6.3.4.13: phosphoribosylamine-glycine ligase

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For detailed information about phosphoribosylamine-glycine ligase, go to the full flat file.

Reaction

Synonyms

2-Amino-N-ribosylacetamide 5'-phosphate kinosynthase, 5'-Phosphoribosylglycinamide synthetase, ade5, EC 6.3.1.3, GAR synthetase, GAR-syn, GARS, GARSase, GART, Glycinamide ribonucleotide synthetase, glycinamide ribotide synthetase, Glycineamide ribonucleotide synthetase, Phosphoribosylglycinamide synthetase, Phosphoribosylglycineamide synthetase, PRG synthetase, PUR2,5, Synthetase, phosphoribosylglycinamide, trifunctional purine biosynthetic protein adenosine-3

ECTree

     6 Ligases

         6.3 Forming carbon-nitrogen bonds

             6.3.4 Other carbon-nitrogen ligases

                6.3.4.13 phosphoribosylamine-glycine ligase

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Results	in table
43746	AA Sequence
1	Application
1	CAS Registry Number
13	Cloned(Commentary)
1	Cofactor
5	Crystallization (Commentary)
10	Disease/ Diagnostics
4	General Information
1	General Stability
4	Inhibitors
19	KM Value [mM]
1	Localization
1	Metals/Ions
14	Molecular Weight [Da]
31	Natural Substrates/ Products (Substrates)
95	Organism
8	Pathway
32	PDB ID
2	pH Optimum
1	pH Range
2	Protein Variants
10	Purification (Commentary)
21	Reaction
1	Reaction Type
54	Reference
12	Source Tissue
8	Specific Activity [micromol/min/mg]
3	Storage Stability
105	Substrates and Products (Substrate)
11	Subunits
21	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]
3	Temperature Range [°C]
1	Temperature Stability [°C]
8	Turnover Number [1/s]

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Application on EC 6.3.4.13 - phosphoribosylamine-glycine ligase

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APPLICATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

medicine

Homo sapiens

P22102

high GART expression is observed in glioma and is related to the grade of malignancy. GART overexpression is significantly associated with overall survival. Transfecting cells with GART-siRNA suppresses proliferation and enhances temozolomide-induced apoptosis in glioma cells

745966