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6.2.1.8: oxalate-CoA ligase

This is an abbreviated version!
For detailed information about oxalate-CoA ligase, go to the full flat file.

Word Map on EC 6.2.1.8

Reaction

ATP
+
oxalate
+
CoA
=
AMP
+
diphosphate
+
oxalyl-CoA

Synonyms

AAE3, acyl activating enzyme3, acyl-activating enzyme 3, acyl-activating enzyme3, OCS, Oxalate:CoA ligase (AMP), Oxalyl CoA synthetase, Oxalyl coenzyme A synthetase, Oxalyl-CoA synthetase, ScAAE3, Synthetase, oxalyl coenzyme A

ECTree

     6 Ligases
         6.2 Forming carbon-sulfur bonds
             6.2.1 Acid-thiol ligases
                6.2.1.8 oxalate-CoA ligase

Engineering

Engineering on EC 6.2.1.8 - oxalate-CoA ligase

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
H214A
the mutant shows strongly reduced activity compared to the wild type enzyme
H319A
the mutant shows strongly reduced activity compared to the wild type enzyme
K500A
the mutant shows strongly reduced activity compared to the wild type enzyme
R409A
the mutant shows strongly reduced activity compared to the wild type enzyme
S289A
the mutant shows strongly reduced activity compared to the wild type enzyme
C219G
-
the mutant shows 5.6% activity compared to the wild type enzyme
C287G
-
the mutant shows 25.4% activity compared to the wild type enzyme
C363G
-
the mutant shows 7.2% activity compared to the wild type enzyme
C454G
-
the mutant shows 44.5% activity compared to the wild type enzyme
C473G
-
the mutant shows 42.9% activity compared to the wild type enzyme
additional information