetase, PurK

ECTree

     6 Ligases

         6.3 Forming carbon-nitrogen bonds

             6.3.4 Other carbon-nitrogen ligases

                6.3.4.18 5-(carboxyamino)imidazole ribonucleotide synthase

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Results	in table
27228	AA Sequence
2	Application
7	Cloned(Commentary)
4	Cofactor
3	Crystallization (Commentary)
3	General Information
14	IC50 Value
21	Inhibitors
19	kcat/KM [mM/s]
5	Ki Value [mM]
22	KM Value [mM]
1	Metals/Ions
3	Molecular Weight [Da]
7	Natural Substrates/ Products (Substrates)
21	Organism
7	Pathway
7	PDB ID
3	pH Optimum
27	Protein Variants
4	Purification (Commentary)
1	Reaction
3	Reaction Type
17	Reference
1	Specific Activity [micromol/min/mg]
13	Substrates and Products (Substrate)
4	Subunits
33	Synonyms
1	Systematic Name
4	Temperature Optimum [°C]
12	Turnover Number [1/s]

KCat KM Value

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KCat KM Value on EC 6.3.4.18 - 5-(carboxyamino)imidazole ribonucleotide synthase

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kcat/KM VALUE [1/mMs^-1]

SUBSTRATE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

120 - 130

5-amino-1(5-phospho-D-ribosyl)imidazole

2 entries

0.67 - 5500

5-amino-1-(5-phospho-D-ribosyl)imidazole

8 entries

84 - 89

ATP

2 entries

0.017 - 16.7

HCO3-

7 entries

120

5-amino-1(5-phospho-D-ribosyl)imidazole

Escherichia coli

-

pH 8.0, 25°C, wild-type PurK

706630

130

5-amino-1(5-phospho-D-ribosyl)imidazole

Escherichia coli

-

pH 8.0, 25°C, chimeric mutant with PurK activity

706630

0.67

5-amino-1-(5-phospho-D-ribosyl)imidazole

Aspergillus clavatus

-

mutant E73A

702382

2

5-amino-1-(5-phospho-D-ribosyl)imidazole

Aspergillus clavatus

-

mutant D153A

702382

8.3

5-amino-1-(5-phospho-D-ribosyl)imidazole

Aspergillus clavatus

-

mutant Y152A

702382

100

5-amino-1-(5-phospho-D-ribosyl)imidazole

Aspergillus clavatus

-

mutant R155A

702382

175

5-amino-1-(5-phospho-D-ribosyl)imidazole

Staphylococcus aureus

A0A0H3KFM7

mutant enzyme F78W, in 50 mM HEPES, 80 mM KCl, 20 mM MgCl2, at 22°C, pH not specified in the publication

726578

308

5-amino-1-(5-phospho-D-ribosyl)imidazole

Staphylococcus aureus

A0A0H3KFM7

mutant enzyme F78I, in 50 mM HEPES, 80 mM KCl, 20 mM MgCl2, at 22°C, pH not specified in the publication

726578

1783

5-amino-1-(5-phospho-D-ribosyl)imidazole

Staphylococcus aureus

A0A0H3KFM7

wild type enzyme, in 50 mM HEPES, 80 mM KCl, 20 mM MgCl2, at 22°C, pH not specified in the publication

726578

5500

5-amino-1-(5-phospho-D-ribosyl)imidazole

Aspergillus clavatus

-

wild-type enzyme

702382

84

ATP

Escherichia coli

-

pH 8.0, 25°C, chimeric mutant with PurK activity

706630

89

ATP

Escherichia coli

-

pH 8.0, 25°C, wild-type PurK

706630

0.017

HCO3-

Aspergillus clavatus

A1CII2

mutant enzyme R271K, in 50 mM HEPES, pH 7.8, at 37°C

727030

6.7

HCO3-

Aspergillus clavatus

A1CII2

mutant enzyme Y152A, in 50 mM HEPES, pH 7.8, at 37°C

727030

8.3

HCO3-

Aspergillus clavatus

A1CII2

mutant enzyme E73A, in 50 mM HEPES, pH 7.8, at 37°C

727030

15

HCO3-

Aspergillus clavatus

A1CII2

mutant enzyme D153A, in 50 mM HEPES, pH 7.8, at 37°C

727030

16.7

HCO3-

Aspergillus clavatus

A1CII2

mutant enzyme R155A, in 50 mM HEPES, pH 7.8, at 37°C

727030

16.7

HCO3-

Aspergillus clavatus

A1CII2

mutant enzyme Y152F, in 50 mM HEPES, pH 7.8, at 37°C

727030

16.7

HCO3-

Aspergillus clavatus

A1CII2

wild type enzyme, in 50 mM HEPES, pH 7.8, at 37°C

727030