6.3.4.13: phosphoribosylamine-glycine ligase

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For detailed information about phosphoribosylamine-glycine ligase, go to the full flat file.

Word Map on EC 6.3.4.13

6.3.4.13

transformylase

aminoimidazole

formyltransferase

amidotransferase

phosphoribosylaminoimidazole

phosphoribosylpyrophosphate

medicine

Reaction

Synonyms

2-Amino-N-ribosylacetamide 5'-phosphate kinosynthase, 5'-Phosphoribosylglycinamide synthetase, ade5, EC 6.3.1.3, GAR synthetase, GAR-syn, GARS, GARSase, GART, Glycinamide ribonucleotide synthetase, glycinamide ribotide synthetase, Glycineamide ribonucleotide synthetase, Phosphoribosylglycinamide synthetase, Phosphoribosylglycineamide synthetase, PRG synthetase, PUR2,5, Synthetase, phosphoribosylglycinamide, trifunctional purine biosynthetic protein adenosine-3

ECTree

6 Ligases

6.3 Forming carbon-nitrogen bonds

6.3.4 Other carbon-nitrogen ligases

6.3.4.13 phosphoribosylamine-glycine ligase

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Results	in table
43746	AA Sequence
1	Application
1	CAS Registry Number
13	Cloned(Commentary)
1	Cofactor
5	Crystallization (Commentary)
10	Disease/ Diagnostics
4	General Information
1	General Stability
4	Inhibitors
19	KM Value [mM]
1	Localization
1	Metals/Ions
14	Molecular Weight [Da]
31	Natural Substrates/ Products (Substrates)
95	Organism
8	Pathway
32	PDB ID
2	pH Optimum
1	pH Range
2	Protein Variants
10	Purification (Commentary)
21	Reaction
1	Reaction Type
54	Reference
12	Source Tissue
8	Specific Activity [micromol/min/mg]
3	Storage Stability
105	Substrates and Products (Substrate)
11	Subunits
21	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]
3	Temperature Range [°C]
1	Temperature Stability [°C]
8	Turnover Number [1/s]

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Engineering on EC 6.3.4.13 - phosphoribosylamine-glycine ligase

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Go to Protein Variants Search

P294L

Escherichia coli

P15640

loss of function

649840

additional information

Danio rerio

zygotic gart and paic mutants have pigmentation defects in which xanthophore and iridophore pigmentation is almost completely absent, and melanin-derived pigmentation is significantly decreased, even though pigment cells are present in normal amounts and distributions. Zygotic gart and paics mutants are also microphthalmic, resulting from defects in cell cycle exit of proliferative retinoblasts within the developing eye, severe phenotypes, overview

703376