6.3.4.13: phosphoribosylamine-glycine ligase
This is an abbreviated version!
For detailed information about phosphoribosylamine-glycine ligase, go to the full flat file.
Reaction
Synonyms
2-Amino-N-ribosylacetamide 5'-phosphate kinosynthase, 5'-Phosphoribosylglycinamide synthetase, ade5, EC 6.3.1.3, GAR synthetase, GAR-syn, GARS, GARSase, GART, Glycinamide ribonucleotide synthetase, glycinamide ribotide synthetase, Glycineamide ribonucleotide synthetase, Phosphoribosylglycinamide synthetase, Phosphoribosylglycineamide synthetase, PRG synthetase, PUR2,5, Synthetase, phosphoribosylglycinamide, trifunctional purine biosynthetic protein adenosine-3
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General Information
General Information on EC 6.3.4.13 - phosphoribosylamine-glycine ligase
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malfunction
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gart and paics mutants have pigmentation defects and microphthalmia
metabolism
physiological function
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gart and paics function are required for eye growth. IMP feeds into an ATP pathway required for retinoblast proliferation and a GTP pathway required for pigmentation
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the trifunctional enzyme catalyzes steps 2, 3, and 5 of inosine monophosphate synthesis, followed by paics encoded phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazole succinocarboxamide synthetase, a bifunctional enzyme that catalyzes steps 6 and 7 of this process. Crucial requirement for maternally derived gart and paics. De novo purine synthesis pathway, overview
metabolism
Pur2,5 encodes a bifunctional enzyme that catalyzes the second and the fifth steps of de novo purine biosynthesis pathway andshows dual enzymatic activity - of glycinamide ribotide synthetase and of aminoim-idazole ribotide synthetase