6.2.1.8: oxalate-CoA ligase

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For detailed information about oxalate-CoA ligase, go to the full flat file.

Reaction

Synonyms

AAE3, acyl activating enzyme3, acyl-activating enzyme 3, acyl-activating enzyme3, OCS, Oxalate:CoA ligase (AMP), Oxalyl CoA synthetase, Oxalyl coenzyme A synthetase, Oxalyl-CoA synthetase, ScAAE3, Synthetase, oxalyl coenzyme A

ECTree

     6 Ligases

         6.2 Forming carbon-sulfur bonds

             6.2.1 Acid-thiol ligases

                6.2.1.8 oxalate-CoA ligase

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Results	in table
9	AA Sequence
1	CAS Registry Number
4	Cloned(Commentary)
6	Cofactor
1	Crystallization (Commentary)
3	Expression
11	General Information
8	Inhibitors
14	KM Value [mM]
6	Localization
3	Metals/Ions
9	Natural Substrates/ Products (Substrates)
21	Organism
3	Pathway
6	PDB ID
5	pH Optimum
3	pH Range
11	Protein Variants
5	Purification (Commentary)
1	Reaction
1	Reaction Type
21	Reference
18	Source Tissue
1	Specific Activity [micromol/min/mg]
20	Substrates and Products (Substrate)
2	Subunits
25	Synonyms
1	Systematic Name

Inhibitors

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Inhibitors on EC 6.2.1.8 - oxalate-CoA ligase

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INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

1-ethyl-3-(3-dimethylaminopropyl)carbodiimide

Oryza sativa

-

almost complete inhibition at 5 mM

746008

5,5'-dithiobis-(2-nitrobenzoic acid)

Oryza sativa

-

less than 10% residual activity at 0.1 mM

746008

hydroxylamine

Pisum sativum

-

inhibition of ATP-diphosphate exchange

847

MgCl2

Pisum sativum

-

high concentrations cause a marked inhibition of ATP-diphosphate exchange

847

N-ethylmaleimide

Oryza sativa

-

complete inhibition in Tris-HCl at 0.1 mM

746008

NaF

Pisum sativum

-

slight inhibition of ATP-diphosphate exchange

847

oxalate

Pisum sativum

-

high concentrations cause a slight inhibition of ATP-diphosphate exchange

847

PCMB

Pisum sativum

-

inhibition of ATP-diphosphate exchange. Reversal of inhibition by GSH or cysteine

847