6.3.4.13: phosphoribosylamine-glycine ligase

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For detailed information about phosphoribosylamine-glycine ligase, go to the full flat file.

Reaction

Synonyms

2-Amino-N-ribosylacetamide 5'-phosphate kinosynthase, 5'-Phosphoribosylglycinamide synthetase, ade5, EC 6.3.1.3, GAR synthetase, GAR-syn, GARS, GARSase, GART, Glycinamide ribonucleotide synthetase, glycinamide ribotide synthetase, Glycineamide ribonucleotide synthetase, Phosphoribosylglycinamide synthetase, Phosphoribosylglycineamide synthetase, PRG synthetase, PUR2,5, Synthetase, phosphoribosylglycinamide, trifunctional purine biosynthetic protein adenosine-3

ECTree

     6 Ligases

         6.3 Forming carbon-nitrogen bonds

             6.3.4 Other carbon-nitrogen ligases

                6.3.4.13 phosphoribosylamine-glycine ligase

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Results	in table
43746	AA Sequence
1	Application
1	CAS Registry Number
13	Cloned(Commentary)
1	Cofactor
5	Crystallization (Commentary)
10	Disease/ Diagnostics
4	General Information
1	General Stability
4	Inhibitors
19	KM Value [mM]
1	Localization
1	Metals/Ions
14	Molecular Weight [Da]
31	Natural Substrates/ Products (Substrates)
95	Organism
8	Pathway
32	PDB ID
2	pH Optimum
1	pH Range
2	Protein Variants
10	Purification (Commentary)
21	Reaction
1	Reaction Type
54	Reference
12	Source Tissue
8	Specific Activity [micromol/min/mg]
3	Storage Stability
105	Substrates and Products (Substrate)
11	Subunits
21	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]
3	Temperature Range [°C]
1	Temperature Stability [°C]
8	Turnover Number [1/s]

Disease

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Disease on EC 6.3.4.13 - phosphoribosylamine-glycine ligase

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DISEASE

TITLE OF PUBLICATION

LINK TO PUBMED

Alzheimer Disease

Glycinamide ribonucleotide synthetase activity in lymphocytes from patients with Alzheimer's disease and normal controls.

2289000

Down Syndrome

Variation of glycinamide ribonucleotide synthetase levels during in vitro aging of human fibroblasts: implications for gene dosage studies.

3762234

Lymphoma

Mammalian glycinamide ribonucleotide transformylase. Kinetic mechanism and associated de novo purine biosynthetic activities.

2925682

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